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| 1 | Atg7 is required for acrosome biogenesis during spermatogenesis in mice显示文摘acrosome 是盖住精子原子核的前面的部分并且在授精的过程起一个必要作用的一个专业化细胞器。位于这个 lysosome 相关的细胞器(LRO ) 的生物的续生说下面的分子的机制大部分仍然是未知的。这里,我们显示出房间特定的 Atg7 大美人老鼠是的那个细菌由于在 acrosome 生物的续生说的一个缺点不肥沃并且显示了类似于人的 globozoospermia 的显型;这个繁殖缺点被 intracytoplasmic 精子注射成功地救。而且,在细菌房间的 Atg7 的弄空没影响细菌房间的开发的早阶段,但是精子发生在以后上演,在 Golgi 期间没有通过到保险丝进一个单个 acrosomal 泡的 proacrosomal 泡分阶段执行,它最后导致了不规则或将近 round-headed 精子。Autophagic 流动在弄空 Atg7 的细菌房间被破坏,最后导致 LC3 变化形式的失败到 Golgi 导出仪器的泡。另外, Atg7 部分调整了另一 globozoospermia 相关的蛋白质,联系 Golgi 的 PDZ 卷和卷卷包含主题的蛋白质(GOPC ) ,在 acrosome 生物的续生说期间。最后,任何一个 autophagy 的注射或进睾丸的 lysosome 禁止者导致了类似的显型到细菌的房间特定的 Atg7 大美人老鼠。总的来说,我们的结果揭开为在 acrosome 的生物的续生说的 Atg7 的一个新角色,并且我们提供证据为 acrosome 支持 autolysosome 起源假设。 | Hongna Wang Haifeng Wan Xixia Li Weixiao Liu Qi Chen Yaqing Wang Lin Yang Hongmei Tang Xiujun Zhang Enkui Duan Xiaoyang Zhao Fei Gao Wei Li | 2014 | Cell Research2014，24，7： | 25 |
| 2 | Structural insights into the TRIM family of ubiquitin E3 ligases显示文摘 | Yang Li Han Wu Wei Wu Wei Zhuo Weixiao Liu Yixiao Zhang Minzhang Cheng Ye-Guang Chen Ning Gao Hongtao Yu Linfang Wang Wei Li Maojun Yang | 2014 | Cell Research2014，24，6： | 12 |
| 3 | G protein-coupled receptor 183 facilitates endothelial-to- hematopoietic transition via Notch1 inhibition显示文摘 | Panpan Zhang Qiuping He Dongbo Chen Weixiao Liu Lu Wang Chunxia Zhang Dongyuan Ma Wei Li Bing Liu Feng Liu | 2015 | Cell Research2015，25，10： | 7 |
| 4 | Evaluation of human epidermal growth factor receptor 2 status of breast cancer using preoperative multidetector computed tomography with deep learning and handcrafted radiomics features显示文摘Objective:To evaluate the human epidermal growth factor receptor 2(HER2)status in patients with breast cancer using multidetector computed tomography(MDCT)-based handcrafted and deep radiomics features.Methods:This retrospective study enrolled 339 female patients(primary cohort,n=177;validation cohort,n=162)with pathologically confirmed invasive breast cancer.Handcrafted and deep radiomics features were extracted from the MDCT images during the arterial phase.After the feature selection procedures,handcrafted and deep radiomics signatures and the combined model were built using multivariate logistic regression analysis.Performance was assessed by measures of discrimination,calibration,and clinical usefulness in the primary cohort and validated in the validation cohort.Results:The handcrafted radiomics signature had a discriminative ability with a C-index of 0.739[95%confidence interval(95%CI):0.661-0.818]in the primary cohort and 0.695(95%CI:0.609-0.781)in the validation cohort.The deep radiomics signature also had a discriminative ability with a C-index of 0.760(95%CI:0.690-0.831)in the primary cohort and 0.777(95%CI:0.696-0.857)in the validation cohort.The combined model,which incorporated both the handcrafted and deep radiomics signatures,showed good discriminative ability with a C-index of 0.829(95%CI:0.767-0.890)in the primary cohort and 0.809(95%CI:0.740-0.879)in the validation cohort.Conclusions:Handcrafted and deep radiomics features from MDCT images were associated with HER2 status in patients with breast cancer.Thus,these features could provide complementary aid for the radiological evaluation of HER2 status in breast cancer. | Xiaojun Yang Lei Wu Ke Zhao Weitao Ye Weixiao Liu Yingyi Wang Jiao Li Hanxiao Li Xiaomei Huang Wen Zhang Yanqi Huang Xin Chen Su Yao Zaiyi Liu Changhong Liang | 2020 | Chinese Journal of Cancer Research2020，32，2： | 4 |
| 5 | Revisiting the role of delta-1-pyrroline-5-carboxylate synthetase in drought-tolerant crop breeding显示文摘The delta-1-pyrroline-5-carboxylate synthetase(P5CS)gene exercises a protective function in stressed plants.However,the relationship between proline accumulation caused by P5CS and abiotic stress tolerance in plants is not always clear,as P5CS overexpression has been reported to repress plant growth under normal conditions in several reports.We re-evaluated the role of P5CS in drought-tolerant rice breeding by expressing the AtP5CS1 and feedback-inhibition-removed AtP5CS1(AtP5CS1^(F128A))genes under the regulation of an ABA-inducible promoter to avoid the potential side effects of P5CS overexpression under normal conditions.ABA-inducible AtP5CS1 and AtP5CS1^(F128A) increased seedling growth in a nutrient solution(under osmotic stress)and grain yield in pot plants.However,the evidently deleterious effects of AtP5CS1 on grain quality,tiller number,and grain yield in the field indicated the unsuitability of P5CS for drought-tolerance breeding. | Xuanjun Feng Yue Hu Weixiao Zhang Rongqian Xie Huarui Guan Hao Xiong Li Jia Xuemei Zhang Hanmei Zhou Dan Zheng Ying Wen Qingjun Wang Fengkai Wu Jie Xu Yanli Lu | 2022 | The Crop Journal2022，10，4： | 2 |
| 6 | Remote-controlled flexible pose measurement system and method for a moving target in wind tunnel显示文摘The measurement of position and attitude parameters for the isolated target from a highspeed aircraft is a great challenge in the field of wind tunnel simulation technology.This paper proposes a remote-controlled flexible pose measurement system in wind tunnel conditions for the separation of a target from an aircraft.The position and attitude parameters of a moving object are obtained by utilizing a single camera with a focal length and camera orientation that can be changed based on different measurement conditions.Using this proposed system and method, both the flexibility and efficiency of the pose measurement system can be enhanced in wind tunnel conditions to meet the measurement requirements of different objects and experiments, which is also useful for the development of an intelligent position and attitude measurement system.The position and the focal length of the camera also can be controlled remotely during measurements to enlarge both the vertical and horizontal measurement range of this system.Experiments are conducted in the laboratory to measure the position and attitude of moving objects with high flexibility and efficiency,and the measurement precision of the measurement system is also verified through experiments. | Wei LIU Xin MA Ling CHEN Zhenyuan JIA Weixiao LIU Xiao LI Jiakun ZHANG Jiwen LU | 2018 | Chinese Journal of Aeronautics2018，31，1： | 2 |
| 7 | Resource allocation algorithm for multi-user MIMO-OFDM downlink with correlated channels显示文摘To minimize transmitting power,an adaptive resource allocation algorithm is proposed for multi-user multiple input multiple output-orthogonal frequency division multiplexing(MIMO-OFDM)downlink with correlated channels,which,based on the user’s grouping according to their spatial correlations,combines the shared manner and the exclusive manner to allocate sub-carriers.Between different groups the shared manner with a null steering method based on group marginal users is applied,whereas within a group the exclusive manner is applied.The simulations show that the power efficiency and spectral efficiency are improved;the base station transmitting antenna number and the computational complexity is decreased. | Chengwen ZHANG Zhongzhao ZHANG Weixiao MENG | 2008 | Frontiers of Electrical and Electronic Engineering in China2008，3，3： | 1 |
| 8 | Effects of Dietary Protein and Fat Levels on Growth Performance and Serum Biochemical Parameters of Male Mink显示文摘This experiment was conducted to evaluate the effects of dietary protein and fat levels on growth performance and serum biochemical parameters of male minks during the growing period. A total of 90 healthy male minks at the age of 60 d were randomly assigned into six groups with 15 replicates per group and one mink per replicate. The minks were fed six experimental diets with two protein levels( 32% and 36%) and three fat levels( 10%,20% and 30%) for a 7-day preliminary period and then for 60-day experimental period. The results showed that the final body weight and average daily weight gain( ADWG) were significantly higher in low-protein,middle-fat group and low-protein,high-fat group than those in low-protein,low-fat group and high-protein,low-fat group( P < 0. 01). The final weight and ADWG were increased with dietary fat level increasing,and the two indices of 20% and 30% fat groups were significantly higher than those of 10%fat groups( P < 0. 01). The ratio of feed intake to weight gain( F/G) in low-protein,high-fat group was the lowest,which was significantly lower than that in lowprotein,low-fat group and high-protein,high-fat group( P < 0. 05). Serum urea nitrogen( UN) in low-protein,high-fat group was significantly lower than that in other groups( P < 0. 01). Serum alanine transaminase( ALT) activity in 32% protein groups was significantly higher than that in 36% protein groups( P < 0. 05). Serum triglyceride( TG) content in low-protein,high-fat group and high-protein,high-fat group was significantly higher than that in low-protein,low-fat group and high-protein,low-fat groups( P < 0. 05). Serum TG,total cholesterol( TCHO) and high-density lipoprotein( HDL) contents increased with the increase in dietary fat level,and they were all the highest in low-protein,high-fat group. The growth performance and serum biochemical parameters of minks were not affected by the interaction between dietary protein and fat levels( P > 0. 05). Considering all the factors,when the dietary protein is 32% and the fat level is20% to 30% under the condition of this experiment,the dietary protein and fat utilization rates are higher,and the male minks during the growing period can get a better growth performance. | Zhang Haihua Zhang Tietao Liu Xiaoying Nan Weixiao Li Guangyu | 2017 | Animal Husbandry and Feed Science2017，9，4： | 1 |
| 9 | Stable self-assembled multilayer films of diazo resin and poly (maleic an- hydride-co-styrene) based on charge-transfer interaction 显示文摘 | Zhang Yougjun Cao Weixiao | 2001 | Langmuir2001，17，16： | 1 |
| 10 | Quantitative mRNA expression analysis of selected genes in patientswith early-stage hypothyroidism induced by treatment with iodine-131显示文摘 | Kun Guo Rui Gao Yan Yu Weixiao Zhang Yuxuan Yang Aimin Yang | 2015 | Molecular Medicine Reports2015，，： | 1 |
| 11 | Composite multiobjective optimization beamforming based on genetic algorithms显示文摘 | 史兢 Meng Weixiao Zhang Naitong Wang Zheng | 2006 | High Technology Letters2006，12，3： | 1 |
| 12 | A Friendship that Has Lasted for Decades显示文摘---An account of activities attended by relatives of wartime international friends and the representatives from friendly foreign organizations to mark the 70thanniversary of China’s victory of the War of Resistance against Japanese Aggression(1937-45)and the World Anti-Fascist | Zhang Weixiao | 2015 | Voice of Friendship2015，，4： | 0 |
| 13 | Female Powers in Film and Television显示文摘Only female-themed film and television more in tune with reality and consensus will really resonate with the audience and thrive in the market.On March 8 this year,with guidance from the All-China Women's Federation,Beijing based online video platform Youku released the 2022 report'Women on Screen.' | Si Ruo Zhang Weixiao | 2022 | China Pictorial2022，，4： | 0 |
| 14 | Microbial responses to the use of NaClO in sediment treatment显示文摘Chlorine is often used in algal removal and deodorization of landscape waters,and occasionally used as an emergency treatment of heavily polluted sediments.However,the ecological impact of this practice has not been fully studied and recognized.In this study,NaClO at 0.1 mmol/g based on dry weight sediment was evenly mixed into the polluted sediment,and then the sediment was incubated for 150 days to evaluate its microbial effect.Results showed that NaClO addition enhanced the release of TOC,TN,Cr and Cu from the sediment.The microbial richness in the examined sediment decreased continuously,and the Chao1 index declined from 4241 to 2731,in 150 days.The microbial community composition was also changed.The abundance of Proteobacteria and Bacteroidetes increased to 54.8%and 4.2%within 7 days compared to the control,and linear discriminant analysis(LDA)showed gram-negative bacteria and aerobic bacteria enriched after chlorination.The functional prediction with PICRUSt2 showed the functions of the microbial community underwent major adjustments,and the metabolic-related functions such as carbon metabolism,including pyruvate and methane metabolisms were significantly inhibited;besides,15 out of 22 analyzed key enzymes involved in C cycling and 6 out of 12 key enzymes or genes involved in N cycling were strongly impacted,and the enzymes and genes involved in carbon degradation and denitrification showed remarkable downregulation.It can be concluded that chlorination posed a seriously adverse effect on microbial community structure and function.This study deepens the understanding of the ecological effects of applying chlorine for environmental remediation. | Kun Li Tingming Ye Wang Zhang Jianfeng Peng Yaohui Bai Weixiao Qi Huijuan Liu | 2022 | Frontiers of Environmental Science & Engineering2022，16，2： | 0 |
| 15 | Asymptotic Analysis and Precoding Design of Integrated Access and Backhaul in Full-Duplex mmWave Networks显示文摘In this paper,we consider a full-duplex(FD)millimeter wave(mmWave)multiuser integrated access and backhaul(IAB)system with massive MIMO,and the system asymptotic performance and interference cancellation schemes are investigated.First,the asymptotic performance of the IAB system with massive MIMO is analyzed.As the number of macro base station(MBS)and small base station(SBS)antennas approaches infinity,the FD selfinterference(SI),inter-tier interference and noise can be eliminated,which means that only multiuser interference remains in the system.Then,multiuser interference can be suppressed by the base band(BB)precoders.Since all interference and noise are suppressed,the spectral efficiency of the SBS and users are infinite in theory.Then,two interference suppression precoding schemes are proposed.A block diagonalization(BD)-based interference cancellation scheme is designed based on the channel characteristics and null space projection.The FD SI,intertier interference and multiuser interference are eliminated by BB precoders.Instead of eliminating interference completely,a signal to leakage and noise ratio(SLNR)-based precoding scheme is derived to suppress both interference and noise.By utilizing the Rayleigh-Ritz theorem,the SLNRs of the SBS and users are optimized.Simulation results show that all the interference can be effectively eliminated by the BD-based scheme at the cost of spectral efficiency performance loss,while the SLNR-based scheme can balance interference and noise and achieve higher spectral efficiency with comparatively low interference level.Therefore,the BD-based scheme is more suitable for interference elimination cases,and the SLNRbased scheme can improve the system performance in low interference scenarios. | Yi Zhang Shuai Han Weixiao Meng Xunan Li Yue Chen | 2022 | China Communications2022，19，5： | 0 |
| 16 | Resource allocation for multiuser STBC-BF MIMO-OFDM downlink with imperfect channel information显示文摘To improve the performance of a multiuser MIMO-OFDM system with imperfect channel status information,a downlink adaptive resource allocation algorithm which combines space-time block coding and beam forming(STBC-BF) is proposed.The algorithm allocates the subcarriers with a shared manner.A zero forcing processing with joint Rx-Tx is used to suppress the co-channel interference(CCI) and to construct uncorrelated channels for STBC.An adaptive power allocation for the STBC equivalent channels can increase signal to interference and noise ratio at the receiver.Simulation results show that under the condition of an imperfect CSI,the proposed algorithm improves the system performance and reduces the number of BS transmit antennas required. | Zhang Chengwen Liao Minghong Zhang Zhongzhao Meng Weixiao | 2009 | Journal of Systems Engineering and Electronics2009，20，4： | 0 |
| 17 | Stabilizing and structuring oil–oil interfaces by molecular brush surfactants显示文摘Oil-in-oil emulsions provide a unique platform for numerous applications not compatible with water or aqueous systems.However,the limited types and complicated synthesis process of surfactants are problematic.Here,we put forward a simple,yet powerful strategy to stabilize the oil–oil interface,then prepare oil-in-oil emulsions,by using the co-assembly of polar molecular brushes and nonpolar oligomeric ligands at the DMF–octane interface.Molecular brush surfactants(MBSs)form and assemble in situ at the interface,minimizing the interfacial energy and producing a robust film.We find that the binding energy of MBS to the interface is sufficiently high,leading to the construction of structured liquids by the interfacial jamming of MBSs.Using MBSs as emulsifiers,different types of emulsions including DMF-inoctane,octane-in-DMF,and high internal phase emulsions can be easily prepared,showing promising applications in microreactor systems and advanced composite materials. | Beibei Wang Zhao Zhang Weixiao Feng Jiaqiu Luo Shaowei Shi | 2022 | Aggregate2022，3，6： | 0 |
| 18 | In vitro investigation of a new thrombus aspiration and autologous blood reinfusion system显示文摘Purpose: The aim of the study was to evaluate the feasibility of a new venous-thrombus aspiration and autologous blood(auto-blood) reinfusion system.Materials and methods: We constructed the venous model from polyvinyl chloride(PVC) tubes and three-way unions using a fresh clot of chicken blood as the venous thrombus. Eight French and 12 F aspiration catheters were used to aspirate the thrombus in the right–pulmonary-artery model, 8 French and 14 F aspiration catheters were used in the inferior–vena cava model, and 8 French and 10 F aspiration catheters were used in the left-–iliofemoral-vein model. A thrombus filtration and auto-blood reinfusion bottle was used to filter the thrombus and re-infuse auto-blood. We evaluated the thrombus aspiration capability of each catheter by comparing preaspirated with the post-aspirated thrombus volume, and we evaluated the difference in aspiration capability between the two catheters in each model by comparing their thrombus aspiration rates. We used Student’s t-test for statistical analysis.Results: Differences between pre-aspirated and post-aspirated thrombus volumes for each catheter were insignificant, as were those between the thrombus aspiration rates of the two catheters in each venous model. Using the thrombus aspiration and auto-blood reinfusion system, each aspiration catheter could fluently aspirate the thrombus out of the venous model.Conclusion: In this study, we designed a new venous-thrombus aspiration system. This system could be used to aspirate acute venous thrombi and re-infuse autologous blood. | Weixiao Li Qiang Li Shuiting Zhai Tianxiao Li Nick Cheshire Zhidong Zhang Kai Liang | 2019 | Journal of Interventional Medicine2019，2，1： | 0 |
| 19 | Two-dimensional rectangular bismuth bilayer:A novel dual topological insulator显示文摘Dual topological insulator(DTI),which simultaneously hosts topological insulator(TI)and topological crystalline insulator(TCI)phases,has attracted extensive attention since it has a better robustness of topological nature and broad application prospects in spintronics.However,the realization of DTI phase in two-dimensional(2D)system is extremely scarce.By first-principles calculations,we predict that the 2D rectangular bismuth(R–Bi)bilayer is a novel DTI,featured by topological invariant=1,mirror Chern number C_(M)=–1,and metallic edge states within the bulk band gap.More interestingly,the TCI phase in bilayer is protected by horizontal glide mirror symmetries,rather than the usual mirror symmetry.The bulk band gap can be effectively tuned by vertical electric field and strain.Besides,the electric field can trigger the transition between TI and metallic phases for the bilayer,accompanied by the annihilation of TCI phase.On this basis,a topological field effect transistor is proposed,which can rapidly manipulate spin and charge carriers via electric field.The KBr(110)surface is demonstrated as an ideal substrate for the deposition of bilayer.These findings provide not only a new strategy for exploiting 2D DTI,but also a promising candidate for spintronic applications. | Shengshi Li Weixiao Ji Jianping Zhang Yaping Wang Changwen Zhang Shishen Yan | 2023 | Frontiers of physics2023，18，4： | 0 |
| 20 | High-quality assembled and annotated genomes of Nicotiana tabacum and Nicotiana benthamiana reveal chromosome evolution and changes in defense arsenals显示文摘Nicotiana tabacum and Nicotiana benthamiana are widely used models in plant biology research.However,genomic studies of these species have lagged.Here we report the chromosome-level reference genome assemblies for N.benthamiana and N.tabacum with an estimated 99.5%and 99.8%completeness,respec-tively.Sensitive transcription start and termination site sequencing methods were developed and used for accurate gene annotation in N.tabacum.Comparative analyses revealed evidence for the parental origins and chromosome structural changes,leading to hybrid genome formation of each species.Interestingly,theantiviral silencinggenesRDR1,RDR6,DCL2,DCL3,andAGO2were lost from one or both subgenomes in N.benthamiana,while both homeologs were kept in N.tabacum.Furthermore,the N.benthamiana genome encodes fewer immune receptors and signaling components than that of N.tabacum.These find-ings uncover possible reasons underlying the hypersusceptible nature of N.benthamiana.We developed the user-friendly Nicomics(http:/lifenglab.hzau.edu.cn/Nicomics/)web server to facilitate better use of Nicotiana genomic resources as well as gene structure and expression analyses. | Jubin Wang Qingling Zhang Jeffrey Tung Xi Zhang Dan Liu Yingtian Deng Zhendong Tian Huilan Chen Taotao Wang Weixiao Yin Bo Lij Zhibing Lai Savithramma P.Dinesh-Kumar Barbara Baker Feng Li | 2024 | Molecular Plant2024，17，3： | 0 |
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