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| 1 | Atg7 is required for acrosome biogenesis during spermatogenesis in mice显示文摘acrosome 是盖住精子原子核的前面的部分并且在授精的过程起一个必要作用的一个专业化细胞器。位于这个 lysosome 相关的细胞器(LRO ) 的生物的续生说下面的分子的机制大部分仍然是未知的。这里,我们显示出房间特定的 Atg7 大美人老鼠是的那个细菌由于在 acrosome 生物的续生说的一个缺点不肥沃并且显示了类似于人的 globozoospermia 的显型;这个繁殖缺点被 intracytoplasmic 精子注射成功地救。而且,在细菌房间的 Atg7 的弄空没影响细菌房间的开发的早阶段,但是精子发生在以后上演,在 Golgi 期间没有通过到保险丝进一个单个 acrosomal 泡的 proacrosomal 泡分阶段执行,它最后导致了不规则或将近 round-headed 精子。Autophagic 流动在弄空 Atg7 的细菌房间被破坏,最后导致 LC3 变化形式的失败到 Golgi 导出仪器的泡。另外, Atg7 部分调整了另一 globozoospermia 相关的蛋白质,联系 Golgi 的 PDZ 卷和卷卷包含主题的蛋白质(GOPC ) ,在 acrosome 生物的续生说期间。最后,任何一个 autophagy 的注射或进睾丸的 lysosome 禁止者导致了类似的显型到细菌的房间特定的 Atg7 大美人老鼠。总的来说,我们的结果揭开为在 acrosome 的生物的续生说的 Atg7 的一个新角色,并且我们提供证据为 acrosome 支持 autolysosome 起源假设。 | Hongna Wang Haifeng Wan Xixia Li Weixiao Liu Qi Chen Yaqing Wang Lin Yang Hongmei Tang Xiujun Zhang Enkui Duan Xiaoyang Zhao Fei Gao Wei Li | 2014 | Cell Research2014，24，7： | 25 |
| 2 | The seamless model for three-dimensional datum transformation显示文摘With extensive applications of space geodesy, three-dimensional datum transformation model has been necessarily used to transform the coordinates in the different coordinate systems.Its essence is to predict the coordinates of non-common points in the second coordinate system based on their coordinates in the first coordinate system and the coordinates of common points in two coordinate systems.Traditionally, the computation of seven transformation parameters and the transformation of noncommon points are individually implemented, in which the errors of coordinates are taken into account only in the second system although the coordinates in both two systems are inevitably contaminated by the random errors.Moreover, the coordinate errors of non-common points are disregarded when they are transformed using the solved transformation parameters.Here we propose the seamless (rigorous) datum transformation model to compute the transformation parameters and transform the non-common points integratively, considering the errors of all coordinates in both coordinate systems.As a result, a nonlinear coordinate transformation model is formulated.Based on the Gauss-Newton algorithm and the numerical characteristics of transformation parameters, two linear versions of the established nonlinear model are individually derived.Then the least-squares collocation (prediction) method is employed to trivially solve these linear models.Finally, the simulation experiment is carried out to demonstrate the performance and benefits of the presented method.The results show that the presented method can significantly improve the precision of the coordinate transformation, especially when the non-common points are strongly correlated with the common points used to compute the transformation parameters. | LI BoFeng SHEN YunZhong LI WeiXiao | 2012 | Science China Earth Sciences2012，55，12： | 19 |
| 3 | Structural insights into the TRIM family of ubiquitin E3 ligases显示文摘 | Yang Li Han Wu Wei Wu Wei Zhuo Weixiao Liu Yixiao Zhang Minzhang Cheng Ye-Guang Chen Ning Gao Hongtao Yu Linfang Wang Wei Li Maojun Yang | 2014 | Cell Research2014，24，6： | 12 |
| 4 | G protein-coupled receptor 183 facilitates endothelial-to- hematopoietic transition via Notch1 inhibition显示文摘 | Panpan Zhang Qiuping He Dongbo Chen Weixiao Liu Lu Wang Chunxia Zhang Dongyuan Ma Wei Li Bing Liu Feng Liu | 2015 | Cell Research2015，25，10： | 7 |
| 5 | Evaluation of human epidermal growth factor receptor 2 status of breast cancer using preoperative multidetector computed tomography with deep learning and handcrafted radiomics features显示文摘Objective:To evaluate the human epidermal growth factor receptor 2(HER2)status in patients with breast cancer using multidetector computed tomography(MDCT)-based handcrafted and deep radiomics features.Methods:This retrospective study enrolled 339 female patients(primary cohort,n=177;validation cohort,n=162)with pathologically confirmed invasive breast cancer.Handcrafted and deep radiomics features were extracted from the MDCT images during the arterial phase.After the feature selection procedures,handcrafted and deep radiomics signatures and the combined model were built using multivariate logistic regression analysis.Performance was assessed by measures of discrimination,calibration,and clinical usefulness in the primary cohort and validated in the validation cohort.Results:The handcrafted radiomics signature had a discriminative ability with a C-index of 0.739[95%confidence interval(95%CI):0.661-0.818]in the primary cohort and 0.695(95%CI:0.609-0.781)in the validation cohort.The deep radiomics signature also had a discriminative ability with a C-index of 0.760(95%CI:0.690-0.831)in the primary cohort and 0.777(95%CI:0.696-0.857)in the validation cohort.The combined model,which incorporated both the handcrafted and deep radiomics signatures,showed good discriminative ability with a C-index of 0.829(95%CI:0.767-0.890)in the primary cohort and 0.809(95%CI:0.740-0.879)in the validation cohort.Conclusions:Handcrafted and deep radiomics features from MDCT images were associated with HER2 status in patients with breast cancer.Thus,these features could provide complementary aid for the radiological evaluation of HER2 status in breast cancer. | Xiaojun Yang Lei Wu Ke Zhao Weitao Ye Weixiao Liu Yingyi Wang Jiao Li Hanxiao Li Xiaomei Huang Wen Zhang Yanqi Huang Xin Chen Su Yao Zaiyi Liu Changhong Liang | 2020 | Chinese Journal of Cancer Research2020，32，2： | 4 |
| 6 | Revisiting the role of delta-1-pyrroline-5-carboxylate synthetase in drought-tolerant crop breeding显示文摘The delta-1-pyrroline-5-carboxylate synthetase(P5CS)gene exercises a protective function in stressed plants.However,the relationship between proline accumulation caused by P5CS and abiotic stress tolerance in plants is not always clear,as P5CS overexpression has been reported to repress plant growth under normal conditions in several reports.We re-evaluated the role of P5CS in drought-tolerant rice breeding by expressing the AtP5CS1 and feedback-inhibition-removed AtP5CS1(AtP5CS1^(F128A))genes under the regulation of an ABA-inducible promoter to avoid the potential side effects of P5CS overexpression under normal conditions.ABA-inducible AtP5CS1 and AtP5CS1^(F128A) increased seedling growth in a nutrient solution(under osmotic stress)and grain yield in pot plants.However,the evidently deleterious effects of AtP5CS1 on grain quality,tiller number,and grain yield in the field indicated the unsuitability of P5CS for drought-tolerance breeding. | Xuanjun Feng Yue Hu Weixiao Zhang Rongqian Xie Huarui Guan Hao Xiong Li Jia Xuemei Zhang Hanmei Zhou Dan Zheng Ying Wen Qingjun Wang Fengkai Wu Jie Xu Yanli Lu | 2022 | The Crop Journal2022，10，4： | 2 |
| 7 | Civil Aircraft Assisted Space-Air-Ground Integrated Networks: Architecture Design and Coverage Analysis显示文摘In this paper, we propose a novel AIenabled space-air-ground integrated networks(SAGIN). This new integrated networks architecture consists of LEO satellites and civil aircrafts carrying aerial base stations, called 'civil aircraft assisted SAGIN(CAA-SAGIN)'. The assistance of civil aircrafts can reduce the stress of satellite networks, improve the performance of SAGIN, decrease the construction cost and save space resources. Taking the Chinese mainland as an example, this paper has analyzed the distribution of civil aircrafts, and obtained the coverage characteristics of civil aircraft assisted networks(CAAN). Taking Starlink as the benchmark, this paper has calculated the service gap of CAAN, and designed the joint coverage constellation. The simulation results prove that the number of satellites in CAASAGIN can be greatly reduced with the assistance of civil aircrafts at the same data rate. | Shuxun Li Qian Chen Zhe Li Weixiao Meng Cheng Li | 2022 | China Communications2022，19，1： | 2 |
| 8 | Remote-controlled flexible pose measurement system and method for a moving target in wind tunnel显示文摘The measurement of position and attitude parameters for the isolated target from a highspeed aircraft is a great challenge in the field of wind tunnel simulation technology.This paper proposes a remote-controlled flexible pose measurement system in wind tunnel conditions for the separation of a target from an aircraft.The position and attitude parameters of a moving object are obtained by utilizing a single camera with a focal length and camera orientation that can be changed based on different measurement conditions.Using this proposed system and method, both the flexibility and efficiency of the pose measurement system can be enhanced in wind tunnel conditions to meet the measurement requirements of different objects and experiments, which is also useful for the development of an intelligent position and attitude measurement system.The position and the focal length of the camera also can be controlled remotely during measurements to enlarge both the vertical and horizontal measurement range of this system.Experiments are conducted in the laboratory to measure the position and attitude of moving objects with high flexibility and efficiency,and the measurement precision of the measurement system is also verified through experiments. | Wei LIU Xin MA Ling CHEN Zhenyuan JIA Weixiao LIU Xiao LI Jiakun ZHANG Jiwen LU | 2018 | Chinese Journal of Aeronautics2018，31，1： | 2 |
| 9 | Self-assembly of single-walled carbon nanotube based on diazoresin显示文摘 | Bo Li Tingbing Cao Weixiao Cao | 2003 | Synthetic Met- als2003，132，1： | 1 |
| 10 | Local mean decomposition combined with SVD and application in telemetry vibration signal processing 显示文摘 | Li Zhenxing Dai Weixiao | 2013 | Applied Mechanics and Materials2013，347，2： | 1 |
| 11 | Effects of Dietary Protein and Fat Levels on Growth Performance and Serum Biochemical Parameters of Male Mink显示文摘This experiment was conducted to evaluate the effects of dietary protein and fat levels on growth performance and serum biochemical parameters of male minks during the growing period. A total of 90 healthy male minks at the age of 60 d were randomly assigned into six groups with 15 replicates per group and one mink per replicate. The minks were fed six experimental diets with two protein levels( 32% and 36%) and three fat levels( 10%,20% and 30%) for a 7-day preliminary period and then for 60-day experimental period. The results showed that the final body weight and average daily weight gain( ADWG) were significantly higher in low-protein,middle-fat group and low-protein,high-fat group than those in low-protein,low-fat group and high-protein,low-fat group( P < 0. 01). The final weight and ADWG were increased with dietary fat level increasing,and the two indices of 20% and 30% fat groups were significantly higher than those of 10%fat groups( P < 0. 01). The ratio of feed intake to weight gain( F/G) in low-protein,high-fat group was the lowest,which was significantly lower than that in lowprotein,low-fat group and high-protein,high-fat group( P < 0. 05). Serum urea nitrogen( UN) in low-protein,high-fat group was significantly lower than that in other groups( P < 0. 01). Serum alanine transaminase( ALT) activity in 32% protein groups was significantly higher than that in 36% protein groups( P < 0. 05). Serum triglyceride( TG) content in low-protein,high-fat group and high-protein,high-fat group was significantly higher than that in low-protein,low-fat group and high-protein,low-fat groups( P < 0. 05). Serum TG,total cholesterol( TCHO) and high-density lipoprotein( HDL) contents increased with the increase in dietary fat level,and they were all the highest in low-protein,high-fat group. The growth performance and serum biochemical parameters of minks were not affected by the interaction between dietary protein and fat levels( P > 0. 05). Considering all the factors,when the dietary protein is 32% and the fat level is20% to 30% under the condition of this experiment,the dietary protein and fat utilization rates are higher,and the male minks during the growing period can get a better growth performance. | Zhang Haihua Zhang Tietao Liu Xiaoying Nan Weixiao Li Guangyu | 2017 | Animal Husbandry and Feed Science2017，9，4： | 1 |
| 12 | Surface hydrophobic modification of ultra-fine aluminum silicate by mechanically grinding and heating显示文摘 | LI Liaosha REN Xue JIA Weixiao | | 0，，22： | 1 |
| 13 | EM-based adaptive frequency domain estimation of Doppler shifts with CRLB analysis for CDMA systems 显示文摘 | Wang Tianqi Li Cheng Meng Weixiao | 2012 | IEEE Transactions on Communications2012，60，1： | 1 |
| 14 | Switchable half-metallicity in A-type antiferromagnetic NiI_(2)bilayer coupled with ferroelectric In_(2)Se_(3)显示文摘Electrically controlled half-metallicity in antiferromagnets is of great significance for both fundamental research and practical application.Here,by constructing van der Waals heterostructures composed of two-dimensional(2D)A-type antiferromagnetic NiI_(2)bilayer(bi-NiI_(2))and ferroelectric In_(2)Se_(3)with different thickness,we propose that the half-metallicity is realizable and switchable in the bi-NiI_(2)proximate to In_(2)Se_(3)bilayer(bi-In_(2)Se_(3)).The polarization flipping of the bi-In_(2)Se_(3)successfully drives transition between half-metal and semiconductor for the bi-NiI_(2).This intriguing phenomenon is attributed to the joint effect of polarization field-induced energy band shift and interfacial charge transfer.Besides,the easy magnetization axis of the bi-NiI_(2)is also dependent on the polarization direction of the bi-In_(2)Se_(3).The half-metallicity and magnetic anisotropy energy of the bi-NiI_(2)in heterostructure can be effectively manipulated by strain.These findings provide not only a feasible strategy to achieve and control half-metallicity in 2D antiferromagnets,but also a promising candidate to design advanced nanodevices. | Yaping Wang Xinguang Xu Xian Zhao Weixiao Ji Qiang Cao Shengshi Li Yanlu Li | 2022 | npj Computational Materials2022，，1： | 1 |
| 15 | An Efficient Method for Identifying Lower Limb Behavior Intentions Based on Surface Electromyography显示文摘Surface electromyography(sEMG)is widely used for analyzing and controlling lower limb assisted exoskeleton robots.Behavior intention recognition based on sEMG is of great significance for achieving intelligent prosthetic and exoskeleton control.Achieving highly efficient recognition while improving performance has always been a significant challenge.To address this,we propose an sEMG-based method called Enhanced Residual Gate Network(ERGN)for lower-limb behavioral intention recognition.The proposed network combines an attention mechanism and a hard threshold function,while combining the advantages of residual structure,which maps sEMG of multiple acquisition channels to the lower limb motion states.Firstly,continuous wavelet transform(CWT)is used to extract signals features from the collected sEMG data.Then,a hard threshold function serves as the gate function to enhance signals quality,with an attention mechanism incorporated to improve the ERGN’s performance further.Experimental results demonstrate that the proposed ERGN achieves extremely high accuracy and efficiency,with an average recognition accuracy of 98.41%and an average recognition time of only 20 ms-outperforming the state-of-the-art research significantly.Our research provides support for the application of lower limb assisted exoskeleton robots. | Liuyi Ling Yiwen Wang Fan Ding Li Jin Bin Feng Weixiao Li Chengjun Wang Xianhua Li | 2023 | Computers, Materials & Continua2023，77，12： | 0 |
| 16 | Microbial responses to the use of NaClO in sediment treatment显示文摘Chlorine is often used in algal removal and deodorization of landscape waters,and occasionally used as an emergency treatment of heavily polluted sediments.However,the ecological impact of this practice has not been fully studied and recognized.In this study,NaClO at 0.1 mmol/g based on dry weight sediment was evenly mixed into the polluted sediment,and then the sediment was incubated for 150 days to evaluate its microbial effect.Results showed that NaClO addition enhanced the release of TOC,TN,Cr and Cu from the sediment.The microbial richness in the examined sediment decreased continuously,and the Chao1 index declined from 4241 to 2731,in 150 days.The microbial community composition was also changed.The abundance of Proteobacteria and Bacteroidetes increased to 54.8%and 4.2%within 7 days compared to the control,and linear discriminant analysis(LDA)showed gram-negative bacteria and aerobic bacteria enriched after chlorination.The functional prediction with PICRUSt2 showed the functions of the microbial community underwent major adjustments,and the metabolic-related functions such as carbon metabolism,including pyruvate and methane metabolisms were significantly inhibited;besides,15 out of 22 analyzed key enzymes involved in C cycling and 6 out of 12 key enzymes or genes involved in N cycling were strongly impacted,and the enzymes and genes involved in carbon degradation and denitrification showed remarkable downregulation.It can be concluded that chlorination posed a seriously adverse effect on microbial community structure and function.This study deepens the understanding of the ecological effects of applying chlorine for environmental remediation. | Kun Li Tingming Ye Wang Zhang Jianfeng Peng Yaohui Bai Weixiao Qi Huijuan Liu | 2022 | Frontiers of Environmental Science & Engineering2022，16，2： | 0 |
| 17 | Asymptotic Analysis and Precoding Design of Integrated Access and Backhaul in Full-Duplex mmWave Networks显示文摘In this paper,we consider a full-duplex(FD)millimeter wave(mmWave)multiuser integrated access and backhaul(IAB)system with massive MIMO,and the system asymptotic performance and interference cancellation schemes are investigated.First,the asymptotic performance of the IAB system with massive MIMO is analyzed.As the number of macro base station(MBS)and small base station(SBS)antennas approaches infinity,the FD selfinterference(SI),inter-tier interference and noise can be eliminated,which means that only multiuser interference remains in the system.Then,multiuser interference can be suppressed by the base band(BB)precoders.Since all interference and noise are suppressed,the spectral efficiency of the SBS and users are infinite in theory.Then,two interference suppression precoding schemes are proposed.A block diagonalization(BD)-based interference cancellation scheme is designed based on the channel characteristics and null space projection.The FD SI,intertier interference and multiuser interference are eliminated by BB precoders.Instead of eliminating interference completely,a signal to leakage and noise ratio(SLNR)-based precoding scheme is derived to suppress both interference and noise.By utilizing the Rayleigh-Ritz theorem,the SLNRs of the SBS and users are optimized.Simulation results show that all the interference can be effectively eliminated by the BD-based scheme at the cost of spectral efficiency performance loss,while the SLNR-based scheme can balance interference and noise and achieve higher spectral efficiency with comparatively low interference level.Therefore,the BD-based scheme is more suitable for interference elimination cases,and the SLNRbased scheme can improve the system performance in low interference scenarios. | Yi Zhang Shuai Han Weixiao Meng Xunan Li Yue Chen | 2022 | China Communications2022，19，5： | 0 |
| 18 | Exploitable magnetic anisotropy and half-metallicity controls in multiferroic van der Waals heterostructure显示文摘Two-dimensional(2D)XY ferromagnets have drawn pronounced interest in recent years,but the characteristic of easy-plane magnetization restricts their application in spintronics to some extent.Here,we propose a general strategy for constructing multiferroic van der Waals heterostructures,aiming to achieve electrical control over the magnetic anisotropy in 2D XY ferromagnets.The validity of this strategy is verified by the heterostructure composed of ferromagnetic VBi_(2)Te_(4) and ferroelectric In_(2)Se_(3) monolayers.By manipulating the polarized states of In_(2)Se_(3),the VBi_(2)Te_(4) can be reversibly transformed between 2D XY and Heisenberg ferromagnets,characterized by the switching of easy magnetization axis between in-plane and out-of-plane directions.More interestingly,accompanied by the changes in magnetic anisotropy,the VBi_(2)Te_(4) also demonstrates a phase transition from a semiconductor to a half-metal state,which can be ascribed to the band alignment and interfacial charge transfer.The switchable magnetic and electronic properties enable the heterostructure to be utilized in nonvolatile memory and logic devices.Additionally,the half-metallicity and magnetocrystalline anisotropy energy of the heterostructure can be effectively tuned by biaxial strain.These findings not only pave the way for electrically nonvolatile control of 2D XY ferromagnet,but also facilitate the development of interfacial magnetoelectric physics and applications. | Yaping Wang Xinguang Xu Weixiao Ji Shengshi Li Yanlu Li Xian Zhao | 2023 | npj Computational Materials2023，，1： | 0 |
| 19 | Impacts of opening baffle of city road tunnels on natural ventilation performance显示文摘Based on the opening baffle mode for natural ventilation of city road tunnels,this paper studies the impacts of opening baffle on natural ventilation performance by verifying numerical simulation through model tests.By analyzing the impacts of installation angle,dimension,location,and quantity of opening baffle on ventilation performance,the paper reached the conclusions as follows:1)When installation angle is larger than 45°and tunnel ventilation is well operated,the baffle exhaust could increase by at least 30%compared to when there is no baffle.2)The baffle reaches its optimal performance when the length of the baffle is equal to the width of the city road tunnels.3)Baffle exhaust could increase by 30%when it is installed in the downstream of openings.4)The performance of a single baffle is better than that of multiple baffles. | Weixiao YANG Jincheng XING Jianxing LI Jihong LING Haixian HAO Zhiqiang YAN | 2013 | Frontiers of Structural and Civil Engineering2013，7，1： | 0 |
| 20 | In vitro investigation of a new thrombus aspiration and autologous blood reinfusion system显示文摘Purpose: The aim of the study was to evaluate the feasibility of a new venous-thrombus aspiration and autologous blood(auto-blood) reinfusion system.Materials and methods: We constructed the venous model from polyvinyl chloride(PVC) tubes and three-way unions using a fresh clot of chicken blood as the venous thrombus. Eight French and 12 F aspiration catheters were used to aspirate the thrombus in the right–pulmonary-artery model, 8 French and 14 F aspiration catheters were used in the inferior–vena cava model, and 8 French and 10 F aspiration catheters were used in the left-–iliofemoral-vein model. A thrombus filtration and auto-blood reinfusion bottle was used to filter the thrombus and re-infuse auto-blood. We evaluated the thrombus aspiration capability of each catheter by comparing preaspirated with the post-aspirated thrombus volume, and we evaluated the difference in aspiration capability between the two catheters in each model by comparing their thrombus aspiration rates. We used Student’s t-test for statistical analysis.Results: Differences between pre-aspirated and post-aspirated thrombus volumes for each catheter were insignificant, as were those between the thrombus aspiration rates of the two catheters in each venous model. Using the thrombus aspiration and auto-blood reinfusion system, each aspiration catheter could fluently aspirate the thrombus out of the venous model.Conclusion: In this study, we designed a new venous-thrombus aspiration system. This system could be used to aspirate acute venous thrombi and re-infuse autologous blood. | Weixiao Li Qiang Li Shuiting Zhai Tianxiao Li Nick Cheshire Zhidong Zhang Kai Liang | 2019 | Journal of Interventional Medicine2019，2，1： | 0 |
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