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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Hangzhou criteria as downstaging criteria in hepatocellular ca显示文摘Background:The downstaging of hepatocellular carcinoma(HCC)has been confirmed to benefit liver transplantation(LT)patients whose tumors are beyond the transplantation criteria.Milan criteria(MC),a tumor size and number-based assessment,is currently used as the endpoint in these patients.However,many studies believe that tumor biological behavior should be added to the evaluation criteria for downstaging efficacy.Hence,this study aimed to explore the feasibility of Hangzhou criteria(HC),which introduced tumor grading and alpha-fetoprotein in addition to tumor size and number,as an endpoint of downstaging.Methods:We performed a multicenter and retrospective study of 206 patients accepted locoregional therapy(LRT)as downstaging/bridge treatment prior to LT in three centers of China.Results:Recipients were divided into four groups:failed downstaging to the HC(group A,n=46),successful downstaging to the HC(group B,n=30),remained within the HC all the time(group C,n=113),and tumor progressed(group D,n=17).The 3-year HCC recurrence probabilities of groups B and C were not significantly different(10.3%vs.11.6%,P=0.87).The HCC recurrent rate was significantly higher in group A(52.3%)compared with that in group B/C(P<0.05).Seven patients(7/76,9.2%)whose tumor exceeded the the HC were successfully downstaged to the MC,and 39.5%(30/76)to the the HC.In group B,23 patients remained beyond the MC and their survivals were as well as those of patients within the MC.Conclusions:Compared to the MC,HC downstaging criteria can give more HCC patients access to LT and furthermore,the outcome of these patients is the same as those matching MC downstaging criteria.Hangzhou downstaging criteria therefore is applicable in clinical practice. | Qi-Fan Zhan Sun-Bin Ling Yi-Nan Deng Qiao-Nan Shan Qian-Wei Ye Sheng-Jun Xu Guang-Jiang Jiang Di Lu Xu-Yong Wei Li Zhuang Wu Zhang Tian Shen Bei-Ni Cen Hai-Yang Xie Ji-Min Liu Jian Wu Shu-Sen Zheng Yang Yang Xiao Xu | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，4： | 11 |
| 3 | Berberine prevents stress-induced gut inflammation and visceral hypersensitivity and reduces intestinal motility in rats显示文摘BACKGROUND Irritable bowel syndrome (IBS) is a common chronic non-organic disease of the digestive system. Berberine (BBR) has been used to treat patients with IBS, but the underlying therapeutic mechanism is little understood. We believe that BBR achieves its therapeutic effect on IBS by preventing stress intestinal inflammation and visceral hypersensitivity and reducing bowel motility. AIM To test the hypothesis that BBR achieves its therapeutic effect on IBS by preventing subclinical inflammation of the intestinal mucosa and reducing visceral hypersensitivity and intestinal motility. METHODS IBS was induced in rats via water avoidance stress (WAS). qRT-PCR and histological analyses were used to evaluate the levels of cytokines and mucosal inflammation, respectively. Modified ELISA and qRT-PCR were used to evaluate the nuclear factor kappa-B (NF-κB) signal transduction pathway. Colorectal distention test, gastrointestinal transit measurement, Western blot, and qRT-PCR were used to analyze visceral sensitivity, intestinal motility, the expression of Ckit (marker of Cajal mesenchymal cells), and the expression of brain derived neurotrophic factor (BDNF) and its receptor TrkB.RESULTS WAS led to mucosal inflammation, visceral hyperalgesia, and high intestinal motility. Oral administration of BBR inhibited the NF-κB signal transduction pathway, reduced the expression of pro-inflammatory cytokines [interleukin (IL)- 1β, IL-6, interferon-γ, and tumor necrosis factor-α], promoted the expression of anti-inflammatory cytokines (IL-10 and transforming growth factor-β), and improved the terminal ileum tissue inflammation. BBR inhibited the expression of BDNF, TrkB, and C-kit in IBS rats, leading to the reduction of intestinal motility and visceral hypersensitivity. The therapeutic effect of BBR at a high dose (100 mg/kg) was superior to than that of the low-dose (25 mg/kg) group. CONCLUSION BBR reduces intestinal mucosal inflammation by inhibiting the intestinal NF-κB signal pathway in the IBS rats. BBR reduces the expression of BDNF, its receptor TrkB, and C-kit. BBR also reduces intestinal motility and visceral sensitivity to achieve its therapeutic effect on IBS. | Zhi-Chao Yu Yong-Xin Cen Ben-Hua Wu Cheng Wei Feng Xiong De-Feng Li Ting-Ting Liu Ming-Han Luo Li-Liangzi Guo Ying-Xue Li Li-Sheng Wang Jian-Yao Wang Jun Yao | 2019 | World Journal of Gastroenterology2019，25，29： | 11 |
| 4 | Mucinous colorectal adenocarcinoma:clinical pathology and treatment options显示文摘Mucinous colorectal adenocarcinoma is a distinct subtype of colorectal cancer(CRC)characterized by the pres-ence of abundant extracellular mucin which accounts for at least 50%of the tumor volume.Mucinous colorectal adenocarcinoma is found in 10%-20%of CRC patients and occurs more commonly in female and younger patients.Moreover,mucinous colorectal adenocarcinoma is more frequently located in the proximal colon and diagnosed at an advanced stage.Based on its molecular context,mucinous colorectal adenocarcinoma is associated with the over-expression of mucin 2(MUC2)and mucin 5AC(MUC5AC)proteins.At the same time,it shows higher mutation rates in the fundamental genes of the RAS/MAPK and PI3K/Akt/mTOR pathways.Mucinous colorectal adenocarcinoma also shows higher rates of microsatellite instability(MSI)than non-mucinous colorectal adenocarcinoma which might correlate it with Lynch syndrome and the CpG island methylator phenotype.The prognosis of mucinous colorectal adenocarcinoma as to non-mucinous colorectal adenocarcinoma is debatable.Further,the impaired responses of mucinous colorectal adenocarcinoma to palliative or adjuvant chemotherapy warrant more studies to be performed for a specialized treatment for these patients.In this review,we discuss the molecular background and histopathol-ogy of mucinous colorectal adenocarcinoma,and provide an update on its prognosis and therapeutics from recent literatures. | Cong Luo Shuyi Cen Guojun Ding Wei Wu | 2019 | Cancer Communications2019，39，1： | 8 |
| 5 | Peripheral Lymphocyte Subsets as a Marker of Parkinson's Disease in a Chinese Population显示文摘In this study, we conducted a clinical analysis of lymphocyte subtypes in 268 patients with Parkinson's disease(PD) to assess their clinical impact as a potential marker of advanced PD in Chinese patients. The participants comprised 268 sporadic PD patients and 268 healthy controls. The numbers of natural killer(NK) cells and CD3+, CD3+CD4+, CD3+CD8+, and CD19+ lymphocytes from peripheral blood were determined by immunostaining and flow cytometric analysis and the percentages of these CD+ T cells were calculated. The ratio of regulatory T(Treg)/helper T 17(Th17) lymphocytes from 64 PD patients and 46 controls was determined by flow cytometric analysis.The results showed that the percentage of NK cells was higher in advanced PD patients than in controls(22.92% ±10.08% versus 19.76% ± 10.09%, P = 0.006), while CD3+ T cells are decreased(62.93% ± 9.27% versus65.75% ± 9.13%, P = 0.005). The percentage of CD19+B cells in male patients was lower(P = 0.021) than in female patients, whereas NK cells were increased(P \ 0.0001). The scores on the Unified Parkinson's Disease Rating Scale(UPDRS) and the Non-Motor Symptoms Scale in late-onset PD patients were significantly higher than those in earlyonset patients(P = 0.024 and P = 0.007, respectively). The percentage of CD19+ B cells in patients with UPDRS scores[24 was lower than in those with scores \24(10.17% ±4.19% versus 12.22% ± 5.39%, P = 0.009). In addition, the Treg/Th17 ratio in female patients was higher than that in female controls(13.88 ± 6.32 versus 9.94 ± 4.06, P =0.042). These results suggest that the percentages of NK cells,CD3+ T cells, and CD19+ B cells along with the Treg/Th17 ratio in peripheral blood may be used to predict the risk of PD in Chinese individuals and provide fresh avenues for novel diagnostic biomarkers and therapeutic designs. | Luan Cen Chaohao Yang Shuxuan Huang Miaomiao Zhou Xiaolu Tang Kaiping Li Wenyuan Guo Zhuohua Wu Mingshu Mo Yousheng Xiao Xiang Chen Xinling Yang Qinhui Huang Chaojun Chen Shaogang Qu Pingyi Xu | 2017 | Neuroscience Bulletin2017，33，5： | 5 |
| 6 | Unsedation colonoscopy can be not that painful: Evaluation of the effect of “Lamaze method of colonoscopy”显示文摘AIM: To evaluate the pain relieving effect of intervention with 'Lamaze method of colonoscopy' in the process of colonoscopy.METHODS: Five hundred and eighty-five patients underwent colonoscopy were randomly divided into three groups, Lamaze group, anesthetic group and control group. Two hundred and twenty-four patients of Lamaze group, the 'Lamaze method of colonoscopy' were practiced in the process of colonoscopy. The Lamaze method of colonoscopy is modified from the Lamaze method of childbirth, which helped patients to relieve pain through effective breathing control. One hundred and seventy-eight patients in anesthetic group accepted sedation colonoscopy. For 183 patients in control group, colonoscopy was performed without any intervention. The satisfactory of colon cleaning, intestinal lesions, intubation time, success ratio, pain grading and complications were recorded. All data were statistically analyzed.RESULTS: There were no significant differences at base line of the three groups(P > 0.05). Anesthetic group shows advantage in intubation time than the other two groups(P < 0.05). Lamaze group shows no advantagein intubation time than that in control group(P > 0.05). The anesthetic group showed an apparent advantage in relieving pain(P < 0.01). Therefore, the 'Lamaze method of colonoscopy' performed in colonoscopy could relieve pain effectively comparing with control group(P < 0.05). The patients in anesthetic group had the highest incidence of complications(P < 0.05).CONCLUSION: The performance of the 'Lamaze method of colonoscopy' in the process of colonoscopy could relieve patients' pain, minimize the incidence of complications, and is worthy promotion in clinical practice. | Shao-Ping Yu Xiao-Dong Lin Guang-Yao Wu Song-Hu Li Zong-Quan Wen Xiao-Hong Cen Xian-Guang Huang Mei-Ting Huang | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，15： | 5 |
| 7 | Abrogation of Hn RNP L enhances anti-PD-1 therapy efficacy via diminishing PD-L1 and promoting CD8^(+) T cell-mediated ferroptosis in castration-resistant prostate cancer显示文摘Owing to incurable castration-resistant prostate cancer(CRPC)ultimately developing after treating with androgen deprivation therapy(ADT),it is vital to devise new therapeutic strategies to treat CRPC.Treatments that target programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for human cancers with clinical benefit.However,many patients,especially prostate cancer,fail to respond to anti-PD-1/PD-L1 treatment,so it is an urgent need to seek a support strategy for improving the traditional PD-1/PD-L1 targeting immunotherapy.In the present study,analyzing the data from our prostate cancer tissue microarray,we found that PD-L1 expression was positively correlated with the expression of heterogeneous nuclear ribonucleoprotein L(Hn RNP L).Hence,we further investigated the potential role of Hn RNP L on the PD-L1 expression,the sensitivity of cancer cells to T-cell killing and the synergistic effect with anti-PD-1 therapy in CRPC.Indeed,Hn RNP L knockdown effectively decreased PD-L1 expression and recovered the sensitivity of cancer cells to T-cell killing in vitro and in vivo,on the contrary,Hn RNP L overexpression led to the opposite effect in CRPC cells.In addition,consistent with the previous study,we revealed that ferroptosis played a critical role in T-cell-induced cancer cell death,and Hn RNP L promoted the cancer immune escape partly through targeting YY1/PD-L1 axis and inhibiting ferroptosis in CRPC cells.Furthermore,Hn RNP L knockdown enhanced antitumor immunity by recruiting infiltrating CD8^(+)T cells and synergized with anti-PD-1 therapy in CRPC tumors.This study provided biological evidence that Hn RNP L knockdown might be a novel therapeutic agent in PD-L1/PD-1 blockade strategy that enhanced anti-tumor immune response in CRPC. | Xumin Zhou Libin Zou Hangyu Liao Junqi Luo Taowei Yang Jun Wu Wenbin Chen Kaihui Wu Shengren Cen Daojun Lv Fangpeng Shu Yu Yang Chun Li Bingkun Li Xiangming Mao | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 8 | Hierarchical model for strain generalized streaming potential induced by the canalicular fluid flow of an osteon显示文摘A hierarchical model is developed to predict the streaming potential(SP) in the canaliculi of a loaded osteon. Canaliculi are assumed to run straight across the osteon annular cylinder wall, while disregarding the effect of lacuna. SP is generalized by the canalicular fluid flow. Analytical solutions are obtained for the canalicular fluid velocity, pressure, and SP. Results demonstrate that SP amplitude(SPA) is proportional to the pressure difference, strain amplitude, frequency, and strain rate amplitude. However, the key loading factor governing SP is the strain rate, which is a representative loading parameter under the specific physiological state. Moreover, SPA is independent of canalicular length. This model links external loads to the canalicular fluid pressure, velocity, and SP, which can facilitate further understanding of the mechanotransduction and electromechanotransduction mechanisms of bones. | Xiao-Gang Wu Wei-Lun Yu Hai-Peng Cen Yan-Qin Wang Yuan Guo Wei-Yi Chen | 2015 | Acta Mechanica Sinica2015，31，1： | 4 |
| 9 | Real-time Performance Evaluation of Line Topology Switched Ethernet显示文摘Recently, switched Ethernet has become an active area of research because of its wide uses in industry. However, its uses have various real-time constraints on data communications. This paper analyzes the performance of the line topology switched Ethernet as a data acquisition network. Network calculus theory, which has been successfully applied to assess the real-time performance of packet-switched networks, is used to analyze the networks. To properly describe the activity of switches, a novel approach of modeling data flows into or out of switches is addressed. Based on our model, a concisely analytical expression of the maximal end-to-end delay in line topology switched Ethernet is derived. Finally, the relative simulation results are demonstrated. These results agree well with the analytical results, and thus they validate the data flow modeling techniques. | Fan Cen~* Tao Xing Ke-Tong Wu Institute of Acoustics, the Chinese Academy of Sciences, Beijing 100190, PRC | 2008 | International Journal of Automation and computing2008，5，4： | 4 |
| 10 | Effects of climate change and land-use changes on spatiotemporal distributions of blue water and green water in Ningxia, Northwest China显示文摘Water resources are a crucial factor that determines the health of ecosystems and socio-economic development;however,they are under threat due to climate change and human activities.The quantitative assessment of water resources using the concept of blue water and green water can improve regional water resources management.In this study,spatiotemporal distributions of blue water and green water were simulated and analyzed under scenarios of climate change and land-use changes using the Soil and Water Assessment Tool(SWAT)in Ningxia Hui Autonomous Region,Northwest China,between 2009 and 2014.Green water,a leading component of water resources,accounted for more than 69.00%of the total water resources in Ningxia.Blue water and green water showed a single peak trend on the monthly and annual scales during the study period.On the spatial scale,the southern region of Ningxia showed higher blue water and green water resources than the northern region.The spatiotemporal distribution features of blue water,green water,and green water flow had strong correlations with precipitation.Furthermore,the simulation identified the climate change in Ningxia to be more influential on blue water and green water than land-use changes.This study provides a specific scientific foundation to manage water resources in Ningxia when encountered with climate change together with human activities. | WU Jun DENG Guoning ZHOU Dongmei ZHU Xiaoyan MA Jing CEN Guozhang JIN Yinli ZHANG Jun | 2021 | Journal of Arid Land2021，13，7： | 3 |
| 11 | 危重型新型冠状病毒肺炎患者床边内镜诊疗后内镜再处理流程改良分析显示文摘目的:在疫情期间,需要通过保证内镜处理质量,避免过程环节操作中的接触污染,防止气溶胶的散发,从而保护从业人员,杜绝院内感染。创新点:内镜诊疗对改善重症患者预后及降低患者死亡率有重要作用。该研究依据实际临床工作特质,对内镜再处理过程中的部分方法及化学清洗消毒剂的选择进行了改良与替换。方法:从12例重症患者行23次内镜诊治后的内镜处理操作中提取经验,结合相关指南规范,提出了新型冠状病毒肺炎患者床边内镜诊疗后内镜再处理改良流程。结论:内镜诊疗在重症及危重症患者治疗中不可或缺。临床工作中床旁预处理操作及专线转运流程对于预防院内感染具有重要意义。替换后的化学清洗消毒剂(0.23%过氧乙酸)对新冠病毒可达到高水平消毒。改良后的床边内镜诊疗后内镜再处理操作流程顺畅,感染控制严谨,值得临床进一步推广。 | Qing GU Hua-fen WANG Ying FANG Ye LU Zhe SHEN Yan WANG Xin WU Li CEN Yi-shu CHEN | 2020 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2020，21，5： | 3 |
| 12 | Graphene Array-Based Anti-fouling Solar Vapour Gap Membrane Distillation with High Energy Efficiency显示文摘Photothermal membrane distillation(MD)is a promising technology for desalination and water purification.However,solar-thermal conversion suffers from low energy efficiency(a typical solar-water efficiency of ~50%),while complex modifications are needed to reduce membrane fouling.Here,we demonstrate a new concept of solar vapour gap membrane distillation(SVGMD)synergistically combining self-guided water transport,localized heating,and separation of membrane from feed solution.A free-standing,multifunctional light absorber based on graphene array is custom-designed to locally heat the thin water layer transporting through graphene nanochannels.The as-generated vapour passes through a gap and condenses,while salt/contaminants are rejected before reaching the membrane.The high solar-water efficiency(73.4% at 1 sun),clean water collection ratio(82.3%),excellent anti-fouling performance,and stable permeate flux in continuous operation over 72 h are simultaneously achieved.Meanwhile,SVGMD inherits the advantage of MD in microorganism removal and water collection,enabling the solar-water efficiency 3.5 times higher compared to state-of-the-art solar vapour systems.A scaled system to treat oil/seawater mixtures under natural sunlight is developed with a purified water yield of 92.8 kg m-2 day-1.Our results can be applied for diverse mixed-phase feeds,leading to the next-generation solar-driven MD technology. | Biyao Gong Huachao Yang Shenghao Wu Guoping Xiong Jianhua Yan Kefa Cen Zheng Bo Kostya Ostrikov | 2019 | Nano-Micro Letters2019，11，3： | 3 |
| 13 | Rotation speed measurement of moving particles in a CFB riser显示文摘This paper presents a study on measuring rotation speed of moving glass beads with an average diameter of 500 m in a pilot-scale circulating fluidized bed (CFB) riser with a high-speed digital imaging system. Two methods have been developed to calculate particle rotation speed from the particle images. The first method consists of a fully automated algorithm based on cross-correlation of gray distribution of particle images for particles whose rotation axes are (nearly) perpendicular to the imaging plane, and the second method calculates the speed of particle rotation by identifying its rotation axis using two or more characteristic points on its surface. The reliability of the two methods is verified by using a small sphere with known speed and direction of rotation. The first method is shown to be capable of measuring accurately the rotation speed for the particle with a rotation axis (nearly) perpendicular to the imaging plane and filtering off other particles using an appropriate threshold of correlation coefficient. The second method is shown to be capable of yielding both the speed and direction of particle rotation, with a measurement error of less than 10%. Results of both methods on real glass beads in a CFB riser are compared against each other. | Xuecheng Wu Qinhui Wang Zhongyang Luo Mengxiang Fang Kefa Cen | 2009 | Particuology2009，7，4： | 3 |
| 14 | Effectiveness and Safety of a Novel Approach for Management of Patients with Potential Difficult Mask Ventilation and Tracheal Intubation: A Multi-center Randomized Trial显示文摘 | Ji-Ming Wang Er-Li Ma Qing-Ping Wu Ming Tian Yan-Yan Sun Jing Lin Liang Peng Qiang Xu Wei Wei Hong Tan Cen Yang Xiao-Qiang Li Yun-Xia Zuo Jin Liu | 2018 | Chinese Medical Journal2018，，6： | 3 |
| 15 | Eltrombopag-related renal vein thromboembolism in a patient with immune thrombocytopenia: A case report显示文摘BACKGROUND Eltrombopag is an orally administered thrombopoietin receptor agonist linked to a heightened risk of treatment-related thromboembolism.Both venous and arterial thromboses have been documented in the medical literature.CASE SUMMARY In the absence of nephropathy,a 48-year-old patient receiving eltrombopag for immune thrombocytopenia(ITP)developed renal vein thrombosis and pulmonary embolism.The renal vein thrombus spontaneously resolved during subsequent anticoagulant treatment,restoring venous circulation.CONCLUSION A rapid upsurge in platelets,rather than their absolute number,may trigger thrombotic events in this setting.For patients at high thrombotic risk,individualized eltrombopag dosing and vigilance in platelet monitoring are perhaps needed during treatment of ITP. | Cen Wu Xiao-Ming Zhou Xiao-Dong Liu | 2021 | World Journal of Clinical Cases2021，9，11： | 3 |
| 16 | Developing new understanding of photoelectrochemical water splitting via in-situ techniques:A review on recent progress显示文摘Photoelectrochemical(PEC) water splitting is a promising technology for solar hydrogen production to build a sustainable, renewable and clean energy economy. Given the complexity of the PEC water splitting processes, it is important to note that developing in-situ techniques for studying PEC water splitting presents a formidable challenge. This review is aimed at highlighting advantages and disadvantages of each technique, while offering a pathway of potentially combining several techniques to address different aspects of interfacial processes in PEC water splitting. We reviewed recent progress in various techniques and approaches utilized to study PEC water splitting, focusing on spectroscopic and scanning-probe methods. | Jiajie Cen Qiyuan Wu Mingzhao Liu Alexander Orlov | 2017 | Green Energy & Environment2017，2，2： | 3 |
| 17 | Isoconversional kinetic analysis of decomposition of bastnaesite concentrates with calcium hydroxide显示文摘Isoconversional methods combined with thermogravimetry were applied to investigate the decomposition kinetics of bastnaesite concentrates with different amounts of calcium hydroxide added.The apparent activation energy was calculated,and the results indicate that the overall reaction involves more than one single step.The reaction with a lower content(<15 wt%)of calcium hydroxide can be divided into two steps,while the reaction with a higher content(>15 wt%)involves another step which denotes the decomposition of newly formed calcium carbonate during roasting.The activation energy increases with increasing amount of calcium hydroxide in the lower range(0-15 wt%).This is due to the resistance of calcium hydroxide to heat and mass transport,However,more calcium can promote the decomposition reaction more effectively and thus reduce the activation energy.Nonlinear fitting was performed by fitting the experimental data to Avrami-Erofeev model to determine the reaction model and pre-exponential factor.The theoretical models were proven to be reliable for kinetic prediction. | Peng Cen Xue Bian Wenyuan Wu | 2020 | Journal of Rare Earths2020，38，12： | 3 |
| 18 | Anion recognition with porphyrin-bottomed tetraurea receptors显示文摘Three tetraurea-appended porphyrin derivatives were synthesized and applied as anion receptors to complex with various anions, including F^-,Cl^-, Br^-,I, NO_3^-, HSO_4^-, and AcO^-. The binding stoichiometries were all measured to be 1:1 and high binding abilities of these receptors toward the anions were demonstrated with the association constants of up to 1.1 × 10~8 L/mol. The complexation of the receptors with anions was further unambiguously confirmed by single-crystal X-ray | Wei Lin Tian-Yong Cen Shu-Ping Wang Zibin Zhang Jing Wu Jianying Huang Shijun Li | 2018 | Chinese Chemical Letters2018，29，9： | 3 |
| 19 | Improving slurryability, rheology,and stability of slurry fuel from blending petroleum coke with lignite显示文摘Petroleum coke and lignite are two important fossil fuels that have not been widely used in China.Petroleum coke–lignite slurry(PCLS), a mixture of petroleum coke, lignite, water, and additives, efficiently utilizes the two materials. In this study, we investigate the effects of the proportion(a) of petroleum coke on slurryability, rheological behavior, stability, and increasing temperature characteristics of PCLSs. The results show that the fixedviscosity solid concentration(x0) increases with increasing a. The x0 of lignite-water slurry(LWS, a = 0) is 46.7 %,compared to 71.3 % for the petroleum coke–water slurry(PCWS, a = 100 %), while that of PCLS is in between the two values. The rheological behavior of PCLS perfectly fits the power-law model. The PCWS acts as a dilatant fluid. As a decreases, the slurry behaves first as an approximate Newtonian fluid, and then turns into a pseudo-plastic fluid that exhibits shear-thinning behavior. With increasing a, the rigid sedimentation and water separation ratio(WSR)increase, indicating a decrease in the stability of PCLS.When a is 60–70 %, the result is a high-quality slurry fuel for industrial applications, which has high slurryability(x0= 57–60 %), good stability(WSR \ 2 %), and superior pseudo-plastic behavior(n & 0.9). | Jun-Hong Wu Jian-Zhong Liu Yu-Jie Yu Rui-Kun Wang Jun-Hu Zhou Ke-Fa Cen | 2015 | Petroleum Science2015，12，1： | 3 |
| 20 | 荚膜红细菌(Rhodobacter capsulatus)hemA基因的高效可溶表达及其酶学性质对比研究(英文)显示文摘研究目的:提供一种酶学性质优良的,可在大肠杆菌体内高活性可溶表达的,具有工业应用前景的5-氨基乙酰丙酸合成酶。创新要点:利用E.coli Rosetta(DE3)表达编码荚膜红细菌5-氨基乙酰丙酸合成酶(RC-ALAS)的hemA基因,实现其在大肠杆菌体内高活性可溶表达。以放射形土壤杆菌和类球红细菌hemA基因表达的5-氨基乙酰丙酸合成酶(AR-ALAS和RS-ALAS)为参照,对分离纯化后的RC-ALAS进行酶学性质对比研究。研究方法:工程菌的构建如图1所示,酶的分离纯化采用镍柱亲和层析和凝胶过滤层析,酶学性质的测定采用对比研究法。重要结论:(1)RC-ALAS酶活性高达198.2 U/mg,比AR-ALAS(151.1 U/mg)和RS-ALAS(116.9 U/mg)分别提高31.2%和69.5%;(2)RC-ALAS对底物琥珀酰辅酶A的专一性常数((kcat/Km)S-CoA)为1.4989,高于AR-ALAS(0.7456)和RS-ALAS(1.1699),具有较高的催化效率;(3)对含有荚膜红细菌hemA基因的工程菌进行补料分批发酵,发酵结束时,ALA的产量高达8.8 g/L(67 mmol/L)。 | Jia-wei LOU Li ZHU Mian-bin WU Li-rong YANG Jian-ping LIN Pei-lin CEN | 2014 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2014，15，5： | 2 |
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