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| 1 | Peripheral Lymphocyte Subsets as a Marker of Parkinson's Disease in a Chinese Population显示文摘In this study, we conducted a clinical analysis of lymphocyte subtypes in 268 patients with Parkinson's disease(PD) to assess their clinical impact as a potential marker of advanced PD in Chinese patients. The participants comprised 268 sporadic PD patients and 268 healthy controls. The numbers of natural killer(NK) cells and CD3+, CD3+CD4+, CD3+CD8+, and CD19+ lymphocytes from peripheral blood were determined by immunostaining and flow cytometric analysis and the percentages of these CD+ T cells were calculated. The ratio of regulatory T(Treg)/helper T 17(Th17) lymphocytes from 64 PD patients and 46 controls was determined by flow cytometric analysis.The results showed that the percentage of NK cells was higher in advanced PD patients than in controls(22.92% ±10.08% versus 19.76% ± 10.09%, P = 0.006), while CD3+ T cells are decreased(62.93% ± 9.27% versus65.75% ± 9.13%, P = 0.005). The percentage of CD19+B cells in male patients was lower(P = 0.021) than in female patients, whereas NK cells were increased(P \ 0.0001). The scores on the Unified Parkinson's Disease Rating Scale(UPDRS) and the Non-Motor Symptoms Scale in late-onset PD patients were significantly higher than those in earlyonset patients(P = 0.024 and P = 0.007, respectively). The percentage of CD19+ B cells in patients with UPDRS scores[24 was lower than in those with scores \24(10.17% ±4.19% versus 12.22% ± 5.39%, P = 0.009). In addition, the Treg/Th17 ratio in female patients was higher than that in female controls(13.88 ± 6.32 versus 9.94 ± 4.06, P =0.042). These results suggest that the percentages of NK cells,CD3+ T cells, and CD19+ B cells along with the Treg/Th17 ratio in peripheral blood may be used to predict the risk of PD in Chinese individuals and provide fresh avenues for novel diagnostic biomarkers and therapeutic designs. | Luan Cen Chaohao Yang Shuxuan Huang Miaomiao Zhou Xiaolu Tang Kaiping Li Wenyuan Guo Zhuohua Wu Mingshu Mo Yousheng Xiao Xiang Chen Xinling Yang Qinhui Huang Chaojun Chen Shaogang Qu Pingyi Xu | 2017 | Neuroscience Bulletin2017，33，5： | 5 |
| 2 | Microarray-based analyses of monocytes from Chinese Uygur patients with Parkinson's disease and cognitive impairment显示文摘Parkinson's disease (PD),a complex neurodegenerative disease,is characterized by the loss of dopamine neurons in the substantia nigra of the midbrain.PD patients have varying degrees of cognitive impairment (CI)1 that we term PD-CI.However,the etiology of these changes remains unexplained.We chose three Uygur male patients with PD-CI and three healthy controls of the same of nationality and sex to explore the pathogenesis of Xinjiang Uygur PD-CI using microarray-based gene expression profiling of monocytes. METHODS Subjects The cases were three Uygur men with PD-CI (sporadic) diagnosed by doctors of the First Affiliated Hospital of Xinjiang Medical University between November 2012 and January 2013.They were 65,72,and 75 years old and were screened using the BrainBank diagnostic criteria (United Kingdom).2 When necessary,diagnosis was confirmed using a head MRI or CT scan.Secondary PD,Parkinson's syndrome,hyperthyroidism and other genetic or neural diseases were excluded.The three healthy individuals in the control group were selected from a survey population about the incidence of PD in Urumqi and were of identical gender and ethnicity as the PD patients,but were not genetically related to the patient group.Their ages were 62,67,and 70 years.These six subjects were used for microarray-based analyzes.We also collected 31 cases of Uygur men with PD-CI (sporadic) and 35 healthy Uygur subjects for qRT-PCR verification of the microarray experiments.To investigate cognitive function,we used Mini-Mental State Examination (MMSE).MMSE scores of junior high school level ≤24 are considered to indicate cognitive disorders.This study was conducted in accordance with the Declaration of Helsinki and with approval from the Ethics Committee of the First Affiliated Hospital of Xinjiang Medical University.Written informed consent was obtained from all participants. | Luo Qin Xia Huan Yang Xinling | 2014 | Chinese Medical Journal2014，，12： | 4 |
| 3 | The biomarkers of immune dysregulation and inflammation response in Parkinson disease显示文摘Parkinson’s disease(PD)is referring to the multi-systemicα-synucleinopathy with Lewy bodies deposited in midbrain.In ageing,the environmental and genetic factors work together and overactive major histocompatibility complex pathway to regulate immune reactions in central nerve system which resulting in neural degeneration,especially in dopaminergic neurons.As a series of biomarkers,the human leukocyte antigen genes with its related proteomics play cortical roles on the antigen presentation of major histocompatibility complex molecules to stimulate the differentiation of T lymphocytes and i-proteasome activities under their immune response to the PD-related environmental alteration and genetic variation.Furthermore,dopaminergic drugs change the biological characteristic of T lymphatic cells,affect theα-synuclein presentation pathway,and inhibit T lymphatic cells to release cytotoxicity in PD development.Taking together,the serum inflammatory factors and blood T cells are involved in the immune dysregulation of PD and inspected as the potential clinic biomarkers for PD prediction. | Li Chen Mingshu Mo Guangning Li Luan Cen Lei Wei Yousheng Xiao Xiang Chen Shaomin Li Xinling Yang Shaogang Qu Pingyi Xu | 2016 | Translational Neurodegeneration2016，5，1： | 3 |
| 4 | Exploring the N-terminus region: Synthesis, bioactivity and 3D-QSAR of allatostatin analogs as novel insect growth regulators显示文摘Allatostatins(ASTs), a family of insect neuropeptide, can inhibit juvenile hormone(JH) biosynthesis by the corpora allata(CA) in Diploptera punctata, and therefore be regarded as potential leads for the discovery of new insect growth regulators(IGRs). But several shortcomings, such as their sensitivity to peptidases and high cost, impeded their practical application in pest management. In order to discover new IGRs, one AST analog B1 possessing non-peptide group was discovered with high ability to inhibit JH biosynthesis in vitro(IC_(50): 0.09 mmol/L) in our previous studies. In the present work, two series of B1 analogs with different substituents on the N-terminus region were designed and synthesized. The result suggested that benzene showed better activity than other heterocycles, and the para-substitution on the benzene was beneficial for activity. Moreover, analogs with log P value over 2.0 exhibited good activity,which indicated the hydrophobicity is important to the bioactivity. Three dimension quantitative structure-activity relationship(3D-QSAR) studies were performed to highlight the structural requirements of AST analogs, which demonstrated introduction of bulkier substituents on the N-terminus would increase the activity. Analog Ⅱ12(IC_(50): 0.08 mmol/L) exhibited similar inhibitory activity to the lead B1,but its synthetic route was simpler than B1. Therefore, Ⅱ12 could be used as a new lead compound for the discovery eco-friendly IGRs. | Meizi Wang Li Zhang Xianwei Wang Yun Ling Xiaoqing Wu Xinlu Li Yiduo Mi Xinling Yang | 2018 | Chinese Chemical Letters2018，29，9： | 2 |
| 5 | High-quality instant black tea manufactured using fresh tea leaves by two-stage submerged enzymatic processing显示文摘Repeated thermal treatment could impair the flavor of instant black tea(IBT)as the volatile compounds and characteristic constituents dramatically vary during the manufacturing process.Utilization of fresh leaves as raw material in IBT manufacture at low temperature may become an alternative to conventional extraction methods.This study aimed to improve the quality of IBT using fresh tea leaves by a two-stage enzymatic processing.The influence of combined enzymatic oxidation and extraction conditions for maximal extractable flavour(taste and aroma)characteristics from fresh tea leaves were investigated.The changes of aroma profiles and chemical constituents including theaflavins(TFs),thearubigins(TRs),theabrownines(TBs)and TRs/TFs ratio in converted tea brews under two-stage enzyme catalyzed fermentation and extraction conditions were further compared between different treatments,based on which the optimised conditions were determined.During the two-stage enzymatic processing,75 kinds of volatile compounds were identified in all processed samples,and the contents of TFs,TRs,TBs and TRs/TFs ratio could be optimized by adjusting different procedures and parameters.The overall properties of final product were compared with two types of commercial IBT.High quality IBT with desired properties and antioxidant activity can be manufactured using fresh tea leaves by two-stage enzymatic processing approach. | Junhao Kong Xiufang Yang Xiaobo Zuo Xiaoqin Su Bing Hu Xinle Liang | 2022 | Food Science and Human Wellness2022，11，3： | 2 |
| 6 | A Novel Training Sequence Applied to DCS-Based Channel Estimation显示文摘Studies have indicated that the distributed compressed sensing based(DCSbased) channel estimation can decrease the length of the reference signals effectively. In block transmission, a unique word(UW) can be used as a cyclic prefix and reference signal. However, the DCS-based channel estimation requires diversity sequences instead of UW. In this paper, we proposed a novel method that employs a training sequence(TS) whose duration time is slightly longer than the maximum delay spread time. Based on proposed TS, the DCS approach perform perfectly in multipath channel estimation. Meanwhile, a cyclic prefix construct could be formed, which reduces the complexity of the frequency domain equalization(FDE) directly. Simulation results demonstrate that, by using the method of simultaneous orthogonal matching pursuit(SOMP), the required channel overhead has been reduced thanks to the proposed TS. | Weizhang Xu Xinle Yu Yanfei Li Lu Si Zhanxin Yang | 2018 | China Communications2018，15，11： | 2 |
| 7 | A novel polishing technology for epoxy resin based on 355 nm UV laser显示文摘The electromagnetic shielding film has drawn much attention due to its wide applications in the integrated circuit package,which demands a high surface quality of epoxy resin.However,gaseous Cu will splash and adhere to epoxy resin surface when the Cu layer in PCB receives enough energy in the process of laser cutting,which has a negative effect on the quality of the shielding film.Laser polishing technology can solve this problem and it can effectively improve the quality of epoxy resin surface.The paper studies the mechanism of Cu powder spraying on the compound surface by 355 nm ultraviolet(UV) laser,including the parameters of laser polishing process and the remains of Cu content on compound surface.The results show that minimal Cu content can be realized with a scanning speed of 700 mm/s,a laser frequency of 50 kHz and the distance between laser focus and product top surface of-1.3 mm.This result is important to obtain an epoxy resin surface with high quality. | Xinling Meng | 2017 | Journal of Semiconductors2017，38，5： | 1 |
| 8 | Synthesis and biological activities of 2-oxocycloalkylsulfonamides显示文摘 | XINGHAI LI XINLING YANG XIAOMEI LIANG ZHENPENG KAI HUIZU YUAN DEKAIYUAN JIANJUN ZHANG RUIQING WANG FUXIANG RAN SHUHUA QI YUN LING FUHENG CHEN DAOQUAN WANG | | 0，，08： | 1 |
| 9 | Separation of cyclopropane derivatives with muhi-chiral centers by gas chromatography on modified fl-cyclodextrin stationary phase显示文摘 | SHEN Gangyi YANG Xinling CUI Jian | 2008 | Chem Lett2008，37，5： | 1 |
| 10 | Feeding and growth on bivalve biodeposits by the deposit feeder Stichopus japonicus Selenka (Echinodermata: Holothuroidea) co-cultured in lantern nets显示文摘 | Yi Zhou Hongsheng Yang Shilin Liu Xiutang Yuan Yuze Mao Ying Liu Xinling Xu Fusui Zhang | 2006 | Aquaculture2006，，1： | 1 |
| 11 | Density-dependent effects on seston dynamics and rates of filtering and biodeposition of the suspension-cultured scallop Chlamys farreri in a eutrophic bay (northern China): An experimental study in semi-in situ flow-through systems显示文摘 | Yi Zhou Hongsheng Yang Tao Zhang Peibing Qin Xinling Xu Fusui Zhang | 2005 | Journal of Marine Systems2005，，1： | 1 |
| 12 | Accumulation of tissue advanced glycation end products correlated with glucose exposure dose and associated with cardiovascular morbidity in patients on peritoneal dialysis显示文摘 | Jianping Jiang Pingyan Chen Jianghua Chen Xueqing Yu Di Xie Changlin Mei Fei Xiong Wei Shi Wei Zhou Xusheng Liu Shiren Sun Ping Zhang Xiao Yang Yixiang Zhang Yanmin Zhang Xinling Liang Zhimin Zhang Qizhan Lin Yan Yu Toshio Miyata Jianwei Tian Min Liang We | 2012 | Atherosclerosis2012，，1： | 1 |
| 13 | An analysis of structure fitting and bioactivity between sex pheromone of cotton boll-worm, Helicoverpa armigera (Hübner) and its fluorinated analogs显示文摘A study on the structure-activty relationship between (Z)-hexadec-9-enal (Z-9-16:Ald) and its analog was conducted by comparing the structures of the sex pheromone of cotton bollworm, Helicoverpa armigera (Hübner) with its fluorinated analog using computer molecular fitting. It is demonstrated that the structure of analog substituting for hydrogen atom on the terminal carbon atom is similar to Z-9-16:Ald. The EAG result showed that there is no signifi- cant difference in activities between Z-9-16:Ald and its fluorinated analog synthesized. | KAN Wei ZHANG Zhongning YANG Xinling FANG Yuling XIAO Chun | 2005 | Chinese Science Bulletin2005，50，22： | 1 |
| 14 | Three-dimensional biogenic C-doped Bi_2MoO_6/In_2O_3-ZnO Z-scheme heterojunctions derived from a layered precursor显示文摘Novel 3D biogenic C-doped Bi_2 MoO_6/In_2O_3-ZnO Z-scheme heterojunctions were synthesized for the first time, using cotton fiber as template. The as-prepared samples showed excellent adsorption and photodegradation performance toward the hazardous antibiotic doxycycline under simulated sunlight irradiation. The morphology, phase composition and in situ carbon doping could be precisely controlled by adjusting processing parameters. The carbon doping in Bi_2 MoO_6/In_2O_3-ZnO was derived from the cotton template, and the carbon content could be varied in the range 0.9–4.4 wt.% via controlling the heat treatment temperature. The sample with Bi_2 MoO_6/In_2O_3-ZnO molar ratio of 1:2 and carbon content of1.1 wt.% exhibited the highest photocatalytic activity toward doxycycline degradation,which was 3.6 and 4.3 times higher than those of pure Bi_2 MoO_6 and Zn In Al-CLDH(calcined layered double hydroxides), respectively. It is believed that the Z-scheme heterojunction with C-doping, the 3D hierarchically micro–meso–macro porous structure, as well as the high adsorption capacity, contributed significantly to the enhanced photocatalytic activity. | Hongyan Li Jia Li Ping Yang Dickon H.L.Ng Xinling Cui Fei Ji | 2019 | Journal of Environmental Sciences2019，31，5： | 1 |
| 15 | Thermal and mechanical properties of polyurethane/montmorillonite nanocomposites based on a novel reactive modifier显示文摘 | Jiawen Xiong Yunhang Liu Xiaohui Yang Xinling Wang | 2004 | Polymer Degradation and Stability2004，86，3： | 1 |
| 16 | An Effective Coulomb Interaction in Nuclear Energy Density Functionals显示文摘It is well-known that the charge-violating interaction is usually underestimated in nuclear many-body approaches,the so-called Nolen–Schiffer anomaly.In the framework of the Skyrme–Hartree–Fock(SHF)method,the effective two-body charge-symmetry breaking(CSB)and charge-independent breaking(CIB)interactions in nuclear medium are included. | Dong Jianmin Shang Xinle Zuo Wei Niu Yifei Sun Yang | 2019 | IMP & HIRFL Annual Report2019，，1： | 1 |
| 17 | A Novel Ionic Conduction Mechanism Based on Polyurethane Electrolyte显示文摘 | Zhu Weihua Wang Xinling Yang Bing Tang Xiaozhen | 2001 | Journal of Polymer Science Part B: Polymer Physics2001，39，11： | 1 |
| 18 | Study on Ionpolymer Interaction and Morphologic Structure of Polyurethane/Sah Systems 显示文摘 | Zhu Weihua Yang Bing Wang Xinling Tang Xiaozhen | 2001 | Journal of Shanghai Jiaotong University ( English Edition)2001，6，1： | 1 |
| 19 | Chaperone-mediated Autophagy Regulates Cell Growth by Targeting SMAD3 in Glioma显示文摘Previous studies suggest that the reduction of SMAD3(mothers against decapentaplegic homolog 3)has a great impact on tumor development,but its exact pathological function remains unclear.In this study,we found that the protein level of SMAD3 was greatly reduced in human-grade IV glioblastoma tissues,in which LAMP2A(lysosome-associated membrane protein type 2A)was significantly up-regulated.LAMP2A is a key ratelimiting protein of chaperone-mediated autophagy(CMA),a lysosome pathway of protein degradation that is activated in glioma.We carefully analyzed the amino-acid sequence of SMAD3 and found that it contained a pentapeptide motif biochemically related to KFERQ,which has been proposed to be a targeting sequence for CMA.In vitro,we confirmed that SMAD3 was degraded in either serum-free or KFERQ motif deleted condition,which was regulated by LAMP2A and interacted with HSC70(heat shock cognate 71 kDa protein).Using isolated lysosomes,amino-acid residues 75 and 128 of SMAD3 were found to be of importance for this process,which affected the CMA pathway in which SMAD3 was involved.Similarly,down-regulating SMAD3 or up-regulating LAMP2A in cultured glioma cells enhanced their proliferation and invasion.Taken together,these results suggest that excessive activation of CMA regulates glioma cell growth by promoting the degradation of SMAD3.Therefore,targeting the SMAD3-LAMP2Amediated CMA-lysosome pathway may be a promising approach in anti-cancer therapy. | Hanqun Liu Yuxuan Yong Xingjian Li Panghai Ye Kai Tao Guoyou Peng Mingshu Mo Wenyuan Guo Xiang Chen Yangfu Luo Yuwan Lin Jiewen Qiu Ziling Zhang Liuyan Ding Miaomiao Zhou Xinling Yang Lin Lu Qian Yang Pingyi Xu | 2022 | Neuroscience Bulletin2022，38，6： | 0 |
| 20 | Inhibitory Effects of Different Extractions of Salvia deserta Schang on Human Aldose Reductase显示文摘[Objectives] To explore whether there are natural substances that inhibit human aldose reductase in different extracts of Salvia deserta Schang.[Methods] The inhibitory activities of human aldose reductase from 28 extracts were screened.[Results] The methanol extract of roots of Salvia deserta Schang had the strongest inhibitory effect on human aldose reductase.[Conclusions] It was confirmed that Salvia deserta Schang has inhibitory effect on human aldose reductase. | Qian HE Jie WU Xinling WANG Jian YANG | 2019 | Medicinal Plant2019，10，4： | 0 |
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