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| 1 | Cholangiocarcinoma:A compact review of the literature显示文摘Cholangiocarcinoma(CC) is a devastating cancer aris-ing from biliary epithelia.Unfortunately,the incidence of this disease is increasing in Western countries.These tumors progress insidiously,and liver failure,biliary sepsis,malnutrition and cancer cachexia are general modes of death associated with this disease.To date,no established therapy for advanced dis-ease has been established or validated.However,our knowledge in tumor biology is increasing dramatically and new drugs are under investigation for treatment of this notorious tumor.In clinical practice,there are better diagnostic tools in use to facilitate an earlier diagnosis of CC,at least in those patients with known risk factors.CC is resectable for cure in only a small percentage of patients.Preoperative staging for vas-cular and biliary extension of CC is very important in this tumor.Laparoscopy and recently endosonography seem to protect against unnecessary laparotomies in these patients.During the last 15 years,aggressive surgical approaches,including combined liver resec-tions and vascular reconstructive surgical expertise,have improved survival in patients with CC.Surgery is contraindicated in CC cases having primary sclerosing cholangitis(PSC).Although CC was previously consid-ered a contraindication to liver transplantation,new cautious protocols,including neo-adjuvant chemora-diation therapies and staging procedures before the transplantation,have made it possible to achieve long-term survival after liver transplantation in this disease.New ablative therapies with photodynamic therapy,intraductal high-intensity ultrasonography and chemo-therapy-impregnated plastic biliary endoprosthesis are important steps in the palliative management of extra-hepatic CCs.Radiofrequency and chemo-embolization methods are also applicable for intra-hepatic CCs as palliative modes of treatment.We need more prospec-tive randomized controlled trials to evaluate the role of the new emerging therapies for CC patients. | Yucel Ustundag Yusuf Bayraktar | 2008 | World Journal of Gastroenterology2008，14，42： | 16 |
| 2 | Precut sphincterotomy:A reliable salvage for difficult biliary cannulation显示文摘Even experienced endoscopists have 90% success in achieving deep biliary cannulation with standard methods. Biliary cannulation may become difficult in 10%-15% of patients with biliary obstruction and pre- cut (access) sphincterotomy is frequently chosen as a rescue treatment in these cases. Generally, precut sphincterotomy ensures a rate of 90%-100% success- ful deep biliary cannulation. The precut technique has been performed as either a fistulotomy with a needle knife sphincterotome or as a transpapillary septotomy with a standard sphincterotome. Both methods have similar efficacy and complication rates when adminis- tered to the proper patient. Although precut sphincter- otomy ensures over 90% success of biliary cannula- tion, it has been characterized as an independent risk factor for pancreatitis. The complications of the precut technique are not limited to pancreatitis. Two more important ones, bleeding and perforation, are also re- ported in some publications as being observed more commonly than during standard sphincterotomy. It is also reported that precut sphincterotomy increases morbidity when performed in patients without dilata- tion of their biliary tract. Nevertheless, precut sphinc- terotomy is a good alternative as a rescue method in the setting of a failed standard cannulation method. This paper discusses the technical details, timing, ef- ficacy and potential complications of precut sphincter- otomy. | Ulku Saritas Yucel Ustundag Ferda Harmandar | 2013 | World Journal of Gastroenterology2013，19，1： | 13 |
| 3 | Lipoma within inverted Meckel’s diverticulum as a cause of recurrent partial intestinal obstruction and hemorrhage: A case report and review of literature显示文摘Lipoma within an inverted Meckel's diverticulum presen- ting with hemorrhage and partial intestinal obstruction is an exceptional clinical entity. We report a case of 47-year-old male with a history of recurrent episodes of partial intestinal obstruction and melena due to a subserosal lipoma located in the base of an inverted Meckel's diverticulum. According to our knowledge, this is the first case of a lipoma within a Meckel's diverticulum giving rise to this clinical scenario without the existence of heterotrophic gastric or pancreatic tissues. | Güldeniz Karadeniz Cakmak Ali Ugur Emre Oge Tascilar Sibel Bekta■ Bulent Hamdi Uan Oktay Irkorucu Kemal Karakaya Yucel Ustundag Mustafa Comert | 2007 | World Journal of Gastroenterology2007，13，7： | 11 |
| 4 | Proteasome inhibition-induces endoplasmic reticulum dysfunction and cell death of human cholangiocarcinoma cells显示文摘AIM: To determine if proteasome inhibition induces apoptosis in human cholangiocarcinoma cells, and if so, to elucidate the cellular mechanisms. METHODS: Studies were performed in the human KMCH, KMBC, and Mz-ChA-1 cholangiocarcinoma, and normal rat cell lines. MG132, a peptide aldehyde, which inhibits the chymotrypsin-like activity of the proteaosome was employed for this study. Apoptosis was assessed morphologically by 4'-6-Diamidino-2-phenylindole (DAPI) nuclear staining and fluorescence microscopy. Mitochondrial membrane potential was examined using a fluorescent unquenching assay. Ultrastructural changes during cell death were examined using transmission electron microscopy (TEM). Caspase 3/7 activity was assessed using an enzymatic-based fluorescent assay. Cytosolic-free calcium concentrations were measured using Fura-2 and digitized fluorescent microscopy. RESULTS: MG132, a proteasome inhibitor, induced apoptosis in all the cholangiocarcinoma cell lines examined. In contrast, minimal cytotoxicity was observed in normal rat cholangiocytes. Apoptosis was time-and -concentration-dependent. There was no change in the mitochondrial membrane potential between treated and untreated cells. Ultrastructural examination by transmission electron microscopy displayed the classic features of apoptosis, but in addition, there was also dramatic vacuolization of the endoplasmic reticulum (ER). Unexpectedly, no increase in caspase 3/7 activity was observed in MG132 treated cells, nor did the pancaspase inhibitor, Q-VD-OPh prevent cell death. The protein synthesis inhibitor, cycloheximide, blocked apoptosis induced by proteosome inhibitor indicating that ER dysfunction was dependent upon the formation of new proteins. CONCLUSION: Proteosome inhibition induces ERdysfunction and caspase-independent cell death selectively in human cholangiocarcinoma cells. Proteasome inhibitors warrant evaluation as anticancer agents for the treatment of human cholangiocarcinoma. | Yucel Ustundag Steven F Bronk Gregory J Gores | 2007 | World Journal of Gastroenterology2007，13，6： | 9 |
| 5 | Appendiceal mucocele: Case reports and review of current literature显示文摘The mucocele of the appendix is an uncommon disorder which is often asymptomatic but sometimes causes acute appendicitis-like symptoms. Sometimes, patients with mucocele can present with confusing symptoms. Preoperative suspicion and diagnosis of appendiceal mucocele are important. Ultrasonography and computed tomography are useful tools for the diagnosis of appendiceal mucocele. It may be also recognised by colonoscopy as a smooth submucosal lesion of the cecum. Optima management of the mucocele could be achieved through accurate preoperative diagnosis. Preoperative diagnosis is a major component for minimizing intra-operative and post-operative complications. We herein report five cases and discuss the diagnostic methods and surgical treatment. | Kemal Karakaya Figen Barut Ali Ugur Emre Hamdi Bulent Ucan Guldeniz Karadeniz Cakmak Oktay Irkorucu Oge Tascilar Yucel Ustundag Mustafa Comert | 2008 | World Journal of Gastroenterology2008，14，14： | 8 |
| 6 | Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma显示文摘AIM: To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma(HCC).METHODS: Sixty-eight patients with HCC(mean age of 69.1 ± 10.1), 31 cirrhosis patients(mean age of59.3 ± 6.3) and 33 healthy volunteers(mean age of51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein(AFP) values with HCC clinicopathological features, such as tumor size,number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion(diameters; ≤ 3 cm, 3-5 cmand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer(BCLC)criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at-80 ℃ until use.Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay.RESULTS: In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number,presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls(P <0.001). Prolidase levels were significantly associated with tumor size and number(P < 0.001, P = 0.002,respectively). Prolidase levels also differed in patients in terms of BCLC staging classification(P < 0.001).Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis(P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately(P = 0.032,P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation(r = 0.616; P< 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification,whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels.CONCLUSION: Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. | Sevil Uygun Ilikhan Muammer Bilici Hatice Sahin Ayse Semra Demir Akca Murat Can Ibrahim Ilker Oz Berrak Guven M Cagatay Buyukuysal Yucel Ustundag | 2015 | World Journal of Gastroenterology2015，21，22： | 8 |
| 7 | Pancreatic hyperechogenicity on endoscopic ultrasound examination显示文摘There is an ongoing discussion on how to diagnose a hyperechogenic pancreas and what is the clinical significance of diffusely hyperechogenic pancreas. Computerized tomography and magnetic resonance imaging are the more appropriate methods to diagnose pancreatic hyperechogenicity when compared with transcutaneous or endoscopic ultrasound examination. More importantly, pancreatic hyperechogenicity may not be a certain indicator of pancreatic fat infiltration. Even if it is true, we do not know the clinical significances of pancreatic fat accumulation. Some suggested that excess fat in the pancreas is associated with chronic pancreatitis. However, several histological studies on human alcoholic chronic pancreatitis did not prove the presence of fatty pancreas in such cases. Thus, except for aging, it is very rare to have truly steatotic pancreas in the absence of certain human diseases. | Yucel Ustundag Guray Ceylan Koray Hekimoglu | 2011 | World Journal of Gastroenterology2011，17，15： | 5 |
| 8 | 糖尿病视网膜病变患者高密度脂蛋白-3和总抗氧化能力以及NO_x水平分析(英文)显示文摘目的:比较糖尿病视网膜病变组与对照组数据,以研究高密度脂蛋白-3(HDL_3)、NO_x和总抗氧化状态之间的关系。方法:前瞻性病例对照研究。106例受试者分为3组,84例2型糖尿病有或无视网膜病变患者,对照组为22例正常人。患者均行血清高密度脂蛋白-3的浓度检测和血清NO_x水平测定。用铁还原法(FRAP)测量血浆总抗氧化能力。结果:糖尿病患者(DM)空腹血糖、糖化血红蛋白、甘油三酯显著高于对照组。正常人中HDL_3水平为14.4(12.0)mg/dL,糖尿病视网膜病变患者为18.1(12.6)mg/dL,糖尿病无视网膜病变患者为14.0(12.5)mg/dL,组间差异无统计学意义(P=0.262)。糖尿病患者FRAP水平低于对照组(P=0.003),但糖尿病视网膜病变组与非糖尿病视网膜病变组之间其差异无统计学意义。结论:研究发现:2型糖尿病视网膜病变患者、糖尿病无视网膜病变患者以及对照组间HDL和HDL_3水平无明显不同。HDL_3可能无法预测糖尿病视网膜病变患者的患病风险。糖尿病患者中血清NO_x水平较高,FRAP水平较低。 | Ustundag Yasemin Akdogan Müberra Demirci Hakan Günay Leyla Huysal Kagan Cevik Sadik Gorkem Barazi Ayse | 2017 | 国际眼科杂志2017，17，12： | 3 |
| 9 | Recent trends on wound management:New therapeutic choices based on polymeric carriers显示文摘Wound healing is an unmet therapeutic challenge among medical society since wound assessment and management is a complex procedure including several factors playing major role in healing process.Wounds can mainly be categorized as acute or chronic.It is well referred that the acute wound displays normal wound physiology while healing,in most cases,is seemed to progress through the normal phases of wound healing.On the other hand,a chronic wound is physiologically impaired.The main problem in wound management is that the majority of wounds are colonized with microbes,whereas this does not mean that all wounds will be infected.In this review,we address the problems that clinicians face to manage while treat acute and chronic wounds.Moreover,we demonstrate the pathophysiology,etiology,prognosis and microbiology of wounds.We further introduce the state of art in pharmaceutical technology field as part of wound management aiming to assist health professionals to overcome the current implications on wound assessment.In addition,authors review researches which included the use of gels and dermal films as wound healing agents.It can be said that natural and synthetic drugs or carriers provide promising solutions in order to meet the wound management standards.However,are the current strategies as desirable as medical society wish? | Mehmet Evren Okur Ioannis D.Karantas Zeynep Senyigit Neslihan Ustundag Okur Panoraia I.Siafaka | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，6： | 3 |
| 10 | Remote sensing for agricultural applications显示文摘Agricultural geospatial information is critical for agricultural policy formulation and decision making,land use monitoring,agricultural sustainability,crop acreage and yield estimation,disaster assessment,bioenergy crop inventory,food security policy,environmental assessment,carbon accounting,and other research topics that are of vital importance to agriculture and economy.Remote sensing technology enables | zhengwei yang wu wen-bin liping di berk ustundag | 2017 | Journal of Integrative Agriculture2017，16，2： | 3 |
| 11 | Current update on nanoplatforms as therapeutic and diagnostic tools:A review for the materials used as nanotheranostics and imaging modalities显示文摘In the last decade,the use of nanotheranostics as emerging diagnostic and therapeutic tools for various diseases,especially cancer,is held great attention.Up to date,several approaches have been employed in order to develop smart nanotheranostics,which combine bioactive targeting on specific tissues as well as diagnostic properties.The nanotheranostics can deliver therapeutic agents by concomitantly monitor the therapy response in real-time.Consequently,the possibility of over-or under-dosing is decreased.Various non-invasive imaging techniques have been used to quantitatively monitor the drug delivery processes.Radiolabeling of nanomaterials is widely used as powerful diagnostic approach on nuclear medicine imaging.In fact,various radiolabeled nanomaterials have been designed and developed for imaging tumors and other lesions due to their efficient characteristics.Inorganic nanoparticles as gold,silver,silica based nanomaterials or organic nanoparticles as polymers,carbon based nanomaterials,liposomes have been reported asmultifunctional nanotheranostics.In this review,the imaging modalities according to their use in various diseases are summarized,providing special details for radiolabeling.In further,the most current nanotheranostics categorized via the used nanomaterials are also summed up.To conclude,this review can be beneficial for medical and pharmaceutical society as well as material scientists who work in the field of nanotheranostics since they can use this research as guide for producing newer and more efficient nanotheranostics. | Panoraia I.Siafaka Neslihan Ustundag Okur Ioannis D.Karantas Mehmet Evren Okur Evren Atlihan Gundogdu | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，1： | 3 |
| 12 | Spatial estimation of wind speed:a new integrative model using inverse distance weighting and power law显示文摘Spatial interpolation(SI)is currently one of the most common ways to estimate wind speed(Ws).However,classic SI models either ignore the complex geography[e.g.inverse distance weighting(IDW)],or demand high computational resources(e.g.cokriging).This study aimed to develop a simple yet effective SI model for estimating Ws in Eastern Thrace of Turkey.This new method,named MIDW(Ws),is a modified IDW through the integration of IDW with wind profile model,power law(PL),representing the influence of land cover and topography on Ws.Terrain features and elevation data of PL were obtained using normalized difference vegetation index(NDVI)and digital elevation model(DEM),respectively.Results showed superior and comparable performance of MIDW(Ws)to standard IDW and ordinary kriging(OK)across all months of year.Compared to ordinary cokriging(OCK)using DEM as covariate,MIDW(Ws)generated better results in the arid–semiarid seasons(around summer).Local complex atmospheric conditions during rainy seasons(around winter)may have affected the performance of incorporating PL with MIDW(Ws).Generally,the proposed MIDW(Ws)is simpler and easier to implement compared to OCK.For landscape-scale projects,its high computational efficiency and relatively robust performance show potential to deal with large volumes of datasets. | Emre Ozelkan Gang Chen Burak Berk Ustundag | 2016 | International Journal of Digital Earth2016，9，8： | 2 |
| 13 | Reconstruction of the urethral defects with autologous fascial tube graft in a rabbit model显示文摘瞄准:在尿道缺点重建调查自体同源的筋膜移植片的可行性。方法:在 24 只成年雄的兔子,一个标准化缺点(17 公里) 在每个尿道的中间的部分以内被创造。二厘米的长筋膜管状移植物在尿道的切割结束之间被干预。24 只兔子被划分成 12 个组。在 0, 3, 10, 15, 21, 30, 45, 60, 90, 120, 150,和 180 天手术后地,一个组被打死。在开始的四个组,兔子被打死,标本为组织学的检查被获得。在 21 手术后的天以后,在里面随后八个组,后退 urethrograms 被执行评估尿道的明显和口径,然后,兔子被打死,标本被获得。结果:在组织学的学习,沿着筋膜接枝提供的支架的尿道的变移上皮的前进是坚定的。在第 30 天,新尿道完全被变移上皮盖住。管形成在 24 只兔子中的二个被观察。在 urethrograms,变窄在 16 只兔子中的三个是坚定的。结论:为部分尿道的重建,因为它的快速的上皮的新生能力,低收缩度和薄,筋膜接枝是一个好尿道的代用品。我们因此在人为男性尿道的缺点的重建建议筋膜接枝的使用。 | Cagn Sade Kemal Ugurlu Derya Ozcelik Ilkay Huthut Kursat Ozer Nil Ustundag Ibrahim Saglam Lutfu Bas | 2007 | Asian Journal of Andrology2007，9，6： | 2 |
| 14 | Comparison of a commercial powder and a powder produced from Ti–6Al–4V chips and their effects on compacts sintered by the sinter-HIP method显示文摘The present paper is related to the conversion of Ti–6Al–4V chips into powder and investigates the usability of the produced powder in powder metallurgy applications. In this regard, a disc-milling process was applied to Ti–6Al–4V chips and the obtained powder was subsequently compacted. The compacted samples were sintered by the sinter hot isostatic pressing (sinter-HIP) method at 1200°C under high vacuum, their mechanical properties and microstructure were investigated and compared with those of commercial powder compacts subjected to the same preparation processes. The results showed that the produced powder exhibits greater flowability and higher apparent density than the commercial powder. However, the sintered products prepared from the commercial powder exhibited a higher relative density, lower porosity, and, as a result, greater flexural strength compared with the sintered compacts prepared from the produced powder. In addition, transgranular fracture was greater in the sintered products of the commercial powder. The microstructural studies revealed that the sintered products made from both the commercial and the produced powders consisted of α- and β-phase but contained more α-phase. All of the examined properties were found to be substantially affected by the particle size of the powders. | Mustafa Ustundag Remzi Varol | 2019 | International Journal of Minerals,Metallurgy and Materials2019，26，7： | 2 |
| 15 | The Treatment with Antibody of TNF-α Reduces the Inflammation, Necrosis and Fibrosis in the Non-alcoholic Steatohepatitis Induced by Methionine- and Choline-deficient Diet显示文摘 | Suleyman Serdar Koca Ibrahim Halil Bahcecioglu Orhan Kursat Poyrazoglu Ibrahim Hanifi Ozercan Kazim Sahin Bilal Ustundag | 2008 | Inflammation2008，，2： | 2 |
| 16 | Proteeive effects of vitamin E on carbon tetrachloride induced liver damage in rats显示文摘 | Naziroglu M Cay M Ustundag B | 1999 | Cell Biochem Funct1999，17，： | 2 |
| 17 | Analysis of glomerular filtration rate, serum cystatin C levels, and renal resistive index values in cirrhosis patients显示文摘 | Yucel Ustundag Ufuk Samsar Sereften Acikgoz Mehmet Cabuk Sibel Kiran Eyup Kulah Selim Aydemir | 2007 | Clinical Chemical Laboratory Medicine2007，，7： | 2 |
| 18 | Analysis of glomerular filtration rate, serum cystatin C levels, and renal resistive index values in cirrhosis patients显示文摘 | Yucel Ustundag Ufuk Samsar Sereften Acikgoz Mehmet Cabuk Sibel Kiran Eyup Kulah Selim Aydemir | 2007 | Clinical Chemical Laboratory Medicine2007，，7： | 1 |
| 19 | Serum IL-1beta,IL-2,and IL-6 in insulin-dependent diabetic children显示文摘 | Dogan Y Akarsu S Ustundag B | 2006 | Mediat Inflammat2006，1，59： | 1 |
| 20 | L-Carnitine ameliorates glyc- erol-induced myoglobinuric acute renal failure in rats 显示文摘 | Ustundag S Sen S Yalcin O | 2009 | Ren Fail2009，31，2： | 1 |
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