|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 2 | 3株禽滑液囊支原体分离株致病性的比较和评价(英文)显示文摘【背景】禽滑液囊支原体是感染鸡的一种重要病原体,给我国的家禽养殖业带来了严重的经济损失。【目的】评价从病鸡中分离到的3株禽滑液囊支原体的致病性,以期丰富不同区域来源的分离株对鸡致病性的认识。【方法】分别用分离株CHN-WF224-2016、CHN-BZJ2-2015、CHN-JNB19-2016感染商品肉鸡,并在攻毒后第10天和21天进行实验室解剖,通过气囊和足垫的临床病变、血清学检测结果及气管粘膜病理形态学改变来比较评价分离株的致病力。【结果】CHN-BZJ2-2015和CHN-WF224-2016分离株能引起明显足垫肿胀和关节滑膜炎,其中CHN-BZJ2-2015分离株致病力最强,感染21d后的血清学检测和气管粘膜厚度与CHN-JNB19-2016分离株和MS-H疫苗株比较差异显著(P<0.05)。【结论】本研究表明我国目前流行的禽滑液囊支原体菌株其致病力存在明显差异,强调养殖场要积极控制和预防禽滑液囊支原体感染的重要性,同时为今后该疫苗的研发积累了实验数据。 | 宫晓炜 陈启伟 Ferguson-Noel Naola 郑福英 Stipkovits Laszlo Szathmary Susan 刘永生 | 2019 | 微生物学通报2019，46，4： | 5 |
| 3 | The parallel use of endoscopic fenestration anti a eystoperitoneal shunt with programmable valve to treat araehnoid cysts: experience and hypothesis显示文摘 | Mottolese C Szathmari A Simon E | 2010 | J Neurosurg Pediatr2010，5，： | 1 |
| 4 | Apoptosis is inducedin both drug-s ensitive and multidmg-resistant hepatoma cells bysomatostatin analogue TT-232显示文摘 | Diaconu CC Szathmari M Keri G | 1999 | BrJ Cancer1999，80，8： | 1 |
| 5 | Apoptosis is induced in both drug - sensitive and multidrug - resistant hepatoma cells by somatostatin analogue TT- 232 显示文摘 | Diaconu CC Szathmari M Keri G | 1999 | Br J Cancer1999，80，8： | 1 |
| 6 | Microarray a- nalysis reveals differential gene expression patterns in tumors of the pineal region 显示文摘 | Fvre-Montange M Champier J Szathmari A | 2006 | J Neuropathol Exp Neurol2006，65，7： | 1 |
| 7 | Craniopharyngiomas:Our experience in Lyon显示文摘 | Mottolese C Szathmari A Berlier P | 2005 | Childs Nerv Syst2005，21，89： | 1 |
| 8 | Apoptosis is induced in both drug-semitive and multidrug-resist ant hepatoma cells by somatostatin analogue TT-232 显示文摘 | Diaconu CC Szathmari M Keri G | 1999 | Br J Cancer1999，80，8： | 1 |
| 9 | Apoptosis is induced in both drug-sensitive and multidrug-resistant hepatoma cells by somatostatin analogue TT-232 显示文摘 | Diaconu C C Szathmari M Keri G | 1999 | Br J Cancer1999，80，： | 1 |
| 10 | Apoptosis is induced in both drug-sensitive and multidrug-resistant hepatoma cells by somatostatin analogue TT-232显示文摘 | Diaconu CC Szathmari M Keri G | 1999 | Br J Cancer1999，80，8： | 1 |
| 11 | Bone mineral density in patients with endogenous subclinical hyperthy- roidism: is this thyroid status a risk factor for osteoporo- sis? 显示文摘 | Foldes J Tarjan G Szathmari M | 1993 | Clin Endocrinol (Oxf)1993，39，5： | 1 |
| 12 | Endoscopic third ventriculostomy in obstructive infantile hydrocephalus:remarks about the so-called unsuccessful cases显示文摘 | Gallo P Szathmari A De Biasi S | | 0，，06： | 1 |
| 13 | P-glycoprotein is overexpressed and functional in severely heat-shocked hepatoma cells显示文摘 | Hever-Szabo A Pirity M Szathmari M | 1998 | Anticancer Res1998，18，4： | 1 |
| 14 | Apoptosis is induced in both drug-sensitire and multidrug-resistant hepatoma cells by somatostatin analogue TT-232显示文摘 | Diaconu CC Szathmari M Keri G | 1999 | Br J Cancer1999，80，8： | 1 |
| 15 | Endoscopic third ventriculost0mY in obstructive infantile hydrocephalus: remarks about the so - called 'unsuccessful cases'显示文摘 | GALLO P SZATHMARI A DE BIASI S | 2010 | Pediatr Nettrosurg2010，46，6： | 1 |
| 16 | The effect of Gc genotype on fasting insulin level inDogrib Indians 显示文摘 | Szathmary EJ | 1987 | Hum Genet1987，75，4： | 1 |
| 17 | The risk of lymphoma and immunomodulators in patients with inflammatory bowel diseases: Results from a population-based cohort in Eastern Europe显示文摘 | Peter L. Lakatos Barbara D. Lovasz Gyula David Tunde Pandur Zsuzsanna Erdelyi Gabor Mester Mihaly Balogh Istvan Szipocs Csaba Molnar Erzsebet Komaromi Petra A. Golovics Zsuzsanna Vegh Michael Mandel Agnes Horvath Miklos Szathmari Lajos S. Kiss Laszlo Laka | 2012 | Journal of Crohn’s and Colitis2012，，： | 1 |
| 18 | Microarray analysis reveals differential gene expression patterns in tumors of the pineal region 显示文摘 | Fevre-Montange M Champier J Szathmari A | 2006 | J Neuropathol Exp Neurol2006，65，7： | 1 |
| 19 | Observations on the relation- ship between the extracellular changes of taurlne and glutamate during cortical spreading depression, during ischemia, and within the area surrounding a thrombotic infarct 显示文摘 | Scheller D Szathmary S Kolb J | 2000 | Amino Acids2000，19，34： | 1 |
| 20 | P-glycoprotein is overexpressed and functional in severely heat-shocked hepatoma cells显示文摘 | Hever-Szabo A Pirity M Szathmari M | 1998 | Anticancer-Res1998，18，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员