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| 1 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 2 | The parallel use of endoscopic fenestration anti a eystoperitoneal shunt with programmable valve to treat araehnoid cysts: experience and hypothesis显示文摘 | Mottolese C Szathmari A Simon E | 2010 | J Neurosurg Pediatr2010，5，： | 1 |
| 3 | Microarray a- nalysis reveals differential gene expression patterns in tumors of the pineal region 显示文摘 | Fvre-Montange M Champier J Szathmari A | 2006 | J Neuropathol Exp Neurol2006，65，7： | 1 |
| 4 | Craniopharyngiomas:Our experience in Lyon显示文摘 | Mottolese C Szathmari A Berlier P | 2005 | Childs Nerv Syst2005，21，89： | 1 |
| 5 | Endoscopic third ventriculostomy in obstructive infantile hydrocephalus:remarks about the so-called unsuccessful cases显示文摘 | Gallo P Szathmari A De Biasi S | | 0，，06： | 1 |
| 6 | P-glycoprotein is overexpressed and functional in severely heat-shocked hepatoma cells显示文摘 | Hever-Szabo A Pirity M Szathmari M | 1998 | Anticancer Res1998，18，4： | 1 |
| 7 | Endoscopic third ventriculost0mY in obstructive infantile hydrocephalus: remarks about the so - called 'unsuccessful cases'显示文摘 | GALLO P SZATHMARI A DE BIASI S | 2010 | Pediatr Nettrosurg2010，46，6： | 1 |
| 8 | Microarray analysis reveals differential gene expression patterns in tumors of the pineal region 显示文摘 | Fevre-Montange M Champier J Szathmari A | 2006 | J Neuropathol Exp Neurol2006，65，7： | 1 |
| 9 | P-glycoprotein is overexpressed and functional in severely heat-shocked hepatoma cells显示文摘 | Hever-Szabo A Pirity M Szathmari M | 1998 | Anticancer-Res1998，18，4： | 1 |
| 10 | Treatment of Chiari type I malformation in children: the experience of Lyon显示文摘 | Mottolese C Szathmari A Simon E | 2011 | Nenrol Sci2011，323，： | 1 |
| 11 | The parallel use of endoscopic fenestration and a cystoperitoneal shunt with programmable valve to treat arachnoid cysts: experience and hypothesis显示文摘 | Mottolese C Szathmari A Simon E | 2010 | J Neurosurg Pediatr2010，5，40： | 1 |
| 12 | Endoscopic third ventriculostomy in obstructive infantile hydrocephalus:remarks about the so-called'unsuccessful cases'显示文摘 | Gallo P Szathmari A De Biasi S | 2010 | Pediatr Neurosurg2010，46，6： | 1 |
| 13 | P-glycoprotein is overexpressed and functional in severely heat-shocked hepatoma cells显示文摘 | Hever-Szaho A Pifity M Szathmari M | 1998 | Anticancer Res1998，18，4： | 1 |
| 14 | Craniopharyngiomas:our experience in Lyon显示文摘 | Mottolese C Szathmari A Berlier P | 2005 | Childs Nerv Syst2005，21，89： | 1 |
| 15 | P-glycoprotein is overexpressed and functional in severely heat-shocked hepatoma cells显示文摘 | Hever-Szabo A Pirity M Szathmari M | 1998 | Anticancer Res1998，18，4： | 1 |
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