|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings显示文摘The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011. | LUI Simon S Y SHAM Pak CHAN Raymond C K CHEUNG Eric F C | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 3 | Incidental non-benign gallbladder histopathology after cholecystectomy in an United Kingdom population: Need for routine histological analysis?显示文摘AIM To analyse the range of histopathology detected in the largest published United Kingdom series of cholecystectomy specimens and to evaluate the rational for selective histopathological analysis.METHODS Incidental gallbladder malignancy is rare in the United Kingdom with recent literature supporting selective histological assessment of gallbladders after routine cholecystectomy.All cholecystectomy gallbladder specimens examined by the histopathology department at our hospital during a five year period between March 2008 and March 2013 were retrospectively analysed.Further data was collected on all specimens demonstrating carcinoma,dysplasia and polypoid growths.RESULTS The study included 4027 patients.The majority(97%) of specimens exhibited gallstone or cholecystitis related disease.Polyps were demonstrated in 44(1.09%),the majority of which were cholesterol based(41/44).Dysplasia,ranging from low to multifocal high-grade was demonstrated in 55(1.37%).Incidental primary gallbladder adenocarcinoma was detected in 6 specimens(0.15%,5 female and 1 male),and a single gallbladder revealed carcinoma in situ(0.02%).This large single centre study demonstrated a full range of gallbladder disease from cholecystectomy specimens,including more than 1% neoplastic histology and two cases of macroscopically occult gallbladder malignancies.CONCLUSION Routine histological evaluation of all elective and emergency cholecystectomies is justified in a United Kingdom population as selective analysis has potential to miss potentially curable life threatening pathology. | Krashna Patel Khaled Dajani Satheesh Iype Nikolaos A Chatzizacharias Saranya Vickramarajah Susan Davies Rebecca Brais Siong S Liau Simon Harper Asif Jah Raaj K Praseedom Emmanuel L Huguet | 2016 | World Journal of Gastrointestinal Surgery2016，8，10： | 2 |
| 4 | Longterm multiple color imaging of live cells using quantum dot bioconjugates 显示文摘 | Jaiswal J K Mattoussi H Mauro J M Simon S F | 2003 | Nature Biotechnolgy2003，21，： | 1 |
| 5 | Generalized selection combining based on the log-likelihood ratio显示文摘 | Kim S W Kim Y G and Simon M K | 2004 | IEEE Transactions on Communications2004，52，4： | 1 |
| 6 | Combination chemotherapy of advanced lung cancer:a randomizedtrial显示文摘 | Hansen H H Selawry O S Simon K | 1976 | Cancer1976，38，6： | 1 |
| 7 | Long-term multiple color imaging of live cells using quantum dot bioconjugates显示文摘 | JAISWAL J K MATTOUSSI H D SIMON S M | 2003 | Nature Biotechnol2003，21，1： | 1 |
| 8 | Identifying the important structural elements of brominated furanones for inhibiting biofilm formation by Escherichia coli显示文摘 | HAN Y HOU S SIMON K A | 2008 | Bioorganic&Medicinal Chemistry Letters2008，18，3： | 1 |
| 9 | Thick-restart Lanczos method for large symmetric eigenvalue problems 显示文摘 | Wu K S Simon H | 2000 | SIAM Journal of Matrix Analysis Application2000，22，2： | 1 |
| 10 | Serum and CSF concentrations of brain specific proteins in hydrocephalus显示文摘 | Beems T Simons K S van Geel W J A | 2003 | Acta Neurochirurgica2003，145，1： | 1 |
| 11 | High-dose vasopressin is not superior to norepinephrine in septic shock显示文摘 | Klinzing S Simon M Reinhart K | 2003 | Crit Care Med2003，31，： | 1 |
| 12 | A role for Wnt-4 in renal fibrosis显示文摘 | Surendran K McCaul S P Simon T C | 2002 | Am J Physiol Renal Physiol2002，282，3： | 1 |
| 13 | Secure group communication using key graphs 显示文摘 | Wong C K Gouda M Simon L S | 2000 | IEEE/ACM Transactions on Networking2000，8，1： | 1 |
| 14 | Role of Rab9GTPase in facilitating receptor recruitment by TIP47显示文摘 | Carroll K S Hanna J Simon I | 2001 | Science2001，292，5520： | 1 |
| 15 | Cure kinetics of a thermosetting liquiddicyanate ester monomer / high-Tg polycyanate material显示文摘 | Simon S L Giliham J K | 1993 | Journal of Applied Polymer Science1993，47，3： | 1 |
| 16 | Comprehensive decision tree models in bioinformatics显示文摘 | Gregor S Simon K Igor P | 2012 | PLoS One2012，7，3： | 1 |
| 17 | An ant colony system approach for unit commitment problem显示文摘 | Simon S P Padhy N P Anand K S | 2006 | IEEE Trans on Power Systems2006，28，5： | 1 |
| 18 | Combined high pressure-mild temperature processing for optimal retention of physical and nutritional quality of strawberries (fragaria × ananassa) 显示文摘 | Terefe N S Matthies K Simons L | 2009 | Innovative Food Science and Emerging Technologies2009，10，3： | 1 |
| 19 | Potentials and pitfalls of fluorescent quantum dots for biological imaging 显示文摘 | Jaiswal J K Simon S M | 2004 | TRENDS in Cell Biology2004，14，9： | 1 |
| 20 | On the Energy Detection of Unknown Signals over Fading Channels显示文摘 | Digham F F Alouini M S Simon M K | 2007 | IEEE Transactions on Communications2007，55，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员