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A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings

查看全文 作　　者：LUI Simon S [1,2,3]Y;SHAM [4]Pak;CHAN Raymond C [1]K;CHEUNG Eric F [3]C 高影响力作者 机构地区：[1]Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences;[2]Graduate University of Chinese Academy of Sciences;[3]Castle Peak Hospital;[4]Department of Psychiatry, the University of Hong Kong高影响力机构 出　　处：《Chinese Science Bulletin》索引2011年第56卷第32期,共4页高影响力期刊 基　　金：supported by the Project-Oriented Hundred Talents Programme (O7CX031003);the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-YW-R-131, KSCX2-EW-J-8);a grant from the National Science Fund for Distinguished Young Scholars(81088001) to Raymond Chan 摘　　要：The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011. 关 键 词：精神病患者 稳定 家庭 早期 原理 预计 香港 面部表情识别
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