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| 1 | Correlations for the ignition delay times of hydrogen/air mixtures显示文摘Correlations for the ignition delay times of hydrogen/air mixtures were developed using the method of High Dimensional Model Representation (HDMR).The hydrogen/air ignition delay times for initial conditions over a wide range of temperatures from 800 to 1600 K,pressures from 0.1 to 100 atm,and equivalence ratios from 0.2 to 10 were first calculated utilizing the full chemical mechanism.Correlations were then developed based on these ignition delay times.Two forms of correlations were constructed:the first one is an overall general model covering the whole range of the initial conditions;while the second one is a piecewise correlation model valid for initial conditions within different sub-domains.The performance of these correlations was studied through comparison with results from the full chemical mechanism as well as experimental data.It was shown that these correlations work well over the whole range of initial conditions and that the accuracy can be significantly improved by using different piecewise correlations for different sub-domains.Therefore,piecewise correlations can be used as an effective replacement for the full mechanism when the prediction of chemical time scale is needed in certain combustion modeling. | ZHAO ZhenLong CHEN Zheng CHEN ShiYi | 2011 | Chinese Science Bulletin2011，56，2： | 8 |
| 2 | Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Modulate the Anesthetic Potency of Isoflurane in Mice显示文摘The lateral hypothalamic area(LHA)plays a pivotal role in regulating consciousness transition,in which orexinergic neurons,GABAergic neurons,and melanin-concentrating hormone neurons are involved.Glutamatergic neurons have a large population in the LHA,but their anesthesia-related effect has not been explored.Here,we found that genetic ablation of LHA glutamatergic neurons shortened the induction time and prolonged the recovery time of isoflurane anesthesia in mice.In contrast,chemogenetic activation of LHA glutamatergic neurons increased the time to anesthesia and decreased the time to recovery.Optogenetic activation of LHA glutamatergic neurons during the maintenance of anesthesia reduced the burst suppression pattern of the electroencephalogram(EEG)and shifted EEG features to an arousal pattern.Photostimulation of LHA glutamatergic projections to the lateral habenula(LHb)also facilitated the emergence from anesthesia and the transition of anesthesia depth to a lighter level.Collectively,LHA glutamatergic neurons and their projections to the LHb regulate anesthetic potency and EEG features. | Shiyi Zhao Rui Li Huiming Li Sa Wang Xinxin Zhang Dan Wang Juan Guo Huihui Li Ao Li Tingting Tong Haixing Zhong Qianzi Yang Hailong Dong | 2021 | Neuroscience Bulletin2021，37，7： | 5 |
| 3 | Characterization and Fine Mapping of a Necrotic Leaf Mutant in Maize(Zea mays L.)显示文摘玉米(Zea mays L.) 是商业地重要的庄稼。它的收益能被变化在引起死亡的 biosynthetic 和 degradative 小径减少。在这份报纸,我们描述坏死的叶(nec-t ) 异种,从一根生来的线被获得, 81647。nec-t 异种植物与坏死的点有黄叶子,减少了叶绿素内容,并且变白的幼苗在正常生长条件下面死了。传播电子显微镜学揭示了散布 thylakoids,并且每房间减少了 grana lamellae 和叶绿体的数字。组织化学的染色建议 nec-t 叶子的那点形成可能由于房间死亡。基因分析证明那坏死被一个后退的地点的变化引起。用简单顺序重复标记, Nec-t 基因在染色体 2 的短手臂上在 mmc0111 和 bnlg2277 之间被印射。有从一张 F2 人口的变异的显型的 1287 个个人的一个总数被用于物理印射。Nec-t 基因在标记 T31 和 H8 之间位于 131.7 kb 的一个物理区域以内。 | Lijing Wang Shuai Han Shiyi Zhong Haizhong Wei Yanjun Zhang Yan Zhao Baoshen Liu | 2013 | Journal of Genetics and Genomics2013，40，6： | 5 |
| 4 | Dynamic Variations in Brain Glycogen are Involved in Modulating Isoflurane Anesthesia in Mice显示文摘General anesthesia severely affects the metabolites in the brain.Glycogen,principally stored in astrocytes and providing the short-term delivery of substrates to neurons,has been implicated as an affected molecule.However,whether glycogen plays a pivotal role in modulating anesthesia-arousal remains unclear.Here,we demonstrated that isoflurane-anesthetized mice exhibited dynamic changes in the glycogen levels in various brain regions.Glycogen synthase(GS)and glycogen phosphorylase(GP),key enzymes of glycogen metabolism,showed increased activity after isoflurane exposure.Upon blocking glycogenolysis with 1,4-dideoxy-1,4-imino-Darabinitol(DAB),a GP antagonist,we found a prolonged time of emergence from anesthesia and an enhancedδfrequency in the EEG(electroencephalogram).In addition,augmented expression of glycogenolysis genes in glycogen phosphorylase,brain(Pygb)knock-in(PygbH11/H11)mice resulted in delayed induction of anesthesia,a shortened emergence time,and a lower ratio of EEG-δ.Our findings revealed a role of brain glycogen in regulating anesthesiaarousal,providing a potential target for modulating anesthesia. | Ze Fan Zhihao Zhang Shiyi Zhao Yuanyuan Zhu Dong Guo Bo Yang Lixia Zhuo Jiao Han Rui Wang Zongping Fang Hailong Dong Yan Li Lize Xiong | 2020 | Neuroscience Bulletin2020，36，12： | 2 |
| 5 | Prepa- ration of a diacylglycerol - enriched soybean oil by phos- phalipase A1 catalyzed hydrolysis 显示文摘 | WANG Yong ZHAO Mourning OU Shiyi | 2009 | J Mol Catal B Enzym2009，56，23： | 1 |
| 6 | The Stevens law and the derivation of sensory perception显示文摘The Stevens law,S=kI^(n),is commonly accepted as a landmark achievement in the field of sensory psychophysics and has been widely applied in food sensory research.The theory effectively links the two parameters of very different nature,the intensity of sensory perception(S)and the intensity of physical stimulus(I).However,the Stevens law suffers from two major drawbacks.The equation was self-inconsistent in terms of the units,which makes equation questionable in principle.The Stevens law was also found inapplicable when multiple physical stimuli are involved in the perception of a sensory attribute.To solve the first drawback,we propose to replace the absolute stimulation intensity in the Stevens law with a relative intensity,S=k(I/I_(0))^(n).The modified Stevens law becomes self-consistent when both sides of the equation are dimensionless and the theory is applicable regardless of the unit of the physical stimulus.To solve the second drawback,a concept of sensory derivation is introduced and so sensory properties can be categorized as primary sensory and derived sensory.The former can be described effectively by the Stevens law,while description of the latter is beyond the applicability of the Stevens law because of the involvement of multiple sensory stimuli or multi level sensory derivation.Furthermore,a sensory hierarch is constructed with sensory perception of different nature at different levels,including the primary sensory at the basic level and derived sensory perception at progressing levels.The modified Stevens law provides a self-consistent model for psychophysical analysis of sensory perception.The proposed sensory hierarchy helps to streamline sensory terms and attributes and may be used as a useful guide in establishing instrumental analysis of sensory perception. | Jianshe Chen Shiyi Tian Xinmiao Wang Yuezhong Mao Lei Zhao | 2021 | Journal of Future Foods2021，1，1： | 1 |
| 7 | Prepa- ration of a diacylglycerol - enriched soybean oil by phos- phalipase A1 catalyzed hydrolysis 显示文摘 | WANG Yong ZHAO Mourning OU Shiyi | 2009 | J Mol Catal B Enzym2009，56，23： | 1 |
| 8 | Prepara- tion of a diacylglycerol - enriched soybean oil by phos- phalipase A1 catalyzed hydrolysis 显示文摘 | WANG Yong ZHAO Mourning OU Shiyi | 2009 | J Mol Catal B Enz- ym2009，56，23： | 1 |
| 9 | Prepara- tion of a diaeylglycerol - enriched soybean oil by phospho- lipase A1 catalyzed hydrolysis 显示文摘 | WANG Yong ZHAO Mourning OU Shiyi | 2009 | J Mol Catal B Enz- ym2009，56，： | 1 |
| 10 | Engineering single-molecule fluorescence withasymmetric nano-antennas显示文摘As a powerful tool for studying molecular dynamics in bioscience,single-molecule fluorescence detection providesdynamical information buried in ensemble experiments.Fluorescence in the near-infrared(NIR)is particularly usefulbecause it offers higher signal-to-noise ratio and increased penetration depth in tissue compared with visiblefluorescence.The low quantum yield of most NIR fluorophores,however,makes the detection of single-moleculefluorescence difcult.Here,we use asymmetric plasmonic nano-antenna to enhance the fluorescence intensity ofAlEE1000,a typical NIR dye,by a factor up to 405.The asymmetric nano-antenna achieve such an enhancement mainlyby increasing the quantum yield(to~80%)rather than the local field,which degrades the molecules'photostability.Our coupled-mode-theory analysis reveals that the enhancements stem from resonance-matching between antennaand molecule and,more importantly,from optimizing the coupling between the near-and far-ield modes withdesigner asymmetric structures.Our work provides a universal scheme for engineering single-molecule fluorescence inthe near-infrared regime. | Wenqi Zhao Xiaochaoran Tian Zhening Fang Shiyi Xiao Meng Qiu Qiong He Wei Feng Fuyou Li Yuanbo Zhang Lei Zhou Yan-Wen Tan | 2021 | Light(Science & Applications)2021，10，5： | 1 |
| 11 | Preparation of a diacylglycerol - enriched soybean oil by phosphalipase AI catalyzed hydrolysis 显示文摘 | WANG Yong ZHAO Mourning OU Shiyi | 2009 | Journal of Molecular Catalysis B : Enzymatic2009，56，： | 1 |
| 12 | MOFs-Based Nitric Oxide Therapy for Tendon Regeneration显示文摘Tendon regeneration is still a great challenge due to its avascular structure and low self-renewal capability.The nitric oxide(NO)therapy emerges as a promising treatment for inducing the regeneration of injured tendon by angiogenesis.Here,in this study,a system that NO-loaded metal–organic frameworks(MOFs)encapsulated in polycaprolactone(PCL)/gelatin(Gel)aligned coaxial scaffolds(NMPGA)is designed and prepared for tendon repair.In this system,NO is able to be released in vitro at a slow and stable average speed of 1.67 nM h^−1 as long as 15 d without a burst release stage in the initial 48 h.Furthermore,NMPGA can not only improve the tubular formation capability of endothelial cells in vitro but also obviously increase the blood perfusion near the injured tendon in vivo,leading to accelerating the maturity of collagen and recovery of biomechanical strength of the regenerated tendon tissue.As a NO-loaded MOFs therapeutic system,NMPGA can promote tendon regeneration in a shorter healing period with better biomechanical properties in comparison with control group by angiogenesis.Therefore,this study not only provides a promising scaffold for tendon regeneration,but also paves a new way to develop a NO-based therapy for biomedical application in the future. | Jun Chen Dandan Sheng Ting Ying Haojun Zhao Jian Zhang Yunxia Li He Xu Shiyi Chen | 2021 | Nano-Micro Letters2021，13，2： | 1 |
| 13 | Partial hydrolysis of soybean oil by phospholipase A1 to produce di- acylglycerol - enriched oil 显示文摘 | WANG Yong ZHAO Mouming OU Shiyi | 2009 | Journal of Food Lipids2009，16，： | 1 |
| 14 | Abnormal intensity and polarization of Raman scattered light at edges of layered MoS_(2)显示文摘The edges of two-dimensional(2D)materials can exhibit special structure and thus distinctive properties differing from the interior,such as the modified photoluminescence emission,the improved electrocatalytic activity,and the enhanced nonlinear optical response.In this work,we report the observation of abrupt enhancement of Raman scattered light at edges of layered MoS_(2),which is closely related to the polarization of the incident light.More importantly,the intensity of out-of-plane A1g mode is enhanced much more obviously than the in-plane E_(2g)^(1)mode.The unique optical effect at edges is also reflected on the alteration of Raman selection rule.The forbidden Raman modes are observed at edge region,and the polarization of Raman scattered light can be modulated by the edge structure,which differs obviously from that of the interior.We attribute these particular performances to the modulation of the intensity and distribution of the electric field for the incident and Raman scattered light at the edge.This work provides a systematic research on the intensity and polarization modulation of the Raman scattering at edges,which would be helpful for understanding the distinctive optical properties of the edge structure. | Yan Zhao Liheng Zheng Shiyi Han Bo Xu Zheyu Fang Jin Zhang Lianming Tong | 2022 | Nano Research2022，15，7： | 0 |
| 15 | The Fabrication and SERS Performance of Multi-layer Hollow Au-Ag Alloy Nano Urchins Structure-based SERS Fiber Probe显示文摘Novel hollow Au Ag alloy nano urchins were synthesized via Ag seeds growth method,and self-assembly coated on the wall and end-tip of silica fiber for fiber probe fabrication.The nano urchins homogeneously distributed on fiber surface because of fiber silanization.The sizes and tip sharpness of the nano-urchins could be controlled by Ag seeds.The elements distribution analysis indicated there was high Ag content in tip-top for better surface enhance Raman scattering performance.The detectable concentration could be as low as 10-8 M using crystal violet molecules as analyte.Moreover,the fiber probes were stable in air,due to Au in the alloy.This fiber probe could be used for low content single molecular analysis. | HAO Zhenbang TIAN Qihang CAO Shiyi HAN Xiaoyu ZHANG Jihong XIE Jun ZHAO Xiujian | 2023 | Journal of Wuhan University of Technology(Materials Science)2023，38，2： | 0 |
| 16 | Efficacy of Zhumian Tang formula granules(助眠汤配方颗粒)combined with eszopiclone for the treatment of poor sleep quality:a multi-center,randomized controlled,superiority trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of Zhumian Tang formula granules(助眠汤配方颗粒)combined with eszopiclone for treating poor sleep quality.METHODS:This multi-center,dynamic blockrandomized,parallel-group superiority clinical trial included 130 patients.The combined treatment group received Zhumian Tang formula granules combined with eszopiclone treatment,and the control group received eszopiclone treatment only.The group allocation ratio was 1∶1.The duration of treatment was 2 weeks.Participants were asked to complete questionnaires before treatment,after 1 week of the intervention,after 2 weeks of the intervention,and at the follow-up on week 3.The primary outcomes were the Pittsburgh Sleep Quality Index(PSQI)score and the total effective rate of treatment.The secondary outcome was the rate of adverse effects.RESULTS:Compared with the eszopiclone treatment group,the PSQI score of the combined treatment group was significantly lower after 2 weeks of the intervention(6.98 vs 8.26,P<0.05).However,there was no significant difference in the mean PSQI score after 1 week of the intervention(9.89 vs 9.15,P=0.124).After the follow-up on week 3,the PSQI score of the combined treatment group remained significantly lower than that of the eszopiclone treatment group(6.12 vs 8.31,P<0.001).The total effective rates of treatment of the combined group and the eszopiclone group were 36.92%vs 35.38%(Z=0.033,P=0.855)after 1 week of the intervention,83.08%vs 58.46%(Z=9.519,P<0.05)after 2 weeks of the intervention,and 83.08%vs 61.54%(Z=7.530,P<0.05)and after the follow-up on week 3,respectively.There was no significant difference in the overall rate of adverse reactions between the combined and eszopiclone treatment groups(21.53%vs 31.8%,P=0.318).CONCLUSION:The combination of Zhumian Tang formula granules with eszopiclone was found to be safe and more effective in improving sleep quality than eszopiclone alone.Traditional Chinese medicine can enhance the effectiveness of Western medicine in the treatment of insomnia. | WANG Yichen WU Shiyi WANG Zhengyan CHANG Wenling XIE Zhihao TANG Xing ZHAO Songmei ZHOU Jing CHEN Zehong WANG Chao() YANG Chunxia | 2024 | Journal of Traditional Chinese Medicine2024，44，1： | 0 |
| 17 | Macrophage LMO7 deficiency facilitates inflammatory injury via metabolic-epigenetic reprogramming显示文摘Inflammatory bowel disease(IBD)is a formidable disease due to its complex pathogenesis.Macrophages,as a major immune cell population in IBD,are crucial for gut homeostasis.However,it is still unveiled how macrophages modulate IBD.Here,we found that LIM domain only 7(LMO7)was downregulated in pro-inflammatory macrophages,and that LMO7 directly degraded 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(PFKFB3)through K48-mediated ubiquitination in macrophages.As an enzyme that regulates glycolysis,PFKFB3 degradation led to the glycolytic process inhibition in macrophages,which in turn inhibited macrophage activation and ultimately attenuated murine colitis.Moreover,we demonstrated that PFKFB3 was required for histone demethylase Jumonji domaincontaining protein 3(JMJD3)expression,thereby inhibiting the protein level of trimethylation of histone H3 on lysine 27(H3K27me3).Overall,our results indicated the LMO7/PFKFB3/JMJD3 axis is essential for modulating macrophage function and IBD pathogenesis.Targeting LMO7 or macrophage metabolism could potentially be an effective strategy for treating inflammatory diseases. | Shixin Duan Xinyi Lou Shiyi Chen Hongchao Jiang Dongxin Chen Rui Yin Mengkai Li Yuseng Gou Wenjuan Zhao Lei Sun Feng Qian | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 18 | RePhine: An Integrative Method for Identification of Drug Response-related Transcriptional Regulators显示文摘Transcriptional regulators(TRs)participate in essential processes in cancer pathogenesis and are critical therapeutic targets.Identification of drug response-related TRs from cell line-based compound screening data is often challenging due to low m RNA abundance of TRs,protein modifications,and other confounders(CFs).In this study,we developed a regression-based pharmacogenomic and Ch IP-seq data integration method(Re Phine)to infer the impact of TRs on drug response through integrative analyses of pharmacogenomic and Ch IP-seq data.Re Phine was evaluated in simulation and pharmacogenomic data and was applied to pan-cancer datasets with the goal of biological discovery.In simulation data with added noises or CFs and in pharmacogenomic data,Re Phine demonstrated an improved performance in comparison with three commonly used methods(including Pearson correlation analysis,logistic regression model,and gene set enrichment analysis).Utilizing Re Phine and Cancer Cell Line Encyclopedia data,we observed that Re Phinederived TR signatures could effectively cluster drugs with different mechanisms of action.Re Phine predicted that loss-offunction of EZH2/PRC2 reduces cancer cell sensitivity toward the BRAF inhibitor PLX4720.Experimental validation confirmed that pharmacological EZH2 inhibition increases the resistance of cancer cells to PLX4720 treatment.Our results support that Re Phine is a useful tool for inferring drug response-related TRs and for potential therapeutic applications.The source code for Re Phine is freely available at http://gffzz188fe103f8f1460as9n9w5ob0fvnu65u9.ffgz.tsg.suse.edu.cn/coexps/Re Phine. | Xujun Wang Zhengtao Zhang Wenyi Qin Shiyi Liu Cong Liu Georgi ZGenchev Lijian Hui Hongyu Zhao Hui Lu | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 0 |
| 19 | Field-tuned magnetic structure and phase diagram of the honeycomb magnet YbCl_(3)显示文摘We report thermodynamic and neutron diffraction measurements on the magnetic ordering properties of the honeycomb lattice magnet YbCl_(3). We find YbCl_(3) exhibits a Ne′el type long-range magnetic order at the wavevector(0, 0, 0) below TN= 600 mK.This magnetic order is associated with a small sharp peak in heat capacity and most magnetic entropy release occurs above the magnetic ordering temperature. The magnetic moment lies in-plane, parallel to the monoclinic a-axis, whose magnitude mYb= 0.86(3) μBis considerably smaller than the expected fully ordered moment of 2.24 μBfor the doublet crystal-field ground state. The magnetic ordering moment gradually increases with increasing magnetic field perpendicular to the ab-plane, reaching a maximum value of 1.6(2) μBat 4 T, before it is completely suppressed above ~ 9 T. These results indicate the presence of strong quantum fluctuations in YbCl_(3). | YiQing Hao HongLiang Wo YiMeng Gu XiaoWen Zhang YiQing Gu ShiYi Zheng Yang Zhao GuangYong Xu Jeffrey WLynn Kenji Nakajima Naoki Murai WenBin Wang Jun Zhao | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，3： | 0 |
| 20 | Sequentially releasing self-healing hydrogel fabricated with TGFβ3-microspheres and bFGF to facilitate rat alveolar bone defect repair显示文摘Resorption and loss of alveolar bone leads to oral dysfunction and loss of natural or implant teeth. Biomimetic delivery of growth factors based on stem cell recruitment and osteogenic differentiation, as the key steps in natural alveolar bone regenerative process, has been an area of intense research in recent years. A mesoporous self-healing hydrogel(DFH) with basic fibroblast growth factor(bFGF) entrapment and transforming growth factor β3(TGFβ3)-loaded chitosan microspheres(CMs) was developed. The formulation was optimized by multiple tests of self-healing, in-bottle inversion, SEM, rheological, swelling rate and in vitro degradation. In vitro tubule formation assays, cell migration assays, and osteogenic differentiation assays confirmed the ability of DFH to promote blood vessels, recruit stem cells, and promote osteogenic differentiation. The optimum DFH formula is 0.05 ml 4ArmPEG-DF(20%) added to 1 ml CsGlu(2%) containing bFGF(80 ng) and TGFβ3-microspheres(5 mg). The results of in vitro release studied by Elisa kit, indicated an 95% release of b FGF in7 d and long-term sustained release of TGFβ3. For alveolar defects rat models, the expression levels of CD29 and CD45, the bone volume fraction, trabecular number, and trabecular thickness of new bone monitored by Micro-CT in DFH treatment groups were significantly higher than others(*P < 0.05, vs Model). HE and Masson staining show the same results.In conclusion, DFH is a design of bionic alveolar remodelling microenvironment, that is in early time microvessels formed by b FGF provide nutritious to recruited endogenous stem cells, then TGFβ3 slowly released speed up the process of new bones formation to common facilitate rat alveolar defect repair. The DFH with higher regenerative efficiency dovetails nicely with great demand due to the requirement of complicated biological processes. | Fenglin Yu Dezhi Geng Zhanpeng Kuang Shiyi Huang Yating Cheng Yini Chen Fang Leng Yu Bei Yueping Zhao Qingxia Tang Yadong Huang Qi Xiang | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，3： | 0 |
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