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| 1 | Synthesis and paste properties of octenyl succinic anhydride modified early Indica rice starch显示文摘Octenyl succinic anhydride (OSA) modified early Indica rice starch was prepared in aqueous slurry systems using response surface methodology. The paste properties of the OSA starch were also investigated. Results indicated that the suitable parameters for the preparation of OSA starch from early Indica rice starch were as follows: reaction period 4 h, reaction tem- perature 33.4 °C, pH of reaction system 8.4, concentration of starch slurry 36.8% (in proportion to water, w/w), amount of OSA 3% (in proportion to starch, w/w). The degree of substitution was 0.0188 and the reaction efficiency was 81.0%. The results of paste properties showed that with increased OSA modification, the starch derivatives had higher paste clarity, decreased retro- gradation and better freeze-thaw stability. | SONG Xiao-yan CHEN Qi-he RUAN Hui HE Guo-qing XU Qiong | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，10： | 51 |
| 2 | Broadband diffusion of terahertz waves by multi-bit coding metasurfaces显示文摘The terahertz region is a special region of the electromagnetic spectrum that incorporates the advantages of both microwaves and infrared light waves.In the past decade,metamaterials with effective medium parameters or gradient phases have been studied to control terahertz waves and realize functional devices.Here,we present a new approach to manipulate terahertz waves by using coding metasurfaces that are composed of digital coding elements.We propose a general coding unit based on a Minkowski closed-loop particle that is capable of generating 1-bit coding(with two phase states of 0 and 180°),2-bit coding(with four phase states of 0,90°,180°,and 270°),and multi-bit coding elements in the terahertz frequencies by using different geometric scales.We show that multi-bit coding metasurfaces have strong abilities to control terahertz waves by designing-specific coding sequences.As an application,we demonstrate a new scattering strategy of terahertz waves—broadband and wide-angle diffusion—using a 2-bit coding metasurface with a special coding design and verify it by both numerical simulations and experiments.The presented method opens a new route to reducing the scattering of terahertz waves. | Li-Hua Gao Qiang Cheng Jing Yang Shao-Jie Ma Jie Zhao Shuo Liu Hai-Bing Chen Qiong He Wei-Xiang Jiang Hui-Feng Ma Qi-Ye Wen Lan-Ju Liang Biao-Bing Jin Wei-Wei Liu Lei Zhou Jian-Quan Yao Pei-Heng Wu Tie-Jun Cui | 2015 | Light(Science & Applications)2015，4，1： | 31 |
| 3 | Production of high-quality agarwood in Aquilaria sinensis trees via whole-tree agarwood-induction technology显示文摘我们使用了整个树的 agarwood 感应的技术在 20 个月以内从 Aquilaria sinensis 树生产 agarwood,并且评估了这 agarwood 的质量。结果证明它的特征以质地,化学成分,香精油内容,和乙醇可溶的摘录内容类似于高级野 agarwood 的那些,与远超过繁体中文药 agarwood 的要求的最後的质量,作为在中国药典 2010 显示了。就我们的知识而言,这是第一研究证明高质量的 agarwood 能在整个 A 被生产。经由一种化学上导致的技术的 sinensis 树。 | Xing Li Zhang Yang Yang Liu Jian He Wei Yun Yang Zheng Zhang Jun Qing Huang Huai Qiong Chen Yu Jun Liu | 2012 | Chinese Chemical Letters2012，23，6： | 28 |
| 4 | Oridonin induces apoptosis in gastric cancer through Apaf-1,cytochrome c and caspase-3 signaling pathway显示文摘AIM:To investigate the effect and mechanism of oridonin on the gastric cancer cell line HGC-27 in vitro.METHODS:The inhibitory effect of oridonin on HGC-27 cells was detected using the 3-(4,5-dimethylthiazol2-yl)-2,5-diphenyl tetrazolium bromide assay.After treatment with 10 μg/mL oridonin for 24 h and 48 h,the cells were stained with acridine orange/ethidium bromide.The morphologic changes were observed under an inverted fluorescence microscope.DNA fragmen-tation(a hallmark of apoptosis) and lactate dehydrogenase activity were examined using DNA ladder assay and lactate dehydrogenase-release assay.After treated with oridonin(0,1.25,2.5,5 and 10 μg/mL),HGC-27 cells were collected for anexin V-phycoerythrin and 7-amino-actinomycin D double staining and tested by flow cytometric analysis,and oridonin-induced apoptosis in HGC-27 cells was detected.After treatment with oridonin for 24 h,the effects of oridonin on expression of Apaf-1,Bcl-2,Bax,caspase-3 and cytochrome c were also analyzed using reverse-transcript polymerase chain reaction(RT-PCR) and Western blotting.RESULTS:Oridonin significantly inhibited the proliferation of HGC-27 cells in a dose-and time-dependent manner.The inhibition rates of HGC-27 treated with four different concentrations of oridonin for 24 h(1.25,2.5,5 and 10 μg/mL) were 1.78% ± 0.36%,4.96% ± 1.59%,10.35% ± 2.76% and 41.6% ± 4.29%,respectively,which showed a significant difference(P < 0.05).The inhibition rates of HGC-27 treated with oridonin at the four concentrations for 48 h were 14.77% ± 4.21%,21.57% ± 3.75%,30.31% ± 4.91% and 61.19% ± 5.81%,with a significant difference(P < 0.05).The inhibition rates of HGC-27 treated with oridonin for 72 h at the four concentrations were 25.77% ± 4.85%,31.86% ± 3.86%,48.30% ± 4.16% and 81.80% ± 6.72%,with a significant difference(P < 0.05).Cells treated with oridonin showed typical apoptotic features with acridine orange/ethidium bromide staining.After treatment with oridonin,the cells became round,shrank,and developed small buds around the nuclear membrane while forming apoptotic bodies.Lactate dehydrogenase(LDH) release assay showed that after treated with 1.25 μg/mL and 20 μg/mL oridonin for 24 h,LDH release of HGC-27 caused by apoptosis increased from 22.94% ± 3.8% to 52.68% ± 2.4%(P < 0.001).However,the change in the release of LDH caused by necrosis was insignificant,suggesting thatthe major cause of oridonin-induced HGC-27 cell death was apoptosis.Flow cytometric analysis also revealed that oridonin induced significant apoptosis compared with the controls(P < 0.05).And the apoptosis rates of HGC-27 induced by the four different concentrations of oridonin were 5.3% ± 1.02%,12.8% ± 2.53%,28.5% ± 4.23% and 49.6% ± 3.76%,which were in a dose-dependent manner(P < 0.05).After treatment for 24 h,DNA ladder showed that oridonin induced a significant increase in DNA fragmentation in a dosedependent manner.RT-PCR revealed that mRNA expression levels were up-regulated compared with the controls in caspase-3(0.917 ± 0.103 vs 0.357 ± 0.019,P < 0.05),cytochrome c(1.429 ± 0.111 vs 1.002 ± 0.014,P < 0.05),Apaf-1(0.688 ± 0.101 vs 0.242 ± 0.037,P < 0.05) and Bax(0.856 ± 0.101 vs 0.278 ± 0.027,P < 0.05)(P < 0.05),whereas down-regulated in Bcl-2(0.085 ± 0.012 vs 0.175 ± 0.030,P < 0.05).Western blotting analysis also confirmed this result.CONCLUSION:Apoptosis of HGC-27 induced by oridonin may be associated with differential expression of Apaf-1,caspase-3 and cytochrome c,which are highly dependent upon the mitochondrial pathway. | Ke-Wang Sun Ying-Yu Ma Tian-Pei Guan Ying-Jie Xia Chang-Ming Shao Le-Gao Chen Ya-Jun Ren Hai-Bo Yao Qiong Yang Xu-Jun He | 2012 | World Journal of Gastroenterology2012，18，48： | 25 |
| 5 | Tunable/Reconfigurable Metasurfaces: Physics and Applications显示文摘Metasurfaces,ultrathin metamaterials constructed by planar meta-atoms with tailored electromagnetic(EM)responses,have attracted tremendous attention due to their exotic abilities to freely control EM waves.With active elements incorporated into metasurface designs,one can realize tunable and/or reconfgurable metadevices with functionalities controlled by external stimuli,opening a new platform to dynamically manipulate EM waves.In this article,we briefy review recent progress on tunable/reconfgurable metasurfaces,focusing on their working mechanisms and practical applications.We frst describe available approaches,categorized into diferent classes based on external stimuli applied,to realize homogeneous tunable/reconfgurable metasurfaces,which can ofer uniform manipulations on EM waves.We next summarize recent achievements on inhomogeneous tunable/reconfgurable metasurfaces with constitutional meta-atoms locally tuned by external knobs,which can dynamically control the wave-fronts of EM waves.We conclude this review by presenting our own perspectives on possible future directions and existing challenges in this fast developing feld. | Qiong He Shulin Sun Lei Zhou | 2019 | Research2019，，1： | 26 |
| 6 | High-efficiency surface plasmon meta-couplers: concept and microwave-regime realizations显示文摘Surface plasmon polaritons(SPPs)and their low-frequency counterparts(i.e.,spoof SPPs on artificial surfaces)have recently found numerous applications in photonics,but traditional devices to excite them(such as gratings and prism couplers)all suffer from problems of inherent low efficiency because the generated SPPs can decouple,returning to free space,and reflections at the device surface can never be avoided.Here,we propose a new SPP excitation scheme based on a transparent gradient metasurface and numerically demonstrate that it exhibits inherently high efficiency(~94%)because the designed meta-coupler suppresses both decoupling and surface reflections.As a practical realization of this concept,we fabricated a meta-coupler for operation in the microwave regime and performed near-field and far-field experiments to demonstrate that the achieved excitation efficiency for spoof SPPs reaches~73%,which is several times higher than that achieved by other available devices in this frequency domain.Our findings can motivate the design and fabrication of high-performance plasmonic devices to harvest light–matter interactions,particularly those related to spoof SPPs in the low-frequency domain. | Wujiong Sun Qiong He Shulin Sun Lei Zhou | 2016 | Light(Science & Applications)2016，5，1： | 23 |
| 7 | Incidence and mortality of lung cancer in China, 2008-2012显示文摘Objective: To analyze the incidence and mortality rates of lung cancer in China from 2008 to 2012.Methods: Incident and death cases of lung cancer were retrieved from the National Central Cancer Registry(NCCR) database collecting from 135 cancer registries in China during 2008-2012.The crude incidence and mortality rates of lung cancer were calculated by area(urban/rural),region(eastern,middle,western),gender and age group(0,1-4,5-9,…,85+).China census in 2000 and Segi's world population were applied for agestandardized rates.JoinPoint(Version 4.5.0.1) model was used for time trend analysis.Results: The crude incidence rate of lung cancer was 54.66/100,000 which ranked the first in overall cancers.The age-standardized incidence rates by China population(ASIRC) and by World population(ASIRW) were35.13/100,000 and 34.86/100,000,respectively.The crude mortality of lung cancer in China was 45.60/100,000 and it was the first cause of cancer-related death in overall cancers.The age-standardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were 28.57/100,000 and 28.22/100,000,respectively.Incidence and mortality rates of lung cancer were higher in males than in females and higher in urban areas than in rural areas.Eastern areas had the highest incidence and mortality rates followed by middle and western areas.Incidence and mortality rates of lung cancer retained low level in age groups before 40 years old but increased greatly after and peaked in age group of 80-84.During 2003-2012,the temporal trend of the incidence rate of lung cancer in both sexes in China was general stable(P<0.05).The lung cancer incidence rate increased by 0.71% per year in females(P<0.05) and 2.26% per year in rural areas(P<0.05).The mortality rate of lung cancer decreased slightly annually during 2003-2012 in China(P>0.05).In urban areas,it declined by 0.76%per year(P<0.05),but rose by 2.09% per year(P<0.05) in rural areas.Conclusions: Appropriate targeted prevention,early detection and treatment programs should be carried out to control the local burden of lung cancer. | Shuzheng Liu Qiong Chen Lanwei Guo Xiaoqin Cao Xibin Sun Wanqing Chen Jie He | 2018 | Chinese Journal of Cancer Research2018，30，6： | 19 |
| 8 | Spin-decoupled metasurface for simultaneous detection of spin and orbital angular momenta via momentum transformation显示文摘With inherent orthogonality,both the spin angular momentum(SAM)and orbital angular momentum(OAM)of photons have been utilized to expand the dimensions of quantum information,optical communications,and information processing,wherein simultaneous detection of SAMs and OAMs with a single element and a single-shot measurement is highly anticipated.Here,a single azimuthal-quadratic phase metasurface-based photonic momentum transformation(PMT)is illustrated and utilized for vortex recognition.Since different vortices are converted into focusing patterns with distinct azimuthal coordinates on a transverse plane through PMT,OAMs within a large mode space can be determined through a single-shot measurement.Moreover,spin-controlled dual-functional PMTs are proposed for simultaneous SAM and OAM sorting,which is implemented by a single spin-decoupled metasurface that merges both the geometric phase and dynamic phase.Interestingly,our proposed method can detect vectorial vortices with both phase and polarization singularities,as well as superimposed vortices with a certain interval step.Experimental results obtained at several wavelengths in the visible band exhibit good agreement with the numerical modeling.With the merits of ultracompact device size,simple optical configuration,and prominent vortex recognition ability,our approach may underpin the development of integrated and high-dimensional optical and quantum systems. | Yinghui Guo Shicong Zhang Mingbo Pu Qiong He Jinjin Jin Mingfeng Xu Yaxin Zhang Ping Gao Xiangang Luo | 2021 | Light(Science & Applications)2021，10，4： | 14 |
| 9 | Structure and photocatalytic properties of TiO_2-Graphene Oxide intercalated composite显示文摘TiO2-Graphene Oxide intercalated composite (TiO2-Graphene Oxide) has been successfully prepared at low temperature (80°C) with graphite oxide (GO) and titanium sulfate (Ti(SO4)2) as initial reactants.GO was firstly exfoliated by NaOH and formed single and multi-layered graphite oxide mixture which can be defined as graphene oxide,[TiO]2+ induced by the hydrolysis of Ti(SO4)2 diffused into graphene oxide interlayer by electrostatic attraction.The nucleation and growth of TiO2 crystallites took place at low temperature and TiO2-Graphene Oxide composite was successfully synthesized.Furthermore,the photocatalytic properties of TiO2-Graphene Oxide under the irradiation of UV light were also studied.The results show that the degradation rate of methyl orange is 1.16 mg min-1 g-1(refer to the efficiency of the initial 15 min).Compared with P25 powder,this kind of intercalation composite owns much better efficiency.On the other hand,the reusable properties and stable properties of TiO2-Graphene Oxide intercalated composite are also discussed in this paper.At last,crystalline structure,interface status,thermal properties and microscopic structure of TiO2-Graphene Oxide were characterized by X-ray diffraction (XRD),X-ray photoelectron spectroscopy (XPS),thermogravimetric analysis (TGA),field emission scanning electron microscopy (FESEM) and high-resolution Transmission Electron Microscopy (HRTEM).Also,we have analyzed major influencing factors and mechanism of the composite structures which evidently improve the photocatalytic properties. | ZHANG Qiong HE YunQiu CHEN XiaoGang HU DongHu LI LinJiang YIN Ting JI LingLi | 2011 | Chinese Science Bulletin2011，56，3： | 14 |
| 10 | Double-balloon enteroscopy for mesenchymal tumors of small bowel:Nine years' experience显示文摘AIM:To assess the value of double-balloon enteroscopy(DBE) for the diagnosis of gastrointestinal mesenchymal tumors(GIMTs) in the small bowel and clarify their clinical and endoscopic characteristics.METHODS:A retrospective review in a total of 783 patients who underwent a DBE procedure from January 2003 to December 2011 was conducted.Data from patients with pathologically confirmed GIMTs were analyzed at a single tertiary center with nine years' experience.The primary outcomes assessed included characteristics of patients with GIMTs,indications for DBE,overall diagnostic yield of GIMTs,endoscopic morphology,positive biopsy,comparison of diagnosis with capsule endoscopy,and subsequent interventional management.RESULTS:GIMTs were identified and analyzed in 77 patients.The mean age was 47.74 ± 14.14 years(range:20-77 years),with 63.6% being males.The majority of individuals presented with gastrointestinal bleeding,accounting for 81.8%,followed by abdominal pain,accounting for 10.4%.Small bowel pathologies were found in 71 patients,the detection rate was 92.2%.The diagnostic yield of DBE for GIMTs was 88.3%.DBE was superior to capsule endoscopy in the diagnosis of GIMTs(P = 0.006;McNemar's χ2 test).Gastrointestinal stromal tumor was the most frequent and leiomyoma was the second frequent GIMT.Single and focal lesions were typical of GIMTs,and masses with smooth or unsmooth surface were the most common in the small bowel.GIMTs were removed from all the patients surgically except one patient treated with endoscopic resection.CONCLUSION:DBE is a safe and valuable procedure for patients with suspected GIMTs,and it provides an accurate position for subsequent surgical intervention. | Qiong He Yang Bai Fa-Chao Zhi Wei Gong Hong-Xiang Gu Zhi-Min Xu Jian-Qun Cai De-Shou Pan Bo Jiang | 2013 | World Journal of Gastroenterology2013，19，11： | 11 |
| 11 | Controlling angular dispersions in optical metasurfaces显示文摘Although metasurfaces have shown great potential for manipulating light,most previously realized meta-devices suffer from uncontrolled angular dispersions,making them unfavorable for many applications.Here,we propose a general strategy to realize optical metasurfaces with desired angular dispersions based on carefully controlling both the near-field couplings between meta-atoms and the radiation pattern of a single meta-atom.Utilizing such a strategy,we experimentally demonstrate a series of optical meta-devices with predesigned angular dispersions,including two incident-angle-insensitive absorbers,one incident-angle-selective absorber,and one multifunctional meta-polarizer whose functionality changes from a perfect mirror to a half-waveplate as the excitation angle varies.Finally,we design a gradient meta-device using meta-atom arrays with purposely controlled angular dispersions and numerically demonstrate that it can exhibit distinct wavefront-control functionalities when illuminated at different incident angles.Our findings establish a new platform for achieving angle-multiplexed functional meta-devices,significantly expanding the wave-manipulation capabilities of optical metasurfaces. | Xiyue Zhang Qi Li Feifei Liu Meng Qiu Shulin Sun Qiong He Lei Zhou | 2020 | Light(Science & Applications)2020，9，1： | 11 |
| 12 | A new prognostic histopathologic classification of nasopharyngeal carcinoma显示文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis. | Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao | 2016 | Chinese Journal of Cancer2016，35，6： | 10 |
| 13 | Variable and Robust East Asian Monsoon Rainfall Response to El Nio over the Past 60 Years(1957–2016)显示文摘Severe flooding occurred in southern and northern China during the summer of 2016 when the 2015 super El Nio decayed to a normal condition. However, the mean precipitation during summer(June–July-August) 2016 does not show significant anomalies, suggesting that — over East Asia(EA) — seasonal mean anomalies have limited value in representing hydrological hazards. Scrutinizing season-evolving precipitation anomalies associated with 16 El Nio episodes during 1957–2016 reveals that, over EA, the spatiotemporal patterns among the four categories of El Nio events are quite variable, due to a large range of variability in the intensity and evolution of El Nio events and remarkable subseasonal migration of the rainfall anomalies. The only robust seasonal signal is the dry anomalies over central North China during the El Nio developing summer. Distinguishing strong and weak El Nio impacts is important. Only strong El Nio events can persistently enhance EA subtropical frontal precipitation from the peak season of El Nio to the ensuing summer, by stimulating intense interaction between the anomalous western Pacific anticyclone(WPAC) and underlying dipolar sea surface temperature anomalies in the Indo-Pacific warm pool, thereby maintaining the WPAC and leading to a prolonged El Nio impact on EA. A weak El Nio may also enhance the post-El Nio summer rainfall over EA, but through a different physical process: the WPAC re-emerges as a forced response to the rapid cooling in the eastern Pacific. The results suggest that the skillful prediction of rainfall over continental EA requires the accurate prediction of not only the strength and evolution of El Nio, but also the subseasonal migration of EA rainfall anomalies. | Bin WANG Juan LI Qiong HE | 2017 | Advances in Atmospheric Sciences2017，34，10： | 10 |
| 14 | Permian integrative stratigraphy and timescale of China显示文摘A series of global major geological and biological events occurred during the Permian Period. Establishing a highresolution stratigraphic and temporal framework is essential to understand their cause-effect relationship. The official International timescale of the Permian System consists of three series(i.e., Cisuralian, Guadalupian and Lopingian in ascending order) and nine stages. In China, the Permian System is composed of three series(Chuanshanian, Yansingian and Lopingian) and eight stages, of which the subdivisions and definitions of the Chuanshanian and Yangsingian series are very different from the Cisuralian and Guadalupian series. The Permian Period spanned ~47 Myr. Its base is defined by the First Appearance Datum(FAD) of the conodont Streptognathodus isolatus at Aidaralash, Kazakhstan with an interpolated absolute age 298.9±0.15 Ma at Usolka, southern Urals, Russia. Its top equals the base of the Triassic System and is defined by the FAD of the conodont Hindeodus parvus at Meishan D section, southeast China with an interpolated absolute age 251.902±0.024 Ma. Thirty-five conodont, 23 fusulinid, 17 radiolarian and 20 ammonoid zones are established for the Permian in China, of which the Guadalupian and Lopingian conodont zones have been served as the standard for international correlation. The Permian δ13 Ccarbtrend indicates that it is characterized by a rapid negative shift of 3–5‰ at the end of the Changhsingian, which can be used for global correlation of the end-Permian mass extinction interval, but δ13 Ccarbrecords from all other intervals may have more or less suffered subsequent diagenetic alteration or represented regional or local signatures only. Permian δ18 Oapatitestudies suggest that an icehouse stage dominated the time interval from the late Carboniferous to Kungurian(late Cisuralian). However, paleoclimate began to ameriolate during the late Kungurian and gradually shifted into a greenhouse-dominated stage during the Guadalupian.The Changhsingian was a relatively cool stage, followed by a globally-recognizable rapid temperature rise of 8–10°C at the very end of the Changhsingian. The87 Sr/86 Sr ratio trend shows that their values at the beginning of the Permian were between 0.70800,then gradually decreased to the late Capitanian minimum 0.70680–0.70690, followed by a persistent increase until the end of the Permian with the value 0.70708. Magenetostratigraphy suggests two distinct stages separated by the Illawarra Reversal in the middle Wordian, of which the lower is the reverse polarity Kiaman Superchron and the upper is the mixed-polarity Illawarra Superchron. The end-Guadalupian(or pre-Lopingian) biological crisis occurred during the late Capitanian, when faunal changeovers of different fossil groups had different paces, but generally experienced a relatively long time from the Jinogondolella altudensis Zone until the earliest Wuchiapingian. The end-Permian mass extinction was a catastrophic event that is best constrained at the Meishan section, which occurred at 251.941±0.037 Ma and persisted no more than 61±48 kyr. After the major pulse at Bed 25, the extinction patterns are displayed differently in different sections. The global end-Guadalupian regression is manifested between the conodont Jinogondolella xuanhanensis and Clarkina dukouensis zones and the endChanghsingian transgression began in the Hindeodus changxingensis-Clarkina zhejiangensis Zone. The Permian Period is also characterized by strong faunal provincialism in general, which resulted in difficulties in inter-continental and inter-regional correlation of both marine and terrestrial systems. | Shuzhong SHEN Hua ZHANG Yichun ZHANG Dongxun YUAN Bo CHEN Weihong HE Lin MU Wei LIN Wenqian WANG Jun CHEN Qiong WU Changqun CAO Yue WANG Xiangdong WANG | 2019 | Science China Earth Sciences2019，62，1： | 9 |
| 15 | Efficient manipulations of circularly polarized terahertz waves with transmissive metasurfaces显示文摘The unrestricted control of circularly polarized(CP)terahertz(THz)waves is important in science and applications,but conventional THz devices suffer from issues of bulky size and low efficiency.Although Pancharatnam-Berry(PB)metasurfaces have shown strong capabilities to control CP waves,transmission-mode PB devices realized in the THz regime are less efficient,limiting their applications in practice.Here,based on Jones matrix analysis,we design a trilayer structure(thickness of ~λ/5)and experimentally demonstrate that the structure can serve as a highly efficient transmissive meta-atom(relative efficiency of ~90%)to build PB metadevices for manipulating CP THz waves.Two ultrathin THz metadevices are fabricated and experimentally characterized with a z-scan THz imaging system.The first device can realize a photonic spin Hall effect with an experimentally demonstrated relative efficiency of ~90%,whereas the second device can generate a high-quality background-free CP Bessel beam with measured longitudinal and transverse field patterns that exhibit the nondiffracting characteristics of a Bessel beam.All the experimental results are in excellent agreement with full-wave simulations.Our results pave the way to freely manipulate CP THz beams,laying a solid basis for future applications such as biomolecular control and THz signal transportation. | Min Jia Zhuo Wang Heting Li Xinke Wang Weijie Luo Shulin Sun Yan Zhang Qiong He Lei Zhou | 2019 | Light(Science & Applications)2019，8，1： | 9 |
| 16 | Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference显示文摘Mesenchymal stem cells(MSCs)are multipotent stem cells and capable of differentiating into multiple cell types including osteoblastic,chondrogenic and adipogenic lineages.We previously identified BMP9 as one of the most potent BMPs that induce osteoblastic differentiation of MSCs although exact molecular mechanism through which BMP9 regulates osteogenic differentiation remains to be fully understood.Here,we seek to develop a recombinant adenovirus system to optimally silence mouse BMP9 and then characterize the important role of BMP9 in osteogenic differentiation of MSCs.Using two different siRNA bioinformatic prediction programs,we design five siRNAs targeting mouse BMP9(or simB9),which are expressed under the control of the converging H1 and U6 promoters in recombinant adenovirus vectors.We demonstrate that two of the five siRNAs,simB9-4 and simB9-7,exhibit the highest efficiency on silencing exogenous mouse BMP9 in MSCs.Furthermore,simB9-4 and simB9-7 act synergistically in inhibiting BMP9-induced expression of osteogenic markers,matrix mineralization and ectopic bone formation from MSCs.Thus,our findings demonstrate the important role of BMP9 in osteogenic differentiation of MSCs.The characterized simB9 siRNAs may be used as an important tool to investigate the molecular mechanism behind BMP9 osteogenic signaling.Our results also indicate that recombinant adenovirus-mediated expression of siRNAs is efficient and sustained,and thus may be used as an effective delivery vehicle of siRNA therapeutics. | Shujuan Yan Ruyi Zhang Ke Wu Jing Cui Shifeng Huang Xiaojuan Ji Liping An Chengfu Yuan Cheng Gong Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Bo Liu Rex C.Haydon Michael J.Lee Russell R.Reid Jennifer Moriatis Wolf Qiong Shi Hue H.Luu Tong-Chuan He Yaguang Weng | 2018 | Genes & Diseases2018，5，2： | 8 |
| 17 | Dynamically controlling terahertz wavefronts with cascaded metasurfaces显示文摘Dynamically controlling terahertz(THz)wavefronts in a designable fashion is highly desired in practice.However,available methods working at microwave frequencies do not work well in the THz regime due to lacking suitable tunable elements with submicrometer sizes.Here,instead of locally controlling individual meta-atoms in a THz metasurface,we show that rotating different layers(each exhibiting a particular phase profile)in a cascaded metadevice at different speeds can dynamically change the effective Jonesmatrix property of the whole device,thus enabling extraordinary manipulations on the wavefront and polarization characteristics of a THz beam impinging on the device.After illustrating our strategy based on model calculations,we experimentally demonstrate two proof-of-concept metadevices,each consisting of two carefully designed all-silicon transmissive metasurfaces exhibiting different phase profiles.Rotating two metasurfaces inside the fabricated devices at different speeds,we experimentally demonstrate that the first metadevice can efficiently redirect a normally incident THz beam to scan over a wide solid-angle range,while the second one can dynamically manipulate both the wavefront and polarization of a THz beam.Our results pave the way to achieving dynamic control of THz beams,which is useful in many applications,such as THz radar,and bio-and chemical sensing and imaging. | Xiaodong Cai Rong Tang Haoyang Zhou Qiushi Li Shaojie Ma Dongyi Wang Tong Liu Xiaohui Ling Wei Tan Qiong He Shiyi Xiao Lei Zhou | 2021 | Advanced Photonics2021，3，3： | 8 |
| 18 | Peripheral CD4^(+) T cell signatures in predicting the responses to anti-PD-1/PD-L1 monotherapy for Chinese advanced non-small cell lung cancer显示文摘Limited benefit population of immune checkpoint inhibitors makes it urgent to screen predictive biomarkers for stratifying the patients.Herein,we have investigated peripheral CD4^(+) T cell signatures in advanced non-small cell lung cancer(NSCLC)patients receiving anti-PD-1/PD-L1 treatments.It was found that the percentages of IFN-γand IL-17A secreting naïve CD4^(+) T cells(Tn),and memory CD4^(+) T cells(Tm)expressing PD-1,PD-L1 and CTLA-4 were significantly higher in responder(R)than non-responder(NonR)NSCLC patients associated with a longer progression free survival(PFS).Logistic regression analysis revealed that the baseline IFN-γ-producing CD4^(+) Tn cells and PD-1^(+)CD4^(+) Tm cells were the most significant signatures with the area under curve(AUC)value reaching 0.849.This was further validated in another anti-PD-1 monotherapy cohort.Conversely,high percentage of CTLA-4^(+)CD4^(+) Tm cells was associated with a shorter PFS in patients receiving anti-PD-L1 monotherapy.Our study therefore elucidates the significance of functional CD4^(+) Tn and Tm subpopulations before the treatment in predicting the responses to anti-PD-1 treatment in Chinese NSCLC patients.The fact that there display distinct CD4^(+) T cell signatures in the prediction to anti-PD-1 and anti-PD-L1 monotherapy from our study provides preliminary evidence on the feasibility of anti-PD-1 and anti-PD-L1 combination therapy for advanced NSCLC patients. | Liliang Xia Hui Wang Mingjiao Sun Yi Yang Chengcheng Yao Sheng He Huangqi Duan Weimin Xia Ruiming Sun Yaxian Yao Zhiwei Chen Qiong Zhao Hong Li Shun Lu Ying Wang | 2021 | Science China(Life Sciences)2021，64，10： | 7 |
| 19 | The Intelligent Control System of Traffic Light Based on Fog Computing显示文摘The continuous increase of city motors with the improvement of society has introduced extraordinary demanding situations for the traffic situation of the town.Intelligent traffic has proposed a diversity of solutions to relieve urban traffic accidents and congestion and other troubles. It cannot regulate the cycle of traffic light in real time in keeping with the occurring traffic flux which additionally, may produce the traffic jam to result in the increase for the range of automobiles and the longer of passage time. In purpose to surmount the shortcomings of traditional traffic light control, this paper is presenting a form of intelligent control system for traffic light founding on fog computing. It calculates and shares the traffic flux situation at the intersection and the surrounding intersection through fog computing platform. Regarding the traffic flow at the intersection and the traffic flow at the surrounding intersection as the parameters, the intelligent control algorithm of traffic light is designed for achieving mutual coordination and mutual influence between different intersections, so that the traffic efficiency of each intersection is improved and the traffic flow of the entire transport network is alleviated. The simulation results showed this intelligent control system progress the traffic efficiency of every intersection and relieve the traffic flow of the whole transport network. | WU Qiong HE Fanfan FAN Xiumei | 2018 | Chinese Journal of Electronics2018，27，6： | 7 |
| 20 | Crosstalk-free achromatic full Stokes imaging polarimetry metasurface enabled by polarization-dependent phase optimization显示文摘Imaging polarimetry is one of the most widely used analytical technologies for object detection and analysis.To date,most metasurface-based polarimetry techniques are severely limited by narrow operating bandwidths and inevitable crosstalk,leading to detrimental effects on imaging quality and measurement accuracy.Here,we propose a crosstalkfree broadband achromatic full Stokes imaging polarimeter consisting of polarization-sensitive dielectric metalenses,implemented by the principle of polarization-dependent phase optimization.Compared with the single-polarization optimization method,the average crosstalk has been reduced over three times under incident light with arbitrary polarization ranging from 9μm to 12μm,which guarantees the measurement of the polarization state more precisely.The experimental results indicate that the designed polarization-sensitive metalenses can effectively eliminate the chromatic aberration with polarization selectivity and negligible crosstalk.The measured average relative errors are 7.08%,8.62%,7.15%,and 7.59%at 9.3,9.6,10.3,and 10.6μm,respectively.Simultaneously,the broadband full polarization imaging capability of the device is also verified.This work is expected to have potential applications in wavefront detection,remote sensing,light-field imaging,and so forth. | Yaxin Zhang Mingbo Pu Jinjin Jin Xinjian Lu Yinghui Guo Jixiang Cai Fei Zhang Yingli Ha Qiong He Mingfeng Xu Xiong Li Xiaoliang Ma Xiangang Luo | 2022 | Opto-Electronic Advances2022，5，11： | 6 |
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