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| 1 | Lushan M_S7.0 earthquake:A blind reserve-fault event显示文摘In the epicenter of the Lushan MS7.0 earthquake there are several imbricate active reverse faults lying from northwest to southeast,namely the Gengda-Longdong,Yanjing-Wulong,Shuangshi-Dachuan and Dayi faults.Emergency field investigations have indicated that no apparent earthquake surface rupture zones were located along these active faults or their adjacent areas.Only brittle compressive ruptures in the cement-covered pavements can be seen in Shuangshi,Taiping,Longxing and Longmen Townships,and these ruptures show that a local crustal shortening occurred in the region during the earthquake.Combining spatial distribution of the relocated aftershocks and focal mechanism solutions,it is inferred that the Lushan earthquake is classified as a typical blind reverse-fault earthquake,and it is advised that the relevant departments should pay great attention to other historically un-ruptured segments along the Longmenshan thrust belt and throughout its adjacent areas. | XU XiWei WEN XueZe HAN ZhuJun CHEN GuiHua LI ChuanYou ZHENG WenJun ZHNAG ShiMin REN ZhiQun XU Chong TAN XiBin WEI ZhanYu WANG MingMing REN JunJie HE ZhongTai LIANG MingJian | 2013 | Chinese Science Bulletin2013,58,28: | 35 |
| 2 | Prospect of the QTL-qSB-9^(Tq) utilized in molecular breeding program of japonica rice against sheath blight显示文摘The major QTL-qSB-9Tq conferring partial resistance to rice (Oryza sativa L.) sheath blight (Rhizoctonia solani Kühn) has been verified on chromosome 9 of the indica rice cultivar, Teqing. In this study, the prospect of this QTL utilized in molecular breeding program of japonica rice for sheath blight resistance was investigated. Most of the japonica rice cultivars showed lower level of sheath blight resistance than the indica rice cultivars. At the corresponding site of qSB-9Tq, nine typical japonica rice cultivars from different ecological regions or countries proved to possess the susceptible allele(s). Introgression of qSB-9Tq into these cultivars enhanced their resistance level by decreasing sheath blight score of 1.0 (0.5–1.3), which indicated that qSB-9Tq had a large potential in strengthening the resistance of japonica rice to sheath blight. The use of the three molecular markers, which were polymorphic between Teqing and many japonica rice cultivars, promotes the application of qSB-9Tq in a concrete molecular breeding program. | Shimin Zuo Li Zhang Hui Wang Yuejun Yin Yafang Zhang Zongxiang Chen Yuyin Ma Xuebiao Pan | 2008 | Journal of Genetics and Genomics2008,35,8: | 14 |
| 3 | Fine mapping of an incom-plete recessive gene for leaf rolling in rice (Oryza sativa L.)显示文摘Genetic analysis and fine mapping of genes controlling leaf rolling were conducted using two back-crossed generations (BC4F2, BC4F3) derived from a cross between QMX, a non-rolled leaf cultivar as a recurrent par-ent, and JZB, a rolled leaf NIL of ZB as a donor parent. Re-sults indicated that leaf rolling was mainly controlled by an incompletely recessive major gene, namely rl(t), and at the same time, affected by quantitative trait loci (QTLs) and/or the environment. A genetic linkage map was constructed using MAPMAKER/EXP3.0 with eight polymorphic mark-ers on chromosome 2, which were screened by BAS method from 500 SSR markers and 15 newly developed inser-tion/deletion (InDel) markers. The position of rl(t) was esti-mated with composite interval mapping (CIM) method using WinQTLcart2.5. Gene rl(t) was mapped between markers InDel 112 and RM3763, and 1.0 cM away from InDel 112 using 241 plants in BC4F2 population. To fine map rl(t), one BC4F3 line with 855 plants was generated from one semi-rolled leaf plant in BC4F2. Four new polymorphic InDel markers were developed, including InDel 112.6 and InDel 113 located between markers InDel112 and RM3763. Based on the information of recombination offered by 191 rolled leaf plants and 185 non-rolled leaf plants from the BC4F3 line ,we mapped rl(t) to a 137-kb region between markers InDel 112.6 and InDel 113. Homologous gene analysis sug-gested that rl(t) was probably related to the process of leaf development regulated by microRNA. | SHAO Yuanjia PAN Cunhong CHEN Zongxiang ZUO Shimin ZHANG Yafang PAN Xuebiao | 2005 | Chinese Science Bulletin2005,50,21: | 13 |
| 4 | Video-based running water animation in Chinese painting style显示文摘This paper presents a novel algorithm for synthesizing animations of running water,such as water-falls and rivers,in the style of Chinese paintings,for applications such as cartoon making. All video frames are first registered in a common coordinate system,simultaneously segmenting the water from background and computing optical flow of the water. Taking artists’ advice into account,we produce a painting structure to guide painting of brush strokes. Flow lines are placed in the water following an analysis of variance of optical flow,to cause strokes to be drawn where the water is flowing smoothly,rather than in turbulent areas: this allows a few moving strokes to depict the trends of the water flows. A variety of brush strokes is then drawn using a template determined from real Chinese paintings. The novel contributions of this paper are:a method for painting structure generation for flows in videos,and a method for stroke placement,with the necessary temporal coherence. | ZHANG SongHai CHEN Tao ZHANG YiFei HU ShiMin MARTIN Ralph | 2009 | Science in China(Series F)2009,52,2: | 8 |
| 5 | Electron beam welding of Re and BT5-1 titanium alloy显示文摘Based on the binary alloy phase diagram of Re-Ti, the weldability of Re and BT5-1 titanium alloy was analyzed.Using two methods of direct electron beam welding (EBW-D) and intergradation electron beam welding (EBW-I), Re andBT5-1 was welded. Experimental results show that the joint figuration of EBW-D between Re and BT5-1 is not fine, andthe joint is inclined to brittleness rupture. The joint figuration of EBW-I between Re and BT5-1 is fine. No cracking andother disfigures occur in the intergradation joint. The element distribution of Re, Me, and Ti in the weld metal is progres-sional diversification. | YANG Shanglei XUE Xiaohuai LOU Songnian CHEN Yan LI Shimin | 2005 | Rare Metals2005,24,3: | 5 |
| 6 | Nanoscale zero-valent iron/magnetite carbon composites for highly efficient immobilization of U(Ⅵ)显示文摘Nanoscale zerovalent iron/magnetic carbon(NZVI/MC) composites were successfully synthesized by simply calcining yellow pine and iron precursors. NZVI/MC pyrolyzed at 800°C(NZVI/MC800) had a higher percentage of NZVI and displayed better resistance to aggregation and oxidation of NZVI than samples prepared at other temperatures. The NZVI/MC800 material was applied for the elimination of U(Ⅵ) from aqueous solutions. The results suggested that the NZVI/MC800 displayed excellent adsorption capacity(203.94 mg/g)toward U(Ⅵ). The significant adsorption capacity and fast adsorption kinetics were attributed to the presence of well-dispersed NZVI, which could quickly reduce U(Ⅵ) into U(Ⅳ), trapping the guest U(Ⅳ) in the porous biocarbon matrix. The removal of U(Ⅵ) on the NZVI/MC samples was strongly affected by solution pH. The NZVI/MC samples also displayed outstanding reusability for U(Ⅵ) removal after multiple cycles. These findings indicate that NZVI/MC has great potential for remediation of wastewater containing U(Ⅵ). | Zhimin Lv Shimin Yang Lei Chen Ahmed Alsaedi Tasawar Hayat Changlun Chen | 2019 | Journal of Environmental Sciences2019,31,2: | 5 |
| 7 | Government intervention and investment efficiency: Evidence from China显示文摘 | Shimin Chen Zheng Sun Song Tang Donghui Wu | 2010 | Journal of Corporate Finance2010,,2: | 5 |
| 8 | Isolation and characterization of rl_(t), a gene that controls leaf rolling in rice显示文摘Moderate leaf rolling is one of the most important morphological traits in rice breeding for plant ideotype.Previous studies have shown that the rl(t)gene has a high breeding potential for developing hybrid-rice varieties with an ideal ideotype,because it leads to an appropriate leaf rolling index(LRI)of about 30%in the heterozygous state,and had a positive effect on grain yield.In this study,we isolated rl(t)and performed a preliminary investigation of its function in regulating leaf rolling in rice.DNA sequencing identified a single base change(G to T)in the finely mapped region(11 kb)containing rl(t),and this is located in 30-untranslated region(30-UTR)of the only predicted gene,Roc5(Rice outermost cell-specific).The expression level of Roc5 is significantly higher in the rl(t)mutant than in the wild-type.Using RNAi and overexpression analysis,we found that the expression level of Roc5 correlated with LRI and leaf bulliform area,and wasalso associated with leaf abaxial or adaxial rolling.These results confirmed that Roc5 controls leaf rolling in a dosage-dependent manner.Bioinformatics analysis revealed a conserved 17-nt sequence(called the GU-rich element)in the 30-UTR of HD-GL2(Homeodomain-Glabra2)family genes including Roc5.Based on the model of this element in regulating mRNA stability in mammals,we speculate that the single nucleotide change in this element accounts for the higher expression level of Roc5 in the rl(t)mutant compared to the wild-type,which ultimately leads to adaxial rolling of the leaf.This discovery further enhances our knowledge of the molecular mechanisms underlying leaf rolling in rice. | Lei Li Xiang Xue Zongxiang Chen Yafang Zhang Yuyin Ma Cunhong Pan Junkai Zhu Xuebiao Pan Shimin Zuo | 2014 | Chinese Science Bulletin2014,59,25: | 4 |
| 9 | OsSERK1 regulates rice development but not immunity to Xanthomonas oryzae pv. oryzae or Magnaporthe oryzae显示文摘Somatic embryogenesis receptor kinase(SERK)proteins play pivotal roles in regulation of plant development and immunity. The rice genome contains two SERK genes,OsSerk1 and OsSerk2. We previously demonstrated that OsSerk2 is required for rice Xa21-mediated resistance to Xanthomonas oryzae pv. oryzae(Xoo) and for normal development. Here we report the molecular characterization of OsSerk1. Overexpression of OsSerk1 results in a semi-dwarf phenotype whereas silencing of OsSerk1 results in a reduced angle of the lamina joint. OsSerk1 is not required for rice resistance to Xoo or Magnaporthe oryzae. Overexpression of Os Serk1 in OsSerk2-silenced lines complements phenotypes associated with brassinosteroid(BR) signaling defects, but not the disease resistance phenotype mediated by Xa21. In yeast, OsSERK1 interacts with itself forming homodimers, and also interacts with the kinase domains of OsSERK2 and BRI1, respectively.OsSERK1 is a functional protein kinase capable of auto-phosphorylation in vitro. We conclude that, whereas OsSERK2 regulates both rice development and immunity, OsSERK1 functions in rice development but not immunity to Xoo and M. oryzae. | Shimin Zuo Xiaogang Zhou Mawsheng Chen Shilu Zhang Benjamin Schwessinger Deling Ruan Can Yuan Jing Wang Xuewei Chen Pamela C.Ronald | 2014 | Journal of Integrative Plant Biology2014,56,12: | 4 |
| 10 | Synthesis, characterization, thermodynamic and kinetic investigations on uranium(Ⅵ) adsorption using organic-inorganic composites: Zirconyl-molybdopyrophosphate-tributyl phosphate显示文摘Zirconyl-molybdopyrophosphate-tributyl phosphate(ZMPP-TBP)was a novel organic-inorganic composite adsorbent prepared by co-precipitation method and used in the adsorption of uranium from aqueous solution in batch adsorption experiments.The as-obtained product was characterized using SEM,energy dispersive X-ray spectroscopy(EDX),XRD and BET-N2adsorption measurements.The study had been conducted to investigate the effects of solution pH,temperature,contact time,initial concentration and coexisting ions.A maximum removal of 99.31%was observed for an initial concentration 5 mg/L,at pH6.0 and an adsorbent dose of 1.0 g/L.The isothermal data were fitted with both Langmuir and Freundlich equations,but the data fitted the former better than the latter.According to the evaluation using the Langmuir equation,the maximum adsorption capacity of uranium(Ⅵ)was 196.08 mg/g at 293 K and pH 6.0.The pseudo-first-order kinetic model and pseudo-second-order kinetic model were used to describe the kinetic data,and the pseudo-second-order kinetic model was better.The thermodynamic parameterΔG was calculated,the negativeΔG values of uranium(VI)at different temperature showed that the adsorption process was spontaneous.The good reusability of ZMPP-TBP also indicated that the ZMPP-TBP was a very promising adsorbent for uranium adsorption from aqueous solution. | ZHOU ShiMin CHEN BaiHua LI Yuan GUO JingWei CAI XiaoJiaoX CAI XiaoJiao QIN Zhi BAI Jing NA Ping | 2013 | Science China Chemistry2013,56,11: | 4 |
| 11 | Government intervention and investment efficiency: Evidence from China显示文摘 | Shimin Chen Zheng Sun Song Tang Donghui Wu | 2010 | Journal of Corporate Finance2010,,2: | 3 |
| 12 | Three-dimensional porous composite framework assembled withCuO microspheres as anode current collector for lithium-ionbatteries显示文摘The surface structure and material composition of current collectors have significant effects on the electrochemical performances of lithium-ion batteries(LIBs). In this work, a three-dimensional(3D) porous composite framework is applied as the anode current collector in LIBs. This unique 3D skeleton is composed of conductive carbon fiber/Cu core/shell fibrous structure. With an oxidation treatment upon the copper shell, the porous framework is assembled with CuO microspheres. Using mesocarbon microbead(MCMB) graphite powders as the active material, the cell with this 3D porous composite current collector shows an improved reversible discharge-charge capacity of 415 mAh g^(–1) at a current rate of 0.1 C after 50 cycles, which is much higher than that of the cell with a flat Cu foil(127 mAh g^(–1)). It is demonstrated that this unique fibrous network of the 3D current collector coupled with the morphological effects of the CuO microspheres greatly improve the cell performance in terms of electrical conductivity, reversible capacity and cycling stability. | HUANG ShiMin LUO Jian YUAN Wei ZHAO BoTe CHEN Yu TANG Yong | 2019 | Science China(Technological Sciences)2019,62,1: | 3 |
| 13 | Whole-Genome Sequences Analysis Displays Relationship of SARS-CoV-2 Delta Variant Between Four Local Cases and Passengers of a Flight from South Africa—Shenzhen City,Guangdong Province,China,June 2021显示文摘On June 14,2021,a customs officer(Case A)went to the infirmary at Baoan International Airport in Shenzhen due to a runny nose and fever.He was admitted to the Central Hospital of Baoan immediately.This patient preliminarily tested positive for coronavirus disease 2019(COVID-19)infection,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),using a quantitative realtime reverse transcription polymerase chain reaction(qRT-PCR)method in this hospital.Then,a mixed specimen of nasopharyngeal swab. | Yaqing He Renli Zhang Qiuying Lyu Bo Peng Shujiang Mei Ying Sun Dongfeng Kong Chaoqiong Peng Ziquan Lyu Xinyi Wei Can Zhu Xiaoliang Xiao Shimin Li Qingju Lu Jiancheng Chen Hang Zhang Xuan Zou Tiejian Feng Long Chen | 2021 | China CDC weekly2021,3,50: | 3 |
| 14 | Burden of pancreatitis and associated risk factors in China,1990 to 2019:a systematic analysis for the Global Burden of Disease Study 2019显示文摘Background: Pancreatitis is a common disease of the digestive system. Acute pancreatitis is one of the most common reasons for gastrointestinal hospital admission, and chronic pancreatitis significantly reduces quality of life. However, national epidemiological data on pancreatitis in China are lacking. This study aimed to quantify the disease burden of pancreatitis in China from 1990 to 2019.Methods: This study was based on the Global Burden of Disease Study 2019 dataset. Age-standardized rates of incidence (ASIR), prevalence (ASPR), mortality (ASMR), and disability-adjusted life years (DALYs) were used to describe the disease burden of pancreatitis, and estimated annual percentage change (EAPC) was used to indicate the average change in age-standardized rates. We also described the trend of pancreatitis-related mortality and DALYs, which are attributable to alcohol use by age and sex.Results: From 1990 to 2019, the ASIR, ASPR, ASMR, and age-standardized DALYs of pancreatitis in China decreased by 10.90, 1.50, 0.49, and 15.54 per 100,000, respectively, with EAPCs of -1.35 (95% uncertainty interval [UI]: -1.67, -1.02) and -0.37 (95% UI: -0.43, -0.31), -2.01 (95% UI: -2.07, -1.94) and -2.32 (95% UI: -2.37, -2.28), respectively. Recently, the numbers of incident and prevalent cases have risen, with estimates of 380,018 (95% UI: 308,669-462,767) and 493,765 (95% UI: 416,705-578,675), respectively, in 2019. Among men, the disease burden of pancreatitis was more severe than among women, and with variances in the distribution among different age groups. Age-standardized DALYs caused by alcohol-related pancreatitis have gradually worsened in the past decade, accounting for 34.09% of the total in 2019.Conclusions: The disease burden of pancreatitis in China has declined in the past 30 years, but the exacerbation of population aging poses a challenge to prevention and control of pancreatitis. Alcohol use has gradually become an important factor in the disease burden of pancreatitis in recent years. | Ke Han Shimin Chen Yang Song Chen Du Fei Gao Shaohua Liu Yao He Ningli Chai Enqiang Linghu Miao Liu | 2022 | Chinese Medical Journal2022,,11: | 3 |
| 15 | Effects of tidewater on the feeding ecology of hooded crane ( Grus monacha ) and conservation of their wintering habitats at Chongming Dongtan, China显示文摘 | Zhijun Ma Bo Li Kai Jing Bin Zhao Shimin Tang Jiakuan Chen | 2003 | Ecological Research2003,,: | 3 |
| 16 | RNA interference-mediated silencing of vATPase subunits A and E affect survival and development of the 28-spotted ladybeetle,Henosepilachna vigintioctopunctata显示文摘RNA interference(RNAi)has emerged as a powerful tool for developing novel management strategies for controlling insect pests.The 28-spotted ladybeetle,Henosepilachna vigintioctopunctata is one of the most important pests attacking solanaceous plants in Asia.In this study,the potential of dietary RNAi to manage H.vigintioctopunctata was investigated using both in vitro synthesized and bacterially expressed double-stranded RNAs(dsRNAs)of HvvATPase A and HvvATPase E.The expression levels of HvvATPase A and HvvATPase E were higher in Malpighian tubules than in other tissue types.The silencing of HvvATPase A and HvvATPase E led to significant mortality in H.vigintioctopunctata larvae.In addition,the ingestion of HvvATPase A and HvvATPase E significantly deterred feeding behavior and subsequently arrested the development of H.vigintioctopunctata.Notably,the bacterially expressed dsRNAs consistently caused higher mortality in larvae and adults.Finally,the nontarget effects of the dsRNAs of H.vigintioctopunctata on the predatory ladybeetle Propylaea japonica were evaluated.P.japonica 1st instar larvae were administered vATPase A and vATPase E dsRNAs from H.vigintioctopunctata and P.japonica under the worst-case scenario,in which dsGFP served as negative control.There were significant effects of dsHvvATPase A on P.japonica at the transcriptional level but not at the organismal level,whereas dsHvvATPase E did not effect P.japonica at either the transcriptional or the organismal level.Collectively,the results of the study suggest that HvvATPase A and HvvATPase E can act as novel molecular targets for the control of H.vigintioctopunctata. | Wei Guo Mujuan Guo Chunxiao Yang Zhuoqi Liu Shimin Chen Jing Lu Baoli Qiu Youjun Zhang Xuguo Zhou Huipeng Pan | 2021 | Insect Science2021,28,6: | 3 |
| 17 | Identification of New Resistance Loci Against Sheath Blight Disease in Rice Through Genome-Wide Association Study显示文摘Sheath blight(SB) caused by the soil borne pathogen Rhizoctonia solani is one of the most serious global rice diseases. Breeding resistant cultivar is the most economical and effective strategy to control the disease. However, no rice varieties are completely resistant to SB, and only a few reliable quantitative trait loci(QTLs) linked with SB resistance have been identified to date. In this study, we conducted a genome-wide association study(GWAS) of SB resistance using 299 varieties from the rice diversity panel 1(RDP1) that were genotyped using 44 000 high-density single nucleotide polymorphism(SNP) markers. Through artificial inoculation, we found that only 36.5% of the tested varieties displayed resistance or moderate resistance to SB. In particular, the aromatic and aus sub-populations displayed higher SB resistance than the tropical japonica(TRJ), indica and temperate japonica sub-populations. Seven varieties showed similar resistance levels to the resistant control YSBR1. GWAS identified at least 11 SNP loci significantly associated with SB resistance in the three independent trials, leading to the identification of two reliable QTLs, qSB-3 and qSB-6, on chromosomes 3 and 6. Using favorable alleles or haplotypes of significantly associated SNP loci, we estimated that both QTLs had obvious effects on reducing SB disease severity and can be used for enhancing SB resistance, especially in improving SB resistance of TRJ sub-population rice varieties. These results provided important information and genetic materials for developing SB resistant varieties through breeding. | CHEN Zongxiang FENG Zhiming KANG Houxiang ZHAO Jianhua CHEN Tianxiao LI Qianqian GONG Hongbing ZHANG Yafang CHEN Xijun PAN Xuebiao LIU Wende WANG Guoliang ZUO Shimin | 2019 | Rice science2019,26,1: | 3 |
| 18 | Information environment,market-wide sentiment and IPO initial returns:Evidence from analyst forecasts before listing显示文摘Measuring the information environment of firms using analyst(price)forecast bias and forecast dispersion before listing,we empirically examine the interactive influence of the information environment and market-wide sentiment on the initial returns of initial public offerings(IPOs).We find the smaller the analyst forecast bias/dispersion,the lower the effect market-wide sentiment has on IPO initial returns.This finding indicates that information asymmetry is a basic reason for noise trading occurs and demonstrates the positive effect of financial analysts during IPOs.In addition,the effect of analyst forecasts is more pronounced during periods of rising markets and when IPO prices are not regulated. | Hongjun Zhu Cheng Zhang He Li Shimin Chen | 2015 | China Journal of Accounting Research2015,,3: | 2 |
| 19 | TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis显示文摘 | Honghong Sun Shunyou Gong Ruaidhri J. Carmody Anja Hilliard Li Li Jing Sun Li Kong Lingyun Xu Brendan Hilliard Shimin Hu Hao Shen Xiaolu Yang Youhai H. Chen | 2008 | Cell2008,,: | 2 |
| 20 | Current status,trends,and predictions in the burden of gallbladder and biliary tract cancer in China from 1990 to 2019显示文摘Background:Gallbladder and biliary tract cancer(GBTC)has greatly damaged the health of patients and is accompanied by a dismal prognosis.The worldwide distribution of GBTC shows extensive variance and the updated data in China is lacking.This study was to determine the current status,trends,and predictions in the burden of GBTC over the past 30 years in China.Methods:This was a descriptive,epidemiological,secondary analysis of the Global Burden of Disease,Injuries,and Risk Factor Study 2019 data.Data including incidence,prevalence,mortality,and disability-adjusted life years(DALYs)of GBTC in China by year,age,and sex were assessed.Joinpoint regression analysis was conducted to evaluate trends of disease burden due to GBTC from 1990 to 2019.Nordpred age-period-cohort analysis was applied for the projection of mortality and incidence due to GBTC from 2019 to 2044.Results:Nationally,there were 38,634(95%uncertainty interval[UI]:27,350-46,512)new cases and 47,278(95%UI:32,889-57,229)patients due to GBTC,causing 34,462(95%UI:25,220-41,231)deaths,and 763,584(95%UI:566,755-920,493)DALYs in 2019.Both cases and rates of burden owing to GBTC were heavier among males and at old age.From 1990 to 2019,the age-standardized rates of incidence,prevalence,mortality,and DALYs of GBTC generally increased from 1990 to 2019,with average annual percentage change at 0.8%(95%confidential interval[CI]:0.6-1.0%),1.3%(95%CI:1.1-1.5%),0.4%(95%CI:0.2-0.6%),and 0.2%(95%CI:0.1-0.4%),respectively.Even though the age-standardized incidence rate and agestandardized mortality rate in both sexes were predicted to decline gradually from 2019 to 2044,the number of new cases and deaths were expected to grow steadily.Conclusions:GBTC is becoming a major health burden in China,particularly among males and older individuals.Given the aging population and increasing burden,effective strategies and measurements are urged to prevent or reduce the number of new cases and deaths of GBTC. | Shimin Chen Ke Han Yang Song Shaohua Liu Xuehang Li Shengshu Wang Haowei Li Rongrong Li Jianhua Wang Yao He Miao Liu | 2022 | Chinese Medical Journal2022,,14: | 2 |