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314篇 您的检索式:作者名="Sexton J"
    题名 作者 年代 出处 被引量
1向在人的察觉到钙的受体的 allosteric 药的结构的理解显示文摘allosterically 指向人的察觉到钙的受体(CaSR ) 的药有实质的治疗学的潜力,但是当前被限制。给 CaSR 的高分辨率的结构的缺席,我们把 mutagenesis 与一条新奇分析途径并且开发 “ 的分子的建模相结合; enriched”为在 Ca 2+ 在 CaSRs 7 transmembrane (7TM ) 以内的 o 和 allosteric 调节的人领域。修改多重有约束力的地点以适应在结构上的一个扩大的洞多样的 ligands 被识别。Phenylalkylamines 绑在与通常认为的 Ca 2+ o -binding 地点并且向一个细胞外的门厅延长。相反,在结构上和 pharmacologically 不同的 AC-265347 在 7TM 领域以内更深绑。而且,不同氨基酸网络被发现调停由不同调节的人的 cooperativity。这些调查结果可以与不同、潜在地偏导小径的药理学效果便于 allosteric 调节的人的合理设计。Katie Leach Karen J Gregory Irina Kufareva Elham Khajehali Anna E Cook Ruben Abagyan Arthur D Conigrave Patrick M Sexton Arthur Christopoulos 2016Cell Research2016,26,5:2
2Development of cerium-based conversion coatings on 2024-T3 A1 alloy after rare-earth desmutting 显示文摘HUGHES A E GORMAN J D MILLER P R SEXTON B A PATERSON P J K TAYLOR R J 2004Surface and Interface Analysis2004,36,44:1
3Catheter-related bacteremia and outcome of attempted catheter salvage in patients undergoing hemodialysis显示文摘MARR K A SEXTON D J CONLON P J 1997Ann Intern Med1997,127,4:1
4Eosinophilic cystitis following immediate post-resection intravesical instillation of mitomycin-C 显示文摘Caso J Qin D Sexton WJ 2010Can J Uro12010,17,3:1
5Development and suc- cessful testing of a continuous-wave, logging-while-drill- ing telemetry system显示文摘GODBEY J K SEXTON J H 19771977,,:1
6Epidemiology of Helicobacter pylori infection in six Latin American countries(SWOG Trial S0701)显示文摘PORRAS C NODORA J SEXTON R 2013Cancer Causes&Control2013,24,:1
7The Safety Attitudes Ques- tionnaire: Psychometric properties, benchmarking data, and emerging research 显示文摘Sexton J Helmreich R Neilands T 2006BMC Health Serv Res2006,,6:1
8A routine procedure for estimating serum γ--glutamyl transpeptidase activity显示文摘Naftalin L Sexton M Whitaker J F 1969Clin China Acta1969,26,:1
9Indoor Air pollution : A public health perspective 显示文摘SPENGLER J SEXTON K 1983Science1983,221,4605:1
10Data envelop-ment analysis : Critique and extensions显示文摘SEXTON T R SILKMAN R H HOGAN A J 1986New Direct ProgramEva1986,,32:1
11Patient safety in surgery显示文摘Makary M A Sexton J B Freischlag J A 2006Ann Surg2006,243,5:1
12Microsatellite markers reveal genetic dif-ferentiation among populations of Sclerotinia sclerotiorum from Australiancanola fields显示文摘SEXTON C A HOWLETT J B 2004Curr Genet2004,46,:1
13Fine-root decomposition and N dynamic in coniferous forests of the Pacific Northwest, USA 显示文摘Chen H Harmon M E Sexton J 2002Cana- dian Journal of Forest Research2002,32,2:1
14Novel peptide inhibitors of angiotensin converting enzyme 2 显示文摘HUANG L SEXTON D J SKOGERSON K 2003J Biol Chem2003,278,15:1
15Etomidate for rapid- sequence intubation in young children:hemodynamic ef- fects and adverse events 显示文摘Guldner G Sehuhz J Sexton P 2003Acad Emerg Med2003,10,2:1
16Stability Analysis of Single-point Machining with Varying Spindle Speed 显示文摘SEXTON J S MILN R D STONE B J 1977Applied Mathematical Modeling1977,1,6:1
17Evaluating managerial efficiency of veterans administration medical centers using data envelop- ment analysis 显示文摘Sexton Thomas R Leiken A M Nolan A H Liss S Andrew J Hogan Richard H Silknmn 1989Medical Care1989,27,12:1
18A New Poultry Semen Extender:2 Effect of the Diluent Components on the Fertilizing Capacity of Chicken Semen Stored at 5℃ 显示文摘Sexton T J Fewlass T A 1978Poult Sci1978,57,1:1
19Optimization of Neural Networks: A Comparative Analysis of Genetic Algorithm and Simulated Annealing显示文摘SEXTON R DORSEY R JOHNSON J 1999European Journal of Operational Research1999,114,:1
20Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis显示文摘LI J S SEXTON D J MICK N 2000Clin Infect Dis2000,30,4:1
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