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| 1 | The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts显示文摘Heterogeneous nuclear ribonucleoprotein(hnRNP) C plays a key role in RNA processing but also exerts a dominant negative effect on responses to 1,25-dihydroxyvitamin D(1,25(OH)2D) by functioning as a vitamin D response element-binding protein(VDRE-BP). hnRNPC acts a tetramer of hnRNPC1(huC1) and hnRNPC2(huC2), and organization of these subunits is critical to in vivo nucleic acid-binding. Overexpression of either huC1 or huC2 in human osteoblasts is sufficient to confer VDRE-BP suppression of 1,25(OH)2D-mediated transcription. However, huC1 or huC2 alone did not suppress 1,25(OH)2D-induced transcription in mouse osteoblastic cells. By contrast, overexpression of huC1 and huC2 in combination or transfection with a bone-specific polycistronic vector using a ‘‘self-cleaving'' 2A peptide to co-express huC1/C2 suppressed1,25D-mediated induction of osteoblast target gene expression. Structural diversity of hnRNPC between human/NWPs and mouse/rat/rabbit/dog was investigated by analysis of sequence variations within the hnRNP CLZ domain. The predicted loss of distal helical function in hnRNPC from lower species provides an explanation for the altered interaction between huC1/C2 and their mouse counterparts. These data provide new evidence of a role for hnRNPC1/C2 in 1,25(OH)2D-driven gene expression, and further suggest that species-specific tetramerization is a crucial determinant of its actions as a regulator of VDR-directed transactivation. | Thomas S Lisse Kanagasabai Vadivel S Paul Bajaj Rui Zhou Rene F Chun Martin Hewison John S Adams | 2014 | Bone Research2014，2，2： | 2 |
| 2 | The atmospheric input of trace species to the world ocean显示文摘 | Duce R A Liss P S Merrill J T | 1991 | Global Biogeochemical Cycles1991，5，3： | 1 |
| 3 | Surface properties of sludge and their role in bioflocculation and settleability 显示文摘 | LiaoBQ AllenDG Droppo I G Leppard G G Liss S N | 2001 | Water Research2001，35，2： | 1 |
| 4 | Air-sea gas exchange in rough and stormy seas measured by a dual-tracer technique显示文摘 | Watson A J Upstill Goddard C R Liss P S | 1991 | Nature1991，349，14： | 1 |
| 5 | The atmospheric input of trace species to the world ocean 显示文摘 | Duce R A Liss P S Merrill J T | 1991 | Global Biogeochemical Cy- cles1991，5，3： | 1 |
| 6 | Comparison of immediate release and controlled release carbidopa-levodopa in Parkinson's disease:A multicentre 5-year study显示文摘 | Block G Liss C Reine S | 1997 | Eur Neurol1997，37，： | 1 |
| 7 | Particle concentration effect and adsorption reversibility显示文摘 | PAN Gang LISS P S KROM M D | 1999 | Colloids and Surface A1999，151，12： | 1 |
| 8 | The atmospheric input of trace species to the world ocean 显示文摘 | Duce R A Liss P S Merrill J T | 1991 | Global Biogeochemical Cycles1991，5，： | 1 |
| 9 | The atmospheric input of trace species to the world ocean显示文摘 | Duce R A Liss P S Merrill J T Atlas L L Buat-Menard P Hicks B B Miller J M Prospero J M Arimoto R Church T M Ellis W Galloway F N Hansen L Jickells T D Knap A H Reinhardt K H Schneider B Soudine A Tokos J J Tsunogai S Wollast R Zhou M | 1991 | Global Biogeochemical Cycles1991，5，： | 1 |
| 10 | The atmospheric input of trace species to the world ocean 显示文摘 | Duee R A Liss P S Merrill J T | 1991 | Global Biogeoehemieal Cycles1991，5，3： | 1 |
| 11 | Sulfur:the plankton / climate connection显示文摘 | Malin G Turne R S M Liss P S | 1992 | J Phycol1992，28，： | 1 |
| 12 | The distribution of dimethylsulfide,DMS,and dimethylsulfoniopropionate,DSMP,in waters of the Western Coast of Ireland显示文摘 | Sally Jo Palmer Locarnini Turner S M Liss P S | 1998 | Continental Shelf Research1998，18，： | 1 |
| 13 | Flux of gases across the air-sea interface 显示文摘 | Liss P S Slater P G | 1974 | Nature1974，27，5438： | 1 |
| 14 | Evaluating managerial efficiency of veterans administration medical centers using data envelop- ment analysis 显示文摘 | Sexton Thomas R Leiken A M Nolan A H Liss S Andrew J Hogan Richard H Silknmn | 1989 | Medical Care1989，27，12： | 1 |
| 15 | Flux of gases across the air-sea interface 显示文摘 | Liss P S and Slater P G | 1974 | Nature1974，247，： | 1 |
| 16 | Flux of gases across the sea - air interface 显示文摘 | Liss P S Slater P G | 1974 | Nature1974，247，： | 1 |
| 17 | Redox species in reducing f-ord: euilibrium and kinetic considerations 显示文摘 | Emerson S Scamsotn R E Liss P S | 1985 | Deep-Sea Research1985，26，： | 1 |
| 18 | The surface charge of suspended particles in estuarine and coastal waters显示文摘 | Hunter K A Liss P S | 1979 | Nature1979，282，： | 1 |
| 19 | Isolation of mycoplasmapneumoniae from synovial fluid samples in a patient with pneumoniaand polyarthritis显示文摘 | Davis CP Cochran S Lisse J | 1998 | Arch Intern Med1998，148，4： | 1 |
| 20 | Processes of gas exchange across an air-water interface显示文摘 | Liss P S | 1973 | DeeI>Sea Research1973，20，： | 1 |
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