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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Eosinophilic cystitis following immediate post-resection intravesical instillation of mitomycin-C 显示文摘 | Caso J Qin D Sexton WJ | 2010 | Can J Uro12010，17，3： | 1 |
| 3 | Stapled renal vein with in situ tumor thrombus: a useful intraoperative maneuver to facilitate radical nephrectomy and inferior vena cava thrombectomy显示文摘 | Caso J Tidwell J Tsivian M | 2011 | Urology2011，77，1： | 1 |
| 4 | Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke 显示文摘 | CASO J R PRADILLO J M HURTADO O | 2007 | Circulation2007，115，12： | 1 |
| 5 | Changes in writing self-efficacy and writing products and processes through specific training in the self-efficacy beliefs of students with learning disabilities 显示文摘 | Garcia J N & de Caso A M | 2006 | Learning Disabilities : A Contem- porary Journal2006，，2： | 1 |
| 6 | Results of hemiarthroplasty in complex fractures of the proximal humerus显示文摘 | J de Caso J Itarte I Proubasta | 2005 | Journal of Bone and Joint Surgery (British)2005，87，1： | 1 |
| 7 | Circumferential resection of the inferior vena cava for primary and recurrent malignant tumors 显示文摘 | Caso J Seigne J Back M | 2009 | J Urol2009，182，3： | 1 |
| 8 | Cefotetan-induced hemolytic anemia after bariatric procedures显示文摘 | Allen J W Acosta J Casos S R | 2006 | Surg Obes Relat Dis2006，2，3： | 1 |
| 9 | Toll-like receptor 4 is in- volved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke 显示文摘 | Caso J R Pradillo J M Hurtado O | 2008 | Stroke2008，39，4： | 1 |
| 10 | Design requirements for SiC/SiC composites structural material in fusion power reactor blankets显示文摘 | BONAL J P CASO A | 1998 | Fusion Engineering and Design1998，41，： | 1 |
| 11 | Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke显示文摘 | Caso J R Pradillo J M Hurtado O | 2008 | Stroke2008，39，4： | 1 |
| 12 | Structural characteristics of the Streptomyces bacteriophage φC31显示文摘 | SUAREZ J E CASO J L RODRIGUE Z | 1984 | FEMS Microbiology Letters1984，22，： | 1 |
| 13 | Structure of the DNA of five bacteriophages infecting Micromonospora显示文摘 | CASO J L HARDISSON C SUAREZ J E | 1990 | Microbiologia1990，6，2： | 1 |
| 14 | Renal function out- comes after laparoscopie renal cryoablation 显示文摘 | TSIVIAN M CASO J KIMURA M | 2011 | J Endourol2011，25，8： | 1 |
| 15 | The stressedCNS : when glucocorticoids aggravate inflammation 显示文摘 | SORRELLS S F CASO J R MUNHOZ C D | 2009 | Neuron2009，64，1： | 1 |
| 16 | Environmental factors and cervical artery dissection显示文摘 | Caso V Paciaroni M Bogousslavsky J | 2005 | Fron Neurol Neurosci2005，20，： | 1 |
| 17 | The effect of carbohydrate re- striction on prostate cancer tumor growth in a castrate mouse xenograft model显示文摘 | Caso J Masko EM Li JA | 2013 | Prostate2013，73，5： | 1 |
| 18 | Involvement of IL-1 beta in acute stress-induced worsening of cerebral ischaemia in rats显示文摘 | Caso J R Moro M A Lorenzo P | 2007 | Eur Neuropsychophamacol2007，17，9： | 1 |
| 19 | Eosinophilic cystitis following immediate post-resection intravesical instillation of mitomycin-C 显示文摘 | Caso J Qin D Sexton WJ | 2010 | Can J Urol2010，17，： | 1 |
| 20 | Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke显示文摘 | Caso J R Pradilo J M H urtado O | 2007 | Circulation2007，115，12： | 1 |
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