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| 1 | One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system显示文摘 | Haifeng Wan Chunjing Feng Fei Teng Shihua Yang Baoyang Hu Yuyu Niu Andy Peng Xiang Weizhen Fang Weizhi Ji Wei Li Xiaoyang Zhao Qi Zhou | 2015 | Cell Research2015，25，2： | 39 |
| 2 | Stability analysis for a second-order continuous finite-time control system subject to a disturbance显示文摘In this paper, using finite-time control method, we consider the disturbance analysis of a second-order system with unknown but bounded disturbance. We show that the states of the second-order system will be stabilized to a region containing the origin. The radius of this region is determined by the control parameters and can be rendered as small as desired. The rigorous stability analysis is also given. Compared with the conventional PD control law, the finite-time control law yields a better disturbance rejection performance. Numerical simulation results show the effectiveness of the method. | Shihong DING Shihua LI Qi LI | 2009 | 控制理论与应用(英文版)2009，7，3： | 25 |
| 3 | 从可持续发展战略看炫耀性消费显示文摘本文从探索炫耀性消费的理论源头出发,重点分析了炫耀性消费的负面效应。提出,根据我国国情,我们必须 选择可持续的消费模式,坚持走可持续发展道路。 | 李时华 龚志民 Gong Zhimini Li Shihua | 2005 | 消费经济2005，21，1： | 18 |
| 4 | A Chromosome-Scale Genome Assembly of Paper Mulberry(Bmussonetia papyrifera)Provides New Insights into Its Forage and Papermaking Usage显示文摘Paper mulberry(Broussonetia papyrifera)is a well-known woody tree historically used for Cai Lun papermaking,one of the four great inventions of ancient China.More recently,Paper mulberry has also been used as forage to address the shortage of feedstuff because of its digestible crude fiber and high protein contents.In this study,we obtained a chromosome-scale genome assembly for Paper mulberry using integrated approaches,including Illumina and PacBio sequencing platform as well as Hi-C,optical,and genetic maps.The assembled Paper mulberry genome consists of 386.83 Mb,which is close to the estimated size,and 99.25%(383.93 Mb)of the assembly was assigned to 13 pseudochromosomes.Comparative genomic analysis revealed the expansion and contraction in the flavonoid and lignin biosynthetic gene families,respectively,accounting for the enhanced flavonoid and decreased lignin biosynthesis in Paper mulberry.Moreover,the increased ratio of syringyl-lignin to guaiacyl-lignin in Paper mulberry underscores its suitability for use in medicine,forage,papermaking,and barkcloth making.We also identified the rootassociated microbiota of Paper mulberry and found that Pseudomonas and Rhizobia were enriched in its roots and may provide the source of nitrogen for its stems and leaves via symbiotic nitrogen fixation.Collectively,these results suggest that Paper mulberry might have undergone adaptive evolution and recruited nitrogen-fixing microbes to promote growth by enhancing flavonoid production and altering lignin monomer composition.Our study provides significant insights into genetic basis of the usefulness of Paper mulberry in papermaking and barkcloth making,and as forage.These insights will facilitate further domestication and selection as well as industrial utilization of Paper mulberry worldwide. | Xianjun Peng Hui Liu Peilin Chen Feng Tang Yanmin Hu Fenfen Wang Zhi Pi Meiling Zhao Naizhi Chen Hui Chen Xiaokang Zhang Xueqing Yan Min Liu Xiaojun Fu Guofeng Zhao Pu Yao Lili Wang He Dai Xuming Li Wei Xiong Wencai Xu Hongkun Zheng Haiyan Yu Shihua Shen | 2019 | Molecular Plant2019，12，5： | 18 |
| 5 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 6 | Species-dependent neuropathology in transgenic SOD' aigs显示文摘 | Huaqiang Yang Guohao Wang Haitao Sun Runzhe Shu Tao Liu Chuan-En Wang Zhaoming Liu Yu Zhao Bentian Zhao Zhen Ouyang Dongshan Yang Jiao Huang Yueling Zhou Shihua Li Xiaodan Jiang Zhicheng Xiao Xiao-Jiang Li Liangxue Lai | 2014 | Cell Research2014，24，4： | 13 |
| 7 | Adaptive fault-tolerant controller design for airbreathing hypersonic vehicle with input saturation显示文摘The problem of fault-tolerant control is discussed for the longitudinal model of an airbreathing hypersonic vehicle(AHV) with actuator faults and external disturbances.Firstly,a fault-tolerant control strategy is presented for the longitudinal model of an AHV,which guarantees that velocity and altitude track their reference trajectories at an exponential convergence rate.However,this method needs to know the minimum value of the actuator efficiency factor and the upper bound of the external disturbances,which makes it not easy to implement.Then an improved adaptive fault-tolerant control scheme is proposed,where two adaptive laws are employed to estimate the upper bound of the external disturbances and the minimum value of the actuator efficiency factor,respectively.Secondly,the problem of designing a control scheme with control constraints is further considered,and a new adaptive fault-tolerant control strategy with input saturation is designed to guarantee that velocity and altitude track their reference trajectories.Finally,simulation results are given to show the effectiveness of the proposed methods. | Haibin Sun Shihua Li Changyin Sun | 2013 | Journal of Systems Engineering and Electronics2013，24，3： | 12 |
| 8 | Mesenchymal stem cells and immune disorders: from basic science to clinical transition显示文摘As a promising candidate seed cell type in regenerative medicine, mesenchymal stem cells (MSCs) have attracted considerable attention. The unique capacity of MSCs to exert a regulatory effect on immunity in an autologous/allergenic manner makes them an attractive therapeutic cell type for immune disorders. In this review, we discussed the current knowledge of and advances in MSCs, including its basic biological properties, i.e., multilineage differentiation, secretome, and immunomodulation. Specifically, on the basis of our previous work, we proposed three new concepts of MSCs, i.e.,“subtotipotent stem cell” hypothesis, MSC system, and “Yin and Yang” balance of MSC regulation, which may bring new insights into our understanding of MSCs. Furthermore, we analyzed data from the Clinical Trials database (http://gffzzd3f38a9638994581hxnfvv59bk9of6cqn.ffgz.tsg.suse.edu.cn) on registered clinical trials using MSCs to treat a variety of immune diseases, such as graft-versus-host disease, systemic lupus erythematosus, and multiple sclerosis. In addition, we highlighted MSC clinical trials in China and discussed the challenges and future directions in the field of MSC clinical application. | Shihua Wang Rongjia Zhu Hongling Li Jing Li Qin Han Robert Chunhua Zhao | 2019 | Frontiers of Medicine2019，13，2： | 12 |
| 9 | CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys显示文摘Dear Editor,PINK1 mutations cause autosomal recessive and early-onset Parkinson’s disease(PD)with selective neurodegeneration.Unfortunately,current PINK1 knockout(KO)mouse1,2 and pig models3,4 are unable to recapitulate the selective and overt neurodegeneration seen in PD patients.Furthermore,endogenous Pink1 in the mouse brain is expressed at very low levels and can only be detected via immunoprecipitation,5 meaning that PINK1’s function in the mammalian brain needs to be assessed using larger animals that are closer to humans.We previously used CRISPR/Cas9 to target the monkey gene in one-cell stage embryos.6 Using the same approach,we designed two gRNAs to target exon 2(T1)and exon 4(T2),which encode a kinase domain in the PINK1 gene of rhesus monkeys(Fig.1a).CRISPR/Cas9 and PINK1 gRNAs were injected into one-cell stage rhesus monkey embryos.A T7E1 assay and sequencing of PCR products from the injected embryos showed high efficiency(61.5%)in targeting PINK1(Fig.1b and Supplementary information,Fig.S1).Transfer of 87 embryos to 28 surrogate rhesus monkeys resulted in 11 pregnancies(39.2%)(Fig.1b).Eleven fetuses developed to term and were born naturally.Of these live monkeys,eight carried PINK1 mutations(M),and three were wild type(WT).However,three mutant monkeys(M1,M3 and M4)were newborn triplets that struggled to survive and died 3-4 days after birth.One WT newborn monkey also died after a difficult labor.Another mutant monkey(M2)died 7 days after birth without noticeable warning signs or symptoms.The other three mutant monkeys(M6,M7 and M8)have lived for three years;M5,however,reduced its food intake and showed weakness at the age of 1.5 years,and died 30 days after anesthesia for MRI examination. | Weili Yang Yunbo Liu Zhuchi Tu Chong Xiao Sen Yan Xishan Ma Xiangyu Guo Xiusheng Chen Peng Yin Zhengyi Yang Su Yang Tianzi Jiang Shihua Li Chuan Qin Xiao-Jiang Li | 2019 | Cell Research2019，29，4： | 12 |
| 10 | Synthesis of Branched Chains with Actuation Redundancy for Eliminating Interior Singularities of 3T1R Parallel Mechanisms显示文摘Although it is common to eliminate the singularity of parallel mechanism by adding the branched chain with actuation redundancy, there is no theory and method for the configuration synthesis of the branched chain with actuation redundancy in parallel mechanism. Branched chains with actuation redundancy are synthesized for eliminating interior singularity of 3-translational and 1-rotational(3T1R) parallel mechanisms. Guided by the discriminance method of hybrid screw group according to Grassmann line geometry, all the possibilities are listed for the occurrence of interior singularities in 3T1R parallel mechanism. Based on the linear relevance of screw system and the principles of eliminating parallel mechanism singularity with actuation redundancy, different types of branched chains with actuation redundancy are synthesized systematically to indicate the layout and the number of the branched chainsinterior with actuation redundancy. A general method is proposed for the configuration synthesis of the branched chains with actuation redundancy of the redundant parallel mechanism, and it builds a solid foundation for the subsequent performance optimization of the redundant actuation parallel mechanism. | LI Shihua LIU Yanmin CUI Hongliu NIU Yunzhan ZHAO Yanzhi | 2016 | Chinese Journal of Mechanical Engineering2016，29，2： | 11 |
| 11 | Therapeutic potential of berberine against neurodegenerative diseases显示文摘Berberine(BBR) is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine. Isolation of this compound was its induction into modern medicine, and its usefulness became quickly apparent as seen in its ability to combat bacterial diarrhea, type 2 diabetes, hypercholesterolemia, inflammation, heart diseases, and more. However, BBR's effects on neurodegenerative diseases remained relatively unexplored until its ability to stunt Alzheimer's disease(AD) progression was characterized. In this review, we will delve into the multi-faceted defensive capabilities and bio-molecular pathways of BBR against AD, Parkinson's disease(PD), and trauma-induced neurodegeneration. The multiple effects of BBR, some of which enhance neuro-protective factors/pathways and others counteract targets that induce neurodegeneration, suggest that there are many more branches to the diverse capabilities of BBR that have yet to be uncovered. The promising results seen provide a convincing and substantial basis to support further scientific exploration and development of the therapeutic potential of BBR against neurodegenerative diseases. | JIANG WenXiao LI ShiHua LI XiaoJiang | 2015 | Science China(Life Sciences)2015，58，6： | 9 |
| 12 | Composite control method for stabilizing spacecraft attitude in terms of Rodrigues parameters显示文摘In this paper, the attitude stabilization problem of a rigid spacecraft described by Rodrigues parameters is investigated via a composite control strategy, which combines a feedback control law designed by a finite time control technique with a feedforward compensator based on a linear disturbance observer (DOB) method. By choosing a suitable coordinate transformation, the spacecraft dynamics can be divided into three second-order subsystems. Each subsystem includes a certain part and an uncertain part. By using the finite time control technique, a continuous finite time controller is designed for the certain part. The uncertain part is considered to be a lumped disturbance, which is estimated by a DOB, and a corresponding feedforward design is then implemented to compensate the disturbance. Simulation results are employed to confirm the effectiveness of the proposed approach. | Sun Haibin Li Shihua | 2013 | Chinese Journal of Aeronautics2013，26，3： | 8 |
| 13 | A comparative study of CuO/TiO_2-SnO_2,CuO/TiO_2 and CuO/SnO_2 catalysts for low-temperature CO oxidation显示文摘Nanometer SnO2 particles were synthesized by sol-gel dialytic processes and used as a support to prepare CuO supported catalysts via a deposition-precipitation method. The samples were characterized by means of TG-DTA,XRD,H 2-TPR and XPS. The catalytic activity of the CuO/TiO2-SnO2 catalysts was markedly depended on the loading of CuO,and the optimum CuO loading was 8 wt.%(T 100 = 80 C) . The CuO/TiO2-SnO2 catalysts exhibited much higher catalytic activity than the CuO/TiO 2 and CuO/SnO 2 catalysts. H 2-TPR result indicated that a large amount of CuO formed the active site for CO oxidation in 8 wt.% CuO/TiO2-SnO2 catalyst. | Kairong Li Yaojie Wang Shurong Wang Baolin Zhu Shoumin Zhang Weiping Huang Shihua Wu | 2009 | Journal of Natural Gas Chemistry2009，18，4： | 8 |
| 14 | Dynamic Characteristics of Multi-degrees of Freedom System Rotor-bearing System with Coupling Faults of Rub-impact and Crack显示文摘Extensive studies on rotor systems with single or coupled multiple faults have been carried out. However these studies are limited to single-span rotor systems. A finite element model for a complex rotor-bearing system with coupled faults is presented. The dynamic responses of the rotor-bearing system are obtained by using the rotor dynamics theory and the modern nonlinear dynamics theory in connection with the continuation-shooting algorithm(commonly used for obtaining a periodic solution for a nonlinear system) for a range of rub-impact clearances and crack depths. The stability and Hopf instability of the periodic motion of the rotor-bearing system with coupled faults are analyzed by using the procedure described. The results indicate that the finite element method is an effective way for determining the dynamic responses of such complex rotor-bearing systems. Further for a rotor system with rub-impact and crack faults, the influences of the clearances are significantly different for different rub-impact stiffness. On the contrary, the influence of crack depths is rather small. The instability speeds of the rotor-bearing system increase due to the presence of the crack fault. The results obtained using the new finite element model, presented for computation and analysis of dynamic responses of the rotor-bearing systems with coupled faults, are in accordance with measurements in experiment. The formulations given can be used for diagnosis of faults, vibration control, and safe and stable operations of real rotor-bearing systems. | REN Zhaohui ZHOU Shihua LI Chaofeng WEN Bangchun | 2014 | Chinese Journal of Mechanical Engineering2014，27，4： | 7 |
| 15 | Soil concentrations and soil-air exchange of organochlorine pesticides along the Aba profile, east of the Tibetan Plateau, western China显示文摘MianzhuAba 侧面,西藏的高原的东方,被选择沿着一个高度的坡度学习 organochlorine 杀虫剂(OCP ) 的出现。在表面土壤的 Dichlorodiphenyltrichloroethanes (DDT ) , hexachlorocyclohexanes (HCH ) 和 Aldrin,狄氏剂和 Endrin (Drins ) 在冬季(三月) 和夏天(7 月) 被检测。 | Hongxia LIU Shihua QI Dan YANG Ying HU Feng LI Jia LIU Xinli XING | 2013 | Frontiers of Earth Science2013，7，4： | 6 |
| 16 | 寨卡病毒引起小鼠睾丸损伤并导致雄性不育显示文摘虽然寨卡病毒与其他黄病毒属成员,如登革热病毒、乙型脑炎病毒和两尼罗病毒都是通过蚊媒传播,但是前人的研究发现寨卡病毒在精液中存在数月之久,暗示其性接触传播的可能性。本研究表明寨卡病毒影响雄性生殖系统,提示了其对男性健康的潜在危害。 | Wenqiang Ma Shihua Li Shuoqian Ma Lina Jia Fuchun Zhang Yong Zhang Jingyuan Zhang Gary Wong Shanshan Zhang Xuancheng Lu Mei Liu Jinghua Yan Wei Li Chuan Qin Daishu Han Chengfeng Qin Na Wang 李向东 高福 | 2017 | 科学新闻2017，19，4： | 5 |
| 17 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 18 | INSTANTANEOUS KINEMATIC CHARACTERISTICS OF ASPECIAL 3-UPU PARALLEL MANIPULATOR显示文摘The instantaneous kinematics of a special 3-UPU parallel platform manipulator is dis-cussed. First, the instantaneous motions of the 3-UPU manipulator in four kinds of positions and aspecial manipulator are studied by reciprocal screw theory. Then, the principal screws in one of fourpositions are obtained. It is shown that the moving platform has five degrees of freedom (DOF) in theinitial position or after a translation along the 2-axis; In the generic position, the mechanism only hasthree DOF, moreover the three DOF characteristics are different in different position. The instantane-ous kinematic characteristics of alike 3-UPU mechanisms are very different in different position andspecial structure. The results presented are important to the use of alike 3-UPU parallel manipulatorand contribute to the mechanism | Li Shihua Huang Zhen | 2005 | Chinese Journal of Mechanical Engineering2005，18，3： | 5 |
| 19 | Simulations and Experimental Investigation on Motion Stability of a Flexible Rotor-bearing System with a Transverse Crack显示文摘In the classical process for stability studies on the rotor-bearing system with crack faults,the simple discrete model is adopted for research on such problems,which neglect some needful dynamical influence factor,such as the material damping,shearing effect and gyroscopic effects,etc.Therefore,it is necessary to find a precise calculation model for simulation of the rotor-bearing system with cracks faults.In this paper,instead of the traditional simple discrete model,finite element(FE)model is adopted to investigate the motion stability of a nonlinear rotor system with crack fault.According to finite element theory,the FE model of the cracked rotor system is established firstly.It should be pointed out that the element where the crack occurs is modeled by a particular crack element and the supports at both ends are simulated by two nonlinear loads.Then,based on dimensionless and dimensionality reduction,the Newmark-βmethod and the shooting method are employed to study the effect of eccentricity and the depth of crack on instability speed and bifurcation feature.Furthermore,the simulation results are verified by some corresponding experiments.The simulation and experimental results show that instability speed does not change monotonically,but decreases firstly and then increases when the amount of eccentricity increases.Moreover,as the type of instability changes,the instability speed jumps concomitantly.Additionally,the presence of crack fault can disturb the oil whirl,as a result,instability speed tends to increase slightly,but it does not affect the type of instability and jumping phenomenon.This research presents an effective and convenient method which uses the finite element method(FEM)to research the motion stability of the nonlinear rotor-bearing system with cracked faults and other nonlinear force,and the proposed method can provide a theoretical reference for stability analysis and vibration control in more complex relevant rotor-bearing system. | LI Chaofeng YU Hexing ZHOU Shihua WEN Bangchun | 2013 | Chinese Journal of Mechanical Engineering2013，26，6： | 5 |
| 20 | Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src显示文摘Senescent endothelial cells (ECs) could impair the integrity of the blood vessel endothelium, leading to vascular aging and a series of diseases, such as atherosclerosis, diabetes. Preventing or mitigating EC senescence might serve as a promising therapeutic paradigm for these diseases. Recent studies showed that small extracellular vesicles (sEV) have the potential to transfer bioactive molecules into recipient cells and induce phenotypic changes. Since mesenchymal stem cells (MSCs) have long been postulated as an important source cell in regenerative medicine, herein we investigated the role and mechanism of MSC-derived sEV (MSC-sEV) on EC senescence. In vitro results showed that MSC-sEV reduced senescent biomarkers, decreased senescence-associated secretory phenotype (SASP), rescued angiogenesis, migration and other dysfunctions in senescent EC induced by oxidative stress. In the In vivo natural aging and type-2 diabetes mouse wound-healing models (both of which have senescent ECs), MSC-sEV promoted wound closure and new blood vessel formation. Mechanically, miRNA microarray showed that miR-146a was highly expressed in MSC-sEV and also upregulated in EC after MSC-sEV treatment. miR-146a inhibitors abolished the stimulatory effects of MSC-sEV on senescence. Moreover, we found miR-146a could suppress Src phosphorylation and downstream targets VE-cadherin and Caveolin-1. Collectively, our data indicate that MSC-sEV mitigated endothelial cell senescence and stimulate angiogenesis through miR-146a/Src. | Xian Xiao Meiqian Xu Hongliang Yu Liping Wang Xiaoxia Li Janusz Rak Shihua Wang Robert Chunhua Zhao | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 5 |
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