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| 1 | Liposomes and lipid disks traverse the BBB and BBTB as intact forms as revealed by two-step F?rster resonance energy transfer imaging显示文摘The blood–brain barrier(BBB) and the blood–brain tumor barrier(BBTB) prevent drug and nano-drug delivery systems from entering the brain. However, ligand-mediated nano-drug delivery systems have significantly enhanced the therapeutic treatment of glioma. In this study we investigated the mechanism especially the integrity of liposomes and lipid disks while traversing the BBB and BBTB both in vitro and in vivo. Fluorophores(DiO, DiI and DiD) were loaded into liposomes and lipid disks to form F?rster resonance energy transfer(FRET) nano-drug delivery systems. Using brain capillary endothelial cells as a BBB model, we show that liposomes and disks are present in the cytoplasm as their intact forms and traverse the BBB with a ratio of 0.68‰ and 1.67‰, respectively. Using human umbilical vein endothelial cells as BBTB model, liposomes and disks remained intact and traversed the BBTB with a ratio of 2.31‰and 8.32‰ at 3 h. Ex vivo imaging and immunohistochemical results revealed that liposomes and disks could traverse the BBB and BBTB in vivo as intact forms. In conclusion, these observations explain in part the mechanism by which nano-drug delivery systems increase the therapeutic treatment of glioma. | Tongcheng Dai Kuan Jiang Weiyue Lu | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 8 |
| 2 | Toughening Poly(lactic acid) with Imidazolium-based Elastomeric Ionomers显示文摘Imidazolium-based elastomeric ionomers(i-BIIR) were facilely synthesized by ionically modified brominated poly(isobutylene-co-isoprene)(BIIR) with different alkyl chain imidazole and thoroughly explored as novel toughening agents for poly(lactic acid)(PLA). The miscibility, thermal behavior, phase morphology and mechanical property of ionomers and blends were investigated through dynamic mechanical analyses(DMA), differential scanning calorimetry(DSC), scanning electron microscopy(SEM), tensile and impact testing. DMA and SEM results showed that better compatibility between the PLA and i-BIIR was achieved compared to the PLA/unmodified BIIR elastomer. A remarkable improvement in ductility with an optimum elongation at break up to235% was achieved for the PLA/i-BIIR blends with 1-dodecylimidazole alkyl chain(i-BIIR-12), more than 10 times higher than that of pure PLA. The impact strengths of PLA were enhanced from 1.9 kJ/m^2 to 4.1 kJ/m^2 for the PLA/10 wt% i-BIIR-12 blend. Toughening mechanism had been established by systematical analysis of the compatibility, intermolecular interaction and phase structures of the blends. Interfacial cavitations initiated massive shear yielding of the PLA matrix owing to a suitable interfacial adhesion which played a key role in the enormous toughening effect in these blends. We believed that introducing imidazolium group into the BIIR elastomer was vital for the formation of a suitable interfacial adhesion. | Lu Chen Kuan Hu Si-Ting Sun Hai Jiang Dong Huang Kun-Yu Zhang Li Pan Yue-Sheng Li | 2018 | Chinese Journal of Polymer Science2018，36，12： | 7 |
| 3 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 4 | Reconstructing the size of individual trees using log data from cut-to-length harvesters in Pinus radiata plantations: a case study in NSW, Australia显示文摘With their widespread utilization, cut-to-length harvesters have become a major source of ‘‘big data'' for forest management as they constantly capture, and provide a daily flow of, information on log production and assortment over large operational areas. Harvester data afford the calculation of the total log length between the stump and the last cut but not the total height of trees. They also contain the length and end diameters of individual logs but not always the diameter at breast height overbark(DBHOB) of harvested stems largely because of time lapse, operating and processing issues and other system deficiencies. Even when DBHOB is extracted from harvester data, errors and/or bias of the machine measurements due to the variation in the stump height of harvested stems from that specified for the harvester head prior to harvesting and diameter measurement errors may need to be corrected. This study developed(1) a system of equations for estimating DBHOB of trees from diameter overbark(DOB) measured by a harvester head at any height up to 3 m above ground level and(2) an equation to predict the total height of harvested stems in P. radiata plantations from harvester data. To generate the data required for this purpose, cut-to-length simulations of more than 3000 trees with detailed taper measurements were carried out in the computer using the cutting patterns extracted from the harvester data and stump height survey data from clearfall operations. The equation predicted total tree height from DBHOB, total log length and the small end diameter of the top log. Prediction accuracy for total tree height was evaluated both globally over the entire data space and locally within partitioned subspaces through benchmarking statistics. These statistics were better than that of the conventional height-diameter equations for P. radiata found in the literature, even when they incorporated stand age and the average height and diameter of dominant trees in the stand as predictors. So this equation when used with harvester data would outperform the conventional equations in tree height prediction. Tree and stand reconstructions of the harvested forest is the necessary first step to provide the essential link of harvester data to conventional inventory, remote sensing imagery and Li DAR data. The equations developed in this study will provide such a linkage for the most effective combined use of harvester data in predicting the attributes of individual trees, stands and forests, and product recovery for the management and planning of P. radiata plantations in New South Wales, Australia. | Kuan Lu Huiquan Bi Duncan Watt Martin Strandgard Yun Li | 2018 | Journal of Forestry Research2018，29，1： | 4 |
| 5 | Nonlinear Parametric Vibration of a Fluid-Conveying Pipe Flexibly Restrained at the Ends显示文摘In this paper,the nonlinear parametric vibration of fluid-conveying pipes flexibly restrained at both ends and subjected to the pulsation flow excitation is investigated.The nonlinear equation of motion is derived using Hamilton^principle by considering the Kevin-Voigt viscoelastic damping,the geometric nonlinearity and the translational and rotational springs supported at the ends.The mode functions and eigen-frequencies are determined by the assumed mode method according to the elastic boundary conditions.The Galerkin method is implemented to obtain the natural frequencies and mode shapes of the pipe conveying fluid with different flow velocities.The effects of flexibly restrained conditions on stability of the pipe are analyzed.The nonlinear responses of the pipe under pulsating flow excitation are solved by the direct numerical method.The vibration behaviors are discussed in details,such as time history,frequency spectrum,phase-plane portrait,Poincare map and motion trajectory.The results show that the responses of sub-harmonic resonance and combination resonance can also be reflected in the rigidly supported pipes.The 1/5,1/8 and 1/13 sub-harmonic resonances can occur at certain excitation frequencies of the nonlinear parametric vibration system.The steady-state response amplitudes increase by a large margin and significantly affect the stability of the pipe.The effects of different spring stiffness coefficients on the parametric resonance responses are presented.For larger translational springs and rotational stiffness coefficients,the resonance frequencies shift to higher regions and the resonance amplitudes may reduce by a certain extent in accordance with the rigid-body motion.This study can provide helpful guidance on the analysis and design of piping systems subject to vibrations. | Qian Li Wei Liu Kuan Lu Zhufeng Yue | 2020 | Acta Mechanica Solida Sinica2020，33，3： | 4 |
| 6 | Peptide-based nanomaterials:Self-assembly,properties and applications显示文摘Peptide-based materials that have diverse structures and functionalities are an important type of biomaterials.In former times,peptide-based nanomaterials with excellent stability were constructed through self-assembly.Compared with individual peptides,peptide-based self-assembly nanomaterials that form well-ordered superstructures possess many advantages such as good thermo-and mechanical stability,semiconductivity,piezoelectricity and optical properties.Moreover,due to their excellent biocompatibility and biological activity,peptide-based self-assembly nanomaterials have been vastly used in different fields.In this review,we provide the advances of peptide-based self-assembly nanostructures,focusing on the driving forces that dominate peptide self-assembly and assembly mechanisms of peptides.After that,we outline the synthesis and properties of peptide-based nanomaterials,followed by the applications of functional peptide nanomaterials.Finally,we provide perspectives on the challenges and future of peptide-based nanomaterials. | Tong Li Xian-Mao Lu Ming-Rong Zhang Kuan Hu Zhou Li | 2022 | Bioactive Materials2022，7，5： | 3 |
| 7 | The Flavor and Antioxidant Activity Change Pattern of Shrimp Head Paste During Fermentation显示文摘To study the changes of volatile compounds and antioxidant activity of fast fermented shrimp head paste during the fermentation processing,Penaeus vannamei boone head was used as the raw material,and compound starter was added for fermen-tation.During the 14 days of fermentation,the changes of free amino acids,volatile flavor compounds and main components were determined by SPME-GC-MS and electronic nose.The oxidation-resistance changes of water extract at different fermentation stages were evaluated.The results showed that the total free amino acids increased from original 2320 to 5640 mg(100 mL)^(−1).SPME-GC-MS analysis found that aldehydes,pyrazine compounds increased from 10.80%,1.94%to 24.35%,13.63%respectively during the fermentation process.The HO·scavenging ability of shrimp head paste increased from 52%to 86%.Our results showed that the shrimp paste produced from shrimp head fermentation could obtain good flavor and possess certain antioxidant activity of aquatic fermented condiment. | YU Jing LU Kuan SUN Jinyuan XIE Wancui SONG Lin CHE Hongxia | 2022 | Journal of Ocean University of China2022，21，1： | 2 |
| 8 | Kinetostatic modeling of 3 - RRR compliant micro-motion stages with flexure hinges 显示文摘 | Yong Yuen Kuan Lu Tien-Fu | 2009 | Mechanism and Machine Theory2009，44，6： | 1 |
| 9 | Reconfigurable and nonvolatile terahertz lithography-free photonic devices based on phase change films显示文摘High-performance terahertz(THz)devices with reconfigurable features are highly desirable in many promising THz applications.However,most of the existing reconfigurable THz elements are still limited to volatile responses,single functionality,and time-consuming multistep manufacturing procedures.In this paper,we report a lithography-free approach to create reconfigurable and nonvolatile THz components by exploring the reversible,nonvolatile,and continuous THz modulation capability of the phase change material Ge_(2)Sb_(2)Te_(5).As a proof of concept,THz gratings with significant Rayleigh anomalies and diffraction as well as ultrathin THz flat lenses with subwavelength and ultra-broadband focusing capabilities are designed and fabricated on ultrathin Ge_(2)Sb_(2)Te_(5)films using the presented photo-imprint strategy.Moreover,such a method can also be adopted to create more complex THz devices,such as Pancharatnam–Berry phase metasurfaces and grayscale holographic plates.With these findings,the proposed method will provide a promising solution to realize reconfigurable and nonvolatile THz elements. | XIEYU CHEN SHOUJUN ZHANG KUAN LIU YUEHONG XU XIAOHAN JIANG HAIYANG LI XI FENG QINGWEI WANG YONGCHANG LU KEMENG WANG TUN CAO ZHEN TIAN | 2023 | Photonics Research2023，11，4： | 1 |
| 10 | Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain显示文摘 | Kuan CY Schloemer AJ Lu A | 2004 | J Neurosci2004，24，10： | 1 |
| 11 | Rapid detection of squash leafcurl vims by loop-mediated isothermal amplification显示文摘 | Kuan C P Wu M T Lu Y L | 2010 | VirologicalMethods2010，，169： | 1 |
| 12 | Review of circular flexure hinge design equations and derivation of empirical formulations显示文摘 | Yuen Kuan Yong Tien-Fu Lu Daniel C Handley | 2008 | Precision Engineering2008，32，2： | 1 |
| 13 | Review of circular flexure hinge design equations and derivation of empirical formulations显示文摘 | Yuen Kuan Yong Lu Tien-Fu Daniel C Handley | 2008 | Precision Engineering2008，32，： | 1 |
| 14 | Intention to continue u- sing Facebook fan pages from the perspective of social capital theory显示文摘 | Kuan - Yu Lin Hsi - Peng Lu | 2011 | Cyberpsychology Behavior and So- cial Networking2011，14，10： | 1 |
| 15 | Kinetostatic Modeling of 3-- RRR Compliant Micro--motion Stages with Flex- ure Hinges显示文摘 | Kuan Y Y Lu Tienfu | 2009 | Mechanism and Machine Theory2009，44，： | 1 |
| 16 | Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain显示文摘 | Kuan CY Schloemer AJ Lu A | 2004 | J Neurosci2004，24，10： | 1 |
| 17 | Severe vitreous hemorrhage associated with closed-globe injury显示文摘 | Ling Yeung Tun Lu Chen Ya Hui Kuo An Ning Chao Wei Chi Wu Kuan Jen Chen Yih Shiou Hwang Yen Po Chen Chi Chun Lai | 2006 | Graefe’s Archive for Clinical and Experimental Ophthalmology2006，，1： | 1 |
| 18 | Design, synthesis, and structure- activity relationships of novel benzothiazole derivatives bearing the ortho- hydroxy N-carbamoylhydrazone moiety as potent antitumor agents 显示文摘 | Ma Junjie Chen Dong Lu Kuan S | 2014 | European Journal of Medicinal Chemistry2014，86，： | 1 |
| 19 | 环境友好型AZ31B镁合金交流微弧氧化的表征(英文)显示文摘研究了一种新的AZ31B镁合金交流电微弧氧化(MAO)工艺,采用了对环境更加友好的含硅酸盐的稀碱溶液作为电解质。结果发现氧化过程分为2个阶段,膜厚与微弧氧化时间呈抛物线关系。形貌观察表明,微弧氧化膜由一个致密层和一个多孔层组成。致密层的厚度约占整个膜厚的40%,膜表面的20%均匀分布着直径1~3岬的孔。动电位极化测量显示,该新型微弧氧化膜的耐蚀性有明显提高,腐蚀电流降低了2个数量级,而自腐蚀电位正移了0.07V。盐雾试验结果同样证实微弧氧化膜的耐蚀性有大幅度提高。 | Lu Jianhong Yin Xijiang Annie Tan Lai Kuan Kong Ling Teck Cheng Zuolian | 2012 | 电镀与涂饰2012，31，9： | 1 |
| 20 | Fabrication of silica-based ceramic cores with internal lattice structures by stereolithography显示文摘Ceramic cores are widely used in investment casting,and ideal properties of cores are essential for high-quality castings.Under the circumstances requiring thick cores,solid cores are likely to encounter deformation and cracking defects due to the accumulation of shrinkage.Therefore,with the superiority of ceramic stereolithography in producing complex ceramic parts,hollow cores with lattice structures were designed and fabricated.The dimensional accuracy and properties of the green and sintered bodies were evaluated.Results show the dimensional accuracy of sintered cores is controlled within±0.25 mm benefited from the precise green bodies.The mechanical properties are not obviously deteriorated.The bending strength reaches 11.94 MPa at room temperature and 12.87 MPa at 1,500℃ with a creep deformation of 0.345 mm.Furthermore,casting verifications prove that the hollow cores meet the requirements of investment casting.Smooth casting surfaces are obtained,at the same time,the core-removal efficiency is improved by over 3 times. | Ke-hui Hu Hao-yuan Wang Kuan Lu Qian Feng Dao-ding Yang Jian Cao Bo Zhang Zhi-gang Lü Xing Ran | 2022 | China Foundry2022，19，5： | 1 |
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