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| 1 | Rifaximin ameliorates hepatic encephalopathy and endotoxemia without affecting the gut microbiome diversity显示文摘AIM To determine the efficacy of rifaximin for hepatic encephalopathy(HE) with the linkage of gut microbiome in decompensated cirrhotic patients.METHODS Twenty patients(12 men and 8 women; median age, 66.8 years; range, 46-81 years) with decompensated cirrhosis(Child-pugh score > 7) underwent cognitive neuropsychological testing, endotoxin analysis, and fecal microbiome assessment at baseline and after 4 wk of treatment with rifaximin 400 mg thrice a day. HE was determined by serum ammonia level and number connection test(NCT)-A. Changes in whole blood endotoxin activity(EA) was analyzed by endotoxinactivity assay. Fecal microbiome was assessed by 16 S ribosome RNA(rR NA) gene sequencing.RESULTS Treatment with rifaximin for 4 wk improved hyperammonemia(from 90.6 ± 23.9 μg/d L to 73.1 ± 33.1 μg/dL; P < 0.05) and time required for NCT(from 68.2 ± 17.4 s to 54.9 ± 20.3 s; P < 0.05) in patients who had higher levels at baseline. Endotoxin activity was reduced(from 0.43 ± 0.03 to 0.32 ± 0.09; P < 0.05) in direct correlation with decrease in serum ammonia levels(r = 0.5886, P < 0.05). No statistically significant differences were observed in the diversity estimator(Shannon diversity index) and major components of the gut microbiome between the baseline and after treatment groups(3.948 ± 0.548 at baseline vs 3.980 ± 0.968 after treatment; P = 0.544), but the relative abundances of genus Veillonella and Streptococcus were lowered.CONCLUSION Rifaximin significantly improved cognition and reduced endotoxin activity without significantly affecting the composition of the gut microbiome in patients with decompensated cirrhosis. | Kosuke Kaji Hiroaki Takaya Soichiro Saikawa Masanori Furukawa Shinya Sato Hideto Kawaratani Mitsuteru Kitade Kei Moriya Tadashi Namisaki Takemi Akahane Akira Mitoro Hitoshi Yoshiji | 2017 | World Journal of Gastroenterology2017，23，47： | 14 |
| 2 | A case of small bowel adenocarcinoma in a patient with Crohn’s disease detected by PET/CT and double-balloon enteroscopy显示文摘Small bowel adenocarcinoma (SBA) in patients with Crohn’s disease (CD) is quite rare, difficult to diagnose without surgery, and has a poor prognosis. Here, we report a 48-year-old man with SBA and a 21-year history of CD who was diagnosed by a combination of positron emission tomography/computed tomography (PET/CT) and double-balloon enteroscopy (DBE). Since the age of 27 years, the patient had been treated for ileal CD and was referred to our hospital with persistent melena. Multiple hepatic tumors were found by CT. PET/CT detected an accumulation spot in the small bowel. DBE revealed an ulcerative tumor in the ileum about 100 cm from the ileocecal valve. An endoscopic forceps biopsy specimen showed poorly differentiated adenocarcinoma. There were some longitudinal ulcer scars near the tumor, and the chronic inflammation inthe small bowel appeared to be associated with the cancer development. Previous reports suggest the risk of SBA in patients with CD is higher than in the overall population. Since early diagnosis is extremely difficult in these cases, novel techniques, such as PET/CT and DBE, may be expected to help in making a preoperative diagnosis of the development of SBA in CD. | Chise Kodaira Satoshi Osawa Chihiro Mochizuki Yoshihiko Sato Masafumi Nishino Takanori Yamada Yasuhiro Takayanagi Kosuke Takagaki Ken Sugimoto Shigeru Kanaoka Takahisa Furuta Mutsuhiro Ikuma | 2009 | World Journal of Gastroenterology2009，15，14： | 2 |
| 3 | Multimodal Treatment for Lymph Node Recurrence of Esophageal Carcinoma After Curative Resection显示文摘 | Tsutomu Nakamura MD PhD Masaho Ota MD PhD Kosuke Narumiya MD PhD Takuya Sato MD Takeshi Ohki MD PhD Masakazu Yamamoto MD PhD Norio Mitsuhashi MD PhD | 2008 | Annals of Surgical Oncology2008，，9： | 1 |
| 4 | Claudin-4 Expression Predicts Survival in Pancreatic Ductal Adenocarcinoma显示文摘 | Kosuke Tsutsumi Norihiro Sato Reiko Tanabe Kazuhiro Mizumoto Katsuya Morimatsu Tadashi Kayashima Hayato Fujita Kenoki Ohuchida Takao Ohtsuka Shunichi Takahata Masafumi Nakamura Masao Tanaka | 2012 | Annals of Surgical Oncology2012，，3： | 1 |
| 5 | ADAMTS13 and von Willebrand factor are useful biomarkers for sorafenib treatment efficiency in patients with hepatocellular carcinoma显示文摘BACKGROUND Many advanced hepatocellular carcinoma(HCC) patients are receiving sorafenib treatment. Sorafenib reportedly improves overall survival(OS) significantly in patients with HCC. Prediction of sorafenib response and prognosis in patients with HCC receiving sorafenib treatment are important due to the potentially serious side effects of sorafenib. A disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13(ADAMTS13) and von Willebrand factor(VWF) are associated with the pathophysiology of liver cirrhosis and HCC through their roles in hypercoagulability; they are also associated with angiogenesis via vascular endothelial growth factor(VEGF). The imbalance between ADAMTS13 and VWF was associated with prognosis of various cancers in patients undergoing chemotherapy.AIM To investigate ADAMTS13 and VWF as potential biomarkers for sorafenib response and prognosis in patients with HCC receiving sorafenib treatment.METHODS Forty-one patients with HCC receiving sorafenib treatment were included in this study. The initial daily sorafenib dose was 400 mg in all patients. ADAMTS13 activity(ADAMTS13:AC), VWF antigen(VWF:Ag), VEGF levels were determined by enzyme-linked immunosorbent assay. Univariate andmultivariate analyses were used to determine predictive factors for sorafenib response and prognosis in patients with HCC receiving sorafenib treatment.RESULTS ADAMTS13:AC was significantly higher in patients with stable disease(SD),partial response(PR), and complete response(CR) than in those with progressive disease(PD)(P < 0.05). In contrast, VWF:Ag and the VWF:Ag/ADAMTS13:AC ratio were significantly lower in patients with SD, PR, and CR than in those with PD(P < 0.05 for both). Multivariate analysis showed that the VWF:Ag/ADAMTS13:AC ratio was the only predictive factor for sorafenib response and ADAMTS13:AC was the only prognostic factor in patients with HCC receiving sorafenib treatment. The patients with a low ADAMTS13:AC(<78.0) had significantly higher VEGF levels than those with a high ADAMTS13:AC(≥ 78.0)(P < 0.05).CONCLUSION The VWF:Ag/ADAMTS13:AC ratio and ADAMTS13:AC are potentially useful biomarkers for sorafenib response and prognosis, respectively, in patients with HCC receiving sorafenib treatment. | Hiroaki Takaya Tadashi Namisaki Naotaka Shimozato Kosuke Kaji Mitsuteru Kitade Kei Moriya Shinya Sato Hideto Kawaratani Takemi Akahane Masanori Matsumoto Hitoshi Yoshiji | 2019 | World Journal of Gastrointestinal Oncology2019，11，5： | 1 |
| 6 | Progressive carotid artery stenosis with a novel tRNA phenylalanine mitochondrial DNA mutation显示文摘 | Takahiro Iizuka Yu-ichi Goto Saori Miyakawa Mayumi Sato Zhaoxia Wang Kosuke Suzuki Junichi Hamada Akira Kurata Fumihiko Sakai | 2008 | Journal of the Neurological Sciences2008，，： | 1 |
| 7 | Modeling Real Objects for Kansei-based Shape Retrieval显示文摘很多 3D 模型在计算机上被创造并且为网络可得到。一些基于内容的检索技术是不可缺少的从如此的匿名的数据集发现特别数据。尽管几种形状检索技术被开发了,很少注意都没在人的鈥檚 感觉和印象上被给点(象 Kansei 一样知道) 在常规技术。在这篇论文,作者基于人的鈥檚 Kansei 的形状印象建议形状检索的一个新奇方法。方法的关键作为为形状检索的特征是从 3D 模型的 Gaussian 弯曲分发。然后,它在存储在模型之中由提取特征和措施类似分类 3D 模型。关键词形状检索 - kansei 工程 - 真实目标 Yukihiro Koda 当模特儿在 Hyogo 出生了,日本, 1982。他收到了 B。Sc。在从大阪大学设计科学的度,在 2005 的日本,他当前是设计科学的研究生院的一个学生,大阪大学,日本。他的研究兴趣包括为 3D 建模和数字遗产设计语言,特别埃及纪念碑。Ichi Kanaya 在东京出生了,日本, 1973。他收到了 B。Sc。在来自 Kansai 大学的电力工程,大阪,日本,在 1995。他然后收到了 M。Sc。并且 Ph。D。在从奈良的计算机科学的学位科技开创,奈良,日本在 1997 和 1999,分别地。他当前是设计科学的研究生院的一个助教,大阪大学,日本。他是为 3D-CG 程序员的四元数的介绍的一个作者(I/O 书, 2004,用日语) ,为 3D-CG 程序员的实际四元数(I/O 书, 2004,用日语) ,并且为 3D-CG 程序员的实时 Shader (I/O 书, 2004,用日语) 。他的当前的研究兴趣包括人的计算机相互作用,设计,和埃及考古学的科学途径设计。卡奈阿博士是 IEEE 的一个成员。Kosuke Sato 在广岛出生了,日本, 1961。他收到了 B。Sc, M。Sc。并且 Ph。在从大阪大学设计的控制的 D 学位,在 1983, 1985 和 1988 的日本分别地。他与从 1986 ~ 1994 在大阪大学设计的控制的系,并且与信息科学的研究生院,从 1994 ~ 1999 的科技的奈良研究所,在他保持了副教授的等级的地方。自从 1999,他是设计科学的研究生院的一个教授,大阪大学。他是在机器人学研究所的一个访问科学家, Carnegie-Mellon 大学, PA,从 1988 ~ 1990。他的当前的兴趣包括 3D 范围察觉到并且 3D 数据为计算机视觉处理,机器人视觉,虚拟现实,人机相互作用。 | Yukihiro Koda Ichi Kanaya Kosuke Sato | 2007 | International Journal of Automation and computing2007，4，1： | 1 |
| 8 | New acetogenin katsuurallene from Laurencia saitoi collected from Katsuura, Japan显示文摘We examined the chemical constitution of the red alga Laurencia saitoi Perestenko,collected from Katsuura,Boso Peninsula,Chiba Prefecture,Japan.This specimen produced a new polyhalogenated acetogenin,named katsuural-lene(1),which structure was determined by the spectral methods,along with known diterpene,deoxyparguerol(2)and triterpene,thyrsiferol(3).In this paper we describe the structural elucidation of katsuurallene together with some biological activities. | Yu Minamida Hiroshi Matsuura Takahiro Ishii Miyu Miyagi Yuto Shinjo Kosuke Sato Takashi Kamada Yoshihiro Mihara Iwao Togashi Keisuke Sugimoto Tsuyoshi Abe Norio Kikuchi Minoru Suzuki | 2022 | Natural Products and Bioprospecting2022，12，1： | 0 |
| 9 | Acylcarnitine: Useful biomarker for early diagnosis of hepatocellular carcinoma in non-steatohepatitis patients显示文摘BACKGROUND Early diagnosis of hepatocellular carcinoma(HCC)is necessary to improve the prognosis of patients.However,the currently available tumor biomarkers are insufficient for the early detection of HCC.Acylcarnitine is essential in fatty acid metabolic pathways.A recent study reported that a high level of acylcarnitine may serve as a useful biomarker for the early diagnosis of HCC in steatohepatitis(SH)patients.In contrast,another study reported that the level of acetylcarnitine(AC2)-one of the acylcarnitine species-in non-SH patients with HCC was decreased vs that reported in those without HCC.AIM To investigate the usefulness of acylcarnitine as a biomarker for the early diagnosis of HCC in non-SH patients.METHODS Thirty-three non-SH patients(14 with HCC and 19 without HCC)were enrolled in this study.Blood samples were obtained from patients at the time of admission.The levels of acylcarnitine and AC2 in the serum were determined through tandem mass spectrometry.The levels of vascular endothelial growth factor(VEGF)and VEGF receptor 2(VEGFR-2)were determined by enzymelinked immunosorbent assay.Univariate and multivariate analyses were used to determine early diagnostic factors of HCC.RESULTS The level of acylcarnitine was significantly lower in non-SH patients with HCC vs those without HCC(P<0.05).In contrast,the level of lens culinaris agglutininreactive fraction ofα-fetoprotein(AFP)-AFP-L3%-was significantly higher in non-SH patients with HCC vs those without HCC(P<0.05).However,the levels of total carnitine,free carnitine,AFP,des-γ-carboxy prothrombin,VEGF,and VEGFR-2 were not different between patients with and without HCC.The multivariate analysis showed that a low level of acylcarnitine was the only independent factor for the early diagnosis of HCC.The patients with a low level of AC2 had a significantly higher level of VEGF vs those with a high level of AC2(P<0.05).CONCLUSION The metabolic pathways of fatty acids may differ between SH HCC and non-SH HCC.Further studies are warranted to investigate these differences. | Hiroaki Takaya Tadashi Namisaki Mitsuteru Kitade Naotaka Shimozato Kosuke Kaji Yuki Tsuji Keisuke Nakanishi Ryuichi Noguchi Yukihisa Fujinaga Yasuhiko Sawada Soichiro Saikawa Shinya Sato Hideto Kawaratani Kei Moriya Takemi Akahane Hitoshi Yoshiji | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 0 |
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