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| 1 | Down.regulation of E.cadherin enhances prostate cancer chemoresistance via Notch signaling显示文摘Background:The chemoresistance of prostate cancer(PCa)is invariably associated with the aggressiveness and metastasis of this disease.New emerging evidence indicates that the epithelial-to-mesenchymal transition(EMT)may play pivotal roles in the development of chemoresistance and metastasis.As a hallmark of EMT,E-cadherin is suggested to be a key marker in the development of chemoresistance.However,the molecular mechanisms underlying PCa chemoresistance remain unclear.The current study aimed to explore the association between EMT and chemoresistance in PCa as well as whether changing the expression of E-cadherin would affect PCa chemoresistance.Methods:Parental PC3 and DU145 cells and their chemoresistant PC3-Tx R and DU145-Tx R cells were analyzed.PC3-Tx R and DU145-Tx R cells were transfected with E-cadherin-expressing lentivirus to overexpress E-cadherin;PC3 and DU145 cells were transfected with small interfering RNA to silence E-cadherin.Changes of EMT phenotype-related markers and signaling pathways were assessed by Western blotting and quantitative real-time polymerase chain reaction.Tumor cell migration,invasion,and colony formation were then evaluated by wound healing,transwell,and colony formation assays,respectively.The drug sensitivity was evaluated using MTS assay.Results:Chemoresistant PC3-Tx R and DU145-Tx R cells exhibited an invasive and metastatic phenotype that associated with EMT,including the down-regulation of E-cadherin and up-regulation of Vimentin,Snail,and N-cadherin,comparing with that of parental PC3 and DU145 cells.When E-cadherin was overexpressed in PC3-Tx R and DU145-Tx R cells,the expression of Vimentin and Claudin-1 was down-regulated,and tumor cell migration and invasion were inhibited.In particular,the sensitivity to paclitaxel was reactivated in E-cadherin-overexpressing PC3-Tx R and DU145-Tx R cells.When E-cadherin expression was silenced in parental PC3 and DU145 cells,the expression of Vimentin and Snail was up-regulated,and,particularly,the sensitivity to paclitaxel was decreased.Interestingly,Notch-1 expression was up-regulated in PC3-Tx R and DU145-Tx R cells,whereas the E-cadherin expression was down-regulated in these cells comparing with their parental cells.The use ofγ-secretase inhibitor,a Notch signaling pathway inhibitor,significantly increased the sensitivity of chemoresistant cells to paclitaxel.Conclusion:The down-regulation of E-cadherin enhances PCa chemoresistance via Notch signaling,and inhibiting the Notch signaling pathway may reverse PCa chemoresistance. | Wenchu Wang Lihui Wang Atsushi Mizokami Junlin Shi Chunlin Zou Jinlu Dai Evan T. Keller Yi Lu Jian Zhang | 2017 | Chinese Journal of Cancer2017，36，3： | 16 |
| 2 | 玻璃纤维增强复合材料人行桥模型参数验证显示文摘通过冲击和人工振动刺激结构,对全纤维增强复合材料人行桥进行动载试验。在未知输入刺激的情况下,采用峰点采集方法和随机子空间判定方法获取结构的动力学特征。研究表明:实时方法和仅有输出的方法均适用,较好的结果来自环境的刺激而不是冲击刺激。桁架结构中使用的节点类型,即1跨中的螺栓节点,其他跨中的粘结节点,明显地影响两跨的动力性能。对于来自第1跨的最低自然频率,螺栓节点跨比粘结节点跨小26%~28%。然而,由于螺栓节点的摩擦力,与粘结节点跨相比,螺栓节点跨显示出较高的衰减率。结果显示:试验结构的自然频率与其他纤维增强复合材料桥具有相同的量级。 | Bai Y. Keller T. | 2008 | 钢结构2008，23，7： | 13 |
| 3 | Immune mediators in the tumor microenvironment of prostate cancer显示文摘Prostate cancer tissue is composed of both cancer cells and host cells.The milieu of host components that compose the tumor is termed the tumor microenvironment(TME).Host cells can be those derived from the tissue in which the tumor originates(e.g.,fibroblasts and endothelial cells)or those recruited,through chemotactic or other factors,to the tumor(e.g.,circulating immune cells).Some immune cells are key players in the TME and represent a large proportion of non-tumor cells found within the tumor.Immune cells can have both anti-tumor and pro-tumor activity.In addition,crosstalk between prostate cancer cells and immune cells affects immune cell functions.In this review,we focus on immune cells and cytokines that contribute to tumor progression.We discuss T-regulatory and T helper17 cells and macrophages as key modulators in prostate cancer progression.In addition,we discuss the roles of interleukin-6 and receptor activator of nuclear factor kappa-B ligand in modulating prostate cancer progression.This review highlights the concept that immune cells and cytokines offer a potentially promising target for prostate cancer therapy. | Jinlu Dai Yi Lu Hernan Roca Jill M. Keller Jian Zhang Laurie K. McCauley Evan T. Keller | 2017 | Chinese Journal of Cancer2017，36，3： | 6 |
| 4 | 新型玻璃纤维增强复合材料——轻木夹心桥面板概念、设计及试验验证显示文摘描述了位于瑞士贝克斯(Bex)的阿旺松(Avancon)桥梁的概念、设计和试验验证。通过采用轻质玻璃纤维增强复合材料(GFRP)夹心桥面板与钢主梁进行胶黏结的方式,因施工造成的交通中断时间比传统混擬土现浇方式缩短了近40d(节省约80%的时间),且实现了双车道的扩展。通过半整体式的设计方案,可实现沥青层从桥台至桥面板的连续铺装,从而避免了伸缩缝的使用及简化了维护工作.带有轻木夹心的桥面板在结构性能上满足所有设计准则的要求,包括使用和承载能力极限状态和疲劳性能,然而桥面板尺寸很大程度上取决于选取和采用的设计准则。对于阿旺松桥,德国和英国准则提供了最保守的材料系数,而荷兰准则最不保守;欧洲准则介于两者之间。计算刚度时的材料系数选取会影响桥面板的组成和材料用量。 | 李春生 周兴党 高雁波 颜美 Keller T. Rothe J. De Castro J. Osei-Antwi M. | 2019 | 中外公路2019，39，2： | 6 |
| 5 | A predictive model for outcome after conservative decompression surgery for lumbar spinal stenosis显示文摘 | K. F. Spratt T. S. Keller M. Szpalski K. Vandeputte R. Gunzburg | 2004 | European Spine Journal2004，，1： | 1 |
| 6 | An integrative genetic linkage map of winter wheat (Triticum aestivum L.)显示文摘 | S. Paillard T. Schnurbusch M. Winzeler M. Messmer P. Sourdille O. Abderhalden B. Keller G. Schachermayr | 2003 | Theoretical and Applied Genetics2003，，7： | 1 |
| 7 | Sub-6-fs pulses from a SESAM-assisted Kerr-lens modelocked Ti:sapphire laser: at the frontiers of ultrashort pulse generation显示文摘 | D.H. Sutter L. Gallmann N. Matuschek F. Morier-Genoud V. Scheuer G. Angelow T. Tschudi G. Steinmeyer U. Keller | 2000 | Applied Physics B Lasers and Optics2000，，1： | 1 |
| 8 | Rubber track systems for conventional tractors – Effects on soil compaction and traction显示文摘 | J. Arvidsson H. Westlin T. Keller M. Gilbertsson | 2011 | Soil & Tillage Research2011，，： | 1 |
| 9 | Expression of the cytoskeleton linker protein ezrin in human cancers显示文摘 | Benjamin Bruce Gaurav Khanna Ling Ren Goran Landberg Karin Jirstr?m Charles Powell Alain Borczuk Evan T. Keller Kirk J. Wojno Paul Meltzer Kristin Baird Andrea McClatchey Anthony Bretscher Stephen M. Hewitt Chand Khanna | 2007 | Clinical & Experimental Metastasis2007，，2： | 1 |
| 10 | Arrhythmogenic right ventricular cardiomyopathy: diagnostic and prognostic value of the cardiac MRI in relation to arrhythmia-free survival显示文摘 | Dagmar I. Keller Stefan Osswald Jens Bremerich Georg Bongartz Thomas A. Cron Patrick Hilti Matthias E. Pfisterer Peter T. Buser | 2003 | The International Journal of Cardiac Imaging2003，，： | 1 |
| 11 | Effects of long-term treatment with lovastatin on the clotting system and blood platelets显示文摘 | J. Mayer T. Eller P. Brauer E. M. Solleder R. M. Sch?fer F. Keller K. Kochsiek | 1992 | Annals of Hematology1992，，4： | 1 |
| 12 | CD24 controls Src/STAT3 activity in human tumors显示文摘 | Niko P. Bretz Alexei V. Salnikov Claudia Perne Sascha Keller Xiaoli Wang Claudia T. Mierke Mina Fogel Natalie Erbe-Hofmann Thomas Schlange Gerhard Moldenhauer Peter Altevogt | 2012 | Cellular and Molecular Life Sciences2012，，22： | 1 |
| 13 | Prophylactic Residual Aneurysmal Sac Embolization with Expandable Hydrogel Embolic Devices for Endoleak Prevention: Preliminary Study in Dogs显示文摘 | Takao Hiraki Dusan Pavcnik Barry T. Uchida Hans A. Timmermans Qiang Yin Reng-Hong Wu Mahtab Niyyati Frederick S. Keller Josef R?sch | 2005 | CardioVascular and Interventional Radiology2005，，4： | 1 |
| 14 | Exogenous SPARC Suppresses Proliferation and Migration of Prostate Cancer by Interacting With Integrin β1显示文摘 | Minkyoung Shin Atsushi Mizokami Jungim Kim Mitsuo Ofude Hiroyuki Konaka Yoshifumi Kadono Yasuhide Kitagawa Sotaro Miwa Misako Kumaki Evan T. Keller Mikio Namiki | 2013 | Prostate2013，，11： | 1 |
| 15 | A Flexible Stent with Small Intestinal Submucosa Covering for Direct Intrahepatic Portocaval Shunt: Experimental Pilot Study in Swine显示文摘 | Mahtab Niyyati Bryan D. Petersen Dusan Pavcnik Barry T. Uchida Hans A. Timmermans Takao Hiraki Reng-Hong Wu Elias Brountzos Frederick S. Keller Josef R?sch | 2005 | CardioVascular and Interventional Radiology2005，，2： | 1 |
| 16 | Preventing Vasospasm Improves Outcome After Aneurysmal Subarachnoid Hemorrhage: Rationale and Design of CONSCIOUS-2 and CONSCIOUS-3 Trials显示文摘 | R. Loch Macdonald Randall T. Higashida Emanuela Keller Stephan A. Mayer Andy Molyneux Andreas Raabe Peter Vajkoczy Isabel Wanke Aline Frey Angelina Marr Sébastien Roux Neal F. Kassell | 2010 | Neurocritical Care2010，，3： | 1 |
| 17 | Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease显示文摘 | Jason M. Norman Scott A. Handley Megan T. Baldridge Lindsay Droit Catherine Y. Liu Brian C. Keller Amal Kambal Cynthia L. Monaco Guoyan Zhao Phillip Fleshner Thaddeus S. Stappenbeck Dermot P.B. McGovern Ali Keshavarzian Ece A. Mutlu Jenny Sauk Dirk Gevers | 2015 | Cell2015，，： | 1 |
| 18 | An integrative genetic linkage map of winter wheat (Triticum aestivum L.)显示文摘 | S. Paillard T. Schnurbusch M. Winzeler M. Messmer P. Sourdille O. Abderhalden B. Keller G. Schachermayr | 2003 | Theoretical and Applied Genetics2003，，7： | 1 |
| 19 | Carbonatite dykes at bayan Obo, inner Mongolia, China显示文摘 | M. J. Bas J. Kellere Tao Kejie F. Wall C. T. William Zhang Peishan | 1992 | Mineralogy and Petrology1992，，3： | 1 |
| 20 | Effect of ternary Al, Ni additions on hydrogen absorption behaviour of Ti–45Nb alloys显示文摘 | B. Dutta T. Keller M. Rettenmayr U. Jantsch D.F. Lupton | 2004 | Materials Science & Engineering A2004，，1： | 1 |
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