|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The historical and current research progress on jujube–a superfruit for the future显示文摘Jujube(Ziziphus jujuba Mill.),or Chinese date,is the most important species of Rhamnaceae,a large cosmopolitan family,and is one of the oldest cultivated fruit trees in the world.It originates from the middle and lower reaches of the Yellow River,the‘mother river’of the Chinese people.It is distributed in at least 48 countries on all continents except Antarctica and is becoming increasingly important,especially in arid and semiarid marginal lands.Based on a systematic analysis of the unique characteristics of jujube,we suggest that it deserves to be recognized as a superfruit.We summarized historical research achievements from the past 3000 years and reviewed recent research advances since 1949 in seven fields,including genome sequencing and application,germplasm resources and systematic taxonomy,breeding and genetics,cultivation theory and techniques,pest control,postharvest physiology and techniques,and nutrition and processing.Based on the challenges facing the jujube industry,we discuss eight research aspects to be focused on in the future. | Mengjun Liu Jiurui Wang Lili Wang Ping Liu Jin Zhao Zhihui Zhao Shengrui Yao Florin Stănică Zhiguo Liu Lixin Wang Changwei Ao Li Dai Xiansong Li Xuan Zhao Chunxiang Jia | 2020 | Horticulture Research2020，7，1： | 10 |
| 2 | Comparison of the carbon isotope composition of total organic carbon and long-chain n-alkanes from surface soils in eastern China and their significance显示文摘Surface soil samples collected over a high spatial resolution in eastern China were analyzed for carbon isotope composition(δ 13C) of total organic carbon(TOC) and higher plant-derived long-chain n-alkanes,with the latter reported as weighted mean values.The two sets of δ 13C values are significantly correlated and show similar trends in spatial variation.The spatial distribution of δ 13C shows less negative values in the mid-latitudes between 31°N and 40°N and more negative ones at higher and lower latitudes.This is consistent with previously reported carbon isotope data from surface soil phytoliths in the same region and suggests that the mid-latitude area provides relatively favorable growing conditions for C4 plants.Furthermore,δ 13C values of both TOC and long-chain n-alkanes from 12 surface soil samples collected from a small grassland in north China displayed similar carbon isotope values and the difference between paired δ 13C of a soil samples remains relatively constant.Our data demonstrate that in eastern China,soil δ 13C composition of both TOC and long-chain n-alkanes is effective indicators of C3/C4 ratios of the prevailing vegetation.This work suggests that -22‰ and -32‰ are good estimated end members for the weighted mean δ 13C values of long-chain n-alkanes(C27,C29 and C31 n-alkanes) from soils under dominant C4 or C3 vegetation,allowing us to reconstruct paleovegetation trends. | RAO ZhiGuo JIA GuoDong ZHU ZhaoYu WU Yi ZHANG JiaWu | 2008 | Chinese Science Bulletin2008，53，24： | 10 |
| 3 | Weekly albumin-bound paclitaxel/cisplatin versus gemcitabine/cisplatin as first-line therapy for patients with advanced non-small-cell lung cancer:A phase II open-label clinical study显示文摘Objective: The aim of this trial was to compare both the efficacy and the safety of a weekly nanoparticle albumin-bound paclitaxel(nab-paclitaxel) plus cisplatin vs. gemcitabine plus cisplatin in patients with advanced non-small-cell lung cancer(NSCLC).Methods: A total of 84 participants received either 100 mg/m^2 nab-paclitaxel each week on d 1, 8 and 15 of a 28 day cycle, as well as cisplatin 75 mg/m^2 on d 1 every three weeks(nab-TP arm); or gemcitabine 1,000 mg/m^2 on d 1 and 8, plus cisplatin 75 mg/m^2 on d 1 every three weeks(GP arm). The primary end point was progression-free survival(PFS). The secondary end points were overall response rate(ORR) and overall survival(OS).Results: According to our analysis, the median PFS was 4.8 months for the nab-TP arm vs. 5.2 months for the GP arm(P=0.55). Analysis showed the median OS was 14.6 months for participants who were in the nab-TP arm vs. 15.1 months for those in the GP arm(P=0.94). Besides, nab-TP showed OS advantages over GP in patients harboring epidermal growth factor receptor(EGFR) mutation(26.7 vs. 15.3 months, P=0.046) and patients with a performance status of 0(23.5 vs. 14.7 months, P=0.020). It was found that incidences of drug-related grade 3 or 4 toxicities were comparable between the two treatment arms.Conclusions: Therefore, it can be seen that weekly nab-TP treatment has a similar efficacy and tolerability to GP treatment for patients who are undergoing their first-line treatment for NSCLC. It could be that survival differences among platinum doublets in the context of both EGFR mutation and performance status have the potential to be the basis for our further clinical trials. | Shanshan Qin Hui Yu Xianghua Wu Zhiguo Luo Huijie Wang Si Sun Mingzhu Huang Jia Jin Zhonghua Tao Jie Qiao Yu Feng Jialei Wang Jianhua Chang | 2019 | Chinese Journal of Cancer Research2019，31，2： | 9 |
| 4 | Is the maximum carbon number of long-chain n-alkanes an indicator of grassland or forest? Evidence from surface soils and modern plants显示文摘The molecular distribution of long-chain n-alkanes in 62 soil samples collected from diverse locations across eastern China was analyzed.The long-chain n-alkanes were mostly dominated by n-C29 or n-C31,regardless of the overlying vegetation type at each site.The results were compared with those summarized from the literature,covering more than 100 soil samples within China and more than 300 genera of modern plants distributed worldwide.There were similar n-alkane distribution patterns for most genera, with no clear differences among grasses,shrubs,and trees.The evidence from analyses of surface soils and modern plants indicates that the relationship between the molecular distribution of long-chain n-alkanes of surface soils and source vegetation is highly complex,and is influenced by many factors.Further,it is suggested that source vegetation types should not be simply inferred from distribution patterns of long-chain n-alkanes in sediments. | RAO ZhiGuo WU Yi ZHU ZhaoYu JIA GuoDong HENDERSON Andrew | 2011 | Chinese Science Bulletin2011，56，16： | 9 |
| 5 | Relationship between climatic conditions and the relative abundance of modern C_3 and C_4 plants in three regions around the North Pacific显示文摘Using -24‰ and -14‰ as the endpoints of stable carbon isotopic composition of total organic carbon (δ 13CTOC) of surface soil under pure C3 and C4 vegetation, and surface soil δ 13CTOC data from eastern China, Australia and the Great Plains of North America, we estimate the relative abundance of C3/C4 plants (i.e., the ratio of C3 or C4 biomass to local primary production) in modern vegetation for each region. The relative abundance of modern C3/C4 vegetation from each region is compared to the corresponding climatic parameters (mean annual temperature and precipitation) to explore the relationship between relative C4 abundance and climate. The results indicate that temperature controls the growth of C4 plants. However, even where temperature is high enough for the growth of C4 plants, they will only dominate the landscape when precipitation declines as temperatures increase. Our results are consistent with those of other investigations of the geographic distribution of modern C4 plant species. Therefore, our results provide an important reference for interpretation of past C3/C4 relative abundance records in these three regions. | RAO ZhiGuo ZHU ZhaoYu JIA GuoDong CHEN FaHu BARTON Loukas ZHANG JiaWu QIANG MingRui | 2010 | Chinese Science Bulletin2010，55，18： | 7 |
| 6 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 7 | An ultrasound simulation method for carotid arteries with a wall structure of three membranes显示文摘Ultrasound simulation for carotid arteries is helpful to the performance assessments of vessel wall detection and signal processing methods by using ultrasound techniques.An ultrasound simulation method of carotid artery wall with a three-membrane structure is proposed in present study.According to the ultrasound speckle distributions varying with the shapes and densities of scatterer distributions,as well as the statistic results of the clinical images,the parameters of distributions,densities and intensities of scatterers for different kinds of tissues in the carotid artery phantoms are determined.Each region is acoustically characterized using FIELD II software to produce the radio frequency echo signals,from which ultrasound images are derived.The results based on 30 simulations show that the echo distributions of the intimae,mediae,adventitias and blood are consistent with the clinical ones.Moreover,compared with the results from the central frequency of 8 MHz,the mean measurements for thicknesses of the intima,media and adventitia membranes,as well as the lumen diameter from the simulation images based on 12 MHz are the same as the preset ones,and the maximum relative errors are the 4.01%,1.25%,0.04%and 0.15%,respectively.The simulation under this condition is more realistic. | HU Xiao ZHANG Yufeng GAO Lian CAI Guanghui JIA Zhiguo ZHANG Kexin DENG Li | 2015 | Chinese Journal of Acoustics2015，34，3： | 3 |
| 8 | The design and construction of a pulsed beam generation system based on high intensity cyclotron显示文摘In order to perform the studies on a pulsed beam generation system based on a high intensity cyclotron, a test beam line with a pulsed beam generation for a 10 MeV compact cyclotron (CYCIAE-10) has been designed and constructed at China Institute of Atomic Energy (CIAE). A 70 MHz continuous H- beam can be pulsed to the pulse length of less than 10 ns with a repetition rate of 4.4 MHz. The sine waveform with a frequency of 2.2 MHz is adopted for the chopper and a mesh structure with single drift and dual gaps is used for the 70 MHz buncher. A helical resonator is designed and constructed based on simulations and experiments on the RF matching for the chopper. A helical inductance loop that is exceptionally large of its kind and equipped with water cooling for the resonator has been successfully wound and a 500 W solid RF amplifier has been manufactured. A special measuring device has been designed, which can be used to measure both the DC beam and the pulsed beam. The required pulsed beam was obtained after pulsed beam tuning. | AN ShiZhong YIN ZhiGuo LI PengZhan SONG GuoFang WU LongCheng GUAN FengPing XIE HuaiDong JIA XianLu LU YinLong ZHANG TianJue | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 3 |
| 9 | Comprehensive test stand for high-intensity cyclotron development显示文摘A comprehensive test stand for high-intensity cyclotron development,a 10 MeV 430 μA cyclotron,has been successfully constructed at China Institute of Atomic Energy (CIAE) for the experimental verification of the viability of a 100 MeV high-intensity cyclotron (CYCIAE-100) being constructed at CIAE.The verification includes the overall design technology,detail design and engineering technology for the crucial parts of the machine,e.g.main magnet and beam diagnostics.It will also pave the way for future enhancement of the beam intensity.The test stand consists of a H-ion source,axial injection system,central region,main magnet and coil,RF resonator,stripping extraction,and auxiliary systems,which include the RF power amplifier,high voltage and DC power supplies,electric apparatus,beam diagnostics,control,vacuum,water cooling,pneumatic system,and safety interlock.This paper presents the work regarding the design and sub-system development of the test sand,and the results of the beam commissioning of the machine. | ZHANG TianJue LI ZhenGuo CHU ChengJie XING JianSheng GUAN FengPing ZHONG JunQing JI Bin GE Tao YIN ZhiGuo HOU ShiGang PAN GaoFeng YAO HongJuan LU YinLong WANG ZhenHui WU LongCheng LIN Jun JIA XianLu WEI SuMin WEN LiPeng WANG Feng XIA Le CAI HongRu XIE HuaiDong CHEN RongFan ZHANG Yan ZHANG SuPing LIU GengShou ZOU Jian AN ShiZhong YANG JianJun BI YuanJie YANG Fang | 2011 | Chinese Science Bulletin2011，56，3： | 3 |
| 10 | Mechanisms of chromatin-based epigenetic inheritance显示文摘Multi-cellular organisms such as humans contain hundreds of cell types that share the same genetic information(DNA sequences),and yet have different cellular traits and functions.While how genetic information is passed through generations has been extensively characterized,it remains largely obscure how epigenetic information encoded by chromatin regulates the passage of certain traits,gene expression states and cell identity during mitotic cell divisions,and even through meiosis.In this review,we will summarize the recent advances on molecular mechanisms of epigenetic inheritance,discuss the potential impacts of epigenetic inheritance during normal development and in some disease conditions,and outline future research directions for this challenging,but exciting field. | Wenlong Du Guojun Shi Chun-Min Shan Zhiming Li Bing Zhu Songtao Jia Qing Li Zhiguo Zhang | 2022 | Science China(Life Sciences)2022，65，11： | 2 |
| 11 | Compound-specific hydrogen isotopes of long-chain n-alkanes extracted from topsoil under a grassland ecosystem in northern China显示文摘To investigate characteristics of H isotope variation in long-chain n-alkanes (δDn-alkanes) from higher plants in surface soils under a single ecosystem, 12 samples from a basalt regolith were randomly collected from Damaping in Wanquan County of Zhangjiakou in North China. Molecular distribution and C (δ13Cn-alkanes) and H isotopes of long-chain n-alkanes, as well as C isotopes of TOC (δ13CTOC), were analyzed. Both δ13CTOC and δ13Cn-alkanes values from four representative dominant long-chain n-alkanes (n-C27, n-C29, n-C31, n-C33) derived from terrestrial higher plants show minor variations among the 12 samples, indicating the major contributor is from local grasses with a uniform C3 photosynthetic pathway. In contrast, variations in δDn-alkanes values of the four long-chain n-alkanes are relatively large, with the more abundant homologs generally showing more negative δDn-alkanes values and less variation. However, variation of <30‰ among weighted averaged δDn-alkanes values of the four long-chain n-alkanes is not only less than that among δDn-alkanes values for different modern terrestrial C3 grasses from the specific locations, but also less than the literature values of δDn-alkanes of long-chain n-alkanes for single species over different seasons. Thus, because the sources of long-chain n-alkanes in surface soils and sediments are similarly from multiple individual plants, our results are significant in confirming that paleoclimatic, paleoenvironmental and paleohydrological information can be interpreted more accurately from δDn-alkanes values of long-chain n-alkanes from sediments, particularly terrestrial sediments with organic matter derived from in-situ plants. | RAO ZhiGuo ZHU ZhaoYu JIA GuoDong ZHANG Xiao WANG SuPing | 2011 | Science China Earth Sciences2011，54，12： | 2 |
| 12 | Easy modeling of realistic trees from freehand sketches显示文摘以一个方便方法创造现实主义的 3D 树模型是在由于树结构的多样化和吸藏做的比赛设计和电影的挑战。为快树建模的当前的基于大意、基于图象的途径实际上有限制,速度,和他们通常包括复杂参数调整,它把困难带到新手。在这份报纸,我们在场没有参数调整,为快速产生各种各样的 3D 树的一个简单方法从凭手画的图案当模特儿。在二幅输入图象上,用户拉代表主要树枝和一棵树的王冠剪影的击。系统自动地以高速度生产一棵 3D 树。首先,二架 2D 骨骼从击,和类似于输入图案的 3D 树结构被造被树枝检索从 2D 骨骼造。小树枝基于自我类似和角度限制在勾略的 2D 王冠剪影以内被产生。这个系统在许多例子上被表明。它维持一棵树的主要特征:主要树枝结构和王冠形状,和罐头为树模拟和设计被用作一个方便工具。 | Jia LIU Zhiguo JIANG Hongjun LI Xiaopeng ZHANG | 2012 | Frontiers of Computer Science2012，6，6： | 2 |
| 13 | The Nine - Dash Line in the South China Sea: History, Status, and Implications 显示文摘 | Gao Zhiguo & Jia Bingbing | 2013 | The American Journal of International Law2013，，1： | 1 |
| 14 | Lake-level records support a mid-Holocene maximum precipitation in northern China显示文摘Lake level and its inferred East Asian summer monsoon(EASM)evolution in northern boundary of EASM during the Holocene are highly debated.Here,we present a 15-ka record of glycerol dialkyl glycerol tetraethers(GDGTs)in a closed lake in northern China to address this issue.Surface and downcore sediment data demonstrate sedimentary GDGT-0 and branched GDGTs(brGDGTs)are of aquatic production.Contents of GDGT-0 and brGDGTs increase but brGDGT-based paleo-temperature proxy decreases with water depth in surface sediments along a nearshore to offshore transect.This trend is likely due to an increasingly hypoxic condition,favored by anaerobic microbes producing these GDGT-0 and brGDGTs,in bottom water.Accordingly,brGDGT-derived water temperature and pH would reflect bottom water conditions that are largely regulated by water depth of the lake.Downcore GDGT data and their derived temperature and pH consistently reveal a gradually increasing lake level from the late Pleistocene to the early Holocene,a high level during 9.5-5 ka BP and a decreasing trend afterward.The lake-level records from independent and robust proxies in this study largely agree with pollen records in the region,supporting a mid-Holocene maximum EASM precipitation. | Jiantao CAO Zhiguo RAO Fuxi SHI Ergang LIAN Guodong JIA | 2021 | Science China Earth Sciences2021，64，12： | 1 |
| 15 | Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes显示文摘Dear Editor,The first mitotic division in zygotes is crucial for the beginning of the life cycle for the human.After fertilization,zygotes reactivate cell cycle,both paternal and maternal genomes replicate and reprogram to become totipotent.In the meantime,the male and female pronucleus move to the center of the zygote and merge.Then zygotes enter the metaphase,and sister chromatids separate into two daughter cells(Eckersley-Maslin et al.,2018;Reichmann et al.,2018).This is a sensitive time window and many perturbances may cause the first mitosis to fail. | Beili Chen Jianying Guo Ting Wang Qianhui Lee Jia Ming Fangfang Ding Haitao Li Zhiguo Zhang Lin Li Yunxia Cao Jie Na | 2022 | Protein & Cell2022，13，2： | 1 |
| 16 | Daintain/AIF-1 promotes breast cancer cell migration by up-regulated TNF-α via activate p38 MAPK signaling pathway显示文摘 | Tao Li Zhiguo Feng Shaohui Jia Wei Wang Zhongxia Du Ning Chen Zhengwang Chen | 2012 | Breast Cancer Research and Treatment2012，，3： | 1 |
| 17 | THE NINE-DASH LINE IN THE SOUTH CHINA SEA: HISTORY, STATUS, AND IMPLICATIONS显示文摘 | Gao Zhiguo Jia Bing Bing | 2013 | The American Journal of International Law2013，，1： | 1 |
| 18 | Acupuncture improves cognitive deficits and regulates the brain cell proliferation of SAMP8 mice显示文摘 | Haiyan Cheng Jianchun Yu Zhiguo Jiang Xuezhu Zhang Cunzhi Liu Yingmei Peng Fuyan Chen You Qu Yujie Jia Qingfei Tian Chuan Xiao Qin Chu Kun Nie Bohong Kan Xiaolin Hu Jingxian Han | 2007 | Neuroscience Letters2007，，2： | 1 |
| 19 | THE NINE-DASH LINE IN THE SOUTH CHINA SEA: HISTORY, STATUS, AND IMPLICATIONS显示文摘 | Gao Zhiguo Jia Bing Bing | 2013 | The American Journal of International Law2013，，1： | 1 |
| 20 | ARTIFICIAL INTELLIGENCE(AI)-DRIVEN SPECTRUM MANAGEMENT显示文摘Recent advances in communication and networking technologies are leading to a plethora of novel wireless services that range from unmanned aerial vehicle(UAV)communication to smart cognitive networks and massive Internet of Things(IoT)systems.Enabling these emerging applications over the fifth generation(5G)of wireless cellular systems requires meeting numerous challenges pertaining to spectrum sharing and management.In fact,most 5G applications will be highly reliant on intelligent spectrum management techniques,which should adapt to dynamic network environments while also guaranteeing high reliability and high quality-of-experience(QoE). | Zan Li Zhiguo Ding Jia Shi Walid Saad Lie-Liang Yang | 2020 | China Communications2020，17，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员