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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Resequencing of 145 Landmark Cultivars Reveals Asymmetric Sub-genome Selection and Strong Founder Genotype Effects on Wheat Breeding in China显示文摘Controlled pedigrees and the multi-decade timescale of national crop plant breeding programs offer a unique experimental context for examining how selection affects plant genomes.More than 3000 wheat cultivars have been registered,released,and documented since 1949 in China.In this study,a set of 145 elite cultivars selected from historical points of wheat breeding in China were re-sequenced.A total of 43.75 Tb of sequence data were generated with an average read depth of 17.94x for each cultivar,and more than 60.92 million SNPs and 2.54 million InDels were captured,based on the Chinese Spring RefSeq genome v1.0.Seventy years of breeder-driven selection led to dramatic changes in grain yield and related phenotypes,with distinct genomic regions and phenotypes tar-geted by different breeders across the decades.There are very clear instances illustrating how introduced Italian and otherforeign germplasm was integrated into Chinese wheat programs and reshaped the genomic landscape of local modern cultivars.Importantly,the resequencing data also highlighted significant asymmetric breeding selec-tion among the three sub-genomes:this was evident in both the collinear blocks for homeologous chromosomes and among sets of three homeologous genes.Accumulation of more newly assembled genes in newer cultivars implied the potential value of these genes in breeding.Conserved and extended sharing of linkage disequilibrium(LD)blocks was highlighted among pedigree-related cultivars,in which fewer haplotype differences were detected.Fixation or replacement of haplotypes from founder genotypes after generations of breeding was related to their breeding value.Based on the haplotype frequency changes in LD blocks of pedigree-related cultivars,we propose a strategy for evaluating the breeding value of any given line on the basis of the accumulation(pyramiding)of bene-ficial haplotypes.Collectively,our study demonstrates the influence of 'founder genotypes' on the output of breeding efforts over many decades and also suggests that founder genotype perspectives are in fact more dy-namic when applied in the context of modern genomics-informed breeding. | Chenyang Hao Chengzhi Jiao Jian Hou Tian Li Hongxia Liu Yuquan Wang Jun Zheng Hong Liu Zhihong Bi Fengfeng Xu Jing Zhao Lin Ma Yamei Wang Uzma Majeed Xu Liu Rudi Appels Marco Maccaferri Roberto Tuberosa Hongfeng Lu Xueyong Zhang | 2020 | Molecular Plant2020，13，12： | 9 |
| 3 | RESUSPENSION METHOD FOR ROAD SURFACE DUST COLLECTION AND AERODYNAMIC SIZE DISTRIBUTION CHARACTERIZATION显示文摘Traffic-generated fugitive dust is a source of urban atmospheric particulate pollution in Beijing. This paper introduces the resuspension method, recommended by the US EPA in AP-42 documents, for collecting Beijing road-surface dust. Analysis shows a single-peak distribution in the number size distribution and a double-peak mode for mass size distribution of the road surface dust. The median diameter of the mass concentration distribution of the road dust on a high-grade road was higher than that on a low-grade road. The ratio of PM2.5 to PM10 was consistent with that obtained in a similar study for Hong Kong. For the two selected road samples, the average relative deviation of the size distribution was 10.9% and 11.9%. All results indicate that the method introduced in this paper can effectively determine the size distribution of fugitive dust from traffic. | Jianhua Chen Hongfeng Zheng Wei Wang Hongjie Liu Ling Lu Linfa Bao Lihong Ren | 2006 | China Particuology2006，4，6： | 7 |
| 4 | Devonian Sequence Stratigraphy and Relative Sea Level Changes in Longmenshan Area, Sichuan显示文摘The Longmenshan area is located at the western margin of Yangtze platform, where the Devonian is composed of clastic rocks, mixed clastic-carbonate rocks and carbonate rocks in ascending order, and was formed in the marine environment from nearshore to outer shelf. Based on a study of six sections the Devonian in Longemenshan area is divided into 18 sequences and 5 sequence sets. The maximum transgressive high in the Devonian of this area occurred in Early Frasnian, corresponding to asymmetricus zone. The boundaries among the sequence sets are roughly corresponding to the bottom boundaries of Ⅰa’,Ⅰc’,Ⅱa, and Ⅱd in the Devonian of West Europe and North America, respectively. The frequencies of the relative sea level changes in this area vary in different periods, but can be correlated with those in the other regions of the world. | Liu Wenjun Chen Yuanren Zheng Rongcai Wang Hongfeng Li Xianghui (Chengdu Institute of Technology, Chengdu 610059) | 1996 | Journal of Earth Science1996，15，1： | 5 |
| 5 | Less and shrunken pollen 1(LSP1) encodes a member of the ABC transporter family required for pollen wall development in rice(Oryza sativa L.)显示文摘Pollen fertility is an agronomic trait that strongly influences rice yield. Recent studies have revealed that the development of the pollen wall is required for pollen fertility and is regulated by several genes. However, the mechanisms underlying pollen and pollen wall development in rice remain largely unknown. In the present study, a point mutation in a gene on chromosome 1 was identified that resulted in the production of less and shrunken pollen(LSP) and led to defects in pollen wall formation. This gene was named LSP1 and was found to encode a member of the adenosine triphosphate-binding cassette(ABC)transporter G subfamily, OsABCG3. Two other loss-of-function mutants of LSP1/OsABCG3,generated using CRISPR/Cas9 technology, showed the same male sterile phenotype. The LSP1/OsABCG3 gene showed a spatio-temporal expression pattern in the developing anthers, and is an ortholog of the Arabidopsis genes At ABCG1 and At ABCG16, which play an important role in pollen wall development. Mutation of LSP1/OsABCG3 affected the expression of several genes involved in pollen and pollen wall formation. These results suggest that LSP1/OsABCG3 is critical for normal pollen fertility and shed light on the molecular mechanisms underlying rice pollen wall development. | Tao Luo Ting Zou Guoqiang Yuan Zhiyuan He Wenjie Li Yang Tao Miaomiao Liu Dan Zhou Hongfeng Zhao Jun Zhu Yueyang Liang Qiming Deng Shiquan Wang Aiping Zheng Huainian Liu Lingxia Wang Ping Li Shuangcheng Li | 2020 | The Crop Journal2020，8，3： | 4 |
| 6 | Recent Climate Trends on the Northern Slopes of the Tianshan Mountains, Xinjiang, China显示文摘In arid regions, mountains fulfill important ecological and economic functions for the surrounding lowlands. In the scenario of global warming, mountain ecosystems change rapidly, especially in the arid region of northwestern China. This paper provides an assessment of the changes in temperature and precipitation in the historical records of climate on the northern slopes of the eastern Tianshan Mountains. A Mann-Kendall nonparametric trend and Sen's tests are employed to analyze the interannual changes and innerannual variability in temperature and precipitation in the regions of low to high altitude. The present study finds that the largest increases in annual temperature are observed at stations in the low altitude regions. The significant increasing trends in temperature tend to occur mainly in late winter and early spring at stations from middle to high altitude, but in summer and autumn at stations of low altitudes. The increasing trends in annual precipitation are found from the middle to high altitude areas, but decreasing trends are found in the low altitude areas. The significant increasing trends in precipitation occur mostly in winter and earlier spring at stations from the middle to high altitudes, while the increasing and decreasing trend coexists at stations of low altitude with most of the significant trend changes occurring in March, June and August. | ZHANG Hongfeng OUYANG Zhiyun ZHENG Hua WANG Xiaoke | 2009 | Journal of Mountain Science2009，6，3： | 3 |
| 7 | SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate显示文摘Loss-of-function mutations in sorting nexin 14(SNX14)cause autosomal recessive spinocerebellar ataxia 20,which is a form of early-onset cerebellar ataxia that lacks molecular mechanisms and mouse models.We generated Snx14-deficient mouse models and observed severe motor deficits and cell-autonomous Purkinje cell degeneration.SNX14 deficiency disrupted microtubule organization and mitochondrial transport in axons by destabilizing the microtubule-severing enzyme spastin,which is implicated in dominant hereditary spastic paraplegia with cerebellar ataxia,and compromised axonal integrity and mitochondrial function.Axonal transport disruption and mitochondrial dysfunction further led to degeneration of high-energy-demanding Purkinje cells,which resulted in the pathogenesis of cerebellar ataxia.The antiepileptic drug valproate ameliorated motor deficits and cerebellar degeneration in Snx14-deficient mice via the restoration of mitochondrial transport and function in Purkinje cells.Our study revealed an unprecedented role for SNX14-dependent axonal transport in cerebellar ataxia,demonstrated the convergence of SNX14 and spastin in mitochondrial dysfunction,and suggested valproate as a potential therapeutic agent. | Hongfeng Zhang Yujuan Hong Weijie Yang Ruimin Wang Ting Yao Jian Wang Ke Liu Huilong Yuan Chaoqun Xu Yuanyuan Zhou Guanxian Li Lishan Zhang Hong Luo Xian Zhang Dan Du Hao Sun Qiuyang Zheng Yun-Wu Zhang Yingjun Zhao Ying Zhou Huaxi Xu Xin Wang | 2021 | National Science Review2021，8，7： | 1 |
| 8 | Local delivery of superagonist gene based on polymer nanoparticles for cancer immunotherapy显示文摘Cancer is the leading cause that threatens human life expectancy due to the lack of effective therapies.Cancer immunotherapy has been explored to improve the body's immune system against cancer and accompanied by promising results in recent years.Interleukin 15(IL-15),a pleiotropic immunomodulator,is critical for immune cells development and displays great anti-tumor potential in both preclinical and clinical trials.In this study,superagonist IL-15 plasmid(psIL-15)consisting of IL-15Rα-sushi-linker-IL-15 was constructed in order to secret superagonist IL-15(sIL-15)in tumor site.A gene delivery system through self-assembly by methylated polyethylene glycol-b-polylactic acid-b-methylated polyethylene glycol(m PEG-PLA-m PEG)and 1,2-dioleoyl-3-trimethylammonium-propane(DOTAP),named DMAM,was designed to deliver psIL-15.Further study showed that DMAM/psIL-15 could successfully deliver psIL-15 to tumor cells and the supernatants of the tumor cells could further stimulate lymphocytes proliferation as well as activation in vitro.Local delivery of DMAM/psIL-15 in animal models demonstrated significant tumor inhibition through enhancing immune cells responses,reducing angiogenesis,promoting tumor cell apoptosis and inhibiting proliferation,with no evidence of system toxicities.These results indicate that DMAM/psIL-15 may be a promising strategy for cancer immunotherapy. | Zehua Hong Xin Zan Ting Yu Yuzhu Hu Hongfeng Gou Songping Zheng Xiang Gao Peizhi Zhou | 2023 | Chinese Chemical Letters2023，34，3： | 1 |
| 9 | Regulation of autophagic flux by CHIP显示文摘Autophagy is a major degradation system which processes substrates through the steps of autophagosome formation, autophagosome-lysosome fusion, and substrate degradation. Aberrant autophagic flux is present in many pathological conditions including neurodegeneration and tumors. CHIP/STUB1, an E3 ligase, plays an important role in neurodegeneration. In this study, we identified the regulation of autophagic flux by CHIP(carboxy-terminus of Hsc70-interacting protein). Knockdown of CHIP induced autophagosome formation through increasing the PTEN protein level and decreasing the AKT/m TOR activity as well as decreasing phosphorylation of ULK1 on Ser757. However, degradation of the autophagic substrate p62 was disturbed by knockdown of CHIP, suggesting an abnormality of autophagic flux. Furthermore, knockdown of CHIP increased the susceptibility of cells to autophagic cell death induced by bafilomycin A1. Thus, our data suggest that CHIP plays roles in the regulation of autophagic flux. | Dongkai Guo Zheng Ying Hongfeng Wang Dong Chen Feng Gao Haigang Ren Guanghui Wang | 2015 | Neuroscience Bulletin2015，31，4： | 1 |
| 10 | Gefitinib facilitates PINK1/Parkin-mediated mitophagy by enhancing mitochondrial recruitment of OPTN显示文摘Gefitinib,a well-known epidermal growth factor receptor(EGFR)tyrosine kinase inhibitor for the targeted therapy of lung cancer,induces autophagy in association with drug resistance.However,it remains unclear whether gefitinib treatment can affect the selective form of autophagy(i.e.,mitophagy)and be beneficial for the treatment of human diseases with decreased autophagy,such as neurodegenerative diseases.Here,we show that gefitinib treatment promotes PINK1/Parkin-mediated mitophagy in both nonneuronal and neuronal cells,and this effect is independent of EGFR.Moreover,we found that gefitinib treatment increases the recruitment of the autophagy receptor optineurin(OPTN)to damaged mitochondria,which is a downstream signaling event in PINK1/Parkin-mediated mitophagy.In addition,gefitinib treatment significantly alleviated neuronal damage in TBK1-deficient neurons,resulting in impeded mitophagy.In conclusion,our study suggests that gefitinib promotes PINK1/Parkin-mediated mitophagy via OPTN and may be beneficial for the treatment of neurodegenerative diseases that are associated with defective mitophagy. | Ningning Li Shan Sun Guoqiang Ma Hongyu Hou Qilian Ma Li Zhang Zengli Zhang Hongfeng Wang Zheng Ying | 2022 | Fundamental Research2022，2，5： | 0 |
| 11 | Clinical Effect of Magnetic Resonance Imaging and 64-slice Spiral CT in the Diagnosis of Ischemic Heart Disease Patients显示文摘Objective:To explore the clinical methods and clinical effects of applying magnetic resonance imaging(MRI)and 64・slice spiral computed tomography(CT)in the diagnosis of patients with ischemic heart disease.Methods:100 patients with ischemic heart disease were selected as the research objects.Selecting the patients from May 2020 to May 2021 as a sample,the patients were divided into two groups,and different diagnostic methods were used to compare the clinical diagnosis effects.Results:In terms of the diagnostic accuracy of the two groups of patients,the maximum value was 92.00%(experimental group)and the minimum value was 80.00%(control group).There was a big difference in data between the two groups,P<0.05,which was statistically significant.The patient9s(experimental group)diagnosis accuracy rate is highe Conclusion:In the process of research work for patients with ischemic heart disease,it is particularly important to diagnose the patients.The combined application of and 64-slice spiral CT can improve the clinical diagnosis efficiency and achieve significant results. | Jiamei Wang Xianling Zheng Hongfeng Zhang Junjuan Qi Shifeng Xiang | 2021 | Journal of Clinical and Nursing Research2021，5，3： | 0 |
| 12 | Research Progress on the Pharmacological Effects and Quality Analysis Methods of Bupleurum显示文摘Bupleurum has been used as traditional medicine in China,Japan,South Korea,and other Asian countries for more than 2,000 years.The crude extracts and pure compounds isolated from Bupleurum have a variety of biological activities,such as anti-inflammatory,anti-cancer,antipyretic,antibacterial,anti-viral,liver protection,neuroprotection,and immune regxilation.The pharmacological effects of Bupleurum have been classified and summarized in this paper by consulting literatures at home and abroad.At the same time,the quality analysis methods of bupleurum,including high-performance liquid chromatography,thin layer chromatography,ultra-high-performance liquid chromatography mass spectrometry,UPLC-QTOF-MS,and so on,are discussed.This paper provides a reference for further research,development,and application of Bupleurum. | Kai Zhang Xianling Zheng Hongfeng Zhang Xueqiang Zhang Yanmin Xu Shiying Jin Shuang Huo | 2022 | Journal of Clinical and Nursing Research2022，6，3： | 0 |
| 13 | Regulating Electronic Status of Platinum Nanoparticles by Metal-Organic Frameworks for Selective Catalysis显示文摘Selective hydrogenation of alkynes to alkenes remains challenging in the field of catalysis due to the ease of over-hydrogenated of alkynes to alkanes.Favorably,the incorporation of metal nanoparticles(MNPs)into metal-organic frameworks(MOFs)provides an opportunity to adjust the surface electronic properties of MNPs for selective hydrogenation of alkynes.Herein,we used differentmetal-O clusters of MOFs to regulate the electronic status of platinum nanoparticles(Pt NPs)toward overhydrogenation,semihydrogenation,and unhydrogenation of phenylacetylene.Specifically,Pt/Fe-O cluster-based MOFs are found to reduce the electronic density on Pt NPs and inhibit the overhydrogenation of styrene,leading to an 80%increase in selectivity toward a semihydrogenation product(styrene).Meanwhile,Cu-O cluster-based MOFs generate high oxidation states of Pt NPs and release Cu^(2+)ions,which worked together to deactivate Pt NPs in the hydrogenation reaction entirely.Thus,our studies illustrate the critical role of metal-O clusters in governing chemical environments within MOFs for the precise control of selective hydrogenation of alkynes,thereby,offering appealing opportunities for designing MNPs/MOFs catalysts to prompt a variety of reactions. | Yu Shen Ting Pan Peng Wu Jiawei Huang Hongfeng Li Islam EKhalil Sheng Li Bing Zheng Jiansheng Wu Qiang Wang Weina Zhang Wei David Wei Fengwei Huo | 2021 | CCS Chemistry2021，3，5： | 0 |
| 14 | Pulsar candidate selection using ensemble networks for FAST drift-scan survey显示文摘The Commensal Radio Astronomy Five-hundred-meter Aperture Spherical radio Telescope(FAST) Survey(CRAFTS) utilizes the novel drift-scan commensal survey mode of FAST and can generate billions of pulsar candidate signals. The human experts are not likely to thoroughly examine these signals, and various machine sorting methods are used to aid the classification of the FAST candidates. In this study, we propose a new ensemble classification system for pulsar candidates. This system denotes the further development of the pulsar image-based classification system(PICS), which was used in the Arecibo Telescope pulsar survey, and has been retrained and customized for the FAST drift-scan survey. In this study, we designed a residual network model comprising 15 layers to replace the convolutional neural networks(CNNs) in PICS. The results of this study demonstrate that the new model can sort >96% of real pulsars to belong the top 1% of all candidates and classify >1.6 million candidates per day using a dual-GPU and 24-core computer. This increased speed and efficiency can help to facilitate real-time or quasi-real-time processing of the pulsar-search data stream obtained from CRAFTS. In addition, we have published the labeled FAST data used in this study online, which can aid in the development of new deep learning techniques for performing pulsar searches. | HongFeng Wang WeiWei Zhu Ping Guo Di Li SiBo Feng Qian Yin ChenChen Miao ZhenZhao Tao ZhiChen Pan Pei Wang Xin Zheng XiaoDan Deng ZhiJie Liu XiaoYao Xie XuHong Yu ShanPing You Hui Zhang FAST Collaboration | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，5： | 0 |
| 15 | Shexian Bupleurum Alleviates Insomnia and Improves Symptoms of Anxiety and Depression:A Randomized Double-Blind Placebo-Controlled Clinical Trial显示文摘Objective:To observe the clinical efficacy of Shexian bupleurum on insomnia based on evaluation scales and polysomnogram(PSG).Methods:A total of 260 patients suffering from insomnia admitted to the outpatient department of Handan Central Hospital were included in a randomized,double blind,placebo-controlled trial.The patients were randomly divided into two groups:a control group(receiving placebo,n=150),and an intervention group(receiving Shexian bupleurum treatment,n=110).The clinical trial lasted for 4 weeks.The Pittsburgh Sleep Quality Index(PSQI),Insomnia Severity Index(ISI),Patient Health Questionnaire(PHQ)-9,Generalized Anxiety Disorder(GAD)-7,17 items of Hamilton Depression Scale(HAMD-17),and Hamilton Anxiety Scale(HAMA)were used to evaluate the patients at baseline as well as two weeks and four weeks after treatment;the Treatment Emergent Symptom Scale(TESS)was used to evaluate adverse reactions;polysomnography(PSG)was used to monitor and analyze their sleep characteristics at baseline and four weeks after treatment.Results:The PSQI,ISI,PHQ-9,HAMD-17,and HAMA scores of the intervention group significantly decreased compared to the control group,while the total sleep time,rapid eye movement sleep latency,stage 2 sleep,deep sleep,rapid eye movement sleep,and sleep efficiency of the intervention group significantly increased compared to the control group.The PHQ-9 score of the control group only decreased two weeks after treatment(p<0.05)compared to the intervention group.In addition,there were no obvious adverse events in both the intervention group and the control group.Conclusion:Shexian bupleurum not only improves sleep quality,but also relieves depression and anxiety in patients who suffer from insomnia. | Kai Zhang Xianling Zheng Hongfeng Zhang Xueqiang Zhang Yanmin Xu Shiying Jin Shuang Huo | 2022 | Journal of Clinical and Nursing Research2022，6，4： | 0 |
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