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| 1 | Resequencing of 145 Landmark Cultivars Reveals Asymmetric Sub-genome Selection and Strong Founder Genotype Effects on Wheat Breeding in China显示文摘Controlled pedigrees and the multi-decade timescale of national crop plant breeding programs offer a unique experimental context for examining how selection affects plant genomes.More than 3000 wheat cultivars have been registered,released,and documented since 1949 in China.In this study,a set of 145 elite cultivars selected from historical points of wheat breeding in China were re-sequenced.A total of 43.75 Tb of sequence data were generated with an average read depth of 17.94x for each cultivar,and more than 60.92 million SNPs and 2.54 million InDels were captured,based on the Chinese Spring RefSeq genome v1.0.Seventy years of breeder-driven selection led to dramatic changes in grain yield and related phenotypes,with distinct genomic regions and phenotypes tar-geted by different breeders across the decades.There are very clear instances illustrating how introduced Italian and otherforeign germplasm was integrated into Chinese wheat programs and reshaped the genomic landscape of local modern cultivars.Importantly,the resequencing data also highlighted significant asymmetric breeding selec-tion among the three sub-genomes:this was evident in both the collinear blocks for homeologous chromosomes and among sets of three homeologous genes.Accumulation of more newly assembled genes in newer cultivars implied the potential value of these genes in breeding.Conserved and extended sharing of linkage disequilibrium(LD)blocks was highlighted among pedigree-related cultivars,in which fewer haplotype differences were detected.Fixation or replacement of haplotypes from founder genotypes after generations of breeding was related to their breeding value.Based on the haplotype frequency changes in LD blocks of pedigree-related cultivars,we propose a strategy for evaluating the breeding value of any given line on the basis of the accumulation(pyramiding)of bene-ficial haplotypes.Collectively,our study demonstrates the influence of 'founder genotypes' on the output of breeding efforts over many decades and also suggests that founder genotype perspectives are in fact more dy-namic when applied in the context of modern genomics-informed breeding. | Chenyang Hao Chengzhi Jiao Jian Hou Tian Li Hongxia Liu Yuquan Wang Jun Zheng Hong Liu Zhihong Bi Fengfeng Xu Jing Zhao Lin Ma Yamei Wang Uzma Majeed Xu Liu Rudi Appels Marco Maccaferri Roberto Tuberosa Hongfeng Lu Xueyong Zhang | 2020 | Molecular Plant2020，13，12： | 9 |
| 2 | Computer-assisted technique for the design and manufacture of realistic facial prostheses显示文摘 | Zhihong Feng Yan Dong Yimin Zhao Shizhu Bai Bing Zhou Yunpeng Bi Guofeng Wu | 2009 | British Journal of Oral & Maxillofacial Surgery2009，，2： | 1 |
| 3 | In-situ conversion of Ni2P/rGO from heterogeneous self-assembled NiO/rGO precursor with boosted pseudocapacitive performance显示文摘Two-dimensional(2 D)heterostructural Ni2 P/rGO is successfully fabricated by in-situ phosphating selfassembled NiO/rGO composites and shows the enhanced electrochemical performances.In this design,the rGO sheets effectively reduce the lattice strain created during the phase transformation from NiO to Ni2 P,thereby maintaining ultrathin nanostructures of Ni2 P.The resulting Ni2 P/rGO layered heterostructure gives the composite plenty of pores or channels,good electrical conductivity and well-exposed active sites.Density functional theory(DFT)calculation further demonstrates that the Fermi energy level and electron localize of near Ni atoms in Ni2 P is higher than that of NiO,which endow Ni2 P with faster and more reversible redox reactivity in dynamic.Benefiting from their structural and compositional merits,the as-synthesized Ni2 P/rGO exhibits high specific discharge capacity and excellent rate performance.Furthermore,a hybrid supercapacitor built with Ni2 P/rGO and activated carbon shows a high specific energy of 38.6 Wh/kg at specific power of 375 W/kg. | Ge Song Zonglin Yi Lijing Xie Zhihong Bi Qian Li Jingpeng Chen Qingqiang Kong Chengmeng Chen | 2020 | Chinese Chemical Letters2020，31，6： | 0 |
| 4 | Long-term trend analysis of wave characteristics in the Bohai Sea based on interpolated ERA5 wave reanalysis from 1950 to 2020显示文摘Reasonably understanding of the long-term wave characteristics is very crucial for the ocean engineering.A feedforward neural network is operated for interpolating ERA5 wave reanalysis in this study,which embodies a detailed record from 1950 onwards.The spatiotemporal variability of wave parameters in the Bohai Sea,especially the significant wave height(SWH),is presented in terms of combined wave,wind wave and swell by employing the 71 years(1950–2020)of interpolated ERA5 reanalysis.Annual mean SWH decreases at−0.12 cm/a estimated by Theil-Sen estimator and 95th percentile SWH reflecting serve sea states decreases at−0.20 cm/a.Inter-seasonal analysis shows SWH of wind wave has steeper decreasing trend with higher slopes than that of swell,especially in summer and winter,showing the major decrease may attribute to the weakening of monsoon.The inner Bohai Sea reveals a general decreasing trend while the intersection connecting with the Yellow Sea has the lower significance derived by Mann-Kendall test.Meanwhile,95th percentile SWH decreases at a higher rate while with a lower significance in comparison with the mean state.The frequencies of mean wave directions in sub-sector are statistically calculated to find the seasonal prevailing directions.Generally,the dominant directions in summer and winter are south and north.A similar variation concerning to SWH,the trend of the mean wave period is provided,which also shows a decrease for decades. | Jichao Wang Peidong Sun Zhihong Liao Fan Bi Guiyan Liu | 2022 | Acta Oceanologica Sinica2022，41，7： | 0 |
| 5 | gcCov:Linked open data for global coronavirus studies显示文摘Impact Statement We present a method of mapping data from publicly available genomics and publication resources to the Resource Description Framework(RDF)and implement a server to publish linked open data(LOD).As one of the largest and most comprehensive semantic databases about coronaviruses,the resulted gcCov database demonstrates the capability of using data in the LOD framework to promote correlations between genotypes and phenotypes.These correlations will be helpful for future research on fundamental viral mechanisms and drug and vaccine designs. | Wenyu Shi Guomei Fan Zhihong Shen Chuan Hu Juncai Ma Yuanchun Zhou Zhen Meng Songnian Hu Yuhai Bi Liang Wang Haiying Yu Siru Lin Xiuqiang Sun Xinjiao Zhang Dongmei Liu Qinlan Sun Linhuan Wu | 2022 | mLife2022，1，1： | 0 |
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