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| 1 | Synthesis of core-shell acrylic-polyurethane hybrid latex as binder of aqueous pigment inks for digital inkjet printing | Jingfang Zhang a,Xuefeng Li a,Xinhao Shi a,Mei Hua a,Xingping Zhou b,Xiaqin Wang a,a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Donghua University,Shanghai 201620,China b College of Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620,China | 2012 | Progress in Natural Science:Materials International2012，22，1： | 31 |
| 2 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 3 | HBx-DNA probe preparation and its application in study of hepatocarcinogenesis显示文摘HBxDNAprobepreparationanditsapplicationinstudyofhepatocarcinogenesisGAOFengGuang,SUNWenSheng,CAOYingLin,ZHANGLiNing,SON... | GAO FengGuang, SUN WenSheng, CAO YingLin, ZHANG LiNing, SONG Jing, LI HuaFen and YAN ShiKunKeywords hepatitis B virus liver neoplasms/etiology carcinoma, hepatocellular/etiology DNA probe | 1998 | World Journal of Gastroenterology1998，4，4： | 12 |
| 4 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 5 | Engineering of drug nanoparticles by HGCP for pharmaceutical applications显示文摘This paper reviews our work on the fundamental principles of high gravity controlled precipitation (HGCP) technology, and its applications in the production of drug nanoparticles, which was carried out in a rotating packed bed (RPB). Several kinds of drug nanoparticles with narrow particle size distributions (PSDs) were successfully prepared via HGCP, including the 300-nm Cefuroxime Axetil (CFA) particles, 200–400-nm cephradine particles, 500-nm salbutamol sulfate (SS) particles (100 nm in width), and 850-nm beclomethasone dipropionate (BDP) particles, etc. Compared to drugs available in the current market, all the drug nanoparticles produced by HGCP exhibited advantages in both formulation and drug delivery, thus improving the bioavailability of drugs. HGCP is essentially a platform technology for the preparation of poorly water-soluble drug nanoparticles for oral and injection delivery, and of inhalable drugs for pulmonary delivery. Consequently, HGCP offers potential applications in the pharmaceutical industry due to its cost-effectiveness, efficient processing and the ease of scaling-up. | Ting-Ting Hua, Jie-Xin Wanga, Zhi-Gang Shena, Jian-Feng Chena,b, a Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China b Research Center of Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029, China | 2008 | Particuology2008，6，4： | 7 |
| 6 | The magnetic properties of Serbian loess and its environmental significance显示文摘This paper reports a loess-paleosol sequence located in the Danube River basin,Serbia,which formed at least since the latest part of the early Pleistocene,and before the paleomagnetic B/M boundary.Various magnetic parameters of the Serbian V-L1-V-S4 loess-paleosol sequence have been measured and analyzed in the Titel Loess Plateau.These parameters show a very similar magnetic behavior compared with that of the Chinese loess.There is a general positive relationship between magnetic susceptibility() and pedogenesis.The main contributors to are the magnetic grains of SP(superparamagnetic) and SD(single domain) magnetic domains,while MD(multi domain) contributes only a small percentage.The difference in between loess and paleosol mainly is caused by pedogenesis.The very fine magnetic minerals increase gradually with increasing soil development(from loess to soil),and they lead to higher.The thermomagnetic curves show thatmagnetic minerals in the loess layers are magnetite and maghemite,both providing a major contribution to.In contrast the paleosol layers mainly are composed of magnetite,with almost no or a very small amount of maghemite,as implied by a reversible thermomagnetic behavior.This indicates that pedogenic conditions during V-S3 and V-S4 strong soil development have resulted in maghemite that is no longer stable,and has been resolved or converted to other stable phase minerals.This likely indicates that soil moisture during V-S3 and V-S4 development exceeded a critical condition of maghemite stability. | LIU XiuMing LIU Zhi Lü Bin MARKOVI S B CHEN JiaSheng GUO Hui MA MingMing ZHAO GuoYong FENG Hua | 2013 | Chinese Science Bulletin2013，58，3： | 7 |
| 7 | HETEROPHYLLIN-A AND B,TWO CYCLOPEPTIDES,FROM THE ROOTS OF PSEUDOSTELLARIA HETEROPHYLLA显示文摘Two cyclopeptides,heterophyllin A and B,have been isolated from the rootsof Pseudostellaria heterophylla.Their structures were elucidated by chemical,spectroscopic,and enzymatic methods. | Ning Hua TAN Shou Xun ZHAO a Department of Phytochemistry,China Pharmaceutical University,Nanjing,210009 Jun ZHOU Hong Jie ZHANG De Zu WANG Chang Xiang CHEN Xiao Zhu LIU b Laboratory of Phytochemistry,Kunming Institute of Botany,Academia Sinica,Kunming,650204 | 1992 | Chinese Chemical Letters1992，3，8： | 4 |
| 8 | Analysis of species-dependent hydrolysis and protein binding of esmolol enantiomers显示文摘The stereoselective hydrolysis of esmolol in whole blood and in its separated components from rat,rabbit and human was investigated.Blood esterase activities were variable in different species in the order of rat>rabbit>human.Rat plasma showed the high esterase activity and had no stereoselectivity to enantiomers.Rabbit red blood cell(RBC) membrane,RBC cytosol and plasma all hydrolyzed esmolol but with different esterase activity,whereas the hydrolysis in RBC membrane and cytosol showed significant stereoselectivity towards R-(+)-esmolol.Esterase in RBC cytosol from human blood mainly contributed to the esmolol hydrolysis,which was demonstrated with no stereoselctivity.Esterase in human plasma showed a low activity,but a remarkable stereoselectivity with R-(+)-esmolol.In addition,the protein concentration affected the hydrolysis behavior of esmolol in RBC suspension.Protein binding of esmolol enantiomers in human plasma,human serum albumin(HSA) and α_1-acid glycoprotein(AGP) revealed that there was a significant difference in bound fractions between two enantiomers,especially for AGP.Our results indicated that the stereoselective protein binding might play a role in the different hydrolysis rates of esmolol enantiomers in human plasma. | Yi-Hong Tanga,b,1,Jun-Yan Wanga,1,Hai-Hong Hua,Tong-Wei Yaoa,Su Zenga,n aDepartment of Pharmaceutical Analysis and Drug Metabolism,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,Zhejiang 310058,People’s Republic of China bShanghai Institute of Technology,Shanghai 201418,People’s Republic of China | 2012 | Journal of Pharmaceutical Analysis2012，2，3： | 3 |
| 9 | A study of the copper electrode behavior in borax buffer solutions containing chloride ions and benzotriazole-type inhibitors by voltammetry and the photocurrent response method显示文摘 | ZHOU Guo-ding SHAO Hua Loo B H | 1997 | J Eleetroanal Chem1997，421，12： | 1 |
| 10 | Asymptotic performance of optimal gain-and-phase estimators of sensor arrays显示文摘 | CHENG Q HUA Y B STOICA P | 2000 | IEEE Transactions on Signal Processing2000，48，12： | 1 |
| 11 | Integrated optical dull Mach-Zehnder interferometer sensor显示文摘 | Hua P Jonathan L B Quigley G Q | 2002 | Sensors and Actuators B2002，87，2： | 1 |
| 12 | Serotypel - specific monoclonal antibody - based antigen - capture immunoassay for detection of circulating nonstructural protein NS1 : implication for early diagnosis and serotyping of Dengue virus infections显示文摘 | Hua X Di B Che XY | 2006 | J Clin Microbiol2006，44，8： | 1 |
| 13 | lntracellular trehalose improves the survival of human red blood cells by freeze-drying显示文摘 | He H Liu B L Hua Z Z et aI | 2007 | Ener- gy Power Eng2007，1，1： | 1 |
| 14 | Multiperiod integration optimization forproduction planning and utility system in refinery industries 显示文摘 | Zhang B J Hua B Lu M L | 2006 | Shiyou Xuebao Shiyou Jiagong/Acta Petrolei Sinica ( PetroleumProcessing Section)2006，22，2： | 1 |
| 15 | Allogenic mesenehymal stem cells transplantation in refractory systemic lupus ery- thematosus: a pilot clinical study 显示文摘 | Liang J Zhang H Hua B | 2010 | Ann Rheum Dis2010，69，8： | 1 |
| 16 | A DS-AHP approach for multi attribute decision making problem with incomplete information显示文摘 | Hua Z S Gong B G Xu X Y | 2008 | Expert Systems with Applications2008，34，3： | 1 |
| 17 | Construction of a modular yeast two-hybrid cDNA library from human EST clones for the human genome protein linkage map显示文摘 | HUA S B LUO Y ZHU L | 1998 | Gene1998，215，1： | 1 |
| 18 | Stress-indudble expression of GsSAMS2 enhances ,salt tolerance in transgenie Medicago sativa 显示文摘 | Hua Y Zhang B X Cai H | 2012 | African Journal of Biotechnology2012，11，17： | 1 |
| 19 | Construction of a full-length infectious bacterial artificial chromosome clone of duck enteritis virus vaccine strain显示文摘 | Chen L Yu B Hua JG | 2013 | Virology Journal2013，10，： | 1 |
| 20 | Berberine regulates AMP- activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice 显示文摘 | LI W HUA B SAUD S M | 2015 | Mol Carcinog2015，54，10： | 1 |
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