|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Risk factors related to hospital mortality in patients with isolated traumatic acute subdural haematoma: analysis of 308 patients undergone surgery显示文摘背景尖锐 subdural haematoma ( ASDH )是有相对高的死亡 rate.However 的普通创伤的大脑损害,很少研究检验了预言孤立的创伤的 ASDH.This 临床的学习的结果的因素检验了医院死亡并且在为我们收集了的孤立的创伤的 ASDH.Methods 通过手术对待的病人为死亡分析了风险因素为在1999年1月和2007年12月之间的孤立的创伤的 ASDH 经历了神经外科的 308 | TIAN Heng-li CHEN Shi-wen XU Tao HU Jin RONG Bo-ying WANG Gan GAO Wen-wei CHEN Hao | 2008 | Chinese Medical Journal2008，，12： | 10 |
| 2 | Wireless esophageal pH capsule for patients with gastroesophageal reflux disease: A multicenter clinical study显示文摘AIM:To investigate the feasibility and safety of pH capsule to monitor pH in patients with gastroesophageal reflux disease(GERD).METHODS:Ninety-one patients with symptoms suggestive of GERD were enrolled in this study,46 of whom were randomized to the pH capsule group;the remaining 45 patients used the conventional catheter and pH capsule simultaneously.The pH data and traceswere recorded via automatic analysis,and capsule detachment was assessed using X-ray images.All of the patients were required to complete a questionnaire regarding tolerance with the capsule.RESULTS:The capsules were successfully attached on the first attempt,and no early detachment of the capsules was observed.Compared to the 24-h pH data recorded with the conventional catheter,the data collected with the pH capsule showed no significant differences in 24-h esophageal acid exposure.The measurements of esophageal acid exposure over 24 h collected with the two devices showed a significant correlation(r2=0.996,P<0.001).Capsule detachment occurred spontaneously in 89 patients,and 2 capsules required endoscopic removal due to chest pain.The capsule was associated with less interference with daily activity.CONCLUSION:The wireless pH capsule provides a feasible and safe method for monitoring gastroesophageal reflux and therefore may serve as an important tool for diagnosing GERD. | Xiao-Jun Yang Tian Gan Lei Wang Zhuan Liao Xiao-Hong Tao Wei Shen Xiao-Yan Zhao | 2014 | World Journal of Gastroenterology2014，20，40： | 9 |
| 3 | Large-eddy simulation of shock-wave/turbulent boundary layer interaction with and without Spark Jet control显示文摘The efficiency and mechanism of an active control device ‘‘Spark Jet' and its application in shock-induced separation control are studied using large-eddy simulation in this paper.The base flow is the interaction of an oblique shock-wave generated by 8° wedge and a spatially-developing Ma = 2.3 turbulent boundary layer.The Reynolds number based on the incoming flow property and the boundary layer displacement thickness at the impinging point without shock-wave is20000.The detailed numerical approaches were presented.The inflow turbulence was generated using the digital filter method to avoid artificial temporal or streamwise periodicity.The numerical results including velocity profile,Reynolds stress profile,skin friction,and wall pressure were systematically validated against the available wind tunnel particle image velocimetry(PIV) measurements of the same flow condition.Further study on the control of flow separation due to the strong shock-viscous interaction using an active control actuator ‘‘Spark Jet' was conducted.The single-pulsed characteristic of the device was obtained and compared with the experiment.Both instantaneous and time-averaged flow fields have shown that the jet flow issuing from the actuator cavity enhances the flow mixing inside the boundary layer,making the boundary layer more resistant to flow separation.Skin friction coefficient distribution shows that the separation bubble length is reduced by about 35% with control exerted. | Yang Guang Yao Yufeng Fang Jian Gan Tian Li Qiushi Lu Lipeng | 2016 | Chinese Journal of Aeronautics2016，29，3： | 8 |
| 4 | Transretinoic acid inhibits rats gastric epithelial dysplasia induced by N-methyi-N-nitro-N-nitrosoguanidine:influences on cell apoptosis and expression of its regulatory genes显示文摘INTRODUCTIONGastric epithelial dysplasia (GED) hypothetically is a straight-forward concept: dysplastic epithelium replacing the normal gastric epithelium of the stomach [1].In the stomach ,like any other segment of the gut ,it is defined as an unequivocal non-invasive epithelial change[2,3].The observation of gastric dysplasia as a cancerous lesion was recognized over a century ago ,but it is only after the advent of gastroscopy that its clinical significance has been stressed[4-7]. | Ru Tao Cui~1 Gan Cai~2 Zhao Bao Yin~(2*) Yong Cheng~2 Qiu Hong Yang~1 Tao Tian~(3#) ~1Liver Center,Beijing Friendship Hospital Affiliated to CapitalUniversity of Medical Sciences~2Department of Gastroenterology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai China and Department of Pathophysiology.Shanghai Medical University.Shanghai,China ~3Pathological Department,Shanghai Medical University (?)Now working at UCLA,USA ~#Now working at University of Michigan,USADr.Ru Tao Cui graduated and got the bachelor degree from Shandong University of Traditional Chinese Medicine in 1994,got doctor degree from Shanghai University of Traditional Chinese Medicine in 2000,now studying as a postdoc,majoring gastroenterology,having 29 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 8 |
| 5 | Short- and long-term outcomes associated with enhanced recovery after surgery protocol vs conventional management in patients undergoing laparoscopic gastrectomy显示文摘BACKGROUND At present,the enhanced recovery after surgery(ERAS)protocol is widely implemented in the field of gastric surgery.However,the effect of the ERAS protocol on the long-term prognosis of gastric cancer has not been reported.AIM To compare the effects of ERAS and conventional protocols on short-term outcomes and long-term prognosis after laparoscopic gastrectomy.METHODS We retrospectively analyzed the data of 1026 consecutive patients who underwent laparoscopic gastrectomy between 2012 and 2015.The patients were divided into either an ERAS group or a conventional group.The groups were matched in a 1:1 ratio using propensity scores based on covariates that affect cancer survival.The primary outcomes were the 5-year overall and cancer-specific survival rates.The secondary outcomes were the postoperative short-term outcomes and inflammatory indexes.RESULTS The patient demographics and baseline characteristics were similar between the two groups after matching.Compared to the conventional group,the ERAS group had a significantly shorter postoperative hospital day(7.09 d vs 8.67 d,P<0.001),shorter time to first flatus,liquid intake,and ambulation(2.50 d vs 3.40 d,P<0.001;1.02 d vs 3.64 d,P<0.001;1.47 d vs 2.99 d,P<0.001,respectively),and lower medical costs($7621.75 vs$7814.16,P=0.009).There was a significantly higher rate of postoperative complications among patients in the conventional group than among those in the ERAS group(18.1 vs 12.3,P=0.030).Regarding inflammatory indexes,the C-reactive protein and procalcitonin levels on postoperative day 3/4 were significantly different between the two groups(P<0.001 and P=0.025,respectively).The ERAS protocol was associated with significantly improved 5-year overall survival and cancer-specific survival rates compared with conventional protocol(P=0.013 and 0.032,respectively).When stratified by tumour stage,only the survival of patients with stage III disease was significantly different between the two groups(P=0.044).CONCLUSION Adherence to the ERAS protocol improves both the short-term outcomes and the 5-year overall survival and cancer-specific survival of patients after laparoscopic gastrectomy. | Yu-Long Tian Shou-Gen Cao Xiao-Dong Liu Ze-Qun Li Gan Liu Xing-Qi Zhang Yu-Qi Sun Xin Zhou Dao-Sheng Wang Yan-Bing Zhou | 2020 | World Journal of Gastroenterology2020，26，37： | 8 |
| 6 | The integrative analysis of microRNA and mRNA expression in Apis mellifera following maze-based visual pattern learning显示文摘蜜蜂(Apis mellifera ) 是有强壮的感觉能力和多样的行为的全部剧目的一只社会昆虫并且为学习学习和记忆的 neurobiological 基础作为一个好模型有机体被认出。在这研究,我们在 microRNA (miRNA ) 和跟随用下一代的小 RNA 定序和介绍的 Solexa/lllumina 数字基因表示标签(DGE ) 的基于迷宫的视觉学习的送信人 RNA (mRNA ) 分析了变化。为定序的小 RNA,我们分别地从迷宫和控制组获得了 13367770 和 13132655 个干净标签。40 差别的一个总数表示了已知的 miRNAs 在这二件样品之间被检测,并且所有他们在与控制组相比的迷宫组是起来调整的。为 DGE, 5681320 和 5939855 个干净标签分别地从迷宫和控制组被检测。有 388 差别的一个总数表示了在这二件样品之间的基因,与起来调整的 45 基因和在迷宫组下面调整的 343 基因,与控制组相比。另外, 10 差别的表示层次表示了基因被量的反向的抄写聚合酶链反应(qRT-PCR ) 证实,他们中的八个的表示趋势与 DGE 结果一致,尽管变化的度在振幅是更低的。miRNA 和 mRNA 表示的综合分析显示出那,在表示的 40 差别之中已知的 miRNAs 和 388 差别表示了基因, miRNA/mRNA 的 60pairs 是在我们的现在的学习共同表示被识别。这些结果建议 miRNA 和 mRNA 可以在在蜜蜂学习和记忆的进程起一个枢轴的作用。我们的定序的数据为基于迷宫的视觉学习提供全面 miRNA 和基因表达式信息,它将便于蜜蜂学习和存储器的分子的机制的理解。 | Qiu-Hong Qin Zi-Long Wang Liu-Qing Tian Hai-Yan Gan Shao-Wu Zhang Zhi-Jiang Zeng | 2014 | Insect Science2014，21，5： | 8 |
| 7 | Effect of a transverse plasma jet on a shock wave induced by a ramp显示文摘We conducted experiments in a wind tunnel with Mach number 2 to explore the evolution of a transverse plasma jet and its modification effect on a shock wave induced by a ramp with an angle of 24°. The transverse plasma jet was created by arc discharge in a small cylindrical cavity with a 2 mm diameter orifice. Three group tests with different actuator arrangements in the spanwise or streamwise direction upstream from the ramp were respectively studied to compare their disturbances to the shock wave. As shown by a time-resolved schlieren system, an unsteady motion of the shock wave by actuation was found: the shock wave was significantly modified by the plasma jet with an upstream motion and a reduced angle. Compared to spanwise actuation, a more intensive impact was obtained with two or three streamwise actuators working together. From shock wave structures, the control effect of the plasma jet on the shock motion based on a thermal effect, a potential cause of shock modification, was discussed. Furthermore, we performed a numerical simulation by using the Improved Delayed Detached Eddy Simulation(IDDES) method to simulate the evolution of the transverse plasma jet plume produced by two streamwise actuators. The results show that flow structures are similar to those identified in schlieren images. Two streamwise vortices were recognized, which indicates that the higher jet plume is the result of the overlap of two streamwise jets. | Hongyu WANG Jun LI Di JIN Hui DAI Tian GAN Yun WU | 2017 | Chinese Journal of Aeronautics2017，30，6： | 7 |
| 8 | Timing the termination of the Doushantuo negative carbon isotope excursion: evidence from U-Pb ages from the Dengying and Liuchapo formations,South China显示文摘The Doushantuo negative carbon isotope excursion(DOUNCE) is the largest known marine inorganic carbon isotope anomaly. The origin of this pronounced negative excursion is still an enigmatic issue that attracts geologists. Time constraints on the excursion are the critical information that would provide insight into its genesis. In previous decades, the timing of its termination has been constrained by the widely cited zircon U-Pb age of 550.5 ± 0.8 Ma for the tuff at the top of the Miaohe Member at the Jiuqunao section in the Yangtze Gorges area, South China. However, results of recent studies indicate that the reliability of this time constraint needs to be re-evaluated. Here, a geochronological study was carried out using two K-bentonites from Fanglong in South China. A K-bentonite in the lower Dengying Formation yielded a U-Pb age of 557 ± 3 Ma, while a K-bentonite in the basal Liuchapo Formation yielded an age of 550 ± 3 Ma. Based on regional correlations between the Ediacaran successions in South China,the age(557 ± 3 Ma) for the K-bentonite in the lower Dengying Formation may serve as a second critical timing constraint for the ending of the DOUNCE. Combined with available estimates of the DOUNCE duration, our new data indicate that the DOUNCE has a maximum onset age ~570 Ma. | Mingzhong Zhou Taiyi Luo Warren D.Huff Zhiqing Yang Guanghong Zhou Tian Gan Hua Yang Di Zhang | 2018 | Science Bulletin2018，63，21： | 6 |
| 9 | Effects of interactions between environmental factors and KIF1B genetic variants on the risk of hepatocellular carcinoma in a Chinese cohort显示文摘AIM: To examine the effect of the potential interaction between KIF1 B variants(rs17401966 and rs3748578) and environmental factors on the risk of hepatocellular carcinoma(HCC) in a high-risk region in China.METHODS: Three hundred and six patients with HCC and 306 hospital-based control participants residing in the Shunde region of Guangdong Province, China were enrolled. Clinical characteristics were collected by reviewing the complete medical histories from the patient archives, and epidemiological data were collected using a questionnaire and clinical examination. Two single nucleotide polymorphisms(SNPs) of KIF1B(rs17401966 and rs3748578) were chosen for the current study. All subjects were genotypedusing a Taq Man real-time polymerase chain reaction. Multiplicative and additive logistic regression models were used to evaluate various gene-environment interactions.RESULTS: Smoking, frequent consumption of raw freshwater fish, hepatitis B virus(HBV) infection, and a family history of HCC were important risk factors for HCC in this population. Chronic infection with HBV was the most important environmental risk factor for HCC [odds ratio(OR) = 12.02; 95% confidence interval(95%CI): 6.02-24.00]. No significant association was found between the KIF1 B variants alone and the risk of HCC. Nevertheless, a significant additive effect modification was observed between rs17401966 and alcohol consumption(P for additive interaction = 0.0382). Compared with non-drinkers carrying either the AG or GG genotype of rs17401966, individuals classified as alcohol consumers with the AA genotype of rs17401966 had a significantly increased risk of HCC(OR = 2.36; 95%CI: 1.49-3.74).CONCLUSION: The gene-environment interaction between the KIF1 B rs17401966 variant and alcohol consumption may contribute to the development of HCC in Chinese individuals. | Jun-Hu Chen Yan-Yan Wang Wei-Biao Lv Yu Gan Wei Chang Na-Na Tian Xiao-Hui Huang Li Liu Xin-Fa Yu Si-Dong Chen | 2016 | World Journal of Gastroenterology2016，22，16： | 6 |
| 10 | A Phytophthora capsid Effector Targets ACD11 Binding Partners that Regulate ROS-Mediated Defense Response in Arabidopsis显示文摘Reactive oxygen species (ROS) play a vital role in plant immune response, but the genes involved in the regulation of ROS are scantily reported. Phytophthora pathogens produce a large number of effectors to promote infection, but the modes of action adopted are largely unknown. Here, we report that RxLR207 could activate ROS-mediated cell death in Nicotiana benthamiana and was essential for virulence of P. capsici. We found that this effector targeted BPA1 (binding partner of ACD11) and four members of BPLs (BPAl-Like proteins)in Arabidopsis, and the bpa1 and bpl mutants had enhanced ROS accumulation and cell death under biotic or abiotic stresses. Furthermore, we showed that BPA1 and several BPLs functioned redundantly in plant immunity to P. capsici. We discovered that BPA1 and all six BPLs interacted with ACD11, and stabilization of ACD11 was impaired in the bpa 1, bpl2, bpl3, and bpl4 mutants. RxLR207 could promote the degradation of BPA1, BPL1, BPL2, and BPL4 to disrupt ACD11 stabilization in a 26S proteasome-dependent manner. Taken together, these fin dings indicate the important roles of Arabidopsis BPA1 and its homologs in ROS homeostasis and defense response, highlighting the usefulness of a pathogen effector-directed approach as a promising strategy for the discovery of novel plant immune regulators. | Qi Li Gan Ai Danyu Shen Fen Zou Ji Wang Tian Bai Yanyu Chen Shutian Li Meixiang Zhang Maofeng Jing Daolong Dou | 2019 | Molecular Plant2019，12，4： | 5 |
| 11 | Metal-organic frameworks nanoswitch:Toward photo-controllable endo/lysosomal rupture and release for enhanced cancer RNA interference显示文摘Endo/lysosomal escape and gene release are two critical bottlenecks in gene delivery.Herein,a novel photo-controllable metal-organic frameworks(MOFs)nanoswitch is rationally designed for enhancing small interfering RNA(siRNA)delivery.One single laser triggers the“off-to-on”switching of MOFs nanocomplexes,inducing significant siRNA release accompanied by rapid MOFs dissociation into protonatable 2-methylimidazalo and osmotic rupturing Zn2+ions,which cooperatively contribute to remarkable endo/lysosomal rupture(∼90%).The simultaneous endo/lysosomal rupture and release enable a high spatio-temporal control on RNA interference for effective cancer therapy.Notably,the“off-to-on”switching also activates fluorescence recovery for real-time monitoring siRNA delivery.The nanoswitch could easily be extended to deliver other therapeutic agents(e.g.,DNA,protein,anticancer drug)for overcoming endo/lysosomal entrapment. | Gan Lin Yang Zhang Long Zhang Junqing Wang Ye Tian Wen Cai Shangui Tang Chengchao Chu JiaJing Zhou Peng Mi Xiaoyuan Chen Gang Liu | 2020 | Nano Research2020，13，1： | 5 |
| 12 | Genetic Variants in the ELOVL5 but not ELOVL2 Gene Associated with Polyunsaturated Fatty Acids in Han Chinese Breast Milk显示文摘现在的学习被设计检验丰满的酸 elongase (ELOVL ) 的贡献基因多型性到多元不堡和的层次在母奶的丰满的酸(PUFA ) 。209 位健康的汉中国母亲在学习被包括。在 ELOVL5 的 SNP ( rs2397142 和 rs9357760 )的次要的等位基因的搬运人与罂酸的酸( LA )的高水平被联系, dihomo --亚麻酸的酸( DGLA ), arachidonic 酸( AA ), docosatetraenoic 酸( DTA ), docosahexenoic 酸( DHA ),当在 ELOVL5 的 rs209512 次要的等位基因的搬运人与主要同质接合体等位基因相比有 DTA 的底层时( P 从 0.004-0.046 ),并且遗传上解释的可变性为 LA 为 eicosapentaenoic 酸( EPA )从3.2% 到6.0%。我们的调查结果证明在把限制率的酶编码为 PUFA 的新陈代谢的 ELOVL5 基因的普通变化在母奶贡献 PUFA。 | LI Xiang GAN Zhen Wei DING Zhen WU Yi Xia CHEN Xue Yan TIAN Hui Min LIU Guo Liang YANG Ye Tong XIE Lin | 2017 | Biomedical and Environmental Sciences2017，30，1： | 5 |
| 13 | Genetic Relationship between Natural Gas Dispersal Zone and Uranium Accumulation in the Northern Ordos Basin, China显示文摘Ordos 盆为油,天然气,煤和铀的共存是著名的。然而,几乎没有很少研究讨论在他们之间的基因关系。在这篇论文,在 Dongsheng 的 Zaohuohao 区域的案例研究,内部蒙古,中国,被进行调查在天然气和铀累积之间的基因关系。从忍受铀的沙岩样品的液包体数据显示液包体在一条煤气水的过渡带形成了。用与忍受烃的包括同时代的水的包括的同类的温度,与埋葬的历史 andpaleo 温度数据结合了,煤气水的过渡带在大约 110 妈到达了区域。根据这,铀(U) 的内容和样品的全部的器官的碳(TOC ) 被分析,并且在他们之间没有明显的关系。关于从出版物和这研究的可得到的数据, U 矿化作用与煤气水的疏开地区有空间与时间的一致,这被发现。因此,在煤气水的地区的天然气是到充满氧的忍受 U 潜水的有效 reducer,这被相信,它是到 U 累积的主要因素。这结果能被用作预言并且勘探的 U 矿的参考。 | GAN Huajun XIAO Xianming LU Yongchao JIN Yongbin TIAN Hui LIU Dehan | 2007 | Acta Geologica Sinica(English Edition)2007，81，3： | 4 |
| 14 | Dual template approach for the synthesis of hierarchically mesocellular carbon foams显示文摘我们为教主的联盟者中央的合成表明了一条简单、有效的双模板的途径由使用 sorbitan 的非离子的表面活化剂的细胞的碳泡沫是的单音的油酸盐和硅石胶体粒子是的牺牲的模板,和树脂分 / 甲醛碳来源。代表性的碳泡沫有 4 和 10 nm 的双中央毛孔尺寸,并且拥有 580 m 2/g 和 0.80 厘米 3/g 的全部的毛孔体积的特定的表面区域。 | Ming Xian Liu Li Hua Gan Ci Tian Jian Chun Zhu Zi Jie Xu Zhi Xian Hao Long Wu Chen | 2009 | Chinese Chemical Letters2009，20，1： | 3 |
| 15 | Effects of Increased Night Temperature on Cellulose Synthesis and the Activity of Sucrose Metabolism Enzymes in Cotton Fiber显示文摘Temperature is one of the key factors that influence cotton fiber synthesis at the late growth stage of cotton. In this paper, using two early-maturing cotton varieties as experimental materials, night temperature increase was stimulated in the field using far-infrared quartz tubes set in semi-mobile incubators and compared with the normal night temperatures (control) in order to investigate the effects of night temperature on the cotton fiber cellulose synthesis during secondary wall thickening. The results showed that the activity of sucrose synthase (SuSy) and sucrose phosphate synthase (SPS) quickly increased and remained constant during the development of cotton fiber, while the activity of acid invertase (AI) and alkaline invertase (NI) decreased, increased night temperatures prompted the rapid transformation of sugar, and all the available sucrose fully converted into cellulose. With night temperature increasing treatment, an increase in SuSy activity and concentration of sucrose indicate more sucrose converted into UDPG (uridin diphosphate-glucose) during the early and late stages of cotton fiber development. Furthermore, SPS activity and the increased concentration of fructose accelerated fructose degradation and reduced the inhibition of fructose to SuSy; maintaining higher value of allocation proportion of invertase and sucrose during the early development stages of cotton fiber, which was propitious to supply a greater carbon source and energy for cellulose synthesis. Therefore, the minimum temperature in the nightime was a major factor correlated with the activity of sucrose metabolism enzymes in cotton fiber. Consequently, soluble sugar transformation and cellulose accumulation were closely associated with the minimum night temperature. | TIAN Jing-shan HU Yuan-yuan GAN Xiu-xia ZHANG Ya-li HU Xiao-bing GOU Ling LUO Hong-hai ZHANG Wang-feng | 2013 | Journal of Integrative Agriculture2013，12，6： | 3 |
| 16 | Near infrared light triggered nitric oxide releasing platform based on upconversion nanoparticles for synergistic therapy of cancer stem-like cells显示文摘Near infrared(NIR) light-driven nitric oxide(NO) release nano-platform based on upconversion nanoparticles(UCNPs) and light sensitive NO precursor Roussin's black salt(RBS) was fabricated to generate NO upon 808 nm irradiation. The application of 808 nm laser as the excitation source could achieve better penetration depth and avoid overheating problem. The combination of UCNPs and RBS could realize the on-demand release of NO at desired time and location by simply controlling the output of NIR laser.Cellular uptake results showed that more nanoparticles were internalized in cancer stem-like cells(CSCs)rather than non-CSCs. Therefore, a synergistic cancer therapy strategy to eradicate both CSCs and nonCSCs simultaneously was developed. Traditional chemo-drug could inhibit non-CSCs but has low killing efficiency in CSCs. However, we found that the combination of NO and chemotherapy could efficiently inhibit CSCs in bulk cells, including inhibiting mammosphere formation ability, decreasing CD44^+/CD24^- subpopulation and reducing tumorigenic ability. The mechanism studies confirmed that NO could not only induce apoptosis but also increase drug sensitivity by declining drug efflux in CSCs. This UCNPsbased platform may provide a new combinatorial strategy of NO and chemotherapy to improve cancer treatment. | Xiao Zhang Zhao Guo Jing Liu Gan Tian Kui Chen Shicang Yu Zhanjun Gu | 2017 | Science Bulletin2017，62，14： | 3 |
| 17 | Tissue distribution and tumor uptake of folate receptor–targeted epothilone folate conjugate,BMS-753493,in CD2F1 mice after systemic administration显示文摘To assess targeting of an epothilone folate conjugate(BMS-753493) to the folate receptor(FR)-overexpressed tumor in mice bearing both FRt and FR– tumors,a series of experiments were conducted by quantitative whole-body autoradiography(QWBA) and LC–MS/MS following i.v.administration of BMS-753493 or its active moiety,BMS-748285 in mice bearing FRt(98M109) and FR–(M109) tumors.QWBA showed [3H]BMS-753493–derived radioactivity was extensively distributed to various tissues.The FR over-expressing 98M109 tumors showed consistently higher level of radioactivity than FR-negative tumors(i.e.,M109 tumors) up to 48 h post dose of [3H]BMS-753493,despite the magnitude of difference between the tumors is relatively small(generally 3 5-fold).The radioactivity level in 98M109 tumors was 2 12-fold of normal tissues except intestine/content at 48 h post dose.No selective radioactivity uptake into 98M109 tumors over M109 or normal tissues was observed after i.v.administration of the active epothilone,[3H]BMS-748285.LC–MS/MS measurements demonstrated that the concentrations of BMS-748285,presumably from hydrolysis of the folate conjugate,in 98M109 tumors were greater than those in M109 tumors after i.v.administration of BMS-753493(2–3-fold) whereas no differential uptake in the tumors following BMS-748285 administration.Those data were consistent with radioactivity determinations.Those results demonstrated that the folate conjugation in BMS-753493 enabled moderately preferential distribution of the active epothilone to FR overexpressing 98M109 tumors,thereby supporting targeted delivery of cytotoxics through the folate receptor. | Hong Shen Lifei Wang Weiqi Chen Krista Menard Yang Hong Yuan Tian Samuel J.Bonacorsi W.Griffith Humphreys Francis Y.Lee Jinping Gan | 2016 | Acta Pharmaceutica Sinica B2016，6，5： | 3 |
| 18 | Delivery of acetylthevetin B, an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells显示文摘Acetylthevetin B (ATB ) ,从 Thevetia peruviana (Pers ) 的种子的心脏的 glycoside K Schum (黄夹竹桃) ,展出不仅 antitumor 活动而且潜在的心脏的毒性。在现在的学习,我们试图提高它的 antitumor 行动和减少它经由 chitosan-Pluronic P123 (CP ) micelle 封装的不利效果。二装载 ATB 的 CP 微粒(ATB-CP1, ATB-CP2 ) 用一种乳剂 / 溶剂蒸发技术被准备。他们在有 40-50 nm 的一种粒子尺寸的形状是球形的,显示出一个中立希腊语的第六个字母潜力,并且有可接受的封装效率(>90%) 。比作免费 ATB (IC 50=2.94 mol/L ) ,装载 ATB 的 CP 微粒与更低的 IC 50 价值对人的肺癌症 A549 房间施加了强壮得多的 cytotoxicity (为 ATB-CP1 和 ATB-CP2 的 0.76 和 1.44 mol/L,分别地) 。在在老鼠的单个剂量的管理以后,分别地,在肿瘤和肺的装载 ATB 的 CP1 微粒的累积象免费 ATB 的一样高是 15.31 褶层和 9.49 褶层。为 21 d 与装载 ATB 的 CP1 微粒对待的 A549 异种皮移植肿瘤鼠标显示出最小的肿瘤卷(那中的四分之一个个在控制组织) 并且在所有治疗之中的最高的抑制率(85.6%) 组织。在 21-d 治疗以后,没有重要病理学的变化在心和另外的主要纸巾被观察。在摘要, ATB 可以用作有希望的 antitumor 为肺癌症的化学疗法的代理人,和它的 antitumor 功效被 CP 微粒显著地改进,与更低的不利效果。 | Jing-jing ZHU Xin-xin ZHANG Yun-qiu MIAO Shu-fang HE Dan-mei TIAN Xin-sheng YAO Jin-shan TANG Yong GAN | 2017 | Acta Pharmacologica Sinica2017，38，2： | 3 |
| 19 | Flow field design and process stability in electrochemical machining of diamond holes显示文摘The metal grille, commonly composed of an amount of diamond holes, has been growingly used as a key structure on stealth aircraft. Electrochemical machining(ECM) promises to be increasingly applied in aircraft manufacturing on the condition that process stability is guaranteed.In this work, a flow field model was designed to improve the process stability. This model is endowed with a variety of flow channel features, together with vibrating feeding modes. The flow field distribution on the bottom surface of the diamond hole was discussed and evaluated as well.The numerical results show that a short arc flow channel could significantly enhance the uniformity of electrolyte velocity distribution and a vibrating feeding of the cathode enables to reduce both fluctuations of the electrolyte velocity and pressure on the bottom surface of the diamond hole.Consequently, the flow field mutations were eliminated. It is verified from the experimental results that a short arc flow channel, when combined with vibrating feeding, is capable of improving machining localization and process stability markedly. What is more, the side gap on the bottom surface of the diamond hole could also be reduced by the abovementioned approach. | Zhao Jianshe Wang Feng Liu Zhuang Zhang Xiangli Gan Weimin Tian Zongjun | 2016 | Chinese Journal of Aeronautics2016，29，6： | 3 |
| 20 | Preparation of Highly Dispersed Antimony-doped Tin Oxide Nano-powder via Ion-exchange Hydrolysis of SnCl_4 and SbCl_3 and Azeotropic Drying显示文摘Antimony-doped tin hydroxide colloid precipitates have been synthesized by hydrolysis of SnCl4 and SbCl3 using: (1) an ion-exchange hydrolysis to remove chlorine ions, and (2) isoamyl acetate as an azeotropic solvent to obviate water. The obtained dried powder is of high dispersivity without any need for further grinding. The size and dispersivity of the final particles are investigated with the aid of TG-DTA, BET, XRD and TEM. After having calcined, the antimony-doped tin oxide nanopowder possesses a tetragonal rutile structure with high dispersivity, uniform particles and low hard agglomeration. | YANG Fen ZHANG Xue-jun TIAN Fang WU Xu GAN Fu-xing | 2007 | Chinese Journal of Aeronautics2007，20，2： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员