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| 1 | Exploring porous zeolitic imidazolate frame work-8(ZIF-8)as an efficient filler for high-performance poly(ethyleneoxide)-based solid polymer electrolytes显示文摘Nano Research volume 13,pages2259–2267(2020)Cite this article 277 Accesses 1 Altmetric Metrics details Abstract The incorporation of inorganic fillers into poly(ethyleneoxide)(PEO)-based solid polymer electrolytes(SPEs)is well known as a low-cost and effective method to improve their mechanical and electrochemical properties.Porous zeolitic imidazolate framework-8(ZIF-8)is firstly used as the filler for PEO-based SPEs in this work.Due to the introduction of ZIF-8,an ionic conductivity of 2.2×10^−5 S/cm(30℃)is achieved for the composite SPE,which is one order of magnitude higher than that of the pure PEO.ZIF-8 also accounts for the broader electrochemical stability window and lithium ion transference number(0.36 at 60℃)of the composite SPE.Moreover,the improved mechanism of ZIF-8 to the composite SPE is investigated by zeta potential and Fourier transform infrared spectrograph characterizations.The stability at the composite SPE/lithium interface is greatly enhanced.The LiFePO4||Li cells using the composite SPE exhibit high capacity and excellent cycling performance at 60℃,i.e.,85%capacity retention with 111 mA·h/g capacity retained after 350 cycles at 0.5 C.In comparison,the cells using the pure PEO show fast capacity decay to 74 mA·h/g maintaining only 68 capacity.These results indicate that the PEO-based SPEs with ZIF-8 are of great promise for the application in solid-state lithium metal batteries. | Zhiwen Lei Jinlai Shen Weide Zhang Qingrong Wang Jun Wang Yonghong Deng Chaoyang Wang | 2020 | Nano Research2020，13，8： | 5 |
| 2 | Nano-Medicine for Thrombosis:A Precise Diagnosis and Treatment Strategy显示文摘Thrombosis is a global health issue and one of the leading factors of death.However,its diagnosis has been limited to the late stages,and its therapeutic window is too narrow to provide reasonable and effective treatment.In addition,clinical thrombolytics suffer from a short half-life,allergic reactions,inactivation,and unwanted tissue hemorrhage.Nano-medicines have gained extensive attention in diagnosis,drug delivery,and photo/sound/magnetic-theranostics due to their convertible properties.Furthermore,diagnosis and treatment of thrombosis using nano-medicines have also been widely studied.This review summarizes the recent advances in this area,which revealed six types of nanoparticle approaches:(1)in vitro diagnostic kits using“synthetic biomarkers”;(2)in vivo imaging using nano-contrast agents;(3)targeted drug delivery systems using artificial nanoparticles;(4)microenvironment responsive drug delivery systems;(5)drug delivery systems using biological nanostructures;and(6)treatments with external irradiation.The investigations of nano-medicines are believed to be of great significance,and some of the advanced drug delivery systems show potential applications in clinical theranotics. | Min Su Qixuan Dai Chuan Chen Yun Zeng Chengchao Chu Gang Liu | 2020 | Nano-Micro Letters2020，12，8： | 1 |
| 3 | Confined growth of ZIF-8 in dendritic mesoporous organosilica nanoparticles as bioregulators for enhanced mRNA delivery in vivo显示文摘Zeolitic imidazolate framework-8(ZIF-8)and its composites have diverse applications.However,ZIF-8-based nanocomposites are mainly used as carriers in biomolecular delivery,with the functions of metal ions and ligands rarely used to modulate the biofunctions.In this work,dendritic mesoporous organosilica nanoparticles(DMONs)with tetrasulfide bond were used to confine ZIF-8 growth partially inside mesopores as a novel nanocomposite for m RNA delivery.Each component in the resultant DMONs-ZIF-8 contributed to m RNA delivery applications,including high loading benefitting from positively charged ZIF-8 and large mesopores of DMONs,endosomal escape promoted by the imidazole ring of ZIF-8,and long-term glutathione depletion mediated by both zinc ions and tetrasulfide bond.Combined together,DMONs-ZIF-8 demonstrated enhanced m RNA translation and better transfection efficiency than commercial products and toxic polymer-modified DMONs in vitro and in vivo. | Yue Wang Hao Song Chao Liu Ye Zhang Yueqi Kong Jie Tang Yannan Yang Chengzhong Yu | 2021 | National Science Review2021，8，8： | 1 |
| 4 | A step-by-step multiple stimuli-responsive metal-phenolic network prodrug nanoparticles for chemotherapy显示文摘Currently,chemotherapy is the main clinical therapy of tumors.Depressingly,most chemotherapeutic drugs such as doxorubicin and paclitaxel(PTX)have poor water solubility,leading to low bioavailability and serious side effects.Till now,although a variety of nanoparticulate drug delivery systems have been designed to ameliorate the above disadvantage of chemotherapy drugs,their application is still severely limited due to the complex preparation,poor stability,low drug loading,and premature drug release.Herein,a metal phenolic network-based drug delivery system with superior stability,satisfactory drug loading capacity,good biocompatibility,reduced undesired premature release,and excellent anti-tumor ability has been established for achieving step-by-step multiple stimuli-responsive drug delivery.Firstly,the redox-responsive dimeric paclitaxel(diPTX)prodrug was synthesized.Then diPTX@Fe&tannic acid(diPTX@Fe&TA)complex nanoparticles with satisfactory PTX loading capacity were obtained by deposition of Fe&TA network complex on the nanocore of diPTX rapidly with a simple method.The diPTX@Fe&TA nanoparticles have a hydrodynamic diameter of 152.6±1.2 nm,long-term colloidal stability,and high PTX loading content of 24.7%.Besides,diPTX@Fe&TA could expose to the acidic lysosomal environment and the reduction cytoplasmic environment continuously,resulting in the sequential release of diPTX and PTX when it was phagocytosed by tumor cells.Meanwhile,PTX showed almost no release under physiological condition(pH 7.4),which effectively inhibited the undesirable premature release of PTX.More importantly,diPTX@Fe&TA could suppress the growth of tumor effectively in vivo,along with negligible toxicity for organs.This work developed a simple and novel approach for the construction of a stepwise multiple stimuli-responsive drug delivery system with superior stability and satisfactory drug loading capacity to inhibit tumor growth effectively. | Xiaoqing Yi Weijia Zeng Cui Wang Ying Chen Liangyuan Zheng Xinlin Zhu Yuqiu Ke Xiaoyan He Ying Kuang Qitong Huang | 2022 | Nano Research2022，15，2： | 1 |
| 5 | 生物合成的磁性纳米笼:实现安全有效的磁-催化联合癌症治疗显示文摘Magnetic nanoparticles(MNPs)based hyperthermia therapy offers a promising cancer treatment owing to its high controllability and safety nature[1].However,several fundamental challenges remain regarding the clinical translation of existing MNPs[2]. | 林凎 张阳 刘刚 | 2021 | Science Bulletin2021，66，7： | 0 |
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