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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Recurrence of primary breast lymphoma in contralateral breast:case report and review of the literature显示文摘 | Earnest R E Downey D M Fox J P | | 0，，05： | 1 |
| 3 | Effects of low frequeney ultrasound on Properties of restructured beef rolls显示文摘 | Vimini R J Kem P J D Fox J D | 1983 | Journal of Food Seience1983，48，5： | 1 |
| 4 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 5 | Evaluation of realtime PCR for diagnosis of Bordetella pertussis infection显示文摘 | KNORR L FOX J D TILLEY P A | 2006 | BMC Infect Dis2006，，6： | 1 |
| 6 | The effect of N fertilizer source on grain yield, N uptake, soil pH and lime requirement in No-Till Corn 显示文摘 | Fox P H Hoffman L D | 1981 | Agronomy Journal1981，73，5： | 1 |
| 7 | Trends in Biotechnology,显示文摘 | Fox D B Moody T S | 2001 | 19:292001，19，： | 1 |
| 8 | Effect of tea,coffee and cocoa extracts on the colloidal stability of milk and concentrated milk显示文摘 | O' Connell J E Fox P D Tan-Kintia R | 1998 | Int Dairy J1998，，8： | 1 |
| 9 | Damage mechanisms of coated systems under thermomechanical fatigue显示文摘 | Zhang Y H Withers P J Fox M D | 1999 | Materials Science and Technology1999，15，： | 1 |
| 10 | Trim5 a accelerates degradation of cytosolic capsid associated with productive HIV-1 Entry 显示文摘 | Chatterji U Bobardt M Gaskill P Sheeter D Fox H Gallay R 2006 | 2006 | J Biol Chem2006，281，37： | 1 |
| 11 | Prediction of ruminal volatile fatty acids and pH within thd net carbohydrate and protein system显示文摘 | Pitt R E Van Kessel J S Fox D G Pell A N Barry M C Van Soest P J | 1996 | Journal of Animal Science1996，74，： | 1 |
| 12 | Correlation of CT findings with clinical evalua- tions in 261 patients with symptomatic bronehieetasis显示文摘 | Lynch DA Newell J Hale V Dver D Corkerv K Fox NL Ger-end P Fick R | 1999 | AJR Am J Roentyenol1999，173，1： | 1 |
| 13 | Poly(A) addition during maturation of frog oocytes:distinct nuclear and cytoplasmic activities and regulation by the sequence UUUUUAU 显示文摘 | Fox C A Sheets M D Wickner M P | 1989 | Genes Dev1989，3，： | 1 |
| 14 | Tunable-focus Liquid Lens Controlled Using Aservo Motor显示文摘 | Ren H Fox D Anderson P A | 2006 | OPTICS EXPRESS2006，14，18： | 1 |
| 15 | Build- ing an integrative model of extra role work behav- iors:A comparison of counterproductive work behav- ior with organizational citizenship behavior 显示文摘 | Miles D E Borman W E Spector P E Fox S | 2002 | In- ternational Journal of Selection and Assessment2002，10，2： | 1 |
| 16 | The afterglow of GRB 050709 and the nature of the short-hard γ-ray bursts显示文摘 | FOX D B FRAIL D A PRICE P A | 2005 | Nature2005，437，： | 1 |
| 17 | Work-related stressand intention to quit in newly graduated nurses 显示文摘 | Wu T Y Fox D P Stokes C | 2012 | Nurse Educ Today2012，32，6： | 1 |
| 18 | The use of ~(188)Re to treat instent re-stenosis of coronary arteries显示文摘 | Fox RA Barker P Guy D | 2001 | Australas Phys Eng Sci Med2001，24，3： | 1 |
| 19 | Efficacy of transcranial magnetic stimulation targets for depression is related to intrinsic functional connectivity with the subgenual cingulate显示文摘 | Fox M D Buckner R L White M P | 2012 | Biological psychiatry2012，72，7： | 1 |
| 20 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
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