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| 1 | Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。 | Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng | 2009 | Cell Research2009，19，3： | 9 |
| 2 | MoS2/metal composite coating deposited by closed-field unbalanced magnetron sputtering: Tribological properties and industrial uses显示文摘 | Fox V Hampshire J Teer D | 1999 | Surf Coat Technol1999，112，13： | 2 |
| 3 | Development of a PCR ELISA assay for the identification of Campylobacter jejuni and Campylobacter coli 显示文摘 | SAILS A D FOX A J BOLTON F J | 2001 | Mol Cell Probe2001，15，： | 1 |
| 4 | Fractal feature analysis and classification in medical imaging显示文摘 | CHEN Chi-chang Daponte J S Fox M D | 1989 | IEEE Transactions on Medical Imaging1989，8，2： | 1 |
| 5 | Mitochondria genome a rearrangement leads to extension and relocation of the cytochrome C oxidase Subunit I gene in sorghum显示文摘 | Bailey Serres J Hanson D K Fox T D | 1986 | Cell1986，47，： | 1 |
| 6 | The timing of skin acidification in very low birth weight infants显示文摘 | Fox C Nelson D Wareham J | 1998 | J Perinatol1998，18，4： | 1 |
| 7 | Recurrence of primary breast lymphoma in contralateral breast:case report and review of the literature显示文摘 | Earnest R E Downey D M Fox J P | | 0，，05： | 1 |
| 8 | Effects of low frequeney ultrasound on Properties of restructured beef rolls显示文摘 | Vimini R J Kem P J D Fox J D | 1983 | Journal of Food Seience1983，48，5： | 1 |
| 9 | Determination of the in situ forces in the human posterior cruciate ligament using robotic technology 显示文摘 | Fox R J Harner C D Sakane M | 1998 | American Journal of Sports and Medicine1998，26，： | 1 |
| 10 | Calcineurin regulation in fungi and beyond 显示文摘 | Site J Fox D | 2008 | Eukaryotic Cell2008，7，2： | 1 |
| 11 | Ferro-electrically induced ferromagnetism 显示文摘 | Fox D L Scott J F | 1977 | Journal of Physics C-Solid State Physics1977，，10： | 1 |
| 12 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 13 | Viral infection in adults hospitalized with community-acquired pneumonia: prevalence, pathogens, and presentation显示文摘 | Johnstone J Majumdar S R Fox J D | 2008 | Chest2008，134，6： | 1 |
| 14 | MoS2/metal composite coating deposited by closed-field unbalanced magnetron sputtering:tribological properties and industrial uses 显示文摘 | Fox V Hampshire J Teer D | 1999 | Surf Coat Technol1999，112，13： | 1 |
| 15 | Use of detachable balloons for proximal artery occlusion in the treatment of unclippable cerebral aneurysms显示文摘 | Fox A J Vinuela F Pelz D M | 1987 | J Neurosurg1987，66，1： | 1 |
| 16 | Evaluation of realtime PCR for diagnosis of Bordetella pertussis infection显示文摘 | KNORR L FOX J D TILLEY P A | 2006 | BMC Infect Dis2006，，6： | 1 |
| 17 | Activity and safety of crizotinib in patients with ALK -positive non-small-cell lung cancer: updated results from a phase 1 study显示文摘 | D Ross Camidge Yung-Jue Bang Eunice L Kwak A John Iafrate Marileila Varella-Garcia Stephen B Fox Gregory J Riely Benjamin Solomon Sai-Hong I Ou Dong-Wan Kim Ravi Salgia Panagiotis Fidias Jeffrey A Engelman Leena Gandhi Pasi A J?nne Daniel B Costa Geoffrey | 2012 | Lancet Oncology2012，，10： | 1 |
| 18 | Learning and inferring transportation routines显示文摘 | Liao L Patterson D J Fox D | 2007 | Artificial Intelligence2007，171，5： | 1 |
| 19 | Leaf litter decomposition of canopy trees,bamboo and moss in a montane moist evergreen broad-leaved forest on Ailao Mountain,Yunnan,south-west China显示文摘 | Liu Wenyao Fox J E D Xu Zaifu | 2000 | Ecological Research2000，15，4： | 1 |
| 20 | Effect of tea,coffee and cocoa extracts on the colloidal stability of milk and concentrated milk显示文摘 | O' Connell J E Fox P D Tan-Kintia R | 1998 | Int Dairy J1998，，8： | 1 |
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