|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | An investigation in-to the structure and bioavailability of alpha-tocopherol dispersionsin Gelucire 44/14 显示文摘 | Barker S A Yap S P Yuen K H | 2003 | J Controlled Release2003，91，3： | 1 |
| 3 | Surgical manage- ment of metastatic disease of the proximal part of the femur显示文摘 | ISSACK P S BARKER J BAKER M | 2014 | J Bone Joint Surg Am2014，96，24： | 1 |
| 4 | An investigation into the structure and bioavailability of alpha-tocopherol dispersions in Gelucire 44/14显示文摘 | Barker S A Yap S P Yuen K H | 2003 | J Control Release2003，491，3： | 1 |
| 5 | Diffusion magnetic resonance imaging:Its principle and applieations显示文摘 | Mori S Barker P B | 1999 | The Anatomical Record1999，257，3： | 1 |
| 6 | Plasminogen fragmentation and increased production of extracellular matrix degrading proteinase are associated with serous epithelial ovarian progression 显示文摘 | Murthi P Barker G Nowell C J | 2004 | Gynecol Oncol2004，92，1： | 1 |
| 7 | Denitrification behavior in biologics phosphorus removal activated sludge systems显示文摘 | Barker P S Dold P L | 1996 | Water Research1996，30，4： | 1 |
| 8 | Microvascular decompression for hemifacial spasm 显示文摘 | Barker FG 2nd Jannetta P J Bissonette DJ | 1995 | J Neurosurg1995，82，2： | 1 |
| 9 | The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro 显示文摘 | Fick J Barker FG 2nd Dazin P | 1995 | Proc Natl Acad Sci USA1995，92，11： | 1 |
| 10 | The weibull distribution function and wind power statistics显示文摘 | Bowden G J Barker P R Shestopal V O | 1983 | Wind Engineering1983，7，： | 1 |
| 11 | Identification in the self-managing organization: Characteristics of target and tenure显示文摘 | Barker J R Tompkins P K | 1994 | Human Communication Research1994，21，： | 1 |
| 12 | The carbon isotope geochemistry of a small groundwater system in northeastern Ontario显示文摘 | FRITZ P REARDON E J BARKER J | 1987 | Water Resources Research1987，14，6： | 1 |
| 13 | Hybrid-ion a lithium-ion cell based on a sodium insertion material显示文摘 | Barker J Gover R K B Burns P | 2006 | Electrochemical and Solid-State Letters2006，9，4： | 1 |
| 14 | The long-term outcome of microvascular decompression for trigeminal neuralgia 显示文摘 | Barker F Jannetta P Bissonnette D | 1996 | N Engl J Med1996，334，： | 1 |
| 15 | Liberation of staling aldehydes during storage of beer 显示文摘 | Barker R L Gracey D E F Irwin A J Pipasts P Leiska E | 1983 | J Inst Brew1983，89，： | 1 |
| 16 | Magnetic resonance imaging of anal fistulae显示文摘 | LUNNISS PJ ARMSTRONG P BARKER PG | 1992 | Lancet1992，340，8816： | 1 |
| 17 | Changing incidence and survival for heart failure in a well-de-fined older population,1970-1974and 1990-1994显示文摘 | BARKER W H MULLOOLY J P GETCHELL W | 2006 | Circula-tion2006，113，6： | 1 |
| 18 | The Weibull distribution function and wind power statistics显示文摘 | Bowden G J Barker P R Shestopal V O | 1983 | Wind Engineering1983，，7： | 1 |
| 19 | IrLAP protocol performance analysis of IrDA wireless communications显示文摘 | Barker P | 1998 | Electronics Letters1998，34，25： | 1 |
| 20 | Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4显示文摘 | Korinek V Barker N Moerer P | 1998 | Nat Genet1998，19，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员