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| 1 | Early Serum HBsAg Kinetics as Predictor of HBsAg Loss in Patients with HBeAg-Negative Chronic Hepatitis B after Treatment with Pegylated Interferonα-2a显示文摘Hepatitis B surface antigen(HBsAg)loss is an ideal treatment endpoint for patients with chronic hepatitis B(CHB).We investigated the predictive value of on-treatment HBsAg levels for HBsAg loss in hepatitis B e antigen(HBe Ag)-negative CHB patients who received 120-week PEG-IFNα-2a treatment.Serum HBV DNA,HBsAg,and anti-HBs levels were assayed at baseline and every 3 months during the treatment.Of 81 patients,12 achieved HBsAg loss,20 achieved HBsAg\100 IU/mL,and 49 maintained HBs Ag C 100 IU/mL.HBsAg loss rate was only 3.7%at 48 weeks,while it reached to 11.1%and 14.8%after treatment of 96 weeks and 120 weeks.The cutoff HBs Ag levels at 12 weeks predicting HBsAg loss at 96 weeks and 120 weeks of treatment were 400 IU/mL and 750 IU/mL,with AUC 0.725 and 0.722,positive predictive value(PPV)29.41%and 30.56%,and negative predictive value(NPV)93.75%and 97.78%,respectively.The cutoff HBsAg levels at 24 weeks predicting HBsAg loss at 96 weeks and 120 weeks of treatment were 174 IU/m L and 236 IU/mL respectively,with AUC 0.925 and 0.922,PPV 40.0%and 46.15%,and both NPV 100%.The predictive ability of the cutoff HBsAg levels at 24 weeks was better than that at 12 weeks for HBs Ag loss at either 96 or 120 weeks(χ~2=3.880,P=0.049 andχ~2=4.412,P=0.036).These results indicate that extended therapy is critical to HBsAg loss in HBe Ag-negative CHB patients during PEG-IFN treatment,and the HBsAg level at 24 weeks can be used to predict HBsAg loss during tailoring PEG-IFN therapy. | Minghui Li Lu Zhang Yao Lu Qiqi Chen Huihui Lu Fangfang Sun Zhan Zeng Gang Wan Linqing Zhao Yao Xie | 2021 | Virologica Sinica2021，36，2： | 15 |
| 2 | Effect of diosmetin on airway remodeling in a murine model of chronic asthma显示文摘支气管的气喘,最普通的过敏疾病之一,被航线 hyperresponsiveness (AHR ) 描绘,发炎,并且改变。抗氧化剂黄酮 aglycone diosmetin 改善在胰腺炎的发炎,而是很少在气喘上对它的影响被知道。在这研究,长期的气喘上的 diosmetin 的效果在航线在与 ovalbumin (卵) 质问的 BALB/c 老鼠改变的调整上与一个重音被调查。diosmetin 显著地在气喘的老鼠的肺减轻了煽动性的细胞渗入,离脚玻璃杯或瓷杯细胞增生,和骨胶原免职并且显著地在这些动物减少了 AHR,这被发现。全部的房间的导致卵的增加和在 bronchoalveolar lavage 液体的嗜曙红血球计数被颠倒,并且在浆液的卵特定的免疫球蛋白 E 的水平被 diosmetin 管理稀释,暗示 diosmetin 的一项 anti-Th2 活动。而且, diosmetin 显著地压制了光滑的肌肉肌动朊 alpha 链的表示,显示航线上的 diosmetin 的有势力 anti-proliferative 效果光滑的肌肉房间(ASMC ) 。矩阵 metallopeptidase-9,转变生长 factor-1,和脉管的 endothelial 生长因素层次是也由 diosmetin 减轻了,建议航线改变的宽恕可能被归因于这些蛋白质的衰落。一起拿,我们的调查结果向 diosmetin 的新奇侧面提供了改变反的治疗学的好处,在在长期的气喘汇寄 ASMC 增长加亮 diosmetin 的一个新潜力。 | Ai Ge Yanan Liu Xiaoning Zeng Hui Kong Yuan Ma Jiaxiang Zhang Fangfang Bai Mao Huang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 7 |
| 3 | Trace Element Compositions of Pyrite from the Shuangwang Gold Breccias,Western Qinling Orogen,China:Implications for Deep Ore Prediction显示文摘The Shuangwang gold deposit, located in the Fengxian-Taibai fore-arc basin in the western Qinling Orogen of Central China, has yielded over 70 tons of gold. It is an orogenic gold deposit occurring in an NW-trending breccia belt. Most of the ores are hydrothermal breccia type containing fragments of adjacent strata cemented by ankerite and pyrite. Pyrite is the most abundant metallic mineral and the major gold-bearing mineral in the ores. A total of 58 pyrite samples from main ore bodies of the Shuangwang gold deposit have been analysed for 44 trace elements by HR-ICP-MS. Sb, Ba, Cu, Pb, Zn, Bi, Mo, Co are selected as indicator elements to investigate the potential usefulness of trace elements in pyrite as an indicator in gold exploration. The results show that the supra-ore halo elements Sb and Ba, which may have been more active than other near-ore halo elements and sub-ore halo elements, are best to characterize the shape of ore bodies. Five target areas are pointed out for deep ore exploration based on a comprehensive study of supra-ore, near-ore and sub-ore halos. This study provides evidence that trace elements in pyrite can be used to depict the deep extension of ore bodies and to vector towards undiscovered ore bodies. | Jianping Wang Zhenjiang Liu Jiajun Liu Xiangtao Zeng Kexin Wang Bizheng Liu Huan Wang Chonghao Liu Fangfang Zhang | 2018 | Journal of Earth Science2018，29，3： | 3 |
| 4 | NSC-640358 acts as RXRa ligand to promote TNFa-mediated apoptosis of cancer cell显示文摘 | Fan Chen Jiebo Chen Jiacheng Lin Anton V. Cheltsov Lin Xu Ya Chen Zhiping Zeng Liqun Chen Mingfeng Huang Mengjie Hu Xiaohong Ye YuqiZhou Guanghui Wang Ying su Long Zhang Fangfang Zhou Xiao-kun Zhang HU Zhou | 2015 | Protein & Cell2015，6，9： | 2 |
| 5 | Rhodamine 6G-based Chemosensor for the Visual Detection of Cu2+ and Fluorescent Detection of Hg2+ in Water显示文摘 | HE Song LIU Qiuchen LI Yuanyuan WEI Fangfang CAI Songtao LU Yan ZENG Xianshun | 2014 | Chemical Research in Chinese Universities2014，30，1： | 1 |
| 6 | Trends of Mortality in End-Stage Liver Disease—China,2008–2020显示文摘Introduction:Liver cancer and cirrhosis represent the most prevalent forms of end-stage liver diseases(ESLDs).Notably,in China,deaths attributed to ESLDs contribute significantly to the global mortality rate of these disorders.Enhanced comprehension of the mortality profile associated with ESLDs in China could provide crucial insights into intervention prioritization,which could in turn help reduce the overall global burden of these diseases.Methods:Data were obtained from China’s Disease Surveillance Points system.The presentation includes both crude and age-standardized mortality rates,stratified by sex,residential location,and region.Using Joinpoint Regression,trends in annual mortality rates were estimated from the period of 2008 to 2020 and expressed as the average annual percentage change(AAPC).Results:In 2020,the gross mortality rate of ESLD stood at 30.08 cases per 100,000 individuals.A higher age-standardized ESLD mortality rate was observed in males and rural populations in comparison to their female and urban counterparts,respectively.Noticeably,the highest mortality rates associated with liver cancer and cirrhosis were reported in South and Southwest China,respectively.A positive correlation was noticed between age-specific ESLD mortality rates and advancing age.Interestingly,an annual decrease in the ESLD mortality rate was observed from 2008 to 2020.In urban contexts,the AAPC of cirrhosis was noted to be higher than that of liver cancer.Conclusions:The mortality rate associated with ESLDs in China decreased between 2008 and 2020.Nevertheless,the death burden attributable to ESLD continues to be alarmingly high.Future initiatives should prioritize the reduction of ESLD mortality in particular populations:males,elderly individuals,and those residing in rural regions of South and Southwest China.The emphasis of future interventions should beplaced on antiviral therapy for adults diagnosed with viral hepatitis,and on the prevention of hepatitis B virus(HBV)infection across all demographics. | Xiaoxiao Wang Huixin Liu Jinlei Qi Fangfang Zeng Lijun Wang Peng Yin Feng Liu Hongbo Li Yunning Liu Jiangmei Liu Lai Wei Xiaofeng Liang Yu Wang Huiying Rao Maigeng Zhou | 2023 | China CDC weekly2023，5，30： | 1 |
| 7 | Image encryption based on a reality-preserving fractional discrete cosine transform and a chaos-based generating sequence显示文摘 | Jianhua Wu Fangfang Guo Pingping Zeng Nanrun Zhou | 2013 | Journal of Modern Optics2013，，20： | 1 |
| 8 | Comprehensive investigation of HBV-related hepatocellular carcinoma and choice of anti-HBV therapy显示文摘Chronic hepatitis B virus(HBV)infection is a global public health problem,which can cause chronic hepatitis,liver cirrhosis,hepatocellular carcinoma(HCC),and other diseases.Antiviral therapy is the most critical measure to slow down the progression of chronic hepatitis B,prevent or delay cirrhosis,HCC,and other kinds of liver decompensation events.At present,the anti-hepatitis B virus drugs are mainly nucleoside(acid)analogues(NAs)and interferon.Each kind of antiviral drug has different effects on the clinical outcome of hepatitis B patients(such as HCC).In this paper,we discussed the biological characteristics,natural course and prognosis of HBV infection,the mechanism of HBV-related HCC,the effect of different antiviral drugs on patients’outcome,predictive biomarkers and model for HBV clinical outcome,predictors of sustained response and recurrence after withdrawal of antiviral therapy,consideration of expanding therapeutic indications and antiviral therapy,hoping to give a hand to the clinical diagnosis and treatment of HBV. | Huihui Lu Wei Yi Fangfang Sun Zhan Zeng Lu Zhang Minghui Li Yao Xie | 2021 | Biosafety and Health2021，3，4： | 1 |
| 9 | Porcine skeletal muscle differentially expressed gene ATP5B : molecular characterization, expression patterns, and association analysis with meat quality traits显示文摘 | Haixia Xu Yongjie Xu Xiaojuan Liang Yanbo Wang Fangfang Jin Dengying Liu Yun Ma Hongyu Yuan Xinqiang Song Wenxian Zeng | 2013 | Mammalian Genome2013，，3： | 1 |
| 10 | An Old Story Retold: Loss of G1 Control Defines A Distinct Genomic Subtype of Esophageal Squamous Cell Carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC) has a high mortality rate. To determine the molecular basis of ESCC development, this study sought to identify characteristic genome-wide alterations in ESCC, including exonic mutations and structural alterations. The clinical implications of these genetic alterations were also analyzed. Exome sequencing and verification were performed for nine pairs of ESCC and the matched blood samples, followed by validation with additional samples using Sanger sequencing. Whole-genome SNP arrays were employed to detect copy number alteration(CNA) and loss of heterozygosity(LOH) in 55 cases, including the nine ESCC samples subjected to exome sequencing. A total of 108 non-synonymous somatic mutations(NSSMs) in102 genes were verified in nine patients. The chromatin modification process was found to be enriched in our gene ontology(GO) analysis. Tumor genomes with TP53 mutations were significantly more unstable than those without TP53 mutations. In terms of the landscape of genomic alterations, deletion of 9p21.3 covering CDKN2A/2B(30.9%), amplification of 11q13.3 covering CCND1(30.9%), and TP53 point mutation(50.9%) occurred in two-thirds of the cases. These results suggest that the deregulation of the G1 phase during the cell cycle is a key event in ESCC.Furthermore, six minimal common regions were found to be significantly altered in ESCC samples and three of them, 9p21.3, 7p11.2, and 3p12.1, were associated with lymph node metastasis. With the high correlation of TP53 mutation and genomic instability in ESCC, the amplification of CCND1, the deletion of CDKN2A/2B, and the somatic mutation of TP53 appear to play pivotal roles via G1 deregulation and therefore helps to classify this cancer into different genomic subtypes.These findings provide clinical significance that could be useful in future molecular diagnoses and therapeutic targeting. | Qiyan Wang Jian Bai Amir Abliz Ying Liu Kenan Gong Jingjing Li Wenjie Shi Yaqi Pan Fangfang Liu Shujuan Lai Haijun Yang Changdong Lu Lixin Zhang Wei Chen Ruiping Xu Hong Cai Yang Ke Changqing Zeng | 2015 | Genomics, Proteomics & Bioinformatics2015，13，4： | 1 |
| 11 | The way of SARS-CoV-2 vaccine development:success and challenges显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the causative agent of coronavirus disease 2019(COVID-19).To halt the pandemic,multiple SARS-CoV-2 vaccines have been developed and several have been allowed for emergency use and rollout worldwide.With novel SARS-CoV-2 variants emerging and circulating widely,whether the original vaccines that were designed based on the wild-type SARS-CoV-2 were effective against these variants has been a contentious discussion.Moreover,some studies revealed the long-term changes of immune responses post SARS-CoV-2 infection or vaccination and the factors that might impact the vaccine-induced immunity.Thus,in this review,we have summarized the influence of mutational hotspots on the vaccine efficacy and characteristics of variants of interest and concern.We have also discussed the reasons that might result in discrepancies in the efficacy of different vaccines estimated in different trials.Furthermore,we provided an overview of the duration of immune responses after natural infection or vaccination and shed light on the factors that may affect the immunity induced by the vaccines,such as special disease conditions,sex,and pre-existing immunity,with the aim of aiding in combating COVID-19 and distributing SARS-CoV-2 vaccines under the prevalence of diverse SARS-CoV-2 variants. | Yetian Dong Tong Dai Bin Wang Lei Zhang Ling-hui Zeng Jun Huang Haiyan Yan Long Zhang Fangfang Zhou | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 12 | Long-Term Trend Analysis of Major Human Helminth Infections — Guangdong Province, China, 1988–2021显示文摘Introduction:Although helminth infections threaten millions of people worldwide,the spatiotemporal characteristics remain unclear across China.This study systematically describes the spatiotemporal changes of major human helminth infections and their epidemiological characteristics from 1988 to 2021 in Guangdong Province,China.Methods:The survey data in Guangdong Province were primarily obtained from 3 national surveys implemented during 1988–1992,2001–2004,and 2014–2016,respectively,and from the China Information System for Disease Control and Prevention during 2019–2021.A modified Kato-Katz technique was used to detect parasite eggs in collected fecal samples.Results:The overall standardized infection rates(SIRs)of any soil-transmitted helminths(STH)and Clonorchis sinensis decreased from 65.27%during 1988–1992 to 4.23%during 2019–2021.In particular,the SIRs of STH had even more of a decrease,from 64.41%during 1988–1992 to 0.31%during 2019–2021.The SIRs of Clonorchis sinensis in the 4 surveys were 2.40%,12.17%,5.20%,and 3.93%,respectively.This study observed different permutations of gender,age,occupation,and education level on the SIRs of helminths.Conclusions:The infection rate of STH has substantially decreased.However,the infection rate of Clonorchis sinensis has had fewer changes,and it has become the dominant helminth. | Yueyi Fang Jiong Wang Guanhao He Qiming Zhang Jianpeng Xiao Jianxiong Hu Zuhua Rong Lihua Yin Fangfang Zeng Pan Yang Xiaomei Dong Dan Liu Xiaofeng Liang Zhuohui Deng Tao Liu Wenjun Ma | 2022 | China CDC weekly2022，4，41： | 1 |
| 13 | The Sizes of Sitophilus zeamais in Different Life Stage显示文摘Knowing the developmental states of stored grain insects, especially for the immature stages hidden in cereal kernel, such as Sitophilus zeamais, could be in favor of monitoring early and controlling effectively. Atlas and scale parameters on different developmental stages of S. zeamais in wheat kernel were captured and described by three-dimensional microscope of super depth of field observation. The four instars of larva, pre-pupa, pupa, new adult, old adult in kernel could be seen by dissecting the infested kernels. The length, height, and width of larva body increased with insect development and centralized the sizes corresponding to the four instars of larva. The length of larva body centralized near 554, 746, 1 462, and 2 147 μm. The height of larva body centralized about 388, 575, 847, and 1 651 μm. The width of larva body centralized near 340, 598, 798, and 1 568 μm. Head capsule width was in same size for each exuviating period, centralized near 203, 317, 535, and 603 μm, and got big sharply with the instar changed. Developmental duration of four larva instars was about 21 days reared in wheat, less than 28 days reared in maize as published. The atlas and description should be helpful for monitoring the S. zeamais development hidden in cereal kernels and designing control strategy. | JI Le WANG Dianxuan ZHAO Chao ZHANG Ruijie ZENG Fangfang | 2018 | Grain & Oil Science and Technology2018，1，4： | 0 |
| 14 | When and How to Adjust Non-Pharmacological Interventions Concurrent with Booster Vaccinations Against COVID-19—Guangdong,China,2022显示文摘Introduction:With the large-scale roll-out of the coronavirus disease 2019(COVID-19)booster vaccination effort(a vaccine dose given 6 months after completing primary vaccination)in China,we explore when and how China could lift non-pharmacological interventions(NPIs)against COVID-19 in 2022.Methods:Using a modified susceptible-infectiousrecovered(SIR)mathematical model,we projected the COVID-19 epidemic situation and required medical resources in Guangdong Province,China.Results:If the number of people entering from overseas recovers to 20%of the number in 2019,the epidemic in 2022 could be controlled at a low level by a containment(215 local cases)or suppression strategy(1,397 local cases).A mitigation strategy would lead to 21,722 local cases.A coexistence strategy would lead to a large epidemic with 6,850,083 local cases that would overwhelm Guangdong’s medical system.With 50%or 100%recovery of the 2019 level of travelers from overseas,the epidemic could also be controlled with containment or suppression,but enormous resources,including more hotel rooms for border quarantine,will be required.However,coexistence would lead to an uncontrollable epidemic with 12,922,032 local cases.Discussion:With booster vaccinations,the number of travelers from overseas could increase slightly in 2022,but a suppression strategy would need to be maintained to ensure a controllable epidemic. | Guanhao He Fangfang Zeng Jianpeng Xiao Jianguo Zhao Tao Liu Jianxiong Hu Sicong Zhang Ziqiang Lin Huaiping Zhu Dan Liu Min Kang Haojie Zhong Yan Li Limei Sun Yuwei Yang Zhixing Li Zuhua Rong Weilin Zeng Xing Li Zhihua Zhu Xiaofeng Liang Wenjun Ma | 2022 | China CDC weekly2022，4，10： | 0 |
| 15 | PINK1-mediated Drp1^(S616) phosphorylation modulates synaptic development and plasticity via promoting mitochondrial fission显示文摘Dynamic change of mitochondrial morphology and distribution along neuronal branches are essential for neural circuitry formation and synaptic efficacy.However,the underlying mechanism remains elusive.We show here that Pink1 knockout(KO)mice display defective dendritic spine maturation,reduced axonal synaptic vesicles,abnormal synaptic connection,and attenuated long-term synaptic potentiation(LTP).Drp1 activation via ^(S616) phosphorylation rescues deficits of spine maturation in Pink1 KO neurons. | Qingtao Gao Runyi Tian Hailong Han Jesse Slone Caifang Wang Xiao Ke Tongmei Zhang Xiangyu Li Yuhong He Panlin Liao Fang Wang Ye Chen Shiqing Fu Kexuan Zhang Fangfang Zeng Yingxuan Yang Zhuo Li Jieqiong Tan Jiada Li Youming Lu Taosheng Huang Zhonghua Hu Zhuohua Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 0 |
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