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| 1 | 3D Positional and Quantitative Prediction of the Xiaoqinling Gold Ore Belt in Tongguan, Shaanxi, China显示文摘Quantitative prediction of deep orebody based on 3D visualization technology is of great significance in mineral exploration. Based on the 2D traditional quantitative predicting method, the geoanomaly theory and the mineral exploration model idea, we constructed 3D models of the topography, strata, structure, magmatite and prospecting engineering of the study area using the commercial 3D modeling software Micromine, delineated eight prospective areas and estimated the gold resources amount with methods of Abundance Estimation and Volume Estimation. Then, we compared and counted the known ore blocks and the predicted blocks, which quantitatively explains this prediction's validity. The results show that Xiaoqinling gold belt in Tongguan has convincing potential for gold development and utilization and the prediction method based on 3D visualization technology proves to be effective. | CHEN Jianping SHI Rui CHEN Zhenping WANG Limei SUN Yan | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 14 |
| 2 | Lyzl4, a novel mouse sperm-related protein, is involved in fertilization显示文摘鸡类型(c 类型) 溶解酵素的角色,原型溶解酵素,在免疫在许多有机体被描绘了。在这研究,我们克隆新奇 c 类型像溶解酵素的基因, Lyzl4,它位于老鼠染色体 9F4 并且与通常认为的信号肽和一个朊酶劈开地点编码了 145 氨基酸。在酵母表示的成熟 recombinant Lyzl4 蛋白质没显示出 bacteriolytic 活动。顺序排列分析证明在 c 类型溶解酵素的 20 不变的残余中的 3 个在 Lyzl4 被改变。改变的氨基酸(D52G ) 之一位于催化领域。Lyzl4 mRNA 有选择地在成年鼠标在睾丸和 epididymis 被表示,与改变越过不同发展阶段的表达式水平。Lyzl4 蛋白质的高水平在 acrosomal 区域和尾巴的主要的片的精子上被发现。在有它的特定的抗体的精子的 Lyzl4 蛋白质的免疫中立化显著地以一种剂量依赖者方式在 vitro 授精百分比减少了,建议 Lyzl4 可能为授精是重要的。 | Ruilin Sun Ruling Shen Jun Li Guojiang Xu Jun Chi Limei Li Jianke Ren Zhugang Wang Jian Fei | 2011 | Acta Biochimica et Biophysica Sinica2011，43，5： | 9 |
| 3 | Syntheses and characterization of anti-thrombotic and anti-oxidative Gastrodin-modified polyurethane for vascular tissue engineering显示文摘Vascular grafts must avoid negative inflammatory responses and thrombogenesis to prohibit fibrotic deposition immediately upon implantation and promote the regeneration of small diameter blood vessels(<6 mm inner diameter).Here,polyurethane(PU)elastomers incorporating anti-coagulative and anti-inflammatory Gastrodin were fabricated.The films had inter-connected pores with porosities equal to or greater than 86%and pore sizes ranging from 250 to 400μm.Incorporation of Gastrodin into PU films resulted in desirable mechanical properties,hydrophilicity,swelling ratios and degradation rates without collapse.The released Gastrodin maintained bioactivity over 21 days as assessed by its anti-oxidative capability.The Gastrodin/PU had better anti-coagulation response(less observable BSA,fibrinogen and platelet adhesion/activation and suppressed clotting in whole blood).Red blood cell compatibility,measured by hemolysis,was greatly improved with 2Gastrodin/PU compared to other Gastrodin/PU groups.Notably,Gastrodin/PU upregulated anti-oxidant factors Nrf2 and HO-1 expression in H2O2 treated HUVECs,correlated with decreasing pro-inflammatory cytokines TNF-αand IL-1β in RAW 264.7 cells.Upon implantation in a subcutaneous pocket,PU was encapsulated by an obvious fibrous capsule,concurrent with a large amount of inflammatory cell infiltration,while Gastrodin/PU induced a thinner fibrous capsule,especially 2Gastrodin/PU.Further,enhanced adhesion and proliferation of HUVECs seeded onto films in vitro demonstrated that 2Gastrodin/PU could help cell recruitment,as evidenced by rapid host cell infiltration and substantial blood vessel formation in vivo.These results indicate that 2Gastrodin/PU has the potential to facilitate blood vessel regeneration,thus providing new insight into the development of clinically effective vascular grafts. | Meng Zheng Jiazhi Guo Qing Li Jian Yang Yi Han Hongcai Yang Mali Yu Lianmei Zhong Di Lu Limei Li Lin Sun | 2021 | Bioactive Materials2021，6，2： | 7 |
| 4 | PTEN regulates RPA1 and protects DNA replication forks显示文摘肿瘤 suppressor PTEN 通过多重机制调整细胞的活动和控制染色体稳定性。在这研究,我们报导 PTEN 为对复制应力的 DNA 复制叉的保护是必要的。我们证明 PTEN 的那删除在叉拖延跟随 hydroxyurea 导致的核苷酸弄空之上导致复制叉倒塌和 chromosomal 不稳定性。PTEN 身体上与复制蛋白质 A 被联系 1 (RPA1 ) 经由 RPA1 C 终端领域。暴风雨和 iPOND 表明 PTEN 在复制地点是局部性的并且在复制叉上支持 RPA1 累积。PTEN 成员调停的 deubiquitinase OTUB1 RPA1 deubiquitination。RPA1 删除授与象与复制叉拖延在 PTEN 猛烈房间观察了那一样的显型。PTEN 和 RPA1 的表示在 colorectal 癌症显示出强壮的关联。RPA1 的异质接合的混乱在老鼠支持 tumorigenesis。这些结果证明 PTEN 为 DNA 复制叉保护是必要的。我们建议 RPA1 是在叉保护的 PTEN 功能的一个目标并且 PTEN 通过 DNA 复制的规定维持染色体稳定性。 | Guangxi Wang Yang Li Pan Wang Hui Liang Ming Cui Minglu Zhu Limei Guo Qian Su Yujie Sun Michael A McNut Yuxin Yin | 2015 | Cell Research2015，25，11： | 6 |
| 5 | Numerical simulation and processoptimization for producing large-sized castings显示文摘3-Dvelocity and temperature fields of mold filling and solidification processes of large-sized castingswere calculated,and the efficiency and accuracy of numerical calculation were studied.The mold filling andsolidification processes of large-sized stainless steel,iron and aluminum alloy castings were simulated by using ofnew scheme;their casting processes were optimized,and then applied to produce castings. | Wang Junqing Sun Xun Guan Yang Wang Penghua Li Hailan Bai Limei Sun Xinzhi | 2008 | China Foundry2008，5，3： | 6 |
| 6 | Motion-based pH sensing using spindle-like micromotors显示文摘在这研究,我们报导一台像锭子的微电机。这台设备,用一个一步舞 electrospinning 方法被制作,由可被细菌破坏的 polycaprolactone 和 anionic 表面活化剂组成。有趣地,不是仅仅,产生微电机能为时间的一个长时期在水的表面上独立地移动(~ 40 min )由于 Marangoni 效果,但是在表面活化剂的版本在不同 pH 条件下面引起的表面紧张由于变化察觉到行为也展出 pH 。更有趣地,我们表明察觉到性质的基于运动的 pH 是尺寸依赖者,与展出更高的敏感的更小的结构。另外,自从 polycaprolactone 是可被细菌破坏的材料,微电机在这描述了学习能容易在答案被降级。因此,象一步舞制造,运动读出,和 biodegradability 那样的特征显示这台微电机察觉到应用的一个吸引人的候选人。 | Limei Liu Yonggang Dong Yunyu Sun Mei Liu Yajun Su Hui Zhang Bin Dong | 2016 | Nano Research2016，9，5： | 4 |
| 7 | Bio-inspired Superhydrophobic Self-healing Surfaces with Synergistic Anticorrosion Performance显示文摘The past decade has witnessed significant efforts in addressing the global metallic corrosion challenge,with a focus on avoiding or mitigating huge economic losses incurred by corrosion and on the development of protective coatings on metals.Herein,a synergistic anticorrosion coating with both superhydrophobicity and self-healing properties was reported,through a facile replica molding method by mixing the polyvinylidene fluoride(PVDF)matrix with nano-sized SiO2 particles and 2-mercaptobenzothiazole(MBT)loaded halloysites(HNTs).The surface exhibits robust self-cleaning behavior under harsh conditions and high liquid repellence to withstand the osmosis of corrosive ions.The self-healing performance of the coating,due to the introduction of MBT-loaded HNTs,enhances the anticorrosion capability,which is still valid once the protective layer is damaged.Potentiodynamic polarization(PDP)and Electrochemical Impedance Spectroscopy(EIS)measurements demonstrate that the synergetic effects in anticorrosion performances significantly enhance the long-term corrosion protection of metals.Hence,this type of dual-action coating may find unique applications in metal corrosion resistance where both super-repellency and self-healing properties are desired. | Xiaona Yang Limei Tian Wei Wang Yong Fan Jiyu Sun Jie Zhao Luquan Ren | 2020 | Journal of Bionic Engineering2020，17，6： | 4 |
| 8 | The relationships among aerosol optical depth, ice, phytoplankton and dimethylsulfide and the implication for future climate in the Greenland Sea显示文摘The sea-to-air flux of dimethylsulphide(DMS) is one of the major sources of marine biogenic aerosol, and can have an important radiative impact on climate, especially in the Arctic Ocean. Satellite-derived aerosol optical depth(AOD) is used as a proxy for aerosol burden which is dominated by biogenic aerosol during summer and autumn. The spring sea ice melt period is a strong source of aerosol precursors in the Arctic. However, high aerosol levels in early spring are likely related to advection of continental pollution from the south(Arctic haze).Higher AOD was generally registered in the southern part of the study region. Sea ice concentration(SIC) and AOD were positively correlated, while cloud cover(CLD) and AOD were negative correlation. The seasonal peaks of SIC and CLD were both one month ahead of the peak in AOD. There is a strong positive correlation between AOD and SIC. Melting ice is positively correlated with chlorophyll a(CHL) almost through March to September,but negatively correlated with AOD in spring and early summer. Elevated spring and early summer AOD most likely were influenced by combination of melting ice and higher spring wind in the region. The peak of DMS flux occurred in spring due to the elevated spring wind and more melting ice. DMS concentration and AOD were positively correlated with melting ice from March to May. Elevated AOD in early autumn was likely related to the emission of biogenic aerosols associated with phytoplankton synthesis of DMS. The DMS flux would increase more than triple by 2100 in the Greenland Sea. The significant increase of biogenic aerosols could offset the warming in the Greenland Sea. | QU Bo GABRIC Albert J. ZHAO Li SUN Wenjing LI Hehe GU Peijuan JIANG Limei ZENG Meifang | 2018 | Acta Oceanologica Sinica2018，37，5： | 4 |
| 9 | MS1 is essential for male fertility by regulating the microsporocyte cell plate expansion in soybean显示文摘Male sterility is an essential trait in hybrid seed production,especially for monoclinous and autogamous food crops.Soybean male-sterile ms1 mutant has been known for more than 50 years and could be instrumental in making hybrid seeds.However,the gene responsible for the male-sterile phenotype has remained unknown.Here,we report the map-based cloning and characterization of the MS1 gene in soybean.MS1 encodes a kinesin protein and localizes to the nucleus,where it is required for the male meiotic cytokinesis after telophase Ⅱ.We further substantiated that MS1 colocalizes with microtubules and is essential for cell plate formation in soybean male gametogenesis through immunostaining.Both ms1 and CRISPR/Cas9 knockout mutants show complete male sterility but are otherwise phenotypically normal,making them perfect tools for producing hybrid seeds.The identification of MS1 has the practical potential for assembling the sterility system and speeding up hybrid soybean breeding. | Xiaolong Fang Xiaoyuan Sun Xiangdong Yang Qing Li Chunjing Lin Jie Xu Wenjun Gong Yifan Wang Lu Liu Limei Zhao Baohui Liu Jun Qin Mengchen Zhang Chunbao Zhang Fanjiang Kong Meina Li | 2021 | Science China(Life Sciences)2021，64，9： | 4 |
| 10 | Busuishengxue ranules mediate their effects upon non-severe aplastic anemia via mitogen-activated protein kinase/extracellular signal-regulated kinase pathway显示文摘OBJECTIVE:To observe the clinical efficacy of Busuishengxue granules on non-severe aplastic anemia(NSAA)and investigate its effect on the mitogen-activated protein kinase/extracellular signal-regulated kinase(MAPK/ERK)pathway.METHODS:Sixty NSAA patients were divided equally into two groups.Subjects in the experimental group were treated with Busuishengxue granules,and the control group with Zaizaoshengxue tablets.The treatment course was 6 months and cu-rative efficacy was compared between the two groups as well as with 10 healthy individuals.Flow cytometry(FCM)was used to detect the intracellular concentration of Ca2+([Ca2+]i).Western blotting was employed to detect the expression of enzymes in the MAPK/ERK pathway.RESULTS:The efficacy of Busuishengxue granules was significantly better than that of Zaizaoshengxue tablets(P<0.05).Before treatment,expression of JNK,phospho-ERK 1/2 and p-JNK was higher,and[Ca2+]i higher,than that of the control group(P<0.05).After treatment with Busuishengxue granules,expression of all enzymes related to signal transduction pathways in the blood cells of NSSA patients were altered to different degrees.CONCLUSION:Busuishengxue granules had a better effect with regard to improving symptom scores,increasing the number of blood leukocytes,and increasing hemoglobin levels than Zaizaoshengxue tablets,and they differed slightly in terms of increasing the number of platelets. | Jinhuan Wang Feng Sun Weizheng Sun Yanli Yong Haitao Shi Sijia Liu Limei Liu | 2014 | Journal of Traditional Chinese Medicine2014，34，1： | 3 |
| 11 | Dual-Fuel-Driven Bactericidal Micromotor显示文摘In this paper, we report fabrication of the bimetallic Janus microsphere, a magnesium microsphere with a silver surface coating, through thermal evaporation technique. Because of the Janus structure, this micromotor can be propelled in two different directions by the surface silver or magnesium ‘engine' and hydrogen peroxide or water fuel. In addition, due to the bactericidal property of silver, this autonomous micromotor is capable of killing bacteria in solution. As compared to the static one, the micromotor is able to kill the bacteria at a much faster rate(about nine times of that of the static one),demonstrating the superiority of the motion one. We thus believe that the micromotor shown in the current study is potentially attractive for the environmental hygiene applications. | Ya Ge Mei Liu Limei Liu Yunyu Sun Hui Zhang Bin Dong | 2016 | Nano-Micro Letters2016，8，2： | 3 |
| 12 | Novel Anti-fouling Strategies of Live and Dead Soft Corals(Sarcophyton trocheliophorum):Combined Physical and Chemical Mechanisms显示文摘At present,biomimetic antifouling research objects are mostly concentrated on the fast-moving marine organism,but the anti-fouling effect of the low-speed or static marine equipment is not obvious.This paper describes the anti-fouling mechanism of soft coral(Sarcophyton trocheliophorum),including the physical defense mechanism and the bactericidal ability of mucus and coral powder.As a sessile organisms,soft coral lacks escape mechanism.Therefore,the study on its antibacterial strategy is significant because it can provide theoretical guidance for static antifouling.Results showed that the live soft coral would molt in unfriendly environment,and the secreted mucus could defend themselves against fouling microorganism.Then,Liquid Chromatography-Mass Spectrometry(LC-MS)analysis was conducted to identify the bioactive compounds of the coral powder and mucus.Results revealed that both powder and mucus contained a wide variety of toxic components,which had bactericidal effects.Moreover,at the same concentration,the inhibitory effect of the main components on Gram-negative bacteria was stronger than that on positive bacteria.These findings enhance the understanding about the antifouling mechanism of soft coral and provide new ideas for design and prepare novel antifouling strategy to combat biofouling under static condition. | Limei Tian E Jin Benli Yu Hang Sun Yangeng Shang Wei Bing | 2020 | Journal of Bionic Engineering2020，17，4： | 2 |
| 13 | Sodium Tanshinone IIA Sulfonate Inhibits Canonical Transient Receptor Potential Expression in Pulmonary Arterial Smooth Muscle from Pulmonary Hypertensive Rats显示文摘 | Wang Jian Jiang Qian Wan Limei Yang Kai Zhang Yi Chen Yuqin Wang Elizabeth Lai Ning Zhao Lei Jiang Hua Sun Yueqian Zhong Nanshan Ran Pixin Lu Wenju | 2013 | American Journal of Respiratory Cell and Molecular Biology2013，，1： | 1 |
| 14 | Pd–Ru/C as the electrocatalyst for hydrogen peroxide reduction显示文摘 | Limei Sun Dianxue Cao Guiling Wang | 2008 | Journal of Applied Electrochemistry2008，，10： | 1 |
| 15 | MALE STERILITY 3 encodes a plant homeodomain-finger protein for male fertility in soybean显示文摘Male-sterile plants are used in hybrid breeding to improve yield in soybean(Glycine max(L.)Merr.).Developing the capability to alter fertility under different environmental conditions could broaden germplasm resources and simplify hybrid production.However,molecular mechanisms potentially underlying such a system in soybean were unclear.Here,using positional cloning,we identified a gene,MALE STERILITY 3(MS3),which encodes a nuclear-localized protein containing a plant homeodomain(PHD)-finger domain.A spontaneous mutation in ms3 causing premature termination of MS3 translation and partial loss of the PHD-finger.Transgenetic analysis indicated that MS3 knockout resulted in nonfunctional pollen and no selfpollinated pods,and RNA-seq analysis revealed that MS3 affects the expression of genes associated with carbohydrate metabolism.Strikingly,the fertility of mutant ms3 can restore under longd conditions.The mutant could thus be used to create a new,more stable photoperiod-sensitive genic male sterility line for two-line hybrid seed production,with significant impact on hybrid breeding and production. | Jingjing Hou Weiwei Fan Ruirui Ma Bing Li Zhihui Yuan Wenxuan Huang Yueying Wu Quan Hu Chunjing Lin Xingqi Zhao Bao Peng Limei Zhao Chunbao Zhang Lianjun Sun | 2022 | Journal of Integrative Plant Biology2022，64，5： | 1 |
| 16 | Combined organic-inorganic fertilization builds higher stability of soil and root microbial networks than exclusive mineral or organic fertilization显示文摘Plant health and performance are highly dependent on the root microbiome.The impact of agricultural management on the soil microbiome has been studied extensively.However,a comprehensive understanding of how soil types and fertilization regimes affect both soil and root microbiome is still lacking,such as how fertilization regimes affect the root microbiome's stability,and whether it follows the same patterns as the soil microbiome.In this study,we carried out a longterm experiment to see how different soil types,plant varieties,and fertilizer regimens affected the soil and root bacterial communities.Our results revealed higher stability of microbial networks under combined organic-inorganic fertilization than those relied solely on inorganic or organic fertilization.The root microbiome variation was predominantly caused by total nitrogen,while the soil microbiome variation was primarily caused by pH and soil organic matter.Bacteroidetes and Firmicutes were major drivers when the soil was amended with organic fertilizer,but Actinobacteria was found to be enriched in the soil when the soil was treated with inorganic fertilizer.Our findings demonstrate how the soil and root microbiome respond to diverse fertilizing regimes,and hence contribute to a better understanding of smart fertilizer as a strategy for sustainable agriculture. | Luhua Yang Renhua Sun Jungai Li Limei Zhai Huiling Cui Bingqian Fan Hongyuan Wang Hongbin Liu | 2023 | Soil Ecology Letters2023，5，2： | 1 |
| 17 | Two Cameras Vision Model for the 3D Shape Recovery显示文摘 | LiMei Song Jing Luo BaoShan Sun | 2009 | ICNC 20092009，5，： | 1 |
| 18 | The effect of classroom wall color on learning performance: A virtual reality experiment显示文摘The wall color has the certain impact on the learning performance of college students in the classroom.To find the suitable wall color to improve the learning performance,this study used the virtual reality(VR)technology to build five virtual classrooms with yellow,red,white,blue,and green walls,while the subjective evaluation and objective physiological indicators of college students were collected.The subjective survey showed the cold-colored walls such as blue and green had the highest levels of relaxation and pleasure,while the warm-colored walls such as yellow and red had the better attention and learning performance.And the white-walled classroom had the lowest subjective evaluation and the worst learning performance,but the white wall was widely used in the present class room.Physiological test results showed the yellow wall had the higher HRV-nLF/nHF and low-β&high-βfrequencies in the FP2 channel in the frontal,but the white wall had the lowest scores.Moreover,the correlation analysis had confirmed electroencephalography(EEG)and electrocardiogram(ECG)indicators could be employed to evaluate the learning performance.These findings provide an effective reference for the spatial design of university classrooms and a basis for the study of physiological indicators. | Chao Liu Yalin Zhang Limei Sun Weijun Gao Qiuyun Zang Jiaxin Li | 2022 | Building Simulation2022，15，12： | 1 |
| 19 | Blocking TRAIL-DR5 signaling with soluble DR5 reduces delayed neuronal damage after transient global cerebral ischemia显示文摘 | Min Cui Limei Wang Xiaohong Liang Xuelian Ma Yugang Liu Mingfeng Yang Kejing Liu Xinbing Wei Zhiqiang Zhou Youhai H. Chen Wensheng Sun | 2010 | Neurobiology of Disease2010，，2： | 1 |
| 20 | Dispersion properties of a water-soluble phenol-formaldehyde resin显示文摘 | Sun Limei Li Mingyuan Lin Meiqin | 2009 | Journal of Dispersion Science and Technology2009，30，5： | 1 |
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