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| 1 | Polysaccharides from Tricholoma matsutake and Lentinus edodes enhance 5-fluorouracil-mediated H22 cell growth inhibition显示文摘OBJECTIVE: Few studies have investigated the effects produced by combinations of polysaccharides and chemotherapeutic drugs in cancer treatment.We hypothesized that a combinationo fpolysaccha rides(COP) from Lentinus edodes and Tricholoma matsutake would improve the efficacy of 5-fluorouracil(5-FU)-mediated inhibition of H22 cell growth.METHODS: Mice were injected H22 cells and then treated with either 5-FU, polysaccharides from Tricholoma matsutake(PTM), polysaccharides from Lentinus edodes(PL), PTM+PL, 5-FU+PTM, 5-FU+PL, or 5-FU+COP. The tumor weight and volume,and splenic CD4 + and CD8 + T cell frequencies,were determined. Additionally, splenic natural killer(NK) cell and cytotoxic Tlymphocyte (CTL) activities were assessed and the serum levels of tumor necrosis factor-α(TNF-α),Interleukin-2(IL-2),and Interferon-γ (IFN-γ) were measured. 5-FU, PL, PTM, PTM+PL, 5-FU+PL, and 5-FU+PTM groups, mice treated with 5-FU+COP showed:(a)significantly reduced tumor weight and volume(P<0.05);(b) significantly higher serum levels ofTNF-α,IL-2, and IFN-γ(P<0.05);(c) significantly increased CD4+andCD8+Tcell frequencies in the spleen(P<0.05); and(d) significantly increased splenic NK cell and CTL activities(P<0.05). The tumor weight and volume in mice treated with 5-FU+PL or 5-FU+PTM were significantly reduced compared with mice treated with 5-FU alone(P<0.05). Serum levels of TNF-α, IL-2, and IFN-γ, frequencies of CD4 + and CD8+T cells in the spleen, and splenic NK and CTL activities were also significantly increased in mice treated with 5-FU+PL or 5-FU+PTM compared with mice treated with 5-FU alone (P<0.05).CONCLUSION: Polysaccharides from Lentinus edodes and Tricholoma matsutake could enhance the efficacy of 5-FU-mediated H22 cell growth inhibition. | Ming Ren Lingyan Ye Xiaoshi Hao Zhixing Ren Shuping Ren Kun Xu Juan Li | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 15 |
| 2 | Influence of N on precipitation behavior,associated corrosion and mechanical properties of super austenitic stainless steel S32654显示文摘The influence of N on the precipitation behavior,associated corrosion,and mechanical properties of S32654 were investigated by microstructural,electrochemical,and mechanical analyses.Increasing the N content results in several alterations:(1) grain refinement,which promotes intergranular precipitation;(2) a linear increase in the driving force for Cr2 N and Mo activity,which accelerates the precipitation of intergranular Cr2 N and π phase,respectively;(3) a linear decrease in the driving force for σ phase and Cr activity,which suppresses the formation of intragranular σ phase.The total amount of precipitates first decreased and then increased with the N content increasing.Furthermore,the intergranular corrosion susceptibility depended substantially on the total amount of precipitates and also first exhibited a decreasing and then an increasing trend as the N content increased.In addition,aging precipitation caused a considerable decrement in the ultimate tensile strength(UTS) and a remarkable increment in the yield strength(YS).Both the UTS and YS always increased with N content increasing throughout the solution and aging process.Whereas the elongation was considerably sensitive to the aging treatment,it exhibited marginal variation with the N content increasing. | Shucai Zhang Huabing Li Zhouhua Jiang Zhixing Li Jingxi Wu Binbin Zhang Fei Duan Hao Feng Hongchun Zhu | 2020 | Journal of Materials Science & Technology2020，42，7： | 10 |
| 3 | Effect of lithium or aluminum substitution on the characteristics of graphite for anode of lithium ion batteries显示文摘Modification of graphite for anode of lithium ion batteries is investigated. Results of X-ray diffraction shows lithium and aluminum exists as Li compound (CH3COOLi@2H2O) and Al compound (AlD3) in the graphite, respectiovely.The Bmnauer-Emmer-Teller (BET) surface area of the modified graphite increases. According to the electrochemical measurements of Li/C cell and prototype Li-ion batteries, the Li-doped graphite has large reversible capacity of 312.2mA@h/g, low irreversible capacity of 52.9 mA@h/g, and high initial coulombic efficiency of 85.51%. The 063448 size prototype battery with Li-doped graphite anode has large discharge capacity of 845 mA@h and good cycling performance. The initial charge/discharge characteristic of Al-doped graphite is close to those of undoped graphite, but the prototype battery with Al-doped anode shows the best cycling performance with capacity retention ratio of 94.06% at the 200th cycle. | GUO Huajun, LI Xinhai, WANG Zhixing, PENG Wenjie, and GUO YongxingCollege of Metallurgical Science and Engineering, Central South University, Changsha 410083, China | 2003 | Rare Metals2003，22，4： | 9 |
| 4 | Performance and capacity fading reason of LiMn_2O_4/graphite batteries after storing at high temperature显示文摘Spinel LiMn2O4 was synthesized by a solid-state method. A 204468-size battery was fabricated and stored at 55°C. The structure and morphology of the LiMn2O4 cathode were analyzed by X-ray diffraction (XRD) and scanning electron microscopy (SEM) technique. Energy dispersive spectroscopy (EDS) was used to analyze the surface component of the carbon anode. The discharge capacities of LiMn2O4 stored for 0, 24, 48, and 96 h are 106, 98, 96, and 92 mAh?g?1, respectively. The cyclic performance is improved after storage. The capacity retentions of LiMn2O4 stored for 0, 24, 48, and 96 h are 83.8%, 85.8%, 86.9%, and 88.6% after 180 cycles. The intensity of all the LiMn2O4 diffraction peaks is weakened. Mn is detected from the carbon electrode when the battery is stored for 96 h. Cyclic voltammograms and electrochemical impedance spectroscopy (EIS) were used to examine the surface state of the electrode after storage. The results show that the resistance and polarization of LiMn2O4/electrolyte is increased after storage, which is responsible for the fading of capacity. | LIU Yunjian LI Xinhai GUO Huajun WANG Zhixing HU Qiyang PENG Wenjie YANG Yong | 2009 | Rare Metals2009，28，4： | 7 |
| 5 | Enhancing mixing of cohesive particles by baffles in a rotary drum显示文摘 | Zhixing Zhou Jihong Li Jingzhi Zhou Shizhong Li Junxiao Feng | 2016 | Particuology2016，14，2： | 7 |
| 6 | Improving the electrochemical performance of LiMn_2O_4/graphite batteries using LiF additive during fabrication显示文摘LiMn2O4/graphite batteries using LiF additive were fabricated and their electrochemical performance including discharge,cycling and storage performances were tested and compared with LiF-free LiMn2O4/graphite batteries.The LiMn2O4/graphite battery with LiF added shows better capacity (107.5 mAh/g),cycling performance (capacity retention ratio of 93% after 100 cycles),and capacity recovery ratio (98.1%) than the LiF-free battery.The improvement in electrochemical performance of the LiF-added LiMn2O4/graphite battery was due to the fact that LiF can restrain the dissolution of Mn from the spinel LiMn2O4 cathode into the electrolyte,leading to a smaller resistance and polarization. | LIU Yunjian GUO Huajun LI Xinhai WANG Zhixing | 2011 | Rare Metals2011，30，2： | 6 |
| 7 | Carrier dynamic overlapping switching frequency optimal pulse width modulation method for modular multilevel converters显示文摘Modular multilevel converters(MMCs) operate in the low modulation index region in many applications.However, when utilized at the low modulation index region, large harmonics appear in the output voltage, which degrade the performance of the MMC. To improve the harmonic characteristic in the low modulation index, the carrier dynamic overlapping switching frequency optimal pulse width modulation(CDOSFOPWM) method is proposed for the MMC here. The whole modulation index region is divided into three regions: high modulation index region, middle modulation index region, and low modulation index region. The carrier amplitude, carrier overlap ratio, and frequency of triangular carriers are chosen dynamically according to the modulation index region of the modulation signals, to achieve the optimal harmonic characteristic in the whole modulation index region and maintain the switching loss. The number of on-state submodules(SMs) can be calculated by CDOSFOPWM, and the selection of SMs is performed by a reducing switching frequency voltage balancing algorithm. Finally, the proposed method is verified by simulation and experimental results. | Fayun ZHOU Qianming XU An LUO Zhixing HE Yan LI Ning XIE Yichao WANG | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，6： | 5 |
| 8 | Cooperation of nitrogen-doping and catalysis to improve the Li-ion storage performance of lignin-based hard carbon显示文摘Hard carbon draws great interests as anode material in lithium ion batteries(LIBs)due to its high theoretical capacity,high rate capability and abundance of its precursors.Herein we firstly synthesize the lignin-melamine resins by grafting melamine onto lignin.Afterwards,nitrogen doped hard carbon is prepared by the pyrolysis of lignin-melamine resins with the aid of catalyst(Ni(NO_3)_2·6H_2O)at 1000°C.Compared with the samples without nitrogen-doping and catalysis,as-prepared nitrogen doped hard carbon exhibits higher reversible capacity(345 mAh g^(–1)at 0.1 A g^(-1)),higher rate capability(145 mAh g^(-1)at 5 A g^(–1))and excellent cycling stability.The superior electrochemical performance is ascribed to the synergistic effect of nitrogen doping,graphitic structure and amorphous structure.Among them,nitrogen doping could create the vacancies around the nitrogen sites,which enhance the reactivity and the electronic conductivity of materials.Additionally,graphitic structure also enhances the electronic conductivity of materials,thus improving the electrochemical performance of hard carbon.It is worthwhile that lignin,renewable and abundant biopolymer,is converted to hard carbon with good electrochemical performance,which realizes the high value utilization of lignin. | Zhewei Yang Huajun Guo Feifei Li Xinhai Li Zhixing Wang Lizhi Cui Jiexi Wang | 2018 | Journal of Energy Chemistry2018，27，5： | 5 |
| 9 | Bifunctional Li6CoO4 serving as prelithiation reagent and pseudocapacitive electrode for lithium ion capacitors显示文摘Lithium ion capacitors(LICs)have been widely used as energy storage devices due to their high energy density and high power density.For LICs,pre-lithiation of negative electrode is necessary.In this work,we employ a bifunctional Li6CoO4(LCO)as cathodic pre-lithiation reagent to improve the electrochemical performance of LICs.The synthesized LCO exhibited high first charge specific capacity of 721 mAh g-1and extremely low initial coulombic efficiency of 3.19%,providing sufficient Li+ for the pre-lithiation of negative electrode in the first charge.Simultaneously,Li6–xCoOy is generated from LCO during the first charge process,which exhibits pseudocapacitive property and contributes to capacity in form of surface capacitance during subsequent cycles,increasing the capacity of capacitive positive electrode.With the appropriate amounts of addition to the positive side in LICs,this bifunctional prelithiation reagent LCO shows significantly improved the electrochemical performance with the energy density of 78.5 Wh kg-1after 300 cycles between 2.0 and 4.2 V at 250 mA g-1. | Yuntao Guo Xinhai Li Zhixing Wang Huajun Guo Jiexi Wang | 2020 | Journal of Energy Chemistry2020，29，8： | 3 |
| 10 | Effects of cultivation of Osr HSA transgenic rice on functional diversity of microbial communities in the soil rhizosphere显示文摘With the widespread cultivation of transgenic crops, there is increasing concern about unintended effects of these crops on soil environmental quality. In this study, we used the Biolog method and ELISA to evaluate the possible effects of Osr HSA transgenic rice on soil microbial utilization of carbon substrates under field conditions. There were no significant differences in average well-color development(AWCD) values, Shannon–Wiener diversity index(H), Simpson dominance indices(D) and Shannon–Wiener evenness indices(E) of microbial communities in rhizosphere soils at eight samplings between Osr HSA transgenic rice and its non-transgenic counterpart. The main carbon sources utilized by soil microbes were carbohydrates, carboxylic acids, amino acids and polymers. The types,capacities and patterns of carbon source utilization by microbial communities in rhizosphere soils were similar throughout the detection period. We detected no Osr HSA protein in the roots of Osr HSA transgenic rice. We concluded that Osr HSA transgenic rice and the r HSA protein it produced did not alter the functional diversity of microbial communities in the rhizosphere. | Xiaobing Zhang Xujing Wang Qiaoling Tang Ning Li Peilei Liu Yufeng Dong Weimin Pang Jiangtao Yang Zhixing Wang | 2015 | The Crop Journal2015，3，2： | 3 |
| 11 | Efficacy of an Yinyanghuo(Herba Epimedii Brevicornus)-Xianmao(Rhizoma Curculiginis)drug pair in a rat model of polycystic ovary syndrome显示文摘OBJECTIVE:To identify active compounds in an Yinyanghuo(Herba Epimedii Brevicornus)-Xianmao(Rhizoma Curculiginis)drug pair(ECD)and investigate its efficacy on polycystic ovary syndrome(PCOS),and its possible mechanism in a rat model of PCOS.METHODS:A network pharmacology approach involving a characteristic drug assessment,active compound and target prediction,PCOS gene collection as well as network analysis was employed.The ovary morphology after treatment was observed using an animal model and western blotting and real-time PCR were used to verify AKT1 as the molecular target.RESULTS:Six networks were constructed,an active compound-target network for the ECD(C-T network),a drug-target network(D-T network),a related genes network,a targets interaction network,a key genes interaction network,and a gene-pathway network.A total of 41 compounds and 261 targets were identified for the ECD,232 PCOS-related genes,31 cogenes,and 14 pathways.These pathways may be involved in the efficacy of ECD on PCOS.The proteins most involved in the signal pathways for all targets were AKT1,IL6,INSR,ESR,and GSK3B.The AKT1 target was selected for experimental verification.Based on the Western blot and real-time PCR results,the expression of AKT1 in the PCOS model varied after treatment with ECD.CONCLUSIONS:Our findings suggest that the ECD can reverse the negative morphological changes in ovarian tissue that occur in model rats of PCOS.AKT1 may be a key mediator of the observed ability of the ECD to protect against PCOS in the model rats. | LIU Chang LIU Lihong LI Nan XIU Aihui ZHANG Zhixing AI Hao | 2021 | Journal of Traditional Chinese Medicine2021，41，4： | 2 |
| 12 | Transarterial infusion chemotherapy with FOLFOX for advanced hepatocellular carcinoma:a multi-center propensity score matched analysis of real-world practice显示文摘Background:To compare the treatment effectiveness and safety among transarterial infusion chemotherapy(TAI)with FOLFOX regimen,transarterial chemoembolization(TACE),and sorafenib in patients with BCLC stage C hepatocellular carcinoma(HCC).Methods:The data of consecutive patients with BCLC stage C HCC treated with TAI,TACE,or sorafenib from January 2015 to December 2018 at three centers were retrospectively analyzed.Propensity-score matched(PSM)analysis was pairwise performed to reduce selection bias.Treatment effectiveness and safety were evaluated and compared using the Kaplan-Meier method,log-rank test,Cox regression models,andχ2 test.Results:The median overall survival(OS)in the matched TAI cohort was significantly longer than the sorafenib cohort(19.6 vs.7.5 months,P=0.009),and the TACE cohort(estimated 27.8 vs.6.6 months,P<0.001).The difference in median progression-free survival(PFS)between the matched TAI and sorafenib cohorts was not significant(5.8 vs.2.3 months,P=0.219).The median PFS in the matched TAI cohort was significantly longer than the TACE cohort(6.5 vs.2.8 months,P<0.001).The objective response rate(ORR)in the matched TAI cohort was significantly higher than the sorafenib cohort(36.4%vs.0.0%,P<0.001)and the TACE cohort(48.7%vs.4.7%,P<0.001).The incidences of adverse events(AEs)were similar among these three cohorts.Conclusions:TAI with FOLFOX regimen was an effective and safe therapy that improved survival of patients with BCLC stage C HCC. | Shaohua Li Jie Mei Qiaoxuan Wang Feng Shi Hongyan Liu Ming Zhao Lianghe Lu Yihong Ling Zhixing Guo Yabing Guo Xiaoming Chen Ming Shi Wan Yee Lau Wei Wei Rongping Guo | 2021 | Hepatobiliary Surgery and Nutrition2021，10，5： | 2 |
| 13 | Relationship between Tanlu Fault and Hydrocarbon Accumulation in Liaozhong Sag, Bohai Bay, Eastern China显示文摘Tanlu fault(Liaozhong segment) goes straight through Liaodong Bay along NNE direction and it is divided into three segments, i.e., the northern segment, the middle segment and the southern segment, according to the differences in structural features. There are obvious changes in deposit thickness, sag structure, tectonic nature and other aspects of the layers. Tanlu fault is a special controlling factor concerning the reservoir formation in Liaozhong sag. First, its activities affect paleogeomorphology and paleogeographic framework and control the distribution of the sedimentary facies and then they proceed to control the distribution of the source rock and reservoir sand bodies. Second, its activities affect the formation and deformation of the structure, control the formation of abundant traps and cause the destruction of some traps. Third, its activities also affect the juxtaposition relation among the fault, the sand bodies and unconformity surfaces and control the function and efficacy of the three as the main hydrocarbon translocation system. In this paper the hydrocarbon reservoir formation process of JZ21-1, JX1-1 and LD27-2 oil and gas fields, the representatives of Tanlu strike slip fault zone are mainly analyzed. The modes of hydrocarbon reservoir formation can be generalized as follows—hydrocarbon source acts as 'soil' and oil and gas as 'nutrient'; hydrocarbon expulsion relies on 'roots'; hydrocarbon migration relies on 'trunks'; reservoir forms in 'brunches' and the whole process follows the pattern that 'hydrocarbon accumulates in strike slips and oil and gas reservoir forms like the growth of trees'. | Guosheng Xu Zhixing Xu Deyu Gong Donghong Zhou Changrong Wu Xiaoping Luo Jianping Li | 2014 | Journal of Earth Science2014，25，2： | 2 |
| 14 | Apparent ages of suspended sediment and soil erosion of the Pearl River (Zhujiang) drainage basin显示文摘The carbon isotopic composition (Δ 14 C,δ 13 C) and apparent ages of suspended sediment were determined in the Pearl River in the years 1998,2000 and 2005.These results indicate that suspended POC consists mostly of young carbon and some 'old carbon'.Apparent ages of suspended POC range from 540 to 2050 a BP.The apparent ages are older in the Xijiang and Beijiang Rivers,while these values are variable in the Dongjiang River,including old and young samples.The suspended POCδ 13 C values increase with increasing Δ 14 C in the Pearl River,indicating that its source is soil and bedrock from depths under 15 30 cm.Since the organic carbon of the surface soil is quickly decomposed when it enters the rivers,its carbon isotopic characteristics are insignificant in suspended sediment.In the Pearl River drainage basin,there are areas with more severe soil erosion than others.For example,erosion is much more severe in the Xijiang River drainage basin when compared to the light soil erosion in the Dongjiang River drainage basin. | WEI XiuGuo SHEN ChengDe LI NingLi WANG FuShun DING Ping WANG Ning GUO ZhiXing LIU KeXin | 2010 | Chinese Science Bulletin2010，55，15： | 2 |
| 15 | Overexpression of sigma-1 receptor inhibits ADAM10 and ADAM17 mediated shedding in vitro显示文摘The sigma-1 receptor is a molecular chaperone protein highly enriched in the brain.Recent studies linked it to many diseases,such as drug addition,Alzheimer’s disease,stroke,depression,and even cancer.Sigma-1 receptor is enriched in lipid rafts,which are membrane microdomains essential in signaling processes.One of those signaling processes is ADAM17-and ADAM10-dependent ectodomain shedding.By using an alkaline phosphatase tagged substrate reporter system,we have shown that ADAM10-dependent BTC shedding was very sensitive to both membrane lipid component change and sigma-1 receptor agonist DHEAS treatment while ADAM17-dependent HB-EGF shedding was not;and overexpression of sigma-1 receptor diminished ADAM17-and ADAM10-dependent shedding.Our results indicate that sigma-1 receptor plays an important role in modifying the function of transmembrane proteases. | Juan Li Bin Liu Xiaofei Gao Zhixing Ma Tianyi CaoSong Yan-ai Mei Yufang Zheng | 2012 | Protein & Cell2012，3，2： | 2 |
| 16 | Extraction of valuable metals from lepidolite显示文摘 | Qunxuan Yan Xinhai Li Zhixing Wang Xifei Wu Huajun Guo Qiyang Hu Wenjie Peng Jiexi Wang | 2012 | Hydrometallurgy2012，，： | 1 |
| 17 | A novel concept for convective heat transfer enhancement 显示文摘 | GUO Zengyuan LI Zhixing WANG Buxuan | 1998 | Heat Mass Transfer1998，41，14： | 1 |
| 18 | Electrochemical performance and capacity fading reason of LiMn 2 O 4 /graphite batteries stored at room temperature显示文摘 | Liu Yunjian Li Xinhai Guo Huajun Wang Zhixing Hu Qiyang Peng Wenjie Yang Yong | 2008 | Journal of Power Sources2008，，1： | 1 |
| 19 | A facile synthesis of graphite/silicon/graphene spherical composite anode for lithium-ion batteries显示文摘 | Lei Gan Huajun Guo Zhixing Wang Xinhai Li Wenjie Peng Jiexi Wang Silin Huang Mingru Su | 2013 | Electrochimica Acta2013，，： | 1 |
| 20 | Extraction of valuable metals from lepidolite显示文摘 | Qunxuan Yan Xinhai Li Zhixing Wang Xifei Wu Huajun Guo Qiyang Hu Wenjie Peng Jiexi Wang | 2012 | Hydrometallurgy2012，，： | 1 |
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