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| 1 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu | 2020 | Science China(Life Sciences)2020，63，3： | 157 |
| 2 | Surveillance, epidemiology, and pathogen spectrum of hand, foot, and mouth disease in mainland of China from 2008 to 2017显示文摘Hand,foot and mouth disease(HFMD)was reported in May 2,2008 to be the 38th legally notifiable disease in China's National Notifiable Disease Reporting and Surveillance System.In order to solve the infection,an extensive three-level HFMD surveillance laboratory network was established.In this study,the framework of that network is assessed and the incidence of HFMD in China from 2008 to 2017 is reported using a descriptive epidemiologic method.During these 10 years,a series of techniques have been widely applied in all the network laboratories.Using information and material obtained from the network,a virus bank and database containing 18,238 viruses were established.Nationally,18,184,834 HFMD cases,including 152,436 severe cases and 3633 fatal cases,were reported in mainland of China.The average annual incidence in the population was 133.99/100,000 people,with a maximum incidence of 205.06/100,000 people in 2014.The incidence and mortality rates of HFMD were the highest in children aged 1–2 years.The numbers of reported cases fluctuated,with a high incidence observed every 2 years.An overall increase in the number of reported cases was also observed throughout the study period.Despite this,the incidence of severe cases and the mortality rate have been decreasing.High-risk regions are located in southern,eastern,and central China.Two peaks of HFMD infection cases were observed annually except for Northeast China.Different proportions of enterovirus serotypes were observed during the studied years.The predominant enterovirus varies from year to year,but the disease severity is always closely related to the specific serotype.EV-A71 is the dominant serotype associated with severe and fatal cases,with constituent ratios of 70.03%and 92.23%,respectively.The studied highly sensitive and efficient surveillance network provides information that is critical for prevention and control of the disease.It is extremely necessary and important to continuously conduct extensive virological surveillance for HFMD. | Tianjiao Ji Taoli Han Xiaojuan Tan Shuangli Zhu Dongmei Yan Qian Yang Yang Song Aili Cui Yan Zhang Naiying Mao Songtao Xu Zhen Zhu Dandan Niu Yong Zhang Wenbo Xu | 2019 | Biosafety and Health2019，1，1： | 26 |
| 3 | Inhibition of PI3K/Akt/m TOR signaling pathway enhances the sensitivity of the SKOV3/DDP ovarian cancer cell line to cisplatin in vitro显示文摘The activation of the PI3K/AKT/m TOR pathway plays a key role in ovarian cancer tumorigenesis, progression and chemotherapy resistance. This study aimed to explore the possible mechanism that PI-103, a dual inhibitor of phosphatidylinositide 3-kinase and m TOR, enhances the sensitivity of SKOV3/DDP ovarian cancer cell line to cisplatin chemotherapy. The results showed that PI-103 could significantly increase the sensitivity of SKVO3/DDP cells to cisplatin through inhibiting the activation of PI3K/Akt/m TOR signaling pathway and inducing cell cycle arrest and apoptosis. | Yunlang Cai Xiaoqiang Tan Jun Liu Yang Shen Di Wu Mulan Ren Peilin Huang Dandan Yu | 2014 | Chinese Journal of Cancer Research2014，26，5： | 11 |
| 4 | Ascorbic acid accelerates Wallerian degeneration after peripheral nerve injury显示文摘Wallerian degeneration occurs after peripheral nerve injury and provides a beneficial microenvironment for nerve regeneration.Our previous study demonstrated that ascorbic acid promotes peripheral nerve regeneration,possibly through promoting Schwann cell proliferation and phagocytosis and enhancing macrophage proliferation,migration,and phagocytosis.Because Schwann cells and macrophages are the main cells involved in Wallerian degeneration,we speculated that ascorbic acid may accelerate this degenerative process.To test this hypothesis,400 mg/kg ascorbic acid was administered intragastrically immediately after sciatic nerve transection,and 200 mg/kg ascorbic acid was then administered intragastrically every day.In addition,rat sciatic nerve explants were treated with 200μM ascorbic acid.Ascorbic acid significantly accelerated the degradation of myelin basic protein-positive myelin and neurofilament 200-positive axons in both the transected nerves and nerve explants.Furthermore,ascorbic acid inhibited myelin-associated glycoprotein expression,increased c-Jun expression in Schwann cells,and increased both the number of macrophages and the amount of myelin fragments in the macrophages.These findings suggest that ascorbic acid accelerates Wallerian degeneration by accelerating the degeneration of axons and myelin in the injured nerve,promoting the dedifferentiation of Schwann cells,and enhancing macrophage recruitment and phagocytosis.The study was approved by the Southern Medical University Animal Care and Use Committee(approval No.SMU-L2015081)on October 15,2015. | Lixia Li Yizhou Xu Xianghai Wang Jingmin Liu Xiaofang Hu Dandan Tan Zhenlin Li Jiasong Guo | 2021 | Neural Regeneration Research2021，16，6： | 6 |
| 5 | Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. | Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang | 2020 | National Science Review2020，7，6： | 6 |
| 6 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 7 | A hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier ocular drug delivery platform显示文摘The objective of this study was to develop a novel hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier(NLC) drug delivery platform. An ophthalmic antiinflammatory drug, baicalin(BN) was chosen as the model drug. BN –NLC was prepared using melt-emulsification combined with ultra-sonication technique. Additionally, a dual pH-and thermo-sensitive hydrogel composed of carboxymethyl chitosan(CMCS) and poloxamer 407(F127) was fabricated by a cross-linking reaction with a nontoxic crosslinker genipin(GP). GP-CMCS/F127 hydrogel was characterized by FTIR, NMR, XRD and SEM. The swelling studies showed GP-CMCS/F127 hydrogel was both pH-and thermo-sensitive. The results of in vitro release suggested BN –NLC gel can prolong the release of baicalin comparing with BN eye drops and BN –NLC. Ex vivo cornea permeation study was evaluated using Franz diffusion cells. The apparent permeability coefficient(Papp) of BN –NLC gel was much higher(4.46-fold) than that of BN eye drops. Through the determination of corneal hydration levels, BN –NLC gel was confirmed that had no significant irritation to cornea. Ex vivo precorneal retention experiments were carried out by a flow-through approach. The results indicated that the NLC-based hydrogel can prolong precorneal residence time. In conclusion, the hybrid NLCbased hydrogel has a promising potential for application in ocular drug delivery. | Yibin Yu Ruoxi Feng Jinyu Li Yuanyuan Wang Yiming Song Guoxin Tan Dandan Liu Wei Liu Xinggang Yang Hao Pan Sanming Li | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，4： | 3 |
| 8 | PORK PRODUCTION SYSTEMS IN CHINA:A REVIEW OF THEIR DEVELOPMENT,CHALLENGES AND PROSPECTS IN GREEN PRODUCTION显示文摘This paper reviews the changes in pork production in China,the largest pork producing and consuming nation in the world.The pork sector in China has changed dramatically since the 1990s,with large-scale intensive pork production systems replacing the former,exclusively family-based pork production systems.Modern breeding,feeding,vaccinating,and management technologies are widely used now.However,smallholders still account for a large proportion of the total production.The intensification and specialization of the pork sector is expected to continue in the future,but there is increasing awareness and pressure to develop more environmentally-sustainable production systems.The relative shortage of domestically produced feed,the low utilization efficiency of feed ingredients,the large emissions of nitrogen and phosphorus to the environment,the high use of antibiotics,and the presence of residual metals in manures are very large challenges for the pork sector nowadays.To solve these problems,techniques including new feed resource utilization,precise feeding,low-protein diets,alternatives to antibiotics and increased manure recycling are all important topics and research directions today.With new techniques and management approaches,it is possible to build more sustainable pork production systems in China. | Shuai ZHANG Xin WU Dandan HAN Yong HOU Jianzhuang TAN Sung Woo KIM Defa LI Yulong YIN Junjun WANG | 2021 | Frontiers of Agricultural Science and Engineering2021，8，1： | 2 |
| 9 | Assessment of urban air quality in China using air pollution indices (APIs)显示文摘 | Litao Wang Pu Zhang Shaobo Tan Xiujuan Zhao Dandan Cheng Wei Wei Jie Su Xuemei Pan | 2013 | Journal of the Air & Waste Management Association2013，，2： | 1 |
| 10 | A modified Sutherland equation for obtaining diffusivities in liquid and its effect on microstructure simulation of WC-Ti(C,N)-Co gradient cement-ed carbides显示文摘 | Chen Weimin Zhang Lijun Du Yong Liu Dandan Zhang Weibin Cui Senlin Tan Chengyu Wang Shequan Wen Guanghua Xie Wen | 2012 | Metall Mater Trans A2012，，： | 1 |
| 11 | Recent progress in organic color-tunable phosphorescent materials显示文摘Organic color-tunable phosphorescent materials depend upon multiple emission centers to achieve colortunable phosphorescence with changes in excitation wavelength,temperature,time,and other external factors.Organic color-tunable phosphorescent materials are becoming increasingly popular due to their potential applications in anticounterfeiting,encryption and sensing.This brief review focuses on the formation of multiple emission centers in organic color-tunable phosphorescent materials and how to ensure that these multiple emission centers can simultaneously emit.In the future,materials with a large color tunable ranges,increased efficiency,and relatively long lives will be developed. | Zhengshuo Wang Hua Yuan Yongzhi Zhang Dandan Wang Junping Ju Yeqiang Tan | 2022 | Journal of Materials Science & Technology2022，，6： | 1 |
| 12 | Research progress on the luminescence of biomacromolecules显示文摘Luminescent materials show great potential in various applications.Traditional aggregation-induced emission(AIE)luminogens are mostly produced by complex organic synthesis and have poor hydrophilicity and biocompatibility,which limit their practical applications.Therefore,it is of great significance to develop fluorescent materials with good hydrophilicity and biocompatibility,and biomacromolecules with these properties have attracted our attention.Partial biomacromolecules can generate unique new fluorophores during the gelation process to obtain hydrogels with good fluorescence properties.In addition,biomacromolecules can be modified with fluorescent groups to obtain fluorescent materials with excellent performance,thus improving the hydrophilicity and biocompatibility of fluorophore.In particular,grafting aggregation-caused quenching(ACQ)luminogens onto biomacromolecules can even effectively inhibit the aggregation and self-quenching of luminogens.It is well known that aromatic biological macromolecules such as green fluorescent protein have intrinsic fluorescence.Intrinsic fluorescence is also observed in nonaromatic biological macromolecules without traditional chromophores such as chitosan,cellulose and sodium alginate.The luminescence of nonaromatic biomacromolecule can be rationalized by the clustering-triggered emission(CTE)mechanism,namely,clustering of nonconventional chromophores and subsequent electron overlap and conformation rigidification are accountable for the emssion.In this review,fluorescence gels obtained from biomacromolecules,biomacromolecules modified with fluorophores,and the intrinsic luminescence of biomacromolecular luminogens are assessed.This review will help to develop low-cost,biocompatible luminescent materials and has great significance for comprehending the luminescence of nonconventional luminophores and expanding the application of luminescent compounds. | Dandan Wang Junping Ju Shuang Wang Yeqiang Tan | 2021 | Journal of Materials Science & Technology2021，，17： | 0 |
| 13 | Discovery of 4-cyclopropyl-3-(2-((1-cyclopropyl-1H-pyrazol-4-yl) amino) quinazolin-6-yl)-N-(3-(trifluoromethyl) phenyl) benzamides as potent discoidin domain receptor inhibitors for the treatment of idiopathic pulmonary fibrosis显示文摘Idiopathic pulmonary fibrosis(IPF)is a chronic fatal lung disease with a median survival time of 3–5 years.Inaccurate diagnosis,limited clinical therapy and high mortality together indicate that the development of effective therapeutics for IPF is an urgent need.In recent years,it was reported that DDRs are potential targets in anti-fibrosis treatment.Based on previous work we carried out further structure modifications and led to a more selective inhibitor 47 by averting some fibrosis-unrelated kinases,such as RET,AXL and ALK.Extensive profiling of compound 47 has demonstrated that it has potent DDR1/2 inhibitory activities,low toxicity,good pharmacokinetic properties and reliable in vivo anti-fibrosis efficacy.Therefore,we confirmed that discoidin domain receptors are promising drug targets for IPF,and compound 47 would be a promising candidate for further drug development. | Qi Wang Bixi Tang Dandan Sun Ying Dong Yinchun Ji Huanyu Shi Liwei Zhou Yueyue Yang Menglan Luo Qian Tan Lin Chen Yue Dong Cong Li Rongrong Xie Yi Zang Jingkang Shen Bing Xiong Jia Li Danqi Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
| 14 | Isolation of a carbon nanohoop with Mobius topology显示文摘Carbon nanohoop,a class of constrained molecular architecture consisting of linked arene units,has attracted considerable interest from both experimental and theoretical chemists due to its synthetic challenge and aesthetic architectures.Another fascinating and synthetically challenging species,the Mobius-type molecule,has been attracting the scientific community with its elegant structure and aromaticity.Thus,combining two things together,synthesizing a carbon nanohoop with Mobius topology remains more challenging to date.Here we report a cyclophenylene featuring Mobius strip characterized by X-ray crystallography.Theoretical calculations reveal that such type of nanohoop is fully conjugated systems with electrons delocalized both inπsextets and the bridging carbon–carbon bonds.This work highlights that the manipulation of phenylene connection in a carbon nanohoop can help obtain more delicate and aesthetic molecular architectures. | Zhen-Lin Qiu Dandan Chen Zeying Deng Ke-Shan Chu Yuan-Zhi Tan Jun Zhu | 2021 | Science China Chemistry2021，64，6： | 0 |
| 15 | The Emotion-Regulation Benefits of Implicit Reappraisal in Clinical Depression:Behavioral and Electrophysiological Evidence显示文摘Major depressive disorder(MDD)is characterized by emotion dysregulation.Whether implicit emotion regulation can compensate for this deficit remains unknown.In this study,we recruited 159 subjects who were healthy controls,had subclinical depression,or had MDD,and examined them under baseline,implicit,and explicit reappraisal conditions.Explicit reappraisal led to the most negative feelings and the largest parietal late positive potential(parietal LPP,an index of emotion intensity)in the MDD group compared to the other two groups;the group difference was absent under the other two conditions.MDD patients showed larger regulatory effects in the LPP during implicit than explicit reappraisal,whereas healthy controls showed a reversed pattern.Furthermore,the frontal P3,an index of voluntary cognitive control,showed larger amplitudes in explicit reappraisal compared to baseline in the healthy and subclinical groups,but not in the MDD group,while implicit reappraisal did not increase P3 across groups.These findings suggest that implicit reappraisal is beneficial for clinical depression. | Jiajin Yuan Yueyao Zhang Yanli Zhao Kexiang Gao Shuping Tan Dandan Zhang | 2023 | Neuroscience Bulletin2023，39，6： | 0 |
| 16 | Activating MoO_(3) nanobelts via aqueous intercalation as a near-infrared type I photosensitizer for photodynamic periodontitis treatment显示文摘Although molybdenum trioxide nanomaterials have been widely explored as nanoagents for biomedical applications against bacteria through photothermal therapy,chemodynamic therapy,and catalytic therapy,their utilization as photosensitizers for photodynamic therapy(PDT)have been rarely reported so far.Herein,we report the activation of MoO_(3) nanobelts via aqueous co-intercalation of Na+and H_(2)O into their van der Waals gaps as a near-infrared Type I photosensitizer for photodynamic periodontitis treatment.The Na^(+)/H_(2)O intercalation of MoO_(3) nanobelts can shorten its length,generate rich oxygen vacancies,and enlarge its interlayer gaps.Such structural changes thus can induce the color change from white to dark blue with a strong near-infrared(NIR)absorption.When used as a photosensitizer,the I-MoO_(3−x) nanobelts exhibit much higher activities for the generation of superoxide radical(·O_(2)^(−))under an 808 nm laser irradiation than that of the pristine MoO_(3) nanobelts.Therefore,the prepared I-MoO_(3)−x nanobelts show a spectral antibacterial activity against Escherichia coli and Saccharomyces aureus,thus yielding a good clinical therapeutic effect on periodontitis.Our study proves that aqueous intercalation can be a simple but powerful strategy to activate layered MoO_(3) nanomaterials for high-performance PDT. | Bohua Li Dandan Chu Haohao Cui Zhanrong Li Zhan Zhou Chaoliang Tan Jingguo Li | 2023 | SmartMat2023，4，6： | 0 |
| 17 | Electrochemical Reaction Mechanism of Phenacetin at a Carboxylated Multiwall Carbon Nanotube Modified Electrode and Its Analytical Applications显示文摘 | ZHANG Jinlei LAN Cuiling SHI Bingfang LIU Fang ZHAO Dandan TAN Xuecai | 2014 | Chemical Research in Chinese Universities2014，30，6： | 0 |
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