| 1 | Joint land-sea seismic survey and research on the deep structures of the Bohai Sea areas显示文摘This paper presents the survey and research work of two land-sea profiles in the Bohai Sea,China,carried out in 2010–2011,including the seismic sources on land and in the sea,the ocean bottom seismographs(OBS)and their recovery,the coupling of OBS and the environment noise in sea area,the data quality of OBSs,and the result of data analysis.We focused on the investigation of crustal structures revealed by the two NE\EW-trending joint land-sea profiles.In combination with the Pn-velocity distribution and gravitymagnetic inversion results in the North China Craton,we propose that the undulation of the Moho interface in the Bohai and surrounding areas is not strong,and the lithospheric thinning is mainly caused by the thinning of its mantle part.The research result indicates that obvious lateral variations of Moho depth and seismic velocity appear nearby all the large-scale faults in Bohai Sea,and there is evidence of underplating and reforming of the lower crust by mantle material in the Bohai area.However,geophysical evidence does not appear to support the'mantle plume'or'delamination'model for the North China Craton destruction.The crustal structure of the Bohai Sea revealed'a relatively normal crust and obviously thinned mantle lid',local velocity anomalies and instability phenomena in the crust.These features may represent a combined effect of North China-Yangtze collision at an early stage and the remote action of Pacific plate subduction at a late stage. | HAO Tianyao YOU Qingyu LIU Lihua LV Chuanchuan XU Ya LI Zhiwei ZHAO Chunlei ZHENG Yanpeng LIU Chenguang HAN Guozhong | 2013 | Acta Oceanologica Sinica2013，32，12： | 11 |
| 2 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
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