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| 1 | MiR-122 in hepatic function and liver diseases显示文摘As the most abundant liver-specific microRNA,mi-croRNA-122(miR-122)is involved in various physio-logical processes in hepatic function as well as in liver pathology.There is now compelling evidence that miR-122,as a regulator of gene networks and pathways in hepatocytes,plays a central role in diverse aspects of hepatic function and in the progress of liver diseases.This liver-enriched transcription factors-regulated miRNA promotes differentiation of hepatocytes and regulates lipid metabolism.With regard to liver diseases,miR-122 was shown to stimulate hepatitis C virus(HCV)replication through a unique and unusual interaction with two binding sites in the 5′-UTR of HCV genome to mediate the stability of the viral RNA,whereas inhibit the expression and replication of hepatitis B virus(HBV)by a miR-122-cylin G1/p53-HBV enhancer regulatory pathway.In addition,miR-122 acts as a suppressor of cell prolif-eration and malignant transformation of hepatocytes with remarkable tumor inhibition activity.Notably,a clinical trial targeting miR-122 with the anti-miR-122 oli-gonucleotides miravirsen,the first miRNA targeted drug,has been initiated for treatment of HCV infection.With further understanding of the comprehensive roles of miR-122 in hepatic functions and the mechanisms in-volved in miR-122 down-regulation in chronic hepatitis or hepatocellular carcinoma,miR-122 appears to be a promising candidate for effective therapeutic ap-proaches against tumor and infectious diseases. | Jun Hu Yaxing Xu Junli Hao Saifeng Wang Changfei Li Songdong Meng | 2012 | Protein & Cell2012，3，5： | 22 |
| 2 | Competitive virus and host RNAs: the interplay of a hidden virus and host interaction显示文摘在病毒感染期间,病毒的 RNA 和 mRNAs 在天生的免疫作为联系病原体的分子的模式(PAMP ) 为病毒的蛋白质合成并且可能作为蓝图工作。这里,在 microRNAs (miRNAs ) 和竞争内长的 RNA (ceRNAs ) 考虑最近的研究进步,我们作为海绵推测那病毒的 RNA 行为并且能扣押在内的内长的 miRNAs 感染了细胞,这样跨 regulating 稳定性和有分享的 miRNA 反应元素的宿主 mRNAs 的翻译效率。在病毒的 RNA 和主人 mRNAs 之间的这串音和这些相互的相互作用被称为竞争病毒并且主人 RNA (cvhRNAs ) 。我们进一步在肝炎 B 为 cvhRNAs 网络的存在提供最近的试验性的证据病毒(HBV ) ,以及 Herpesvirus saimiri (HVS ) , lysin 的鼠科的 cytomegalovirus (MCMV ) 和人的 cytomegalovirus (HCMV ) 感染。另外, cvhRNA 假设也预言可能在主人和另外的病毒之间跨规定例如丙肝病毒(HCV ) , HIV,流行性感冒病毒,人的乳头状瘤病毒(HPV ) 。因为在 miRNAs 和病毒的 RNA 之间的相互作用不可避免地也导致病毒的 RNA 功能的压抑,我们推测那个病毒可以演变采用 cvhRNA 网络或避免在主机以内为最佳的健康指向的 miRNA。CvhRNA 网络可以因此在病毒的复制,感染建立,和病毒的致病的规定起一个基本作用。 | Changfei Li Jun Hu Junli Hao Bao Zhao Bo Wu Lu Sun Shanxin Peng George F. Gao Songdong Meng | 2014 | Protein & Cell2014，5，5： | 6 |
| 3 | The role of MALAT1 correlates with HPV in cervical cancer显示文摘 | Yan Jiang Yuehui Li Shujuan Fang Binyuan Jiang Changfei Qin Pingli Xie Guohua Zhou Guancheng Li | 2014 | Oncology Letters2014，，6： | 3 |
| 4 | Optimum Operating and Regeneration Parameters of ZnI2 Catalyst for Converting Methanol to Triptane:An Ideal Component of Unleaded Aviation Gasoline显示文摘Conversion of methanol(MeOH) to 2,2,3-trimethylbutane(triptane) over zinc iodide(ZnI_2)catalyst was investigated in a closed batch reactor.Optimum operating parameters were searched and catalyst deactivation and regeneration behaviors were discussed.The fresh,spent and regenerated catalysts were characterized by XRD,TG and XRF measurements to elucidate the related mechanism.The experimental results showed that the triptane yield reached up to 12.2% under the process conditions,including a reaction temperature of 200℃,an initial pressure of 0.35 MPa,a reaction time of 2 h,and a Me OH to ZnI_2 molar ratio of 2.The catalyst was gradually deactivated after several run cycles.A small amount of iodine was lost and a certain amount of ZnO was formed on the deactivated ZnI_2 catalyst.Deactivation of the catalyst could be attributed to the reduction of ZnI_2 amount,resulted from iodine loss and formation of Zn O.It was firstly pointed out from our work that the deactivated catalyst could be well regenerated by the hydrogen iodide(HI) and the tert-butanol compensation method,wherein the latter was added as an initiator into the reaction system.The activity recovery of the deactivated(spent) catalyst might be related to the reformation of ZnI_2 and acceleration of the initiation step of this reaction. | Chen Weiwei Song Yueqin Zong Rui Du Changfei Zhou Xiaolong Li Chenglie | 2018 | China Petroleum Processing & Petrochemical Technology2018，20，2： | 3 |
| 5 | Direct preparation of a novel membrane from unsubstituted cellulose in NaOH complex solution显示文摘 | Zhang Shuai Fu Changfei Li Faxue | 2009 | Iranian Polymer Journal2009，18，10： | 1 |
| 6 | Wireless Positioning:Technologies,Applications,Challenges,and Future Development Trends显示文摘The development of the fifth-generation(5G)mobile communication systems has entered the commercialization stage.5G has a high data rate,low latency,and high reliability that can meet the basic demands of most industries and daily life,such as the Internet of Things(IoT),intelligent transportation systems,positioning,and navigation.The continuous progress and development of society have aroused wide concern.Positioning accuracy is the core demand for the applications,especially in complex environments such as airports,warehouses,supermarkets,and basements.However,many factors also affect the accuracy of positioning in those environments,for example,multipath effects,non-line-of-sight,and clock synchronization errors.This paper provides a comprehensive review of the existing works about positioning for the future wireless network and discusses its key techniques and algorithms,as well as the current development and future directions.We first outline the current traditional positioning technologies and algorithms,which are discussed and analyzed with the relevant literature.In addition,we also discuss application scenarios for wireless localization.By comparing different positioning systems,the challenges and future development directions of existing wireless positioning systems are prospected. | Xingwang Li Hua Pang Geng Li Junjie Jiang Hui Zhang Changfei Gu Dong Yuan | 2024 | Computer Modeling in Engineering & Sciences2024，139，5： | 0 |
| 7 | Designing Uncorrelated Multiple Antennas with Round Patterns Using Handset Metal Frames显示文摘Multiple antennas with low correlations are highly in demand in the mobile handsets for higher data rate.At the same time,the total pattern provided by the antennas should be as round as possible for reliable links.In this paper,by analysing the characteristic modes of the mobile chassis loaded by ultra-thin metal frames,a four-antenna system with a round total pattern is designed at 2.4 GHz.The gain variations are only 3.4 dB and 3.6 dB on two dominant planes.The isolations between antennas are above 15 dB,and the correlations are below 0.01,with intact ground plane and small ground clearance of 2 mm maintained.Afterwards,an eight-port antenna system is designed by taking advantage of the ground clearance and exciting modes with different phases.Low correlations of below 0.07 are obtained.The antenna system is fabricated,with the measured results agreeing well with the simulated ones. | LI Hui XU Jialu DIAO Yunze ZHOU Changfei | 2022 | Chinese Journal of Electronics2022，31，6： | 0 |
| 8 | MHC Class I Assembly Function and Intracellular Transport Routes for Hepatitis B Virus Antigen Cross-presentation by Heat Shock Protein gp96显示文摘Background:During hepatitis B virus(HBV)infection,virus-infected hepatocytes directly cross-present viral antigens and regulate T cell response within the liver microenvironment.However,little is known regarding the regulatory pathways involved in viral antigen presentation in HBV-infected hepatocytes.This study investigated the underlying mechanism of antigen assembly and the HBV antigen-presenting function of major histocompatibility complex(MHC)class I molecules using heat shock protein gp96.Methods:First,western blotting,flow cytometry,co-immuno precipitation,GST pull-down,and confocal microscopic assays were performed to determine whether endogenous gp96 affects MHC-I levels via an antigen presentation pathway.Second,the B3Z assay and an AAV/HBV-infected hepatocyte-specific gp96-deficient mouse model were used to determine whether gp96 knockout functionally impaired peptide cross-presentation and produced a weakened antiviral cytotoxic T cell(CTL)response both in vivo and in vitro.Finally,confocal microscopic analysis and the B3Z assay were employed to show that exogenous gp96-associated peptide was present in MHC-I molecules via the endoplasmic reticulum(ER)-Golgi secretory pathway.Results:Compared with the control,gp96 knockdown significantly reduced the cell surface levels of MHC-I by approximately 75%(P<0.01).Endogenous gp96 interacts with MHC-I and is involved in antigen presentation.Moreover,a weakened antiviral CTL response(34%compared to control mice)has been observed in hepatocyte-specific gp96-deficient mice following HBV infection.gp96 directed exogenous antigen to the ER,and the exogenous gp96-chaperoned peptide was endosome-and proteasome-dependent but not transporter associated with antigen processing dependent.Conclusions:Cellular gp96 promotes the assembly and antigen presentation of MHC class I molecules.In addition,extracellular gp96 served as a natural adjuvant to induce a CTL response in a concerted and regulated manner within different cellular compartments.Our results elucidate the mechanism of assembly of MHC class I molecules by gp96,which may be beneficial for the design of immunotherapy and vaccines. | Lijuan Qin Yongai Liu Yuxiu Xu Yang Li Jun Hu Ying Ju Yu Zhang Shuo Wang Zihai Li Changfei Li Xin Li Songdong Meng | 2022 | Infectious Diseases & Immunity2022，2，3： | 0 |
| 9 | Cellular gp96 upregulates AFP expression by blocking NR5A2 SUMOylation and ubiquitination in hepatocellular carcinoma显示文摘Alpha-fetoprotein (AFP) is the most widely used biomarker for the diagnosis of hepatocellular carcinoma (HCC). However, asubstantial proportion of HCC patients have either normal or marginally increased AFP levels in serum, and the underlyingmechanisms are not fully understood. In the present study, we provided in vitro and in vivo evidence that heat shock protein gp96promoted AFP expression at the transcriptional level in HCC. NR5A2 was identified as a key transcription factor for the AFP gene, andits stability was enhanced by gp96. A further mechanistic study by co-immunoprecipitation, GST pull-down, and molecular dockingshowed gp96 and the SUMO E3 ligase RanBP2 competitively binding to NR5A2 at the sites spanning from aa 507 to aa 539. Thebinding of gp96 inhibited SUMOylation, ubiquitination, and subsequent degradation of NR5A2. In addition, clinical analysis of HCCpatients indicated that gp96 expression in tumors was positively correlated with serum AFP levels. Therefore, our study uncovered anovel mechanism that gp96 regulates the stability of its client proteins by directly affecting their SUMOylation and ubiquitination.These findings will help in designing more accurate AFP-based HCC diagnosis and progression monitoring approaches. | Liyuan Qian Zhentao Liang Zihao Wang Jiuru Wang Xin Li Jingmin Zhao Zihai Li Lizhao Chen Yongai Liu Ying Ju Changfei Li Songdong Meng | 2023 | Journal of Molecular Cell Biology2023，15，5： | 0 |
| 10 | National Perinatal Prevalence of Selected Major Birth Defects--China,2010−2018显示文摘Introduction:An estimated of 900,000 infants are born with birth defects each year in China causing a substantial disease burden.This study aimed to depict the epidemiological patterns of selected major birth defects in Chinese perinatal births and provide important baseline data for future prevention.Methods:Data from the Chinese Birth Defects Monitoring Network(CBDMN)during 2010–2018 were used to analyze the epidemiological pattern in the prevalence of 15 major birth defects and the trends over time.Results:In the period of 2010–2018,the top 10 most frequently-occurring birth defects in China included congenital heart diseases(CHDs),polydactyly,cleft lip with or without palate(CL/P),club foot,syndactyly,hydrocephalus,hypospadias,limb reduction defects(LRD),anotia/microtia,and anorectal atresia/stenosis.There was a decrease in the prevalence of neural tube defects,CL/P,hydrocephalus,LRD,gastroschisis,and omphalocele,but there were increases in the prevalence of CHDs,cleft palate,hypospadias,club foot,polydactyly,and syndactyly.The prevalence of most birth defects varied significantly by maternal age,area types(urban/rural),and geographic regions.Conclusions and Implications for Public Health Practice:The findings indicated that the comprehensive prevention of birth defects should focus on these selected birth defects,elderly pregnant women,rural areas,and western regions. | Wenli Xu Changfei Deng Wenyan Li Ke Wang Jing Tao Yuyang Gao Xiaohong Li Yanping Wang Juan Liang Jun Zhu Hanmin Liu Li Dai | 2020 | China CDC weekly2020，2，37： | 0 |
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