|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | Macrobenthos and multi-molecular markers as indicators of environmental contamina- tion in a South American port (Mar del Plata, Southwest Atlantic)显示文摘 | MARIANO J A PAULO DA C L CLAUDIA B | 2013 | Marine Pollution Bulletin2013，73，： | 1 |
| 3 | Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells显示文摘 | Claudia C Gregorio-King Tamara Gough Gavin J Van Der Meer Jane B Hosking Caryll M Waugh Janet L McLeod Fiona Mc Collier Mark A Kirkland | 2004 | Journal of Steroid Biochemistry and Molecular Biology2004，，3： | 1 |
| 4 | Perceived barriers to medicalerror reporting: an exploratory investigation 显示文摘 | Claudia L Uribe Sharon B Schweikhart | 2002 | Joural of Healthcare Management2002，47，4： | 1 |
| 5 | Results of a laboratory experiment relating spectral reflectance to total suspended solids显示文摘 | Carlos A S Evlyn M L Claudia Z F B | 1991 | Remote Sensing of Environment1991，36，： | 1 |
| 6 | Mechanism and efficiency of atrazine degradation under combined oxidation processes 显示文摘 | CLAUDIA L B CARLO P VITTORIO R | 2006 | Applied Catalysis B : Environmental2006，64，： | 1 |
| 7 | The use of mediation and ontology technologies for software component information retrieval显示文摘 | REGINA M M B MARA M CLAUDIA M L W | 2001 | ACM Sigsoft Software Engineering Notes2001，26，3： | 1 |
| 8 | Sono'photocyta-lytic degradation of 2 -chlorophenol in water: kinetic and energetic comparison with other techniques 显示文摘 | Vittorio R Elena S Claudia L B | 2001 | Ultrasonics Sonochemistry2001，8，3： | 1 |
| 9 | Effects of treatment with myo-inositol or its 1,2,6-triphodphate (PP56) on nerve conduction instreptozocin-diabetes显示文摘 | A L Carrington Nigel A Calcutt Claudia B Ettlinger | 1993 | Eur J of Pharmacology1993，237，： | 1 |
| 10 | Uptake and storage of PCBs by plant cuticles 显示文摘 | Claudia M Gareth O T Jonathan L B | 2008 | Environ Sci Technol2008，42，： | 1 |
| 11 | In vitro and in vivo evaluation of a paclitaxel conjugate with the divalent peptide E- that targets integrin αvβ3 显示文摘 | CLAUDIA R HAGIT M S MARTIN L B | 2009 | Int J Pharm2009，368，12： | 1 |
| 12 | The effect of ginkgo biloba in isolated ischemic/reperfused rat heart显示文摘 | Claudia K Giuseppina B Guide L | 2004 | J Cardiovasc Pharmacol2004，44，3： | 1 |
| 13 | S0no-photocatalytic degradation of 2-chlorophenolin water:Kinetic and energetic comparison with other techniques显示文摘 | Vittorio R Elena S Claudia L B | 2001 | Ultrasonics Sono- chemistry2001，8，3： | 1 |
| 14 | Action of sisal (Agave sisalana, Perrine) extract in the in vitro development of sheep and goat gastrointestinal nematodes显示文摘 | ROBERTA X S CAROLINA S C MARIANA B B MARIA J M LUCIANA M K CAMILA 0 C CLAUDIA M L ALEXSANDRO B ELANE A A SIMONE L B MARIA A O | 2012 | Experimental Parasitology2012，13，： | 1 |
| 15 | Application of Fenton's reagent to regenerate activated carbon saturated with organochloro compounds 显示文摘 | Toledo L C Claudia A Silva B | 2003 | Chemosphere2003，50，： | 1 |
| 16 | Sono-photocyta-lytic degradation of 2-chlorophenol in water:Kinetic and energetic comparison with other techniques显示文摘 | Vittorio R Elena S Claudia L B | 2001 | Ultrasonics Sonochemistry2001，8，3： | 1 |
| 17 | Salmonella entetica serovar enteritidis tatB and tatC mutants are impaired in Caco-2 cell invasion in vitro and show reduced systemic spread in chick- ens 显示文摘 | Claudia S M Po-King S L Emil M B | 2010 | Infect Immun2010，78，8： | 1 |
| 18 | Molecular characterization of global maize breeding germplasm based on genome-wide single nucleotide polymorphisms显示文摘 | LU Y L YAN J B CLAUDIA T | 2009 | Theoretical and Applied Genetics2009，120，： | 1 |
| 19 | Mechanism and efficiency of atrazine degration under combined oxidation processes显示文摘 | CLAUDIA L B CARLO P VITTORIO R | 2006 | Applied Catalysis B:Environmental2006，64，： | 1 |
| 20 | Column polarity matrix algorithm for ternary fixed polarity Reed-Muller expansions 显示文摘 | Jaroslaw F B Claudia L C Susanto R | 2006 | Journal of Circuits Systems and Computers2006，15，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员