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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Hydrocompression settlement of deep fills 显示文摘 | Brandon T L Duncan J M Gardner W S | 1990 | ASCE Journal of Geotech Eng1990，116，10： | 1 |
| 3 | Control of texture in Al2O3 by gelcasting 显示文摘 | CARISEY T WERTH A L BRANDON D G | 1995 | J Eur Ceram Soc1995，15，1： | 1 |
| 4 | First human-caused extinction of a cetacean species?显示文摘 | Turvey Samuel T Pitman Robert L Taylor Barbara L Barlow Jay Akamatsu Tomonari Barrett Leigh A Zhao Xiujiang Reeves Randall R Stewart Brent S Wang Kexiong Wei Zhuo Zhang Xianfeng Pusser L.T Richlen Michael Brandon John R Wang Ding | 2007 | Biology Letters2007，，5： | 1 |
| 5 | Construction and instrumentation of geosynthetically stabilized secondary road test sections 显示文摘 | BRANDON T L AL-QADI I L LACINA B A | 1996 | Transportation Research Record: Journal of the Transportation Research Board1996，1534，： | 1 |
| 6 | Control of Texture in Al2O3 by Gelcasting显示文摘 | Werth A L Brandon D C | 1995 | J Europen Ceram Soc1995，，15： | 1 |
| 7 | Control of Texture in A12O3 by Gelcasting显示文摘 | Carisey T Werth A L Brandon D G | 1995 | J Euro Ceram Soc1995，15，： | 1 |
| 8 | Calibration of AFM cantilever spring constants 显示文摘 | Christopher T Gibsona Brandon L Weeksa Chris Abella ea tl | 2003 | Uhramicroscopy2003，97，： | 1 |
| 9 | The commer- cial feasibility of the use of water vapor as a refrigerant 显示文摘 | Brandon F L J Gregory F N Douglas T R | 2007 | International Journal of Refrigeration2007，30，4： | 1 |
| 10 | Control of texture in Al2O3 by gelcasting显示文摘 | CARISEY T WERTH A L BRANDON D G | 1995 | J Europen Ceram Soc1995，，15： | 1 |
| 11 | Adaptive Compensation of the Mud Pump Noise in a Meas- urement- while-- drilling System显示文摘 | Brandon T L Mintchev M P Tabler H | 1999 | SPE Journal1999，4，2： | 1 |
| 12 | Adaptive compensation of the mud pump noise in a measurement while-drilling system 显示文摘 | Brandon T L Mintchev M P Tabler H | 1999 | SPE Journal1999，4，2： | 1 |
| 13 | Construction and Instrumentation of Geosynthetically Stabilized Secondary Road Test Sections显示文摘 | Brandon T L AL-Qadi I L Lacina B A | 1996 | Transportation Research Board1996，1534，： | 1 |
| 14 | Design and test of a 175-Mb/s, rate-1/2 (128,3,6) low-density paritycheck convolutional code encoder and decoder 显示文摘 | SWAMY R BATES S BRANDON T L | 2007 | IEEE Journal of Solid-State Circuits2007，42，10： | 1 |
| 15 | Factors influencing thermal resistivity of sands显示文摘 | BRANDON T L MITCHELL J K | 1989 | Journal of Geoteehnical Engineering1989，115，12： | 1 |
| 16 | Drained and undrained strength interpretation for low-plasticity silts显示文摘 | BRANDON T L ROSE A T DUNCAN J M | 2006 | American Society of Civil Engineers2006，132，2： | 1 |
| 17 | Duloxetine hydrochloride:a new dual-acting medication for the treatment of major depressive disorder显示文摘 | MELANIE E BRANDON T TAWNY L | | 0，，08： | 1 |
| 18 | Multiuser resource allocation optimization using bandwidth-power product in cognitive radio networks显示文摘 | Yahia T Brandon F L Ian F A | 2012 | IEEE Journal on Selected Areas in Communications2012，31，3： | 1 |
| 19 | Construction and instrumentation of geosynthetically sta- bilized secondary road test sections 显示文摘 | BRANDON T L AL-QADI I L LACINA BA | 1996 | Transportation Research Board1996，1534，： | 1 |
| 20 | Experimental study of effects of fore- body geometry on high angle of attack stability显示文摘 | Brandon J M Nguyen L T | 1988 | Journal of Aircraft1988，25，7： | 1 |
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