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| 1 | On the timing and duration of the destruction of the North China Craton显示文摘The timing and duration of the destruction of the North China Craton, which is pivotal to understanding the destruction mechanism and its geodynamic controlling factors, still remain controversial. On the basis of the principles of magma genesis and evolution, first we outline magmatic expressions that can be related to cratonic destruction, then use magmatic and basin evolution trends to constrain the timescale of the lithospheric thinning in North China. The main conclusions include: (1) the thinning of the lithosphere beneath the North China Craton might have started, at least locally, since late Carboniferous-late Triassic, attained its climax during the late Jurassic-early Cretaceous, and continued till the end of late Cretaceous-early Cenozoic. The destruction of the North China Craton was a relatively slow, rather than a dramatic process. (2) The weakened lithospheric zones along the margins and interiors of the craton played an important role in cratonic destruction, partly accounting for the heterogeneous pattern of cratonic destruction. (3) The tectonic factors that controlled the destruction of the North China Craton may be multiple. The late Carboniferous southward subduction of the Paleo-Asian plate and the late Triassic collision between North China and South China may have re-activated the craton by influencing the thermal and integral structure of the craton. The Pacific subduction underneath the eastern Asian continent played a determinant role in the cratonic destruction, governing the distribution patterns of post-Mesozoic basins and major tectonic configuration, temporal change of magmatism and formation of the North-South gravity lineament. | XU YiGang LI HongYan PANG ChongJin HE Bin | 2009 | Chinese Science Bulletin2009，54，19： | 70 |
| 2 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 3 | Hydrogen sulfide ameliorates vascular calcification induced by vitamin D3 plus nicotine in rats显示文摘瞄准:调查内长的胱硫醚 gamma-synthase (CSE ) 的角色在脉管的石灰化的 /hydrogen 硫化物(H2S ) 小径在活体内。方法:脉管的石灰化建模的一只老鼠被维生素 D3 正烟碱(VDN ) 的管理建立。CSE 和 osteopontin (OPN ) 的数量 mRNA 被使用半量的反向抄写的聚合酶链反应决定。钙内容, 45Ca2+ 累积和硷性磷酸酯酶(高山) 活动被测量。H2S 生产和 CSE 活动被测量。结果:染色的 von Kossa 生产了在钙化的主动脉在中间的层的弹性纤维之中在区域染色的强壮的积极黑 / 棕色。分别地,在钙化的动脉的钙内容, 45Ca2+ 累积和高山活动与控制相比由 6.77- , 1.42- ,和 1.87 褶层增加了。OPN 基因的表示起来调整(P<0.01 ) 。基因低是的 CSE 的表示调整了。然而,在 VDN 正 NaHS 的钙内容, 45Ca2+ 举起和高山活动组织在 VDN 组是比那低的。钙和45Ca2+累积和在主动脉的高山的活动的内容是34.8%,40.75%和63.5%比在 VDN 组在低剂量的 NaHS 组降低,分别地( P<0.01 ),并且45Ca2+的钙内容和高山的活动是83.9%, 37.8 %并且46.2%比在 VDN 组在高剂量的 NaHS 组在主动脉降低,分别地( P<0.01 )。基因低是的 OPN 的表示调整了。结论:H2S 的生产,和 CSE 活动被减少, CSE 基因表示低与脉管的石灰化在老鼠调整了。H2S 能改善脉管的石灰化,建议 H2S/CSE 小径在脉管的石灰化的致病起一个规章的作用。 | Sheng-ying WU Chun-shui PAN Bin GENG Jing ZHAO Fang YU Yong-zheng PANG Chao-shu TANG Yong-fen QI | 2006 | Acta Pharmacologica Sinica2006，27，3： | 29 |
| 4 | Subcellular Cd accumulation characteristic in root cell wall of rice cultivars with different sensitivities to Cd stress in soil显示文摘The variations of grain cadmiun(Cd) concentrations, translocation factors(TFs) of Cd from roots to shoots/grains of six rice cultivars, characterized with different Cd-sensitivities in polluted soil were studied, the selected rice cultivars were Xiangzao 17(R1), Jiayu 211(R2), Xiangzao 42(R3), Zhuliangyou 312(R4), Zhuliangyou 611(R5), and Jinyou 463(R6), respectively. The Cd subcellular distribution and Cd binding characteristics on subcellular fractions of rice root cell wall(CW) were further investigated. The results showed that the rice grain Cd contents varied significantly, with a maximum variation of 47.0% among the cultivars, the largest grain Cd content was observed with cultivar R1(Cd-sensitivity cultivar) and the smallest with R5(Cd-tolerance cultivar). The translocation factors of Cd from roots to shoots(TF_(shoot)) and roots to grains(TF_(grain)) varied greatly among the cultivars. In general, the TFgrain of the cultivars followed the order of R1>R2>R3>R4> R6-R5. The Cd concentration(mg kg^(–1) FW) in the fraction of root CW, the fraction of cell wall removing pectin(CW-P) and the fraction of cell wall removing pectin and hemicellulose(CW-P-HC) of the cultivars generally followed the order of CW-P>CW>CWP-HC; the ratios of Cd concentration(mg kg–1 FW) in the fraction of CW-P to that of CW were mostly more than 1.10, while the ratios of Cd concentration in the fraction of CW-P-HC to that of CW were mostly less than 0.60, indicating that Cd was mainly stored in the hemicellulose of the root CW. The ratios of Cd of CW-P-HC to CW generally followed the descending order of R1~R2>R3>R4>R5~R6 for the cultivars, which implied that hemicellulose is probably the main subcellular pool for transferring Cd into rice grain, and it restrains the translocation of Cd from shoot to the grain, especially for the Cd-tolerance cultivars(R5 and R6), the compartmentation of more Cd in hemicellulose in root CW is probably one of the main mechanisms for Cd tolerance of rice cultivars. | LIU Bin CHEN Li CHEN Shi-bao LI Ning ZHENG Han JIN Ke PANG Huan-cheng MA Yi-bing | 2016 | Journal of Integrative Agriculture2016，15，9： | 13 |
| 5 | Lentivirual vector-mediated doxycycline-inducible iASPP gene targeted RNA interference in hepatocellular carcinoma显示文摘Background and Objective:iASPP, an inhibitory member of the apoptosis-stimulating proteins of p53 (ASPP) family, has been found to be up-regulated in various human tumor types.This study was to construct an efficient doxycycline-regulated, lentiviral vector-mediated knockdown system for iASPP that will allow for inducible down-regulation of iASPP gene expression and preliminary functional analysis.Methods:A pair of complementary oligos with hairpin structures targeting the iASPP gene and a negative control were synthesized, then ligated with pLVTHM vector and sequenced.The fragment containing the shRNA cassette was cloned to pLVCT-tTR-KRAB plasmid.The recombinant vectors were co-transfected with viral packaging mix into 293T cells, and viral supernatant was harvested to determine the titer.After treatment with or without doxycycline, HepG2 cells infected with virus were harvested and the expression of iASPP was detected by reverse transcription-polymerase chain reaction (RT-PCR) and Western blot analysis.Its effects on tumor growth were characterized using MTS assay, soft agar colony formation, and flow cytometry analysis.Results:The lentiviral vector expressing shRNA that targets to the oncogene iASPP was constructed successfully.HepG2 infected with the lentivirus expressing shRNA against iASPP inhibited the expression of iASPP in the presence of doxycycline, which resulted in the repression of tumor cell proliferation and anchorage-independent growth potential.Conclusions:The lentiviral vector-mediated tet-on system demonstrates efficient and inducible knockdown of iASPP in hepatocellular carcinoma cells.iASPP gene may be involved in tumorigenesis and progression of human tumors. | Ming-Shu Pang Xia Chen Bin LU Jian Zhao Bo-Hua Li Yu-Quan Wei Ya-Jun GUO | 2010 | Chinese Journal of Cancer2010，29，9： | 11 |
| 6 | Human umbilical cord mesenchymal stem cells to treat spinal cord injury in the early chronic phase: study protocol for a prospective, multicenter, randomized, placebo-controlled, single-blinded clinical trial显示文摘Human umbilical cord mesenchymal stem cells(hUC-MSCs)support revascularization,inhibition of inflammation,regulation of apoptosis,and promotion of the release of beneficial factors.Thus,they are regarded as a promising candidate for the treatment of intractable spinal cord injury(SCI).Clinical studies on patients with early chronic SCI(from 2 months to 1 year post-injury),which is clinically common,are rare;therefore,we will conduct a prospective,multicenter,randomized,placebo-controlled,single-blinded clinical trial at the Third Affiliated Hospital of Sun Yat-sen University,West China Hospital of Sichuan University,and Shanghai East Hospital,Tongji University School of Medicine,China.The trial plans to recruit 66 early chronic SCI patients.Eligible patients will undergo randomization at a 2:1 ratio to two arms:the observation group and the control group.Subjects in the observation group will receive four intrathecal transplantations of stem cells,with a dosage of 1×106/kg,at one calendar month intervals.Subjects in the control group will receive intrathecal administrations of 10 mL sterile normal saline in place of the stem cell transplantations.Clinical safety will be assessed by the analysis of adverse events and laboratory tests.The American Spinal Injury Association(ASIA)total score will be the primary efficacy endpoint,and the secondary efficacy outcomes will be the following:ASIA impairment scale,International Association of Neural Restoration-Spinal Cord Injury Functional Rating Scale,muscle tension,electromyogram,cortical motor and cortical sensory evoked potentials,residual urine volume,magnetic resonance imaging–diffusion tensor imaging,T cell subtypes in serum,neurotrophic factors and inflammatory factors in both serum and cerebrospinal fluid.All evaluations will be performed at 1,3,6,and 12 months following the final intrathecal administration.During the entire study procedure,all adverse events will be reported as soon as they are noted.This trial is designed to evaluate the clinical safety and efficacy of subarachnoid transplantation of hUC-MSCs to treat early chronic SCI.Moreover,it will establish whether cytotherapy can ameliorate local hostile microenvironments,promote tracking fiber regeneration,and strengthen spinal conduction ability,thus improving overall motor,sensory,and micturition/defecation function in patients with early chronic SCI.This study was approved by the Stem Cell Research Ethics Committee of the Third Affiliated Hospital of Sun Yat-sen University,China(approval No.[2018]-02)on March 30,2018,and was registered with ClinicalTrials.gov(registration No.NCT03521323)on April 12,2018.The revised trial protocol(protocol version 4.0)was approved by the Stem Cell Research Ethics Committee of the Third Affiliated Hospital of Sun Yat-sen University,China(approval No.[2019]-10)on February 25,2019,and released on ClinicalTrials.gov on April 29,2019. | Yang Yang Mao Pang Yu-Yong Chen Liang-Ming Zhang Hao Liu Jun Tan Bin Liu Li-Min Rong | 2020 | Neural Regeneration Research2020，15，8： | 9 |
| 7 | Association Between Serum Uric Acid and Prevalence of Type 2 Diabetes Diagnosed using HbA1c Criteria Among Chinese Adults in Qingdao,China显示文摘Objective To determine whether elevated serum uric acid(UA)levels are associated with type 2 diabetes diagnosed using Hb A1 c levels among Chinese adults.Methods We conducted two population-based cross-sectional studies in Qingdao in China in 2006 and 2009.A total of 6894(39.4% men)subjects aged 35-74 years were included in the data analysis.Newly diagnosed diabetes was defined as Hb A1 c level of ≥6.5%,and prediabetes was classified as Hb A1 c level between 5.7% and 6.4% according to the International Diabetes Federation criteria.Multivariate logistic regression was employed to assess the association between UA and prevalence of type 2 diabetes defined using Glycated hemoglobin A1c(Hb A1 c levels.Results Subjects with prediabetes had higher UA levels than those with normal glucose tolerance,newly diagnosed diabetes,and known diabetes,with corresponding values of 325.1(82.5)μmol/L,310.9(84.2)μmol/L,291.3(81.7)μmol/L,305.2(83.6)μmol/L,respectively(P<0.001 for all comparisons).Binary logistic regression analysis showed that UA was a possible predictor for the prevalence of type 2 diabetes diagnosed using Hb A1 c levels,and the second quartile of UA levels had a higher odds ratio(OR:4.088;95% CI:2.900-5.765)for Hb A1 c than the other quartiles after adjusting for age,body mass index,sex,marital status,education,income,alcohol consumption,smoking,and cardiometabolic parameters.Conclusion Serum UA is significantly associated with type 2 diabetes diagnosed using Hb A1 c levels,independent of other cardiometabolic parameters. | XUE Bai TAN Ji Bin NING Feng SUN Jian Ping ZHANG Ke Yi LIU Li WANG Shao Jie ZHANG Dong Feng QIAO Qing PANG Zeng Chang | 2015 | Biomedical and Environmental Sciences2015，28，12： | 9 |
| 8 | Electroacupuncture at ST25 inhibits jejunal motility:Role ofsympathetic pathways and TRPV1显示文摘AIM: To investigate whether electroacupuncture(EA) at ST25 affects jejunal motility in vivo and if so, whether a sympathetic pathway is involved.METHODS: Jejunal motility was assessed using a manometric balloon placed in the jejunum approximately about 3-5 cm away from the suspensory ligament of the duodenum in anesthetized animals. The effects of EA at ST25 were measured in male Sprague-Dawley rats, some of which were treated with propranolol or clenbuterol(EA intensities: 1, 3, 5, 7, and 9 m A), and in male transient receptor potential vanilloid-1(TRPV1)(capsaicin receptor) knockout mice(EA intensities: 1, 2, and 4 m A).RESULTS: Anesthetized rats exhibited three types of fasting jejunal motor patterns(types A, B, and C), and only type C rats responded to EA stimulation. In type C rats, EA at ST25 significantly suppressed the motor activity of the jejunum in an intensity-dependent manner. The inhibitory effect of EA was weakened by propranolol(β adrenoceptor antagonist) and disappeared with clenbuterol(β adrenoceptor agonist) induced inhibition of motility, suggesting that the effect of EA on motility is mediated via a sympathetic pathway. Compared with wild-type mice, EA at ST25 was less effective in TRPV1 knockout mice, suggesting that this multi-modal sensor channel participates in the mechanism. CONCLUSION: EA at ST25 was found to inhibit jejunal motility in an intensity-dependent manner, via a mechanism in which sympathetic nerves and TRPV1 receptors play an important role. | Zhi Yu Na Zhang Chun-Xia Lu Ting-Ting Pang Kai-Yue Wang Jing-Feng Jiang Bing Zhu Bin Xu | 2016 | World Journal of Gastroenterology2016，22，5： | 9 |
| 9 | The R2R3-MYB transcription factor GhMYB1a regulates flavonol and anthocyanin accumulation in Gerbera hybrida显示文摘Anthocyanins and flavonols have vital roles in flower coloration,plant development,and defense.Because anthocyanins and flavonols share the same subcellular localization and common biosynthetic substrates,these pathways may compete for substrates.However,the mechanism regulating this potential competition remains unclear.Here,we identified GhMYB1a,an R2R3-MYB transcription factor involved in the regulation of anthocyanin and flavonol accumulation in gerbera(Gerbera hybrida).GhMYB1a shares high sequence similarity with that of other characterized regulators of flavonol biosynthesis.In addition,GhMYB1a is also phylogenetically grouped with these proteins.The overexpression of GhMYB1a in gerbera and tobacco(Nicotiana tabacum)resulted in decreased anthocyanin accumulation and increased accumulation of flavonols by upregulating the structural genes involved in flavonol biosynthesis.We further found that GhMYB1a functions as a homodimer instead of interacting with basic helix-loop-helix cofactors.These results suggest that GhMYB1a is involved in regulating the anthocyanin and flavonol metabolic pathways through precise regulation of gene expression.The functional characterization of GhMYB1a provides insight into the biosynthesis and regulation of flavonols and anthocyanins. | Chunmei Zhong Yi Tang Bin Pang Xukun Li Yuping Yang Jing Deng Chengyong Feng Lingfei Li Guiping Ren Yaqin Wang Jianzong Peng Shulan Sun Shan Liang Xiaojing Wang | 2020 | Horticulture Research2020，7，1： | 7 |
| 10 | Herbal medicine in the treatment of patients with type 2 Jiabetes mellitus显示文摘Introduction Type 2 diabetes mellitus (T2DM)is a type of metabolic disease caused by metabolic disorders in the endocrine system and characterized by hyperglycemia.Insufficient insulin secretion and insulin resistance are the basic pathologic characteristics of T2DM. | Guo-Ming Pang Fang-Xu Li Yong Yan Yin Zhang Li-Li Kong Pu Zhu Kai-Feng Wang Fang Zhang Bin Liu Cheng LU | 2019 | Chinese Medical Journal2019，，1： | 6 |
| 11 | A Method for Detection of Main Metabolites in Aromatic Rice Seeds显示文摘[Objective] A method was developed for the analysis of main metabolites in aromatic rice seeds by gas chromatography-mass spectrometry( GC-MS).[Method]The main metabolites in seeds of 9 different aromatic rice varieties were compared and analyzed with two methods. Method 1: the compound was extracted by the mixture of anhydrous ethanol and methylene chloride( V/V = 1∶ 1) at 60 ℃ for 3 h in water bath; the extract was isolated and detected by gas chromatography-mass spectrometry using HP-5 capillary column with scan monitoring mode. Method 2: the main metabolites in aromatic rice seeds were detected using headspace solid phase micro-extraction and gas chromatography mass spectrometry( GC-MS). [Result]Fifteen types of common metabolites were found in 9 different aromatic rice varieties. Method 1 was more effective than method 2 in detecting the main metabolites in aromatic rice seeds. [Conclusion]This study provides an important reference for clarifying the metabolic pathway of main metabolites in aromatic rice and lays the foundation for further rice breeding. | Bo PENG Dongyan KONG Xiaohua SONG Huilong LI Lulu HE Andong GONG Yanfang SUN Ruihua PANG Lin LIU Jintao LI Qiying ZHOU Yaqin HUANG Bin DUAN Shizhi SONG Hongyu YUAN | 2018 | Agricultural Biotechnology2018，7，1： | 6 |
| 12 | Seismic performance assessment of high CFRDs based on fragility analysis显示文摘Due to a large number of high concrete face rockfill dams(CFRDs) being constructed, the seismic safety is crucially important and seismic performance assessment must be performed for such dams. Fragility analysis is a method of great vitality for seismic performance assessment; it can intuitively forecast the structural effects of different ground motion intensities and provide an effective path for structure safety assessment. However, this method is rarely applied in the field of high earth dam risk analysis.This paper introduces fragility analysis into the field of high CFRD safety assessment and establishes seismic performance assessment methods. PGA, Sa(T1, 5%), PGV and PGD are exploited as the earthquake intensity measure(IMs). Relative settlement ratio of dam crest, cumulative sliding displacement of dam slope stability and a new face-slab destroying index(based on DCR and COD) are regarded as the dam damage measures(DMs). The dividing standards of failure grades of high CFRDs are suggested based on each DM. Fragility function is estimated according to incremental dynamic analysis(IDA) and multiple stripes analysis(MSA) methods respectively from a large number of finite element calculations of a certain CFRD, and seismic fragility curves are determined for each DM. Finally, this study analyzes the failure probabilities of the dam under different earthquake intensities and can provide references and bases for the seismic performance design and safety risk assessment of high CFRDs. | PANG Rui XU Bin ZOU DeGao KONG XianJing | 2019 | Science China(Technological Sciences)2019，62，4： | 6 |
| 13 | Biliverdin Protects the Isolated Rat Lungs from Ischemia-reperfusion Injury via Antioxidative, Anti-inflammatory and Anti-apoptotic Effects显示文摘 | Wen-Fang Tian Ping Weng Qiong Sheng Jun-Liang Chen Peng Zhang Ji-Ru Zhang Bin Du Min-Chen Wu Qing-Feng Pang Jian-Jun Chu | 2017 | Chinese Medical Journal2017，，7： | 5 |
| 14 | Dose optimization of intrathecal administration of human umbilical cord mesenchymal stem cells for the treatment of subacute incomplete spinal cord injury显示文摘Human umbilical cord mesenchymal stem cells(hUC-MSCs)are a promising candidate for spinal cord injury(SCI)repair owing to their advantages of low immunogenicity and easy accessibility over other MSC sources.However,modest clinical efficacy hampered the progression of these cells to clinical translation.This discrepancy may be due to many variables,such as cell source,timing of implantation,route of administration,and relevant efficacious cell dose,which are critical factors that affect the efficacy of treatment of patients with SCI.Previously,we have evaluated the safety and efficacy of 4×10^(6) hUC-MSCs/kg in the treatment of subacute SCI by intrathecal implantation in rat models.To search for a more accurate dose range for clinical translation,we compared the effects of three different doses of hUC-MSCs-low(0.25×10^(6) cells/kg),medium(1×10^(6) cells/kg)and high(4×10^(6) cells/kg)-on subacute SCI repair through an elaborate combination of behavioral analyses,anatomical analyses,magnetic resonance imaging-diffusion tensor imaging(MRI-DTI),biotinylated dextran amine(BDA)tracing,electrophysiology,and quantification of mRNA levels of ion channels and neurotransmitter receptors.Our study demonstrated that the medium dose,but not the low dose,is as efficient as the high dose in producing the desired therapeutic outcomes.Furthermore,partial restoration of theγ-aminobutyric acid type A(GABAA)receptor expression by the effective doses indicates that GABAA receptors are possible candidates for therapeutic targeting of dormant relay pathways in injured spinal cord.Overall,this study revealed that intrathecal implantation of 1×10^(6) hUC-MSCs/kg is an alternative approach for treating subacute SCI. | Ting-Ting Cao Huan Chen Mao Pang Si-Si Xu Hui-Quan Wen Bin Liu Li-Min Rong Mang-Mang Li | 2022 | Neural Regeneration Research2022，17，8： | 5 |
| 15 | A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer显示文摘Objective:To compare the efficacy and safety of hyperthermic intravesical chemotherapy(HIVEC)and intravesical chemotherapy(IVEC)in patients with intermediate and high risk nonmuscle-invasive bladder cancer(NMIBC)after transurethral resection.Methods:We included 560 patients diagnosed with primary or recurrent NMIBC between April 2009 and December 2015 at 1 of 6 tertiary centers.We matched 364 intermediate or high risk cases and divided them into 2 groups:the HIVEC+IVEC group[chemohyperthermia(CHT)composed of 3 consecutive sessions followed by intravesical instillation without hyperthermia]and the IVEC group(intravesical instillation without hyperthermia).The data were recorded in the database.The primary endpoint was 2-year recurrence-free survival(RFS)in all NMIBC patients(n=364),whereas the secondary endpoints were the assessment of radical cystectomy(RC)and 5-year overall survival(OS).Results:There was a significant difference in the 2-year RFS between the two groups in all patients(n=364;HIVEC+IVEC:82.42%vs.IVEC:74.18%,P=0.038).Compared with the IVEC group,the HIVEC+IVEC group had a lower incidence of RC(P=0.0274).However,the 5-year OS was the same between the 2 groups(P=0.1434).Adverse events(AEs)occurred in 32.7%of all patients,but none of the events was serious(grades 3–4).No difference in the incidence or severity of AEs between each treatment modality was observed.Conclusions:This retrospective study showed that HIVEC+IVEC had a higher 2-year RFS and a lower incidence of RC than IVEC therapy in intermediate and high risk NMIBC patients.Both treatments were well-tolerated in a similar manner. | Qiang Ruan Degang Ding Bin Wang Chaohong He Xuequn Ren Zhenhua Feng Zhigang Pang Jin Wang Xiangliang Zhang Hongsheng Tang Jiahong Wang Qingjun He Ziying Lei Quanxing Liao Jiali Luo Shuzhong Cui | 2021 | Cancer Biology & Medicine2021，18，1： | 4 |
| 16 | The Effect of Boron on the Properties of Glucomannan: An Experimental and Molecular Dynamics Simulation Study显示文摘The effect of boron on the properties of Konjac Glucomanan (KGM) has been investigated by the method of experiment and molecular dynamic simulation. Upon analysis, the property and structure of KGM are apt to be affected by boron and structural reasons for property change were discussed. In detail, the addition low concentration borax can increase the systematic inherent viscosity, by contrast, high concentration borax has opposite effect on the viscosity. When adding borax, the micropores on KGM film surface decrease or disappear, leading to more compact and uniform on the film surface. The structure of KGM-Boron complex is described as the coor- dination reaction between KGM and boron. The main reaction points are hydroxyl group on C(6) position of sugar as well as those on C(2) and C(3) positions of mannose with two kinds of com- plexes formation: B-K2 and KB-K. And KB-K mainly consists of g-b-m. | PANG Jie SUN Yu-Jing LI Bin TIAN Shi-Ping CHEN Shao-Jun | 2005 | Chinese Journal of Structural Chemistry2005，24，12： | 4 |
| 17 | A potential red-emitting phosphor Ca_(2)YTaO_(6):Eu^(3+):Luminescence properties,thermal stability and applications for white LEDs显示文摘A novel red-emitting phosphor tantalate Ca_(2)YTaO_(6):Eu^(3+)was synthesized by a solid-state reaction.The purity and surface morphology of the phosphors were characterized.The Ca_(2)YTaO_(6):Eu^(3+)phosphors show a sharp emission peak at 612 nm under near-ultraviolet(n-UV) at 395 nm because of the ^(5)D0→^(7)F_(2) transition of Eu^(3+).The optimal Eu^(3+)doping concentration in Ca_(2)YTaO_(6) is 40 mol% and the critical energy-transfer distance of Eu^(3+)ions was calculated to be 0.9 nm.The emission spectra of Ca_(2)YTaO_(6):Eu_(3+)from 300 to 480 K were investigated.The thermal-quenching temperature(T_(0.5)) of Ca_(2)YTaO_(6):Eu^(3+)is above 480 K.The color purity of Ca_(2)YTaO_(6):40 mol%Eu^(3+)is as high as 99.8%.The luminescence lifetime of Ca_(2)YTaO_(6):40 mol%Eu^(3+)was also discussed.The high color purity and high thermal stability of Eu^(3+)-doped Ca_(2)YTaO_(6) phosphors contribute to its application value in white lightemitting diodes(w-LEDs). | Ka Ding Siru A Shuo Pang Leyan Shan Yaqi Zhang Pengfei Sun Bin Deng Ruijin Yu | 2021 | Journal of Rare Earths2021，39，7： | 4 |
| 18 | Fluorescent silicon nanoparticle-based gene carriers featuring strong photostability and feeble cytotoxicity显示文摘安全荧光灯 gene-transfection 向量在对基本生物应用并且为基因治疗研究的大需求。这里,我们介绍基于的光硅 nanoparticle (SiNP ) 的一种新类型对以一种长期、即时的方式决定基因车辆的细胞内部的命运合适的基因搬运人。介绍基于 SiNP 的 nanocarriers 同时展示强壮、稳定的荧光,高装载 DNA 能力和 gene-transfection 效率,以及有利 biocompatibility。利用这些唯一的好处,我们能乐意地在实时房间观察基因搬运人的行为(例如细胞的举起,细胞内部的 trafficking,和 endosomal 逃跑) 以一种长期、即时的方式。结果表明这些的潜在的可用性荧光灯是的基于 SiNP 的基因向量基因治疗的领域里的强大的工具,并且为理解基因搬运人的细胞内部的行为提供无价的信息。 | Jingyang Pang Yuanyuan Su Yiling Zhong Fei Peng Bin Song Yao He | 2016 | Nano Research2016，9，10： | 4 |
| 19 | Effects of Cerium on Microstructures and Mechanical Properties of Zn-22%Al Vibration Damping Alloy显示文摘Using natural aging and artificial aging treatment, the effects of cerium on microstructures and mechanical properties of Zn 22%Al vibration damping alloy were studied by optical microscope, transmission electron microscope and scanning electron microscope. The results show that cerium can refine the microstructure of Zn 22%Al alloy, slow the grain growth and retain the equiaxial degree during aging. The strength of Zn 22%Al (0 07%~0 20%)Ce alloy and Zn 22%Al alloy remains constant after aging below the hot rolling temperature of 80 ℃, and cerium can improve the strength and the stability of mechanical properties of Zn 22%Al alloy. | PANG Shao ping, SHI Yun bao, LI Jun, YANG Bin jiu, QUAN Mei hua, QIAO Yan hui, ZHANG Chi zhong (College of Mechanical Engineering, Beihua University, Jilin 132021, China) | 2000 | Journal of Rare Earths2000，18，4： | 3 |
| 20 | Lake evolution and its implication for environmental changes in China during 1950-2000显示文摘Lakes in China have undergone considerable environmental changes during the past 50 years,e.g. lake level,water area changes,as did in the past several thousands years. The enhanced human activities,such as land reclamation,application of chemical fertilizer,land use and cover,irrigation and industrialization in the catchment etc.,have played an im-portant role on the recent decades’ changes of these lakes,although constrained to a great extent by the natural impact. Comparative study on variations of lake volume (water level,depth and area) in the eastern and western lake regions of China during 1950–2000 indicated that,lake volume in the eastern region had approximately undergone a two-stage change,i.e. a dramatic decrease from the 1950s to 1970s,and a continuous increase between the 1980s and 1990s; while,in the western region,lake volume had been decreasing nearly all the time. Further studies on some typical lakes concluded that,climatic change was a primary factor for the variations of lake volume during the past 50 years,although human activities showed important effect. | HUANG Zhihua XUE Bin YAO Shuchun PANG Yong | 2008 | Journal of Geographical Sciences2008，18，2： | 2 |
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