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| 1 | Current management strategy of hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) still remains a considerable challenge for surgeons.Surgery,including liver transplantation,is the most important therapeutic approach for patients with this disease.HCC is frequently diagnosed at advanced stages and has a poor prognosis with a high mortality rate even when surgical resection has been considered potentially curative.This brief report summarizes the current status of the management of this malignancy and includes a short description of new pharmacological approaches in HCC treatment. | Bernardino Rampone Beniamino Schiavone Antonio Martino Carmine Viviano Giuseppe Confuorto | 2009 | World Journal of Gastroenterology2009，15，26： | 50 |
| 2 | Prevalence of bile reflux in gastroesophageal reflux disease patients not responsive to proton pump inhibitors显示文摘AIM:To determine the prevalence and characteristics of bile reflux in gastroesophageal reflux disease(GERD) patients with persistent symptoms who are non-responsive to medical therapy.METHODS:Sixty-five patients(40 male,25 female;mean age,50 ± 7.8 years) who continued to report symptoms after 8 wk of high-dose proton pump inhibitor(PPI) therapy,as well as 18 patients with Barrett's esophagus,were studied.All patients filled out symptom questionnaires and underwent endoscopy,manometry and combined pH-metry and bilimetry.RESULTS:There were 4 groups of patients:22(26.5%) without esophagitis,24(28.9%) grade A-B esophagitis,19(22.8%) grade C-D and 18(21.6%) Barrett's esophagus.Heartburn was present in 71 patients(85.5%) and regurgitation in 55(66.2%),with 44(53%) reporting simultaneous heartburn and regurgitation.The prevalence of pathologic acid reflux in the groups without esophagitis and with grades A-B and C-D esophagitis was 45.4%,66.6% and 73.6%,respectively.The prevalence of pathologic bilirubin exposure in these 3 groups was 53.3%,75% and 78.9%,respectively.The overall prevalence of bile reflux in non-responsive patients was 68.7%.Pathologic acid and bile reflux was observed in 22.7% and 58.1% of non-esophagitic patients and esophagitic patients,respectively.CONCLUSION:The high percentage of patients poorly responsive to PPI therapy may result from poor control of duodenogastroesophageal reflux.Many patients without esophagitis have simultaneous acid and bile reflux,which increases with increasing esophagitis grade. | Luigi Monaco Antonio Brillantino Francesco Torelli Michele Schettino Giuseppe Izzo Angelo Cosenza Natale Di Martino | 2009 | World Journal of Gastroenterology2009，15，3： | 8 |
| 3 | Laparoscopic approach to Meckel's diverticulum显示文摘AIM: To retrospective review the laparoscopic management of Meckel Diverticulum(MD) in two Italian Pediatric Surgery Centers.METHODS: Between January 2002 and December 2012, 19 trans-umbilical laparoscopic-assisted(TULA) procedures were performed for suspected MD. The children were hospitalized for gastrointestinal bleeding and/or recurrent abdominal pain. Median age at diagnosis was 5.4 years(range 6 mo-15 years). The study included 15 boys and 4 girls. All patients underwent clinical examination, routine laboratory tests, abdominal ultrasound and technetium-99m pertechnetate scan, and patients with bleeding underwent gastrointestinal endoscopy. The abdominal exploration was performed with a 10 mm operative laparoscope. Pneumoperitoneum was establishedbased on the body weight. Systematic overview of the peritoneal cavity allowed the ileum to be grasped with an atraumatic instrument. The complete exploration and surgical treatment of MD were performed extracorporeally, after intestinal exteriorization through the umbilicus. All patients' demographics, main clinical features, diagnostic investigations, operative time, histopathology reports, conversion rate, hospital stay and complications were registered and analyzed.RESULTS: MD was identified in 17 patients, while 1 had an ileal duplication and 1 a jejunal hemangioma. Fifteen patients had painless intestinal bleeding, while 4 had recurrent abdominal pain and exhibited cyst like structures in an ultrasound study. Eleven patients had a positive technetium-99m pertechnetate scan. In the patients with bleeding, gastrointestinal endoscopy did not name the source of hemorrhage. All patients were subjected to a TULA surgical procedure. An intestinal resection/anastomosis was performed in 14 patients, while 4 had a wedge resection of the diverticulum and 1 underwent stapling diverticulectomy. All surgical procedures were performed without conversion to open laparotomy. Mean operative time was 75 min(range 40-115 min). No major surgical complications were recorded. The median hospital stay was 5-7 d(range 4-13 d). All patients are asymptomatic at a median follow up of 4, 5 years(range 10 mo-10 years).CONCLUSION: Trans-umbilical laparoscopic-assisted Meckel's diverticulectomy is safe and effective in the treatment of MD, with excellent results. | Alfonso Papparella Fabiano Nino Carmine Noviello Antonio Marte Pio Parmeggiani Ascanio Martino Giovanni Cobellis | 2014 | World Journal of Gastroenterology2014，20，25： | 7 |
| 4 | Adenocarcinoma of gastric cardia in the elderly: Surgical problems and prognostic factors显示文摘AIM: To analyze retrospectively, our results about patients who underwent surgical treatment for adenocarcinoma of the cardia in relation to age, in order to evaluate surgical problems and prognostic factors.METHODS: From January 1987 to March 2003, 140 patients with adenocarcinoma of the cardia underwent resection in the authors' institution. They were divided into three groups with regard to age. Patients <70 and >60 year old (31) were excluded; we also excluded 18 out of 109 patients with poor general status or systemic metastases. So, we compared 51 elderly (≥ 70 year old)and 58 younger patients (≤ 60 year old). The treatment was esophagectomy for type Ⅰ tumors, and extended gastrectomy and distal esophagectomy for type Ⅱ and Ⅲ lesions.RESULTS: Laparotomy was carried out in 91 patients (83.4%), 38 in the elderly (74.5%) and 53 in younger patients (91.3%, P<0.05). Primary resection was performed in 811 cases (89%) without significant differences between the two groups. Postoperative death was higher in the elderly (12.1%) than the other group (4.1%, P<0.05), while morbidity was similar in both groups. A curative resection (R0) was performed in 59 patients (72.8%), 69.6% in the elderly and 75% in the younger group (P>0.05). The overall 3- and 5-year survival rates were 26.7% and 117.8% respectively for the elderly and 40.7% and 35.1% respectively for younger patients (P = 0.1544). Survival rates were significantly associated with R0 resection,pathological node-positive category and tumor differentiation in both groups.CONCLUSION: As the age of the general population increases, more elderly patients with gastric cardia cancer will be candidates for surgical resection. Age alone should not preclude surgical treatment in elderly patients with gastric cardia cancer and a tumor resection can be carried out safely. Certainly, we should take care in defining the surgical treatment in elderly patients, particularly as regarding the surgical approach; although the surgical approach does not influence the survival rate, the transhiatal way still remains the best one due, to the lower incidence of respiratory morbidity and thoracic pain. | Natale Di Martino Giuseppe Izzo Angelo Cosenza Guido Cerullo Francesco Torelli Antonio Brillantino Alberto del Genio | 2005 | World Journal of Gastroenterology2005，11，33： | 5 |
| 5 | Laparoscopic calibrated total vs partial fundoplication following Heller myotomy for oesophageal achalasia显示文摘AIM:To compare the mid-term outcomes of laparoscopic calibrated Nissen-Rossetti fundoplication with Dor fundoplication performed after Heller myotomy for oesophageal achalasia.METHODS:Fifty-six patients(26 men,30 women;mean age 42.8±14.7 years)presenting for minimally invasive surgery for oesophageal achalasia,were enrolled.All patients underwent laparoscopic Heller myotomy followed by a 180°anterior partial fundoplication in 30 cases(group 1)and calibrated NissenRossetti fundoplication in 26(group 2).Intraoperative endoscopy and manometry were used to calibrate the myotomy and fundoplication.A 6-mo follow-up period with symptomatic evaluation and barium swallow was undertaken.One and two years after surgery,the patients underwent symptom questionnaires,endoscopy,oesophageal manometry and 24 h oesophago-gastric pH monitoring.RESULTS:At the 2-year follow-up,no significant difference in the median symptom score was observed between the 2 groups(P=0.66;Mann-WhitneyU-test).The median percentage time with oesophageal pH< 4 was significantly higher in the Dor group compared to the Nissen-Rossetti group(2;range 0.8-10 vs 0.35;range 0-2)(P<0.0001;Mann-WhitneyU-test).CONCLUSION:Laparoscopic Dor and calibrated Nissen-Rossetti fundoplication achieved similar results in the resolution of dysphagia.Nissen-Rossetti fundoplication seems to be more effective in suppressing oesophageal acid exposure. | Natale Di Martino Antonio Brillantino Luigi Monaco Luigi Marano Michele Schettino Raffaele Porfidia Giuseppe Izzo Angelo Cosenza | 2011 | World Journal of Gastroenterology2011，17，29： | 4 |
| 6 | Current role of hyperthermic intraperitoneal chemotherapy in the treatment of peritoneal carcinomatosis from colorectal cancer显示文摘Peritoneal carcinomatosis is one of the most common routes of dissemination of colorectal cancer (CRC). It is encountered in 7% of patients at primary surgery, while it develops in about 4% to 19% of patients after curative surgery and in up to 44% of patients with recurrent CRC. Peritoneal involvement from colorectal malignancies has been considered traditionally as a manifestation of terminal disease, due to limited response to conventional surgical and chemotherapeutic treatments. In the past few years the introduction of cytoreductive surgery combined with hyperthermic intraperitoneal chemoperfusion has shown promising results in selected patients. Currently, the surgical management of peritoneal surface malignancies of colonic origin with this combined locoregional therapy has resulted in a signif icant improvement in survival of these patients. However, further controlled studies will help to standardize indications and the technique of this locoregional therapy in order to achieve an improvement of morbidity and mortality rates. | Bernardino Rampone Beniamino Schiavone Antonio Martino Giuseppe Confuorto | 2010 | World Journal of Gastroenterology2010，16，11： | 4 |
| 7 | Investigation of compensatory postures with videofluoromanometry in dysphagia patients显示文摘AIM: To investigate the effectiveness of head compensatory postures to ensure safe oropharyngeal transit. METHODS: A total of 321 dysphagia patients were enrolled and assessed with videofluoromanometry (VFM). The dysphagia patients were classified as follows: safe transit; penetration without aspiration; aspiration before, during or after swallowing; multiple aspirations and no transit. The patients with aspiration or no transit were tested with VFM to determine whether compensatory postures could correct their swallowing disorder. RESULTS: VFM revealed penetration without aspiration in 71 patients (22.1%); aspiration before swallowing in 17 patients (5.3%); aspiration during swallowing in 32 patients (10%); aspiration after swallowing in 21 patients (6.5%); multiple aspirations in six patients (1.9%); no transit in five patients (1.6%); and safe transit in 169 patients (52.6%). Compensatory postures guaranteed a safe transit in 66/75 (88%) patients with aspiration or no transit. A chin-down posture achieved a safe swallow in 42/75 (56%) patients, a head-turned posture in 19/75 (25.3%) and a hyperextended head posture in 5/75 (6.7%). The compensatory postures were not effective in 9/75 (12%) cases. CONCLUSION: VFM allows the speech-language therapist to choose the most effective compensatory posture without a trial-and-error process and check the effectiveness of the posture. | Antonio Solazzo Luigi Monaco Lucia Del Vecchio Stefania Tamburrini Francesca Iacobellis Daniela Berritto Nunzia Luisa Pizza Alfonso Reginelli Natale Di Martino Roberto Grassi | 2012 | World Journal of Gastroenterology2012，18，23： | 3 |
| 8 | Protective effect of resveratrol against cadmium-induced toxicity on ovine oocyte in vitro maturation and fertilization显示文摘Background:Heavy metal cadmium(Cd)is a widespread environmental contaminant with a potential toxicity that might negatively affect female reproduction and fertility.It has been reported that Cd exposure impaired the quality of oocytes and led to a defective maturation and fertilization,through oxidative stress induction.Resveratrol(Res)is a natural polyphenol with strong antioxidant properties that exhibited protective role in preventing oocyte redox homeostasis disruption and quality decline.Here,we explored whether the addition of Res to in vitro maturation(IVM)medium might act as a protection against Cd-induced toxicity on ovine oocyte maturation and fertilization.Firstly,we evaluated the effect of supplementing IVM medium with two different Res concentrations(1and 2μmol/L)on nuclear maturation and fertilization of oocytes matured under CdCl2(2μmol/L)exposure.Therefore,the concentration of 1μmol/L Res was selected to analyse the effects of this compound on intracellular ROS levels,mitochondrial(mt)distribution and activity,chromatin configuration,cytoskeleton morphology,cortical granules(CGs)distribution and mRNA expression of genes associated with cellular response to oxidative stress(i.e.SIRT1,SOD 1,GPX1,GSR,CAT)in Cd-exposed in vitro matured oocytes.Results:We found that 1μmol/L Res restored the reduced oocyte meiotic competence induced by Cd exposure as well as,Res sustained oocyte ability to be normally fertilized and decreased polyspermic fertilization at both tested concentrations.Moreover,we demonstrated that 1μmol/L Res mitigated Cd-induced alterations of oocyte cytoplasmic maturation by reducing reactive oxygen species(ROS)accumulation,preventing mt dysfunction,maintaining the correct meiotic spindle and cortical F-actin assembly and the normal cortical granule distribution as well as up-regulating SIRT1,SOD1 and GPX1 genes.Conclusions:Taken together,our findings highlighted the beneficial influence exerted by Res in preventing Cdinduced disturbance of nuclear and cytoplasmic maturation and subsequent fertilization in ovine oocytes.Res treatment may help to establish defence strategies counteracting Cd-induced toxicity on the female gamete. | Anna Rita Piras Federica Ariu Alessio Maltana Giovanni Giuseppe Leoni Nicola Antonio Martino Antonella Mastrorocco Maria Elena Dell’Aquila Luisa Bogliolo | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 3 |
| 9 | miR‐29b negatively regulates human osteoclastic cell differentiation and function: Implications for the treatment of multiple myeloma‐related bone disease显示文摘 | Marco Rossi Maria Rita Pitari Nicola Amodio Maria Teresa Di Martino Francesco Conforti Emanuela Leone Cirino Botta Francesco Maria Paolino Teresa Del Giudice Eleonora Iuliano Michele Caraglia Manlio Ferrarini Antonio Giordano Pierosandro Tagliaferri Pierf | 2013 | J Cell Physiol2013，，7： | 1 |
| 10 | Role of the “Immersion Technique” in Diagnosing Celiac Disease With Villous Atrophy Limited to the Duodenal Bulb显示文摘 | Giovanni Cammarota Paola Cesaro Rossella La Mura Antonio Martino Alessia Cazzato Luca Miele Andrea Lupascu Fabio M. Vecchio Luigi M. Larocca Antonio Grieco Giovanni Gasbarrini | 2007 | Journal of Clinical Gastroenterology2007，，6： | 1 |
| 11 | Biocompatibility, Inflammatory Response, and Recannalization Characteristics of Nonradioactive Resin Microspheres: Histological Findings显示文摘 | José I. Bilbao Alba Martino Esther Luis Lourdes Díaz-Dorronsoro Alberto Alonso-Burgos Antonio Martínez de la Cuesta Bruno Sangro José A. García de Jalón | 2009 | CardioVascular and Interventional Radiology2009，，4： | 1 |
| 12 | Reliability of the “immersion technique” during routine upper endoscopy for detection of abnormalities of duodenal villi in patients with dyspepsia显示文摘 | Giovanni Cammarota Giuseppe A. Pirozzi Antonio Martino Giuseppe Zuccalà Rossella Cianci Lucio Cuoco Veronica Ojetti Matteo Landriscina Massimo Montalto Fabio M. Vecchio Giovanni Gasbarrini Antonio Gasbarrini | 2004 | Gastrointestinal Endoscopy2004，，2： | 1 |
| 13 | Direct visualization of intestinal villi by high-resolution magnifying upper endoscopy: a validation study显示文摘 | Giovanni Cammarota Antonio Martino Giuseppe A. Pirozzi Rossella Cianci Filippo Cremonini Giuseppe Zuccalà Lucio Cuoco Veronica Ojetti Massimo Montalto Fabio M. Vecchio Antonio Gasbarrini Giovanni Gasbarrini | 2004 | Gastrointestinal Endoscopy2004，，5： | 1 |
| 14 | Novel Approach for Disaster Monitoring: Fractal Models and Tools 显示文摘 | Gerardo Di Martino Antonio Iodice Daniele Riccio Giuseppe RuelloA | 2007 | IEEE Transactions on Geoscience and Remote Sensing2007，45，6： | 1 |
| 15 | Impact of genetic polymorphisms on the pathogenesis of idiopathic achalasia: Association with IL33 gene variant显示文摘 | Anna Latiano Orazio Palmieri Fabrizio Bossa Tiziana Latiano Giuseppe Corritore Ermelinda De Santo Giuseppina Martino Antonio Merla Maria Rosa Valvano Antonello Cuttitta Tommaso Mazza Vito Annese Angelo Andriulli | 2014 | Human Immunology2014，，： | 1 |
| 16 | Effect of a Hybrid Zinc Stearate-Silver System on the Properties of Polylactide and Its Abiotic and the Biotic Degradation and Antimicrobial Activity Thereof显示文摘This work investigates the degradation and properties of a thermoplastically prepared composite comprising a polylactide/hybrid zinc stearate-silver system.The influence of the zinc stearate-silver system on the properties of the composite is investigated by electron microscopy,differential scanning calorimetry and tensile tests.Furthermore,the antimicrobial activities of the systems are examined.The degradation behaviour of the composites is studied in both abiotic and biotic(composting) environments at an elevated temperature of 58 °C.The results reveal good dispersion of the additive in the PLA matrix,a stabilizing effect exerted by the same on the polylactide matrix during processing,and slight reduction in glass transition temperature.The zinc stearate-silver component also reduces brittleness and extends elongation of the composite.Abiotic hydrolysis is not significantly affected,which is in contrast with pure PLA,although mineralization during the early stage of biodegradation increases noticeably.The composite exhibits antimicrobial activity,even at the lowest dosage of the zinc stearate/silver component(1 wt%).Moreover,Ag and Zn contents were found to be present in the composite during abiotic hydrolysis,which was demonstrated by minimal diffusion of Ag ions from the matrix and very extensive washing of compounds that contained Zn. | Gabriela Jandikova Petra Stoplova Antonio Di Martino Petr Stloukal Pavel Kucharczyk Michal Machovsky Vladimir Sedlarik | 2018 | Chinese Journal of Polymer Science2018，36，8： | 1 |
| 17 | Reliability of the “immersion technique” during routine upper endoscopy for detection of abnormalities of duodenal villi in patients with dyspepsia显示文摘 | Giovanni Cammarota Giuseppe A. Pirozzi Antonio Martino Giuseppe Zuccalà Rossella Cianci Lucio Cuoco Veronica Ojetti Matteo Landriscina Massimo Montalto Fabio M. Vecchio Giovanni Gasbarrini Antonio Gasbarrini | 2004 | Gastrointestinal Endoscopy2004，，2： | 1 |
| 18 | Direct visualization of intestinal villi by high-resolution magnifying upper endoscopy: a validation study显示文摘 | Giovanni Cammarota Antonio Martino Giuseppe A. Pirozzi Rossella Cianci Filippo Cremonini Giuseppe Zuccalà Lucio Cuoco Veronica Ojetti Massimo Montalto Fabio M. Vecchio Antonio Gasbarrini Giovanni Gasbarrini | 2004 | Gastrointestinal Endoscopy2004，，5： | 1 |
| 19 | Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions显示文摘 | Elizaveta Kon Roberto Buda Giuseppe Filardo Alessandro Di Martino Antonio Timoncini Annarita Cenacchi Pier Maria Fornasari Sandro Giannini Maurilio Marcacci | 2010 | Knee Surgery Sports Traumatology Arthroscopy2010，，4： | 1 |
| 20 | Fossa ovalis radiofrequency perforation in a difficult case of conventional transseptal puncture for atrial fibrillation ablation显示文摘 | Michela Casella Antonio Dello Russo Gemma Pelargonio Annamaria Martino Stefano Paulis Paolo Zecchi Fulvio Bellocci Claudio Tondo | 2008 | Journal of Interventional Cardiac Electrophysiology2008，，3： | 1 |
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