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| 1 | Multidrug resistance 1 gene in inflammatory bowel disease: A meta-analysis显示文摘MDR1 基因是为煽动性的肠疾病(IBD ) 并且也许的致病的吸引人的候选人基因对治疗的反应,与在功能、基因的层次的证据。它的产品, P-glycoprotein (P-gp ) 作为因此影响许多药的布置和反应的 transmembrane 流出泵工作,一些(即 glucocorticoids ) 对 IBD 中央治疗。另外, P-gp 高度在许多上皮的表面被表示,包括的胃肠道(官方补给) 与在减少的一个通常认为的角色吸收内长或外毒素,并且也许主人细菌相互作用。MDR1 基因的许多基因变化被描述了,在为不同 P-gp 表示的一些例子证据,也,药新陈代谢被提供了。然而,数据经常由于采用的基因异质和不同方法论正在冲突。也许,在官方补给的道的 P-gp 的生理的重要性的证据的最大的片来自对老鼠建模的 mdr1 大美人的描述,它在特定的没有病原体的环境开发自发的大肠炎。学习调查到 IBD 的基因多型性和倾向也显示出冲突结果的 MDR1,由于在复杂疾病的已知的困难,特别当建议基因贡献是弱的时。在这研究,我们承担了在 IBD 与二 SNP 多型性(C3435T 和 G2677T/A ) 获得的可得到的调查结果的元分析;3435T 等位基因和 3435TT 遗传型的一个重要协会与 UC 被发现了(或 = 1.17, P = 0.003 并且或 = 1.36, P = 0.017,分别地) 。在对比,有 CD 和 G2677T/A 多型性的协会都不能被表明。 | V Annese MR Valvano O Palmieri A Latiano F Bossa A Andriulli | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 2 | Role of CARD15,DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases显示文摘AIM: To investigate the contribution of variants of CARD15, OCTN1/2 and DLG5 genes in disease predispo- sition and phenotypes in a large Italian cohort of pediatric patients with inflammatory bowel diseases (IBD). METHODS: Two hundred patients with Crohn’s disease (CD), 186 ulcerative colitis (UC) patients, 434 par- ents (217 trios), and 347 healthy controls (HC) were studied. Polymorphisms of the three major variants of CARD15, 1672C/T and -207G/C SNPs for OCTN genes, IGR2096a_1 and IGR2198a_1 SNPs for the IBD5 locus, and 113G/A variant of the DLG5 gene were evaluated. Potential correlations with clinical sub-phenotypes were investigated. RESULTS: Polymorphisms of CARD15 were significantly associated with CD, and at least one variant was found in 38% of patients (15% in HC, OR = 2.7, P < 0.001). Homozygosis for both OCTN1/2 variants was more com- mon in CD patients (1672TT 24%, -207CC 29%) than in HC (16% and 21%, respectively; P = 0.03), with an in- creased frequency of the TC haplotype (44.8% vs 38.3% in HC, P = 0.04). No association with the DLG5 variant was found. CD carriers of OCTN1/2 and DLG5 variants more frequently had penetrating disease (P = 0.04 and P = 0.01), while carriers of CARD15 more frequently had ileal localization (P = 0.03). No gene-gene interaction was found. In UC patients, the TC haplotype was morefrequent (45.4%, P = 0.03), but no genotype/phenotype correlation was observed. CONCLUSION: Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric on- set of CD. Polymorphisms of CARD15, OCTN, and DLG5 genes exert a weak influence on CD phenotype. | S Cucchiara A Latiano O Palmieri AM Staiano R D'Incà G Guariso G Vieni V Rutigliano O Borrelli MR Valvano V Annese | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 3 | Enteropathic spondyloarthropathy:A common genetic background with inflammatory bowel disease?显示文摘The association between spondyloarthropathy and in flammatory bowel disease(IBD) is largely established, although prevalence is variable because of different population selection and diagnostic methodologies.Most studies indicate that as many as 10%15% of cases of IBD are complicated by ankylosing spondylitis(AS) or other forms of spondylarthritis(SpA).Of note, ileal inflammation resembling IBD has been reported in up to two thirds of cases of SpA, and it has been suggested that the presence of ileitis is associated with the chronic ity of articular complications.Although this observation is of interest to unravel the pathophysiology of the disease, systematic screening of patients with SpA by ileocolonos copy is not indicated in the absence of gut symptoms, as only a small proportion of patients with subclinical gut inflammation will develop overt IBD over time.The existence of familial clustering of both IBD and AS, the coexistence of both conditions in a patient, the evidence of an increased risk ratio among f irstand seconddegree relatives of affected AS or IBD patients and f inally, the increased crossrisk ratios between AS and IBD, strongly suggest a shared genetic background.So far, however, IL23R is the only identified susceptibility gene shared by both IBD and AS.Although functional studies are still needed to better understand its pathogenic role, great ef fort is being spent therapeutically targeting this pathway that may prove effective for both disorders. | Elisabetta Colombo Anna Latiano Orazio Palmieri Fabrizio Bossa Angelo Andriulli Vito Annese | 2009 | World Journal of Gastroenterology2009，15，20： | 4 |
| 4 | Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult-and pediatric-onset inflammatory bowel disease in Italy显示文摘AIM: To investigate gene variants in a large Italian inflammatory bowel disease (IBD) cohort, and to analyze the correlation of sub-phenotypes (including age at diagnosis) and epistatic interaction with other IBD genes. METHODS: Total of 763 patients with Crohn's disease (CD, 189 diagnosed at age < 19 years), 843 with ulcerative colitis (UC, 179 diagnosed <19 years), 749 healthy controls, and 546 healthy parents (273 trios) were included in the study. The rs2241880 [autophagy-related 16-like 1 (ATG16L1)], rs11209026 and rs7517847 [interleukin 23 receptor (IL23R)], rs2066844, rs2066845, rs2066847 (CARD15), rs1050152 (OCTN1), and rs2631367 (OCTN2) gene variants were genotyped. RESULTS: The frequency of G allele of ATG16L1 SNP (Ala197Thr) was increased in patients with CD compared with controls (59% vs 54% respectively) (OR = 1.25, CI = 1.08-1.45, P = 0.003), but not in UC (55%). The frequency of A and G (minor) alleles of Arg381Gln, rs11209026 and rs7517847 variants of IL23R were reduced significantly in CD (4%, OR = 0.62, CI = 0.45-0.87, P = 0.005; 28%, OR = 0.64, CI = 0.55-0.75, P < 0.01), compared with controls (6% and 38%, respectively). The A allele (but not G) was also reduced signifi cantly in UC (4%, OR = 0.69, CI = 0.5-0.94, P = 0.019). No association was demonstrated with sub-phenotypes and interaction with CARD15 , and OCTN1/2 genes, although both gene variants were associated with pediatric-onset disease. CONCLUSION: The present study confirms the association of IL23R polymorphisms with IBD, and ATG16L1 with CD, in both adult- and pediatric-onset subsets in our study population. | Anna Latiano Orazio Palmieri Maria Rosa Valvano Renata D'Incà Salvatore Cucchiara Gabriele Riegler Anna Maria Staiano Sandro Ardizzone Salvatore Accomando Gian Luigi de Angelis Giuseppe Corritore Fabrizio Bossa Vito Annese | 2008 | World Journal of Gastroenterology2008，14，29： | 3 |
| 5 | Associations between genetic polymorphisms in IL-33, IL1R1 and risk for inflammatory bowel disease显示文摘 | Latiano A Palmieri O Pastorelli L | 2013 | PLoS One2013，8，62： | 1 |
| 6 | Polymorphism of the IrGM gene might predispose to fistulizing behavior in Crohn's disease显示文摘 | LatiAno A Palmieri O Cucchiara S | 2009 | Am J Gastr oent:erol2009，104，1： | 1 |
| 7 | Sequential evaluation of thiopurine methyltransferase,inosine triphosphate pyrophosphatase,and HPRT1 genes polymorphisms to explain thiopurines' toxicity and efficacy显示文摘 | Palmieri O Latiano A Bossa F | 2007 | Aliment Pharmacol Ther2007，26，5： | 1 |
| 8 | Erythrocytes mediated delivery of dexam ethasone in steroid-dependent IBD patients apilot uncomtrolled study显示文摘 | Annese V Latiano A Rossi L | 2005 | Am J Gasatroenterol2005，100，6： | 1 |
| 9 | Erythrocytes-mediated defivery ofdexamethasone in steroid-dependent IBD patients-a pilot uncon- trolled study显示文摘 | Annes E Latiano A Ressi L | 2005 | Am J Gastroenterol2005，100，6： | 1 |
| 10 | Associations between genetic polymorphisrns in il-33, illrl and risk for inflammatory bowel disease 显示文摘 | Latiano A Palmieri O Pastorelli | 2013 | PLoS One2013，8，4： | 1 |
| 11 | The association of MYO9B gene in Italian patients with inflammatory bowel diseases显示文摘 | Latiano A Palmieri O Valvano MR | 2008 | Aliment Pharmacol Ther2008，27，3： | 1 |
| 12 | Impact of genetic polymorphisms on the pathogenesis of idiopathic achalasia: Association with IL33 gene variant显示文摘 | Anna Latiano Orazio Palmieri Fabrizio Bossa Tiziana Latiano Giuseppe Corritore Ermelinda De Santo Giuseppina Martino Antonio Merla Maria Rosa Valvano Antonello Cuttitta Tommaso Mazza Vito Annese Angelo Andriulli | 2014 | Human Immunology2014，，： | 1 |
| 13 | Associations between genetic polymorphisms in IL-33, IL1R1 and risk for inflammatory bowel disease显示文摘 | Latiano A Palmieri O Pastorelli L | 2013 | PLoS One2013，8，62： | 1 |
| 14 | Investigation of muhiple susceptibility loci for inflammatory bowel disease in an Italian cohort of patients 显示文摘 | Latiano A Palmieri O Latiano T | 2011 | PLoS One2011，6，22： | 1 |
| 15 | On behalf of the Italian Society of Pediatric Gastroenterology and Nutrition Polymorphisms of Tumor Necrosis Factor- but Not MDR1 Influence Response to Medical Therapy in Pediatric-Onset Inflammatory Bowel Disease显示文摘 | Cucchiara S Latiano A Palmieri O | 2007 | Journal of Pediatric Gastroenterology & Nutrition2007，44，2： | 1 |
| 16 | Evaluating the role of the genetic variations of PTPN22, NFKB1, and FeGRIIIA genes in inflammatory bowel disease : a meta-analysis 显示文摘 | Latiano A Palmieri O Valvano M R | 2007 | Inflamm Bowel Dis2007，13，10： | 1 |
| 17 | Polymorphisms of tumor necrosis factor-α but not MDR1 influence response to medical therapy in pediatric-onset inflammatory bowel disease显示文摘 | Cuccchiara S Latiano A Palmieri O | 2007 | Journal of Pediatric Gastroenterology and Nutrition2007，44，： | 1 |
| 18 | Associations between genetic polymorphisms in IL-33, ILIRI and risk for inflammatory bowel disease 显示文摘 | Latiano A Palmieri 0 Pastorelli L | 2013 | PLoS One2013，8，62： | 1 |
| 19 | The association of MYOgB gene in Italian patients with inflammatory bowel diseases 显示文摘 | Latiano A Palmieri O Valvano MR | 2008 | Aliment Pharmacol Ther2008，27，3： | 1 |
| 20 | Erythrocytes as a controlled drug delivery system: Clinical evidences显示文摘 | L. Rossi S. Serafini F. Pierigé M. Castro M.I. Ambrosini D. Knafelz G. Damonte V. Annese A. Latiano F. Bossa M. Magnani | 2006 | Journal of Controlled Release2006，，： | 1 |
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