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| 1 | Surrogate markers of insulin resistance:A review显示文摘Insulin resistance is a hallmark of obesity,diabetes,and cardiovascular diseases,and leads to many of the abnormalities associated with metabolic syndrome. Our understanding of insulin resistance has improved tremendously over the years,but certain aspects of its estimation still remain elusive to researchers and clinicians.The quantitative assessment of insulin sensitivity is not routinely used during biochemical investigations for diagnostic purposes,but the emerging importance of insulin resistance has led to its wider application research studies.Evaluation of a number of clinical states where insulin sensitivity is compromised calls for assessment of insulin resistance. Insulin resistance is increasingly being assessed in various disease conditions where it aids in examining their pathogenesis,etiology and consequences. The hyperinsulinemic euglycemic glucose clamp is the gold standard method for the determination of insulin sensitivity,but is impractical as it is labor-and time-intensive.A number of surrogate indices have therefore been employed to simplify and improve the determination of insulin resistance.The object of this review is to highlight various aspects and methodologies for current and upcoming measures ofinsulin sensitivity/resistance.In-depth knowledge of these markers will help in better understanding and exploitation of the condition. | Bhawna Singh Alpana Saxena | 2010 | World Journal of Diabetes2010，1，2： | 5 |
| 2 | Role of angiotensin converting enzyme and angiotensinogen gene polymorphisms in angiotensin converting enzyme inhibitor-mediated antiproteinuric action in type 2 diabetic nephropathy patients显示文摘AIM To investigate the role of genetic variants of angiotensin converting enzyme(ACE) and angiotensinogen(AGT) genes in the antiproteinuric efficacy of ACE inhibitor therapy in diabetic nephropathy(DN) patients.METHODS In the present study, 270 type 2 diabetes mellitus patients with nephropathy were enrolled and treated with ACE inhibitor(ramipril) and followed at 6 mo for renal function and albumin excretion by estimating serum creatinine, end stage renal disease, and albumin/creatinine ratio(ACR) in urine. Genotyping of ACE I/D and AGT M235 T polymorphisms were performed by using primer specific polymerase chain reaction(PCR) and PCR-RFLP techniques, respectively. RESULTS Forty-eight percent of DN patients(responders) benefited with respect to proteinuria from ACE inhibitor therapy at 6 mo follow-up. A significant reduction in ACR was observed after 6 mo treatment with ACE inhibitor irrespective of whether DN patients were micro-albuminuric(≥ 30 and < 300 mg/g creatinine) or macro-albuminuric(≥ 300 mg/g creatinine) at the time of enrollment. However, macro-albuminuric patients(55%) showed better response to therapy. A reduction in urinary ACR was found independent of genotypes of ACE I/D and AGT M235 T polymorphisms although macro-albuminuric patients having TT genotype showed statistically insignificant increased response(72%). CONCLUSION ACE inhibitor therapy reduced urinary ACR by ≥ 30% in 50% of DN patients and the response is independent of ACE I/D and AGT M235 T polymorphisms. | Neerja Aggarwal Pawan Kumar Kare Parul Varshney Om Prakash Kalra Sri Venkata Madhu Basu Dev Banerjee Anil Yadav Alpana Raizada Ashok Kumar Tripathi | 2017 | World Journal of Diabetes2017，8，3： | 4 |
| 3 | Bariatric, Metabolic, and Diabetes Surgery: What?s in a Name?显示文摘 | Francesco Rubino Alpana Shukla Alfons Pomp Marlus Moreira Soo Min Ahn Gregory Dakin | 2014 | Annals of Surgery2014，，1： | 2 |
| 4 | Actinomycetes from solitary wasp mud nest and swallow bird mud nest: isolation and screening for their antibacterial activity显示文摘 | Vijay Kumar Alpana Bharti Vivek Kumar Gupta Omprakash Gusain Gajraj Singh Bisht | 2012 | World Journal of Microbiology and Biotechnology2012，，3： | 2 |
| 5 | Genetic Diversity Analysis of Rice Germplasm in Tripura State of Northeast India Using Drought and Blast Linked Markers显示文摘We genotyped 74 rice germplasms including Tripura's local landraces, improved varieties, cultivars and breeding lines and other rice varieties using molecular markers for genetic diversity, drought QTLs, and blast resistance genes. The number of alleles per locus ranged from 2 to 5 with an average of 2.9. The polymorphic information content value per locus ranged from 0.059(RM537) to 0.755(RM252) with an average of 0.475. Cluster analysis based on 30 simple sequence repeat markers revealed 5 clusters and also indicated the presence of variability within the rice accessions. The drought QTL q DTY2.1 was found in 56.0% of germplasms and q DTY1.1 was detected in only 6.8% of the germplasms. Out of seven rice blast resistance genes screened, only two rice varieties, RCPL-1-82 and Buh Vubuk(Lubuk), were positive for four blast resistance genes while only Releng possessed two blast resistance genes. Among 74 rice germplasms, only three accessions, Releng, RCPL1-82 and Buh Vubuk(Lubuk), possessed both drought-related QTLs and blast resistance genes. Overall, the 74 indigenous rice genotypes showed low level of genetic diversity, which is in contrast to high level of genetic diversity among rice varieties in northeast India, where highlights the good farming practice, conservation of germplasms and the limitation of molecular markers employed in this study. The presence of both drought related QTLs and blast resistance genes in some of the germplasms can be useful in future breeding programmes. | Alpana ANUPAM Jahangir IMAM Syed Mohammad QUATADAH Anantha SIDDAIAH Shankar Prasad DAS Mukund VARIAR Nimai Prasad MANDAL | 2017 | Rice science2017，24，1： | 2 |
| 6 | NOTCH2 in breast cancer:association of SNPrs11249433 with gene expression in ER-positive breast tumors without TP53 mutations显示文摘 | Yi-Ping Fu Hege Edvardsen Alpana Kaushiva | 2010 | Mol Cancer2010，，： | 1 |
| 7 | Studies on the copolymerization of methyl methacrylate and N-aryl maleimides显示文摘 | Veena Choudhary Alpana Mishra | 1996 | Journal of Applied Polymer Science1996，62，4： | 1 |
| 8 | Direct synthesis of 2,4-diaminoquinazolines from 2-iluoro- benzonitriies 显示文摘 | John B Hynes Alpana Pathak Constantina H Panes | 1988 | Journal of Heterocyclic Chemistry1988，25，4： | 1 |
| 9 | Studies on the copolymerization of methyl methacrylate and N-aryl maleimides显示文摘 | Veena Choudhary Alpana Mishra | 1996 | J Appl Polym Sci1996，，62： | 1 |
| 10 | Scanning electron microscopy of streptomyces without use of any chemical fixatives显示文摘 | Vijay K Alpana B Omprakash G | 2011 | Scanning2011，33，： | 1 |
| 11 | Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI - CDK - cyclin cascade, and caspase 3 and PARP cleavages 显示文摘 | Alpana Tyagi Chapla Agarwal Gail Harrison | 2004 | Carcinogenesis2004，25，9： | 1 |
| 12 | Fluid saturation from well logs using committee neural networks显示文摘 | Hans B H Alpana B | 2002 | Petroleum Geoscience2002，8，10： | 1 |
| 13 | Leptin, IL - 10 and Inflammatory Markers ( TNF - α, IL - 6 and IL - 8 ) in Preeclamptic, Normotensive Pregnant and Healthy Non - Pregnant Women 显示文摘 | Alpana Sharmal | 2007 | American Journal of Reproductive Immunology2007，58，： | 1 |
| 14 | Extraction and purification of an unusual phycoerythrin in a terrestrial desiccation tolerant cyanobacterium Lyngbya arboricola显示文摘 | S. N. Tripathi Shivali Kapoor Alpana Shrivastava | 2007 | Journal of Applied Phycology2007，，： | 1 |
| 15 | Metal(Ⅳ)tungstates as solid acid catalysts for the synthesis of phthalate diester-dioctyl phthalate(DOP)显示文摘 | Alpana P Uma C | 2003 | Indian Journal of Chemical Technology2003，10，1： | 1 |
| 16 | Wavelet-modified fringe-adjusted joint transform correlator显示文摘 | B Alpana K Naveen A K Nishchal | 2008 | Optics & Laser Technology2008，40，1： | 1 |
| 17 | Petrology, palynology and organic geochemistry of Eocene lignite of Matanomadh, Kutch Basin, western India: Implications to depositional environment and hydrocarbon source potential显示文摘 | Suryendu Dutta Runcie P. Mathews Bhagwan D. Singh Suryakant M. Tripathi Alpana Singh Pratul K. Saraswati Santanu Banerjee Ulrich Mann | 2010 | International Journal of Coal Geology2010，，1： | 1 |
| 18 | Extended fractional wavelet joint transform correlator 显示文摘 | Alpana Bhagatji Naveen K Nishchal Arun K Gupta | 2008 | Optical Communications2008，281，： | 1 |
| 19 | Metal(Ⅳ)tungstates as solid acid catalysts for the synthesis of phthalate diester-dioctyl phthalate(DOP)显示文摘 | Alpana P Uma C | 2003 | Indian Journal of Chemical Technology2003，10，1： | 1 |
| 20 | Separation of close boiling point mixtures(p-cresol/m-cresol, guaiacol/alkylphenols, 3-picoline/4-picoline, substituted anilines)through dissociation extractive crystallization显示文摘 | Gaikar V G Alpana Mahapatra Sharma M M | 1989 | Ind Eng Chem Res1989，28，： | 1 |
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