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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Channel morphologic processes of a highly sinuous bend approaching neck cutoff by bank erosion in the middle Yangtze River显示文摘The distal reach of the Lower Jingjiang River(LJR)in the middle of the Yangtze River consists of five adjacent bends,among which the Qigongling Bend is a U-shaped meander with a mean sinuosity of 2.2 and the narrowest neck 525 m in width.This bend is slowly approaching neck cutoff owing to progressive bank erosion.An abnormal phenomenon has occurred in this bend since the Three Gorges Reservoir(TGR)began to operate in 2003 which is erosion in the inner bank zone and deposition in the outer bank zone.This problem has not been fully understood because of the interplay of changes in water-sediment,bank erosion,and artificial bank revetment.In this study,aerial and remote sensing images,hydrological data,channel topography,and an existing bank erosion model are used to reveal channel morphodynamics of this bend and the trend of the potential neck cutoff induced by bank erosion.The study results show that the clear water released from the TGR has provided by forcefully eroded the point bar of inner bank but failed to scour the outer bank due to the protection of bank revetment since the 1990 s.Thus far,the outer bank zone near the bend apex has increasingly widened in conjunction with the formation of 2 emerging sand bars.Consequently,the thalweg of the main channel has laterally shifted toward the inner bank by roughly 800 m.More severely,the rate of bank retreat on the upstream side of the bend neck was about 4.5 m/yr in 2010-2019,but the downstream side of this neck was experienced slight deposition.Bank erosion could be accelerated by progressively increasing erosion and eventually trigger the occurrence of neck cutoff in the next few decades,thereby significantly altering the quasi-equilibrium regime of channel morphodynamics in the LJR. | Zhiwei Li Hanyuan Yang Junqiang Xia Meirong Zhou Shanshan Deng Yingzhen Wang | 2021 | International Journal of Sediment Research2021，36，4： | 5 |
| 3 | The spatio-temporal variation of wintertime subtidal currents in the western Taiwan Strait显示文摘A new data set of observations by six cruises of ship-mounted acoustic doppler current profiler(SADCP) and three 40 d long bottom-mounted ADCPs(BADCPs) is employed to reveal the spatiotemporal variability of tidal and subtidal currents in the western Taiwan Strait(TWS) during winter season. The results confirm the existence of intense cotidal lines for M_2 tidal current, which is located north of 25°N. In this case, no existence of an amphidromic point can be identified. It is also revealed that the counter-wind current(CWC) can extend through the whole western TWS and even occupy the entire water column during winter monsoon relaxation. However,this CWC is observed to be thoroughly overwhelmed by the downwind China coastal current(CCC) during the two big monsoon bloom events in the winter of 2007, and the CCC consequently extends southward throughout the western TWS instead. Most importantly, the variation of the spatial extent for the CWC and the CCC in the western TWS is found to be well explained by the first two modes of the vector empirical orthogonal function(VEOF) analysis, that is, it is mainly controlled by a wind-driven quasi barotropic current as the first mode and slightly modulated by a relatively weak background current with a first-order baroclinic structure as the second mode. | SHEN Junqiang QIU Yun GUO Xiaogang PAN Aijun ZHOU Xiwu | 2017 | Acta Oceanologica Sinica2017，36，11： | 5 |
| 4 | Antibody neutralization to SARS-CoV-2 and variants after 1 year in Wuhan,China显示文摘Most COVID-19 convalescents can build effective anti-SARS-CoV-2 humoral immunity,but it remains unclear how long it can maintain and how efficiently it can prevent the reinfection of the emerging SARS-CoV-2 variants.Here,we tested the sera from 248 COVID-19 convalescents around 1 year post-infection in Wuhan,the earliest known epicenter.SARS-CoV-2 immunoglobulin G(IgG)was well maintained in most patients and potently neutralizes the infection of the original strain and the B.1.1.7 variant.However,varying degrees of immune escape was observed on the other tested variants in a patient-specific manner,with individuals showing remarkably broad neutralization potency.The immune escape can be largely attributed to several critical spike mutations.These results suggest that SARS-CoV-2 can elicit long-lasting immunity but this is escaped by the emerging variants. | Qianyun Liu Qing Xiong Fanghua Mei Chengbao Ma Zhen Zhang Bing Hu Junqiang Xu Yongzhong Jiang Faxian Zhan Suhua Zhou Li Tao Xianying Chen Ming Guo Xin Wang Yaohui Fang Shu Shen Yingle Liu Fang Liu Li Zhou Ke Xu Changwen Ke Fei Deng Kun Cai Huan Yan Yu Chen Ke Lan | 2022 | The Innovation2022，3，1： | 3 |
| 5 | Herbal formula of Bushen Jianpi(补肾健脾方)combined with sorafenib inhibits hepatocellular carcinoma growth by promoting cell apoptosis and blocking the cell cycle显示文摘OBJECTIVE:To investigate the efficacy of an herbal formula of Bushen Jianpi(补肾健脾方,BSJP)combined with sorafenib on hepatocellular carcinoma(HCC)in vitro and in vivo,and to study the underlying mechanisms of action.METHODS:BSJP,a mixture of 12 raw herbs,was extracted in 70%alcohol/30%water and freeze-dried into a powder.The in vitro effects of BSJP alone,sorafenib alone,and their combination on cell survival,apoptosis,and cell cycle distribution were evaluated in HCC cell lines HCCLM3,HepG2,and SMMC-7721.The expression of B-cell lymphoma-2(Bcl-2),caspase-3,and caspase-9 in HCCLM3 cells was measured using Western blots after drug administration.The in vivo effects of BSJP and sorafenib were evaluated in a tumor surgical resection model using 4-week old male athymic BALB/c nude mice injected with HCCLM3 cells.Immunohistochemical analysis of tumor tissues was performed to evaluate the effects of BSJP alone,sorafenib alone,and their combination on the expression of caspase-3,caspase-9,and Bcl-2.RESULTS:BSJP decreased the survival rate of HCC cell lines,and the combination of BSJP and sorafenib further decreased the survival rate.BSJP significantly promoted cell apoptosis and blocked cell-cycle progression in HCCLM3,HepG2,and SMMC-7721 cells in a dose-dependent manner.Furthermore,the administration of BSJP and sorafenib inhibited the growth of HCCLM3 cell xenografts in nude mice,with no reduction in body weight.In vivo and in vitro experiments showed that BSJP combined with sorafenib could significantly decrease the expression of Bcl-2.CONCLUSION:Our findings suggest that the herbal formula of BSJP is a potential HCC antitumor agent. | ZHOU Zhangjie LIU Xinhua WU Tingting QUE Zujue WU Zhonghua WU Weizhong FU Shujuan ZHANG Shiqiang YANG Yun JIANG Haiyan XIA Xiaoting LV Junqiang DU Boqian LI Yun LU Tao ZHANG Zhihui ZHONG Yi | 2021 | Journal of Traditional Chinese Medicine2021，41，2： | 3 |
| 6 | Computational Investigation of Blade slotting on a High-Load Low-Pressure Turbine Profile at various Reynolds Numbers:Part Ⅰ——Slotting Scheme's Verification显示文摘Boundary layer separation and reattachment is often an unavoidable feature of low pressure (LP) turbine,one of the main causes of this phenomenon is the high altitude low Reynolds number experienced by the modern LP turbine stage in aero-engine.Although an excellent turbine airfoil design can avoid flow separation on certain extent,but within flight envelope,LP turbine's characteristic Reynolds number may varied greatly,so it will be still under the risk of the presence of separation bubble.In this two parts paper a new concept of slotted-blade was raised to testify the gain of the blade slotting.A high aerodynamic loading LP turbine blade IET-LPTA was under investigated with different Reynolds number.Computational results reveal that the blade slotting could be a way of choice to suppress separation bubble and reduce profile loss under the condition of low Reynolds number,although its position and geometry need to be further investigated. | Qiang Du Junqiang Zhu Min Zhou Wei Li | 2011 | Journal of Thermal Science2011，20，1： | 3 |
| 7 | Computational Investigation of Blade Slotting on a High-Load Low-Pressure Turbine Profile at Various Reynolds Numbers:Part Ⅱ——Optimization of Slotting Position显示文摘The concept of using blade slotting to suppress the large boundary layer separation of high aerodynamic loading low pressure turbine profile has been developed in Part 1.Calculated results highlight the inability performance accompanied with un-proper blade slotting at high Reynolds number,blade slotting optimization seems like compulsory.Meanwhile,to further dignify the rational for use of blade slotting,slotting position and its geometry needed to be optimized.Comparison of different slotting scheme calculation results promised that blade slotting parameter like outlet angle and outlet position are the most important parameters which must be investigated to satisfy the design purpose. | Qiang Du Junqiang Zhu Min Zhou Wei Li | 2011 | Journal of Thermal Science2011，20，1： | 2 |
| 8 | Deformation mechanisms in aβ-quenched Ti-5321 alloy:In-situ investigation related to slip activity,orientation evolution and stress induced martensite显示文摘The deformation behavior ofβ-quenched nearβTi-5321(Ti-5Al-3Mo-3V-2Cr-2Zr-1Nb-1Fe)alloy was systematically studied using in-situ tensile test monitored by the scanning electron microscopy(SEM).Besides,the electron backscatter diffraction(EBSD)was performed to thoroughly discuss the deformation mechanisms.The results indicated that slip activities,crystal rotation and stress induced martensite transformation were the major deformation mechanisms in theβ-quenched Ti-5321 alloy during in-situ tensile testing.The slip activities were investigated by using the EBSD-trace analysis,which demonstrated that{110}<111>,{112}<111>and{123}<111>slip systems were activated and the{110}<111>slip system dominated.Besides,βgrains rotated about 7.8°to accommodate the increased macrostrain.Notably,the stress induced martensiteα″which was related to the double yielding behavior during tensile process exhibited multiple characteristics.The differentα″variants divided theβmatrix into smallerβblocks with a typical zigzag morphology,in which oneα″variant passed through another one by deflecting its initial growth direction.Moreover,the deformation twinning in martensiteα″and slip bands cutting through martensiteα″effectively accommodated the local strain.These systematically analysis can provide insightful information about the deformation mechanisms in nearβtitanium alloys. | Cong Wu Qinyang Zhao Shixing Huang Yongqing Zhao Lei Lei Junqiang Ren Qiaoyan Sun Lian Zhou | 2022 | Journal of Materials Science & Technology2022，，17： | 2 |
| 9 | 显示文摘 | Wang Liuding Zhou Junqiang Cao Quanxi | 2003 | J Mater Sci Technol2003，19，4： | 1 |
| 10 | Flap side-edge noise mechanism and shape modification noise reduction design显示文摘 | HAN Xiao ZHOU Wangyi BAI Junqiang YU Peixun LI Yi SONG Xiang | 2018 | Chinese Journal of Acoustics2018，37，3： | 1 |
| 11 | Serum carbohydrate antigen-125 is elevated in patients with chronic atrial fibrillation显示文摘Objective: To determine whether CA-125 is elevated in medically stable patients with chronic atrial fibrillation (AF) compared with patients without AF and to examine whether levels of CA-125 are associated with demographic and clinical variables in a sample of patients under study. Methods: 55 patients with chronic AF and 58 control patients in sinus rhythm were included into the study. Patients with acute heart failure (HF), chronic inflammatory or neoplastic disease were excluded from the study. Circulating levels of CA-125 were assessed; all patients underwent clinical examination, assessment and medical records including demographic data, history of comorbid conditions, current use of cardiac medications, and the results of cardiac tests including electrocardiograms. Results: The mean age of the study sample was 53.2±6.5 years and 48% were men. Patients with sinus rhythm were significantly more likely to have lower heart rates, smaller dimensions of left atrium, and to be treated with aspirin. Coumadin, coumadin and digoxin were more often prescribed in patients with chronic AF. The CA-125 levels were significantly higher in patients with chronic AF than in patients in sinus rhythm (48.5±7.65 U/ml and 28.43±5.48 U/ml, P<0.005). An inverse relation was found between CA-125 levels and left ventricular ejection fraction (LVEF) (r=-0.48, P<0.001). CA-125 was significantly related to the left atrium (LA) diameter, left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) and brain natriuretic peptide (BNP). There was no significant correlation between CA-125 and age. Conclusion: In subjects with chronic AF, CA-125 levels are increased; CA-125 was significantly related to the LA diameter, LVEDD, LVESD and BNP. | Pan Junqiang Zhang Dianxin Zhang Zaiwei Lu Ying Zhou Xin Li Guoliang Sun Chaofeng | 2012 | Journal of Medical Colleges of PLA(China)2012，27，5： | 1 |
| 12 | Photonic measurement of microwave frequency based on phase modulation显示文摘 | Zhou Junqiang Fu Songnian Perry Ping Shum | 2009 | Optics Express2009，17，20： | 1 |
| 13 | Stacking monolayers at will:A scalable device optimization strategy for two-dimensional semiconductors显示文摘In comparison to monolayer(1L),multilayer(ML)two-dimensional(2D)semiconducting transition metal dichalcogenides(TMDs)exhibit more application potential for electronic and optoelectronic devices due to their improved current carrying capability,higher mobility,and broader spectral response.However,the investigation of devices based on wafer-scale ML-TMDs is still restricted by the synthesis of uniform and high-quality ML films.In this work,we propose a strategy of stacking MoS_(2) monolayers via a vacuum transfer method,by which one could obtain wafer-scale high-quality MoS_(2) films with the desired number of layers at will.The optical characteristics of these stacked ML-MoS_(2) films(>2L)indicate a weak interlayer coupling.The stacked MLMoS_(2) phototransistors show improved optoelectrical performances and a broader spectral response(approximately 300-1,000 nm)than that of 1L-MoS_(2).Additionally,the dual-gate ML-MoS_(2) transistors enable enhanced electrostatic control over the stacked ML-MoS_(2) channel,and the 3L and 4L thicknesses exhibit the optimal device performances according to the turning point of the current on/off ratio and the subthreshold swing. | Xiaojiao Guo Honglei Chen Jihong Bian Fuyou Liao Jingyi Ma Simeng Zhang Xinzhi Zhang Junqiang Zhu Chen Luo Zijian Zhang Lingyi Zong Yin Xia Chuming Sheng Zihan Xu Saifei Gou Xinyu Wang Peng Gong Liwei Liu Xixi Jiang Zhenghua An Chunxiao Cong Zhijun Qiu Xing Wu Peng Zhou Xinyu Chen Ling Tong Wenzhong Bao | 2022 | Nano Research2022，15，7： | 0 |
| 14 | Oxidations of two-dimensional semiconductors:Fundamentals and applications显示文摘Since the discovery of graphene,two-dimensional(2D)semiconductors have been attracted intensive interest due to their unique properties.They have exhibited potential applications in next generation electronic and optoelectronic devices.However,most of the 2D semiconductor are known to suffer from the ambient oxidation which degrade the materials and therefore hinder us from the intrinsic materials’properties and the optimized performance of devices.In this review,we summarize the recent progress on both fundamentals and applications of the oxidations of 2D semiconductors.We begin with the oxidation mechanisms in black phosphorus,transition metal dichalcogenides and transition metal monochalcogenides considering the factors such as oxygen,water,and light.Then we show the commonly employed passivation techniques.In the end,the emerging applications utilizing controlled oxidations will be introduced. | Junqiang Yang Xiaochi Liu Qianli Dong Yaqi Shen Yuchuan Pan Zhongwang Wang Kui Tang Xianfu Dai Rongqi Wu Yuanyuan Jin Wei Zhou Song Liu Jian Sun | 2022 | Chinese Chemical Letters2022，33，1： | 0 |
| 15 | Design and fabrication of compact Ge-on-SOI coupling structure显示文摘In this paper, we have proposed and demonstrated a simple approach to fabricate vertical integrated structure for coupling between active germanium (Ge) waveguide and silicon-on-insulator (SOI) waveguide. The active Ge waveguide is sputtered after etching the underlying passive silicon (Si) waveguide. This method scuttles away from the difficulty involved in the waveguide fabrication by avoiding the etching process for the Ge waveguide, and thereby the waveguide quality is improved. The influences of the coupling structural parameters on the coupling loss are analyzed and discussed. The optimizing parameters are obtained for the fabrication. The minimal coupling loss is experimentally measured about 2.37 dB, and variation tendency of coupling loss against the structural parameters is consistent with the theoretical result. The proposed approach offers an effective path for vertical coupling between Ge and SOI optical components. | Jianfeng GAO Junqiang SUN Heng ZHOU Jialin JIANG Yang ZHOU | 2019 | Frontiers of Optoelectronics2019，12，3： | 0 |
| 16 | Templated freezing assembly precisely regulates molecular assembly for free-standing centimeter-scale microtextured nanofilms显示文摘Nature provides diverse models for manufacturing complex and hierarchical materials by controlling molecular assembly at scales ranging from sub-nano to macroscale. However, developing artificial strategies for manufacturing hierarchical materials with comparable machining capabilities to nature is extremely challenging. Here, a templated freezing assembly strategy is reported, enabling simultaneously regulating molecular assembly spatiotemporally to obtain hierarchical materials with structure control from sub-nano to macroscale. In this way, unique centimeter-scale freestanding nanofilms are assembled from diverse molecules, e.g., proteins and conjugated polymers. A generated silk fibroin(SF) nanofilm presents a tunable β-sheet fraction from 5% to 47%, fiber width from 30 to 3,000 nm, and micro-textures with desired shapes. Such a strategy will lay the foundation for customizing hierarchical functional materials from single or multi-component molecules, e.g., desired bioscaffolds with controlled cell adhesion. | Junqiang Mao Huimei Cao Jie Liu Xin Zhou Qingrui Fan Jianjun Wang | 2023 | Science China Chemistry2023，66，3： | 0 |
| 17 | Two-dimensional modeling of channel evolution under the influence of large-scale river regulation works显示文摘In the middle and lower reaches of alluvial rivers, various kinds of river regulation projects affecting natural channel evolution often are distributed due to the requirements of flood control, navigation,and channel stability. However, the influence of large-scale river regulation works on fluvial processes is not fully known. Therefore, a two-dimensional(2D) morphodynamic model has been improved to address this problem. The new detailed procedure is presented in this paper:(i) First, each node in the study domain was labeled using a specified point code to distinguish the zones with or without regulation works;and(ii) second, a 2D model was improved to consider the effect of river regulation works. In the refined model, the modules of sediment transport and bed deformation were treated separately in different zones. In the unprotected zones, both bed deposition and erosion were likely to occur. In the protected zones, bed erosion could not occur owing to the protection provided by the river regulation works, unless there was a deposition layer newly formed over the previous simulation periods. The observed data of the years 2004 and 2008 were used to calibrate and verify the improved 2D morphodynamic model which was applied in a 68-km-long reach of the Middle Yangtze River. Satisfactory results were obtained indicating that the improved model can better simulate the process of sediment transport and the morphology adjustment in three central bars in the study reach. | Meirong Zhou Junqiang Xia Shanshan Deng Zhiwei Li | 2022 | International Journal of Sediment Research2022，37，4： | 0 |
| 18 | Rapid Eye Movement Sleep Consolidates Social Memory显示文摘Social memory is one of declarative memory which is essential for animals to exhibit appropriate social behaviors.Evidence suggests that the hippocampus,particularly the CA2 region,plays an important role in encoding and consolidating social memory[1].Rapid eye movement(REM)sleep has been suggested to contribute to social memory consolidation by up-regulating synaptic plasticity,local field potentials,and dendritic activity[2]. | Jingkai Fan Fang Zhou Junqiang Zheng Han Xu | 2023 | Neuroscience Bulletin2023，39，10： | 0 |
| 19 | Variation in reach-averaged bankfull discharge in the Yellow River Estuary in recent years显示文摘The Yellow River Estuary(YRE)alternatively experienced channel aggradation and degradation during the period 1990-2016.To study the variation in flood discharge capacity during the process of river bed evolution,bankfull characteristic parameters were investigated on the basis of measured hydrological data and surveyed cross-sectional profiles,which was crucial for comprehending the processes and the key factors to cause these rapid changes.A reach-averaged method was presented in this study in order to calculate the characteristic bankfull parameters in the YRE,and this method integrated the geometric mean using the logarithmic transformation with a weighted mean based on the distance between the two successive sections.The reach-averaged bankfull parameters in the tail reach of the Yellow River Estuary(the Lijin-Xihekou reach)during the period 1990-2016 were then calculated.Calculated results indicated that the adoption of a concept of reach-averaged bankfull discharge was much more representative than the cross-sectional bankfull discharge,and the results also indicated that bankfull discharges decreased during the process of channel aggradation,and increased during the process of channel degradation.Finally,an empirical formula and a delayed response function were established between the reach-averaged bankfull discharge and the previous 4-year average fluvial erosion intensity during flood seasons,and both of them were adopted to reproduce the reach-averaged bankfull discharges,and calculated results showed high correlations(R^(2)>0.8)of these two methods. | Zhuoyuan YANG Junqiang XIA Meirong ZHOU Shanshan DENG Zenghui WANG Zhiwei LI | 2021 | Frontiers of Earth Science2021，15，3： | 0 |
| 20 | Lighting up Oxytocin Neurons to Nurture the Brain显示文摘The sensory system develops earlier than the systems responsible for higher brain functions such as language and cognition[1].Moreover,sensory experiences in early life are critical for the development of the brain.However,how sensory experiences shape brain development is an important yet unresolved question in neuroscience.Previous work has demonstrated that deprivation of sensory inputs in the early developmental stage causes synaptic dysfunction in the sensory cortex.Interestingly,it has been reported that oxytocin can restore the deficits caused by somatosensory deprivation in neonatal mice,suggesting that oxytocin may play a key role in sensory-mediated synaptogenesis[2].Vision is one of the most important sensory inputs during early development in mammalians including humans[1],but the neural mechanism underlying vision-mediated brain development is still largely unknown. | Fang Zhou Junqiang Zheng Han Xu | 2023 | Neuroscience Bulletin2023，39，5： | 0 |
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