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| 1 | Receiving response of towed line array to the noise of the tow ship in shallow water显示文摘The receiving response of towed line array to the noise radiated from the tow ship is investigated through normal mode modeling and computer simulation.The phenomenon that the maximum output of the towed line array is away from the endfire direction towards the tow ship is explained.The result is important for the understanding of the phenomenon and also for the application research concerning the suppression of the noise from the tow ship as well as adequate application of towed array techniques in shallow water. | MA Yuanliang LIU Mengan ZHANG Zhongbing TONG Li(1 Institute of Acoustic Engineering, Northwestern Polytechnical University Xi’an 710072) (2 Hangzhou Institute of Applied Acoustics Fuyang 311400) | 2003 | Chinese Journal of Acoustics2003，22，1： | 10 |
| 2 | Robust adaptive matched field processing with environmental uncertainty显示文摘在为被动声纳的沿岸的区域的安静目标的察觉和本地化上的主要挑战是复杂声学的繁殖和表面上的大声的轮船干扰的流行。适应的匹配的地处理能提供能力给空表面干扰,而是失配在之间计算并且由于环境无常驾驶向量的实际数组,和目标和干扰的运动能显著地导致数组获得的损失。为了处理环境失配和目标的问题,运动,一个柔韧的运动赔偿算法和一个系统策划因为适应的匹配的地处理被开发了。试验性的数据的数字模拟和分析证明柔韧的 AMFP 计划能大声压制表面干扰并且改进为在水下的弱移动的性能在复杂的浅水里指向的察觉。 | YANG Kunde MA Yuanliang ZHANG Zhongbing ZOU Shixin | 2006 | Chinese Journal of Acoustics2006，25，2： | 9 |
| 3 | Adipocyte-derived SFRP5 inhibits breast cancer cells migration and invasion through Wnt and epithelial-mesenchymal transition signaling pathways显示文摘Objective:Obesity is closely associated with metastasis in breast cancer patients.Secreted frizzled-related protein 5(SFRP5),one of the novel adipokines with anti-inflammatory properties,is associated with obesity.This study aims to study the role of SFRP5 in the crosstalk between obesity and breast cancer metastasis and identify the underlying mechanism.Methods:3T3-L1 pre-adipocytes were differentiated to mature adipocytes and a hypertrophic adipocyte model was induced with palmitic acid(PA).Cell motility was measured in MDA-MB-231 and MCF-7 breast cancer cells co-cultured with adipocytes conditioned medium(CM)with or without SFRP5 protein.Wnt and epithelialmesenchymal transition(EMT)signal pathways were investigated by western blot.Circulating SFRP5 level in 218 breast cancer patients and the association with clinicopathologic characteristics of breast cancer were further determined.Online databases ENCORI and PREDICT Plus were used to exam the link between SFRP5 and prognosis.Results:Reduced SFRP5 level was detected in the hypertrophic adipocyte model.Recombinant SFRP5 protein inhibited MDA-MB-231 and MCF-7 cells invasion and migration induced by PA-treated adipocyte CM,and SFRP5 inhibition by specific antibody reversed the effect of SFRP5.Furthermore,SFRP5 significantly inhibited Wnt and downstream EMT in breast cancer cells.Low circulating SFRP5 level correlated with body mass index(BMI),lymph node(LN)metastasis,TNM stage and high Ki67 expression in breast cancer patients.Increased SFRP5 level was associated with favorable predicted survival.Kaplan-Meier curves showed high SFRP5 level in tumor tissue was associated with better outcome of breast cancer patients.Conclusions:Our findings demonstrated SFRP5 is a vital adipokine that mediates the crosslink between obesity and the metastatic potential of breast cancer.Promotion of SFRP5 expression in the adipose microenvironment may represent a novel approach for preventing breast cancer metastasis. | Wenzhong Zhou Chunmiao Ye Liang Li Liyuan Liu Fei Wang Lixiang Yu Fei Zhou Yujuan Xiang Yongjiu Wang Gengshen Yin Zhongbing Ma Qinye Fu Qiang Zhang Dezong Gao Shuya Huang Zhigang Yu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 5 |
| 4 | Establishment of novel rat models for premalignant breast disease显示文摘 | Wang Feng Ma Zhongbing Wang Fei Fu Qinye Fang Yunzhi Zhang Qiang Gao Dezong Li Yuyang Li Liang Yu Lixiang Yu Zhigang | 2014 | Chinese Medical Journal2014，，11： | 4 |
| 5 | Human Plague Case Diagnosed in Ningxia Tracked to Animal Reservoirs—Inner Mongolia Autonomous Region,China,2021显示文摘Summary What is already known about this topic?There were a total of 4 and 3 human plague cases that occurred in the Inner Mongolia Autonomous Region in 2019 and 2020,respectively,with 1 and 2 deaths in 2019 and 2020 respectively,which indicated that plague still poses a significant threat to human health especially for farmers,shepherds,or residents living in native plague foci.What is added by this report?On August 14,2021,1 patient from the Otog Qi(County)in the Inner Mongolia sought treatment in Yinchuan City(the capital of Ningxia Hui Autonomous Region). | Jianwei Gao Yanhong Hu Cheng Ju Jingyuan Liu Yiting Wang Jiangtao Ma Xiaona Shen Fang Liu Jin Guo Xinxin Yu Wen Zhang Shuyi Wang Kun Li Zhongbing Zhang Biao Kan Wenrui Wang Xianbin Cong Mengguang Fan Wei Li Kuidong Shao Tao Zhang Jianyun Li Yumeng Wang | 2021 | China CDC weekly2021，3，52： | 1 |
| 6 | Defining newly formed and tissue-resident bone marrow-derived macrophages in adult mice based on lysozyme expression显示文摘Tissue-resident macrophages are derived from different precursor cells and display different phenotypes.Reconstitution of the tissue-resident macrophages of inflamed or damaged tissues in adults can be achieved by bone marrow-derived monocytes/macrophages.Using lysozyme(Lysm)-GFP-reporter mice,we found that alveolar macrophages(AMs),Kupffer cells,red pulp macrophages(RpMacs),and kidney-resident macrophages were Lysm-GFP^(−),whereas all monocytes in the fetal liver,adult bone marrow,and blood were Lysm-GFP^(+).Donor-derived Lysm-GFP^(+)resident macrophages gradually became Lysm-GFP−in recipients and developed gene expression profiles characteristic of tissue-resident macrophages.Thus,Lysm may be used to distinguish newly formed and long-term surviving tissue-resident macrophages that were derived from bone marrow precursor cells in adult mice under pathological conditions.Furthermore,we found that Irf4 might be essential for resident macrophage differentiation in all tissues,while cytokine and receptor pathways,mTOR signaling pathways,and fatty acid metabolic processes predominantly regulated the differentiation of RpMacs,Kupffer cells,and kidney macrophages,respectively.Deficiencies in ST2,mechanistic target of rapamycin(mTOR)and fatty acid-binding protein 5(FABP5)differentially impaired the differentiation of tissue-resident macrophages from bone marrow-derived monocytes/macrophages in the lungs,liver,and kidneys.These results indicate that a combination of shared and unique signaling pathways coordinately shape tissue-resident macrophage differentiation in various tissues. | Tong Lei Jiayu Zhang Qian Zhang Xinran Ma Yanan Xu Yang Zhao Lianfeng Zhang Zhongbing Lu Yong Zhao | 2022 | Cellular & Molecular Immunology2022，19，12： | 0 |
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