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| 1 | Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum显示文摘草药的药最近在美国作为导致药的肝损害(DILI ) 的第二个很普通的原因被认出了。然而,识别一些植物的 DILI 诱发性的可靠方法例如 Heshouwu (蓼 multiflorum 的弄干的根) ,留下缺乏。在这研究,有肝机能障碍和 Heshouwu DILI 的 147 个报导文学的案例的 12 307 个住院病人的一个总数被屏蔽。一个一般算法仅仅显示了那 22.5%(9/40 ) 并且(45/147 ) 分别地, 30.6% 所有住院和文学案例报告表明 Heshouwu 的 DILI 诱发性的高概率。由对比,(19/20 )95% 生药学,植物化学,和 metabolomic 有希望地调查的所有情况测试展出高度可能的诱发性,包括不正确地以前被归因的一个病人和从由 pharmacognostic 证据的 Heshouwu 诱发性被排除的一个案例。污染也是的毒素(重金属,杀虫剂,和 mycotoxins ) 从 Heshouwu DILI 诱发性排除了。为 Heshouwu DILI 诊断地址安全的这些屏蔽方法的客观性担心考虑包含芪的草药的药和饮食的补充。 | Jiabo Wang Zhijie Ma Ming Niu Yun Zhu Qingsheng Liang Yanling Zhao Jingyuan Song Zhaofang Bai Yaming Zhang Ping Zhang Na Li Yakun Meng Qi Li Lushan Qin Guangju Teng Junling Cao Baosen Li Shilin Chen Yonggang Li Zhengsheng Zou Honghao Zhou Xiaohe Xiao | 2015 | Frontiers of Medicine2015，9，4： | 47 |
| 2 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum显示文摘典型药用的植物的主要成分,蓼 multiflorum (用汉语的 Heshouwu ) ,那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害,而独唱治疗不能导致看得见的损害。在现在的工作,用成分大美人和敲门在里面策略,我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase, aspartate aminotransferase,和肝 histologic 的重要举起变化,而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且,孤立的 cis- ,并且不它的 trans 异构体,显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外,血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停,我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。 | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2017 | Frontiers of Medicine2017，11，2： | 41 |
| 3 | Motion simulation and test on threshed grains in tapered threshing and transmission device for plot wheat breeding based on CFD-DEM显示文摘Mechanization of field experiments is the only way to improve crop breeding and seed propagation effects.In order to further clarify and improve the working performance of tapered threshing device for plot breeding,and reduce the remaining seeds in the device,the numerical simulation was carried out on the motion process of materials in the longitudinal-axial tapered cylinder threshing and transmission device of the plot wheat breeding combine harvester based on CFD-DEM method.Simulation results showed that,threshing and transmission of particles and short stalks at axial direction could be realized under the influence of air flow.Meanwhile,the material transference and distribution rule and stream field distribution rule of air flow in the threshing and transmission device were obtained,the variations of velocity and displacement of particles and short stalks with time were obtained;the motion trajectories and forms of particles in different types of retention were also studied.At rotating speed of 1300-1600 r/min for the tapered threshing cylinder in the verification test,the particle retention rate in the enclosure was 0-0.13%,while in the simulation the particle retention rate in the enclosure was 0-0.11%,only a 0.02%difference between them.The results proved a favorable feasibility to simulate the working performance of the tapered threshing and transmission device for plot breeding through gas-solid coupling method. | Fei Dai Xuefeng Song Wuyun Zhao Zhengsheng Han Fengwei Zhang Shilin Zhang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，1： | 16 |
| 4 | Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients显示文摘B 房间对再感染在肝炎 B 病毒(HBV ) 和保护的清理起一个重要作用。然而,与长期的 HBV 感染的结果被联系的这些房间的功能的特征仍然保持未知。我们包括地在不同阶段从 CHB 病人调查了外部 B 房间子集的频率,显型,和功能:有免疫力的忍耐(信息技术) ,有免疫力的激活(IA ) ,有免疫力的清理(IC ) ,有 HBsAg seroconversion 的应答者(解决的病人, RP ) ,并且健康控制(HC ) 。IA 病人与另外的组相比显示了外部血记忆 B 房间的更低的百分比。B 房间的全面 polyclonal 激活,由激活标记和 IgG 和 IgM 的分泌物的高水平显示了,在 IA 病人被观察。这 B 房间 hyperactivation 能被增加的 IFN-α 导致;并且在 IA 病人的可溶的 CD40 ligands。尤其是,合作激发器分子 CD80 和浆液 HBsAb 的表示和 HBsAg 特定的 B 房间的频率显著地与 HC 题目相比在信息技术, IA,和 IC 病人被减少。更重要地, B 房间 hyperactivation, co-stimulatory 分子 downregulation 和 HBsAg 特定的 B 房间缺陷在 RP 病人被颠倒。B 房间 hyperactivation 和功能的缺陷的颠倒在长期的肝炎 B 病人与 HBsAg seroconversion 被联系。 | Xiangsheng Xu Qinghua Shang Xinyue Chen Weimin Nie Zhengsheng Zou Ang Huang Ming Meng Lei Jin Ruonan Xu Ji-Yuan Zhang Junliang Fu Lifeng Wang Zirong Tang Yunbo Xie Xiaoming Yang Zheng Zhang Fu-Sheng Wang | 2015 | Cellular & Molecular Immunology2015，12，3： | 15 |
| 5 | Constructing a high-density linkage map for Gossypium hirsutum × Gossypium barbadense and identifying QTLs for lint percentage显示文摘To introgress the good fiber quality and yield from Gossypium barbadense into a commercial Upland cotton variety, a high-density simple sequence repeat(SSR) genetic linkage map was developed from a BC1F1 population of Gossypium hirsutum×Gossypium barbadense. The map comprised 2,292 loci and covered 5115.16 centi Morgan(c M) of the cotton AD genome, with an average marker interval of 2.23 c M. Of the marker order for 1,577 common loci on this new map, 90.36% agrees well with the marker order on the D genome sequence genetic map. Compared with five published high-density SSR genetic maps, 53.14% of marker loci were newly discovered in this map. Twenty-six quantitative trait loci(QTLs) for lint percentage(LP) were identified on nine chromosomes. Nine stable or common QTLs could be used for marker-assisted selection. Fifty percent of the QTLs were from G. barbadense and increased LP by 1.07%–2.41%. These results indicated that the map could be used for screening chromosome substitution segments from G. barbadense in the Upland cotton background, identifying QTLs or genes from G. barbadense, and further developing the gene pyramiding effect for improving fiber yield and quality. | Yuzhen Shi Wentan Li Aiguo Li Ruihua Ge Baocai Zhang Junzhi Li Guangping Liu Junwen Li Aiying Liu Haihong Shang Juwu Gong Wankui Gong Zemao Yang Feiyü Tang Zhi Liu Weiping Zhu Jianxiong Jiang Xiaonan Yu Tao Wang Wei Wang Tingting Chen Kunbo Wang Zhengsheng Zhang Youlu Yuan | 2015 | Journal of Integrative Plant Biology2015，57，5： | 7 |
| 6 | CCAR1 5' UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance显示文摘 | Gaopeng Li Xiaoli Wu Wenchang Qian Huayong Cai Xinbao Sun Weijie Zhang Sheng Tan Zhengsheng Wu Pengxu Qian Keshuo Ding Xuefei Lu Xiao Zhang Hong Yan Haifeng Song Shouhong Guang Qingfa Wu Peter E Lobie Ge Shan Tao Zhu | 2016 | Cell Research2016，26，6： | 3 |
| 7 | Large extracellular vesicles secreted by human iPSC-derived MSCs ameliorate tendinopathy via regulating macrophage heterogeneity显示文摘Tendinopathy is a common musculoskeletal disorder which results in chronic pain and reduced performance.The therapeutic effect of stem cell derived-small extracellular vesicles(sEVs)for tendinopathy has been validated in recent years.However,whether large extracellular vesicles(lEVs),another subset of extracellular vesicles,possesses the ability for the improvement of tendinopathy remains unknown.Here,we showed that lEVs secreted from iPSC-derived MSCs(iMSC-lEVs)significantly mitigated pain derived from tendinopathy in rats.Immuno-histochemical analysis showed that iMSC-lEVs regulated the heterogeneity of infiltrated macrophages and several inflammatory cytokines in rat tendon tissue.Meanwhile,in vitro experiments revealed that the M1 pro-inflammatory macrophages were repolarized towards M2 anti-inflammatory macrophages by iMSC-lEVs,and this effect was mediated by regulating p38 MAPK pathway.Moreover,liquid chromatography-tandem mass spectrometry analysis identified 2208 proteins encapsulated in iMSC-lEVs,including 134 new-found proteins beyond current Vesiclepedia database.By bioinformatics and Western blot analyses,we showed that DUSP2 and DUSP3,the negative regulator of p38 phosphorylation,were enriched in iMSC-lEVs and could be transported to macrophages.Further,the immunomodulatory effect of iMSC-lEVs on macrophages was validated in explant tendon tissue from tendinopathy patients.Taken together,our results demonstrate that iMSC-lEVs could reduce inflammation in tendinopathy by regulating macrophage heterogeneity,which is mediated via the p38 MAPK pathway by delivery of DUSP2 and DUSP3,and might be a promising candidate for tendinopathy therapy. | Teng Ye Zhengsheng Chen Jieyuan Zhang Lei Luo Renzhi Gao Liangzhi Gong Yuhang Du Zongping Xie Bizeng Zhao Qing Li Yang Wang | 2023 | Bioactive Materials2023，，3： | 2 |
| 8 | Cotton flavonoid structural genes related to the pigmentation in brown fibers显示文摘 | Xiao Yuehua Zhang Zhengsheng Yin Menghui | | 0，，1： | 1 |
| 9 | T1 locus in cotton is the candidate gene affecting lint percentage, fiber quality and spiny bollworm (Earias spp.) resistance显示文摘 | Qun Wan Zhengsheng Zhang Meichun Hu Li Chen Dajun Liu Xiao Chen Wei Wang Jing Zheng | 2007 | Euphytica (-)2007，，1： | 1 |
| 10 | Systhesis, characterization and cytotoxicity of phosphoryl choline- grafted water soluble carbon nanotubes显示文摘 | Zhang Tao Xu Min He ling Xi Kai Gu Min Jiang Zhengsheng | 2008 | Carbon2008，46，： | 1 |
| 11 | A construction of locality--aware overlay network: over- lay and its performance显示文摘 | Xin Yan Zhang Qian Zhang Zhengsheng Zhang | 2004 | IEEE Journal on Selected Areas in Communications2004，22，1： | 1 |
| 12 | Imbalanced Intrahepatic Cytokine Expression of Interferon-γ, Tumor Necrosis Factor-α, and Interleukin-10 in Patients With Acute-on-Chronic Liver Failure Associated With Hepatitis B Virus Infection显示文摘 | Zhengsheng Zou Baosen Li Dongping Xu Zheng Zhang Jing-Min Zhao Guangde Zhou Yanling Sun Lei Huang Junliang Fu Yongping Yang Lei Jin Wei Zhang Jun Zhao Ying Sun Shaojie Xin Fu-Sheng Wang | 2009 | Journal of Clinical Gastroenterology2009，，2： | 1 |
| 13 | Photo and photoelectrochemical properties of p-type low-temperature dehydrated nanotube titanic acid显示文摘 | LI Qiuye ZHANG Jingwei JIN Zhengsheng | 2006 | Electrochem Commun2006，8，： | 1 |
| 14 | A construction of locality-aware overlay network:mOverlay and its performance显示文摘 | Zhang Xinyan Zhang Qian Zhang Zhengsheng | 2004 | IEEE Journal on Selected Areas in Communications2004，22，1： | 1 |
| 15 | Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma显示文摘Glioblastoma(GBM)is the most common and aggressive malignant brain tumor in adults and is poorly controlled.Previous studies have shown that both macrophages and angiogenesis play significant roles in GBM progression,and co-targeting of CSF1R and VEGFR is likely to be an effective strategy for GBM treatment.Therefore,this study developed a novel and selective inhibitor of CSFIR and VEGFR,SYHA1813,possessing potent antitumor activity against GBM.SYHA1813 inhibited VEGFR and CSFIR kinase activities with high potency and selectivity and thus blocked the cell viability of HUVECs and macrophages and exhibited anti-angiogenetic effects both in vitro and in vivo.SYHA1813 also displayed potent in vivo antitumor activity against GBM in immune-competent and immune-deficient mouse models,including temozolomide(TMZ)insensitive tumors.Notably,SYHA1813 could penetrate the blood-brain barrier(BBB)and prolong the survival time of mice bearing intracranial GBM xenografts.Moreover,SYHA1813 treatment resulted in a synergistic antitumor efficacy in combination with the PD-1 antibody.As a clinical proof of concept,SYHA1813 achieved confirmed responses in patients with recurrent GBM in an ongoing first-in-human phase I trial.The data of this study support the rationale for an ongoing phase I clinical study(ChiCTR2100045380). | Yingqiang Liu Zhengsheng Zhan Zhuang Kang Mengyuan Li Yongcong Lv Shenglan Li Linjiang Tong Fang Feng Yan Li Mengge Zhang Yaping Xue Yi Chen Tao Zhang Peiran Song Yi Su Yanyan Shen Yiming Sun Xinying Yang Yi Chen Shanyan Yao Hanyu Yang Caixia Wang Meiyu Geng Wenbin Li Wenhu Duan Hua Xie Jian Ding | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 16 | Understanding China’s GDP Growth Target from Multi-Dimensional Perspectives显示文摘The target of GDP growth in 2022 is higher than the actual compound growth rate of the previous two years.It reflects the weakening impact of COVID-19,the GDP growth centers convergence to the potential economic growth rate,and the need to protect market players and to stabilize employment.It is expected that fiscal,monetary and industrial-related policies will form a policy synergy and play a key role in stabilizing the economy. | ZHONG Zhengsheng ZHANG Deli | 2022 | China Forex2022，，2： | 0 |
| 17 | 3 - 26 Threshold Ion Range for Accurate Single Event Upset Measurementin SO1 SRAM Devices显示文摘 | Zhang Zhangang Liu Jie Hou Mingdong Sun Youmei Zhao Fazhan Liu Gang Han Zhengsheng Gu Song Liu Tianqi Geng Chao Xi Kai Yao Huijun Luo Jie Duan Jinglai Mo Dan | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
| 18 | Water-level based discrete integrated dynamic control to regulate the flow for sewer-WWTP operation显示文摘This study aims to propose a multi-point integrated real-time control method based on discrete dynamic water level variations,which can be realized only based on the programmable logic controller(PLC)system without using a complex mathematical model.A discretized water level control model was developed to conduct the real-time control based on data-automation.It combines the upstream pumping stations and the downstream influent pumping systems of wastewater treatment plant(WWTP).The discretized water level control method can regulate dynamic wastewater pumping flow of pumps following the dynamic water level variation in the sewer system.This control method has been successfully applied in practical integrated operations of sewer-WWTP following the sensitive flow disturbances of the sewer system.The operational results showed that the control method could provide a more stabilized regulate pumping flow for treatment process;it can also reduce the occurrence risk of combined sewer overflow(CSO)during heavy rainfall events by increasing transport capacity of pumping station and influent flow in WWTP,which takes full advantage of storage space in the sewer system. | Zhengsheng Lu Moran Wang Mingkai Zhang Ji Li Ying Xu Hanchang Shi Yanchen Liu Xia Huang | 2020 | Frontiers of Environmental Science & Engineering2020，14，3： | 0 |
| 19 | Genetic mapping and identification of Lg^(f) loci controlling green fuzz in Upland cotton(Gossypium hirsutum L.)显示文摘Naturally colored cotton fiber is environment-friendly but has monotonous color and poor fiber quality.Identification of green fiber or fuzz genes would aid in investigating the biosynthesis of green pigments in cotton fibers. In this study, we established a mapping population and found that the Lg^(f) trait(white lint and green fuzz) from Gossypium hirsutum race latifolium is controlled by an incompletely dominant gene.The Lg^(f) locus was mapped to a 71-kb interval on chromosome 21 containing seven genes, including a transcription factor with similarity to Arabidopsis MYB9. Harboring 13 SNPs and a 4-bp insertion/deletion in its promoter, GhMYB9 was highly up-regulated in the critical period for green pigment development in fuzz. Virus-induced gene silencing of GhMYB9 in a green-fuzz accession of G. hirsutum race latifolium TX-41 conferred white or light green fuzz. These results suggest that GhMYB9 is an important contributor to green pigments in cotton fiber and shed light on the regulatory mechanism controlling green pigmentation. | Dexin Liu Xueying Liu Yao Su Xiao Zhang Kai Guo Zhonghua Teng Jian Zhang Dajun Liu Zhengsheng Zhang | 2021 | The Crop Journal2021，9，4： | 0 |
| 20 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb,Polygonum multiflorum显示文摘Erratum to Frontiers of Medicine 201711(2):253–265 http://gffzzd3cc09b8251d45dfsqq65cpf9wq6c6xon.ffgz.tsg.suse.edu.cn/10.1007/s11684-017-0508-9 The original version of this article unfortunately contained some mistakes.The panel of“LPS–/drug–”in Fig.3B(Page 259),the panels of“LPS–/EtoAc+”and“LPS–/Residue+”in Supplementary Fig.3(Page 7 in the online supplementary materials)should be corrected.The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2021 | Frontiers of Medicine2021，15，2： | 0 |
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