|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gd-EOB-DTPA-enhanced magnetic resonance imaging for focal liver lesions in Chinese patients:a multicenter,open-label,phase Ⅲ study显示文摘BACKGROUND:Contrast agents help to improve visibility in magnetic resonance(MR)imaging.However,owing to the large interstitial spaces of the liver,there is a reduction in the natural contrast gradient between lesions and healthy tissue.This study was undertaken to evaluate the efficacy and safety of the liverspecific MR imaging contrast agent gadoxetate disodium(GdEOB-DTPA)in Chinese patients.METHODS:This was a single-arm,open-label,multicenter study in patients with known or suspected focal liver lesions referred for contrast-enhanced MR imaging.MR imaging was performed in 234 patients before and after a single intravenous bolus of Gd-EOB-DTPA(0.025 mmol/kg body weight).Images were evaluated by clinical study investigators and three independent,blinded radiologists.The primary efficacy endpoint was sensitivity in lesion detection.RESULTS:Gd-EOB-DTPA improved sensitivity in lesion detection by 9.46%compared with pre-contrast imaging for the average of the three blinded readers(94.78%vs 85.32%for Gd-EOB-DTPA vs pre-contrast,respectively).Improvements in detection were more pronounced in lesions less than 1cm.Gd-EOB-DTPA improved diagnostic accuracy in lesion classification.CONCLUSIONS:This open-label study demonstrated that Gd-EOB-DTPA improves diagnostic sensitivity in liver lesions,particularly in those smaller than 1 cm.Gd-EOB-DTPA also significantly improves the diagnostic accuracy in lesion classification,and furthermore,Gd-EOB-DTPA is safe in Chinese patients with liver lesions. | Meng-Su Zeng Hui-Yi Ye Liang Guo Wei-Jun Peng Jian-Ping Lu Gao-Jun Teng Josy Breuer Yi Huan Ping Li Jian-Rong Xu Chang-Hong Liang | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 31 |
| 2 | Effects of aminoguanidine on nitric oxide production induced by inflammatory cytokines and endotoxin in cultured rat hepatocytes显示文摘AIM To study the effects of aminoguanidine(AG) and two L-arginine analogues Nω-nitro-L-arginine methyl ester (L-NAME) and Nω-nitro-L-arginine (L-NNA) on nitric oxide (NO) productioninduced by cytokines (TNF-α, IL-11β, and IFN-γ)and bacterial lipopolysaccharide (LPS) mixture(CM) in the cultured rat hepatocytes, andexamine their mechanisms action.METHODS Rat hepatocytes were incubatedwith AG, L-NAME, L-NNA, Actinomycin D (ActD)and dexamethasene in a medium containing CM(LPS plus TNF-α, IL-1β, and IFN-γ) for 24 h. NOproduction in the cultured supernatant wasmeasured with the Griese reaction. IntracellularcGMP level was detected with radioimmunoasey.RESULTS NO production was markedlyblocked by AG and L-NAME in a dose-dependentmanner under inflammatory stimuli conditiontriggered by CM in vitro. The rate of themaximum inhibitory effects of L-NAME (38.9%)was less potent than that obtained with AG(53.7%, P<0.05). There was no significantdifference between the inhibitory effects of AGand two L-arginine analogues on intracellularcGMP accumulation in rat cultured hepatocytes.Non-specific NOS expression inhibitordexamethasone ( DEX ) and iNOS mRNAtranscriptional inhibitor ActD also significantlyinhibited CM-induced NO production. AG(0.1mmol.L-1) and ActD (0.2ng@Lt) wereequipotent in decreasing NO production inducedby inflammatory stimuli in vitro, and botheffects were more potent than that induced bynon-selectivity NOS activity inhibitor L-NAME(0. 1 mmol@ L- 1) under similar stimuli conditions(P | Guo Liang Zhang Ye Hong Wang Hui Ling Teng Zhi Bin Lin Department of Pharmacology,School of Basic Medical Sciences,Beijing University,Beijiog 100083,ChinaDr.Guo Liang Zhang graduated from Xinxiang Medical College in 1982,got Ph.D.at Nagoya City University Medical School,Japan in 1994,finished postdoctoral research at Beijing Medical Univcrsity in 1996,now an associate professor of pharmacology,specialized in hepatic pharmacology,having 15 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 20 |
| 3 | Isolation and Identification of a Di-(2-Ethylhexyl)Phthalate-Degrading Bacterium and Its Role in the Bioremediation of a Contaminated Soil显示文摘Di-(2-ethylhexyl) phthalate(DEHP) is a high-molecular-weight phthalate ester(PAE) that has been widely used in the manufacture of polyvinylchloride and contributes to environmental pollution.The objectives of the present study were to isolate a DEHP degrader that can utilize DEHP as a carbon source and to investigate its capacity to biodegrade DEHP in both liquid culture and soil.A bacterial strain WJ4 was isolated from an intensively managed vegetable soil,which was contaminated with PAEs.The strain WJ4 was affiliated to the genus Rhodococcus and was able to remove DEHP from soil effectively.A period of only 7 d was required to degrade about 96.4%of DEHP(200 mg L^(-1)) in the liquid culture,and more than 55%of DEHP(1.0 g kg^(-1)) in the artificially contaminated soil was removed within 21 d.Furthermore,Rhodococcus sp.strain WJ4 had a strong ability to degrade DEHP without additional nutrients in liquid minimal medium culture and DEHP-contaminated soil and to degrade the homologue of DEHP in both liquid culture and soil.Strain WJ4 represents a novel tool for removing PAEs from contaminated soils and it may have great potential for application in the remediation of environmental pollution by PAEs. | WANG Jun ZHANG Man-Yun CHEN Ting ZHU Ye TENG Ying LUO Yong-Ming Peter CHRISTIE | 2015 | Pedosphere2015，25，2： | 18 |
| 4 | Risk factors and gene polymorphisms of inflammatory bowel disease in population of Zhejiang,China显示文摘AIM:To identify the risk factors and three single nucleotide polymorphisms(SNPs) of NOD2/CARD15 gene in inflammatory bowel disease(IBD) of the population in Zhejiang,China.METHODS:A case-control study was conducted using recall questionnaire to collect data on demographic,socioeconomic,lifestyle characteristics and dietary behaviors from 136 determined IBD patients and 136 paired healthy controls.COX regression method was used to screen the statistically significant risk factors for IBD.The polymorphisms of NOD2/CARD15 gene Arg702Trp,Gly908Arg and Leu1007fsinsC were genotyped and further compared between 60 patients with IBD and 60 healthy controls by polymerase chain reaction and restriction fragment length polymorphism.RESULTS:IBD occurred primarily in young and middle-aged people.The mean age for IBD patients was 42.6 years.The ratio of males to females was 1.23:1.COX regression indicated a higher statistical significance in milk,fried food and stress compared with the other postulated risk factors for IBD.None of the patients with IBD and healthy controls had heterozygous or homozygous SNPs variants.CONCLUSION:Milk,fried food and stress are associated with increased risk of IBD.The common variants in NOD2/CARD15 gene are not associated with IBD in China's Zhejiang population. | Zi-Wei Wang Feng Ji Wei-Jun Teng Xiao-Gang Yuan Xiao-Ming Ye | 2011 | World Journal of Gastroenterology2011，17，1： | 15 |
| 5 | Lymph node dissection in esophageal carcinoma: Minimally invasive esophagectomy vs open surgery显示文摘AIM: To compare lymph node dissection results of minimally invasive esophagectomy(MIE) and open surgery for esophageal squamous cell carcinoma.METHODS: We retrospectively reviewed data from patients who underwent MIE or open surgery for esophageal squamous cell carcinoma from January 2011 to September 2014. Number of lymph nodes resected, positive lymph node(p N+) rate, lymph node sampling(LNS) rate and lymph node metastatic(LNM) rate were evaluated. R E S U LT S : A m o n g 4 4 7 p a t i e n t s i n c l u d e d, 1 2 3 underwent MIE and 324 underwent open surgery. The number of lymph nodes resected did not significantly differ between the MIE and open surgery groups(21.1 ± 4.3 vs 20.4 ± 3.8, respectively, P = 0.0944). The p N+ rate of stage T3 esophageal squamous cell carcinoma in the open surgery group was higher than that in the MIE group(16.3% vs 11.4%, P = 0.031), but no differences was observed for stages T1 and T2 esophageal squamous cell carcinoma. The LNS rate at left para-recurrent laryngeal nerve(RLN) site was significantly higher for open surgery than for MIE(80.2% vs 43.9%, P < 0.001), but no differences were noted at other sites. The LNM rate at left para-RLN site in the open surgery group was significantly higher than that in the MIE group, regardless of pathologic T stage. CONCLUSION: For stages T1 and T2 esophageal squamous cell carcinoma, the lymph node dissection result after MIE was comparable to that achieved by open surgery. However, the efficacy of MIE in lymphadenectomy for stage T3 esophageal squamous cell carcinoma, particularly at left para-RLN site, remains to be improved. | Bo Ye Chen-Xi Zhong Yu Yang Wen-Tao Fang Teng Mao Chun-Yu Ji Zhi-Gang Li | 2016 | World Journal of Gastroenterology2016，22，19： | 12 |
| 6 | Molecular Dissection of Xylan Biosynthesis during Wood Formation in Poplar显示文摘木聚糖,是在 dicot 木头的第二很丰富的多糖,被认为是为 biofuel 贡献木头生物资源固执的因素之一生产。更好作为 biofuel 化工物品利用木头,机能上地描绘在木头期间涉及木聚糖生合成的所有基因是关键的形成。在这份报告,我们在木头形成期间在木聚糖生合成调查了白杨家庭 GT43 和 GT8 glycosyltransferases 的角色。在那里存在在白杨(Populus trichocarpa ) 的染色体的七 GT43 基因,哪个中的五个,也就是 PtrGT43A, PtrGT43B, PtrGT43C, PtrGT43D,和 PtrGT43E,被显示高度在发展中的木头被表示,他们的编码蛋白质在 Golgi 是局部性的。全面基因互补结合了表明的化学分析 PtrGT43A/B/E 然而并非 PtrGT43C/D 的那 overexpression 能救缺点由 Arabidopsis irx9 异种授与的木聚糖,而 PtrGT43C/D 然而并非 PtrGT43A/B/E 的 overexpression 在 Arabidopsis irx14 异种导致了木聚糖缺点的互补。在木聚糖生合成的白杨 GT43 成员的必要角色被 GT43B 的 RNAi 下面规定进一步在在许多在木头,和举起在墙厚度和木聚糖内容导致减小的混合白杨(Populus alba x tremula ) 证实减少结束的木聚糖顺序。伍德消化的好坏分析表明那绗维素酶消化比控制木头免除了更多的葡萄糖白杨 GT43B RNAi 线的木头,显示在木头生物资源固执的减少。而且,另一棵白杨的 RNAi 下面规定联系木头的 glycosyltransferase, PoGT8D,被显示在墙厚度和木聚糖内容以及在许多引起减少减少结束的木聚糖顺序。一起,这些调查结果证明白杨 GT43 成员形成二个机能上地非冗余的组,也就是是的 Arabidopsis IRX9 和 PtrGT43C/D 的 PtrGT43A/B/E 同样功能的 orthologs Arabidopsis IRX14 的功能的 orthologs ,所有哪个涉及木聚糖脊梁的生合成,并且白杨 GT8D 为减少结束的木聚糖的生合成是必要的顺序。 | Chanhui Lee Quincy Teng Ruiqin Zhong Zheng-Hua Ye | 2011 | Molecular Plant2011，4，4： | 8 |
| 7 | BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules显示文摘Error-free mitosis depends on accurate chromosome attachment to spindle microtubules, powered congression of those chromosomes, their segregation in anaphase, and assembly of a spindle midzone at mitotic exit. The centromere-associated kinesin motor CENP-E, whose binding partner is BubR1, has been implicated in congression of misaligned chromosomes and the transition from lateral kinetochore-microtubule association to end-on capture. Although previously proposed to be a pseudokinase, here we report the structure of the kinase domain of Drosophila melanogaster BubR1, revealing its folding into a conformation predicted to be catalytically active. BubR1 is shown to be a bona fide kinase whose phosphorylation of CENP-E switches it from a laterally attached microtubule motor to a plus-end microtubule tip tracker. Computational modeling is used to identify bubristatin as a selective BubR1 kinase antagonist that targets the αN1 helix of N-terminal extension and αC helix of the BubR1 kinase domain. Inhibition of CENP-E phosphorylation is shown to prevent proper microtubule capture at kinetochores and, surprisingly, proper assembly of the central spindle at mitotic exit. Thus, BubR1-mediated CENP-E phosphorylation produces a temporal switch that enables transition from lateral to end-on microtubule capture and organization of microtubules into stable midzone arrays. | Yuejia Huang Lin Lin Xing Liu Sheng Ye Phil Y. Yao Wenwen Wang Fengrui Yang Xinjiao Gao Junying Li Yin Zhang Jiancun Zhang Zhihong Yang Xu Liu Zhenye Yang Jianye Zang Maikun Teng Zhiyong Wang Ke Ruan Xia Ding Lin Li Don W. Cleveland Rongguang Zhang Xuebiao Yao | 2019 | Cell Research2019，29，7： | 8 |
| 8 | Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress显示文摘AMPK, a master regulator of metabolic homeostasis, is activated by both AMP-dependent and AMP-independent mechanisms. The conditions under which these different mechanisms operate, and their biological implications are unclear. Here, we show that, depending on the degree of elevation of cellular AMP, distinct compartmentalized pools of AMPK are activated, phosphorylating different sets of targets. Low glucose activates AMPK exclusively through the AMP-independent, AXIN-based pathway in lysosomes to phosphorylate targets such as ACC1 and SREBP1c, exerting early anti-anabolic and pro-catabolic roles. Moderate increases in AMP expand this to activate cytosolic AMPK also in an AXIN-dependent manner. In contrast, high concentrations of AMP, arising from severe nutrient stress, activate all pools of AMPK independently of AXIN. Surprisingly, mitochondrion-localized AMPK is activated to phosphorylate ACC2 and mitochondrial fission factor (MFF) only during severe nutrient stress. Our findings reveal a spatiotemporal basis for hierarchical activation of different pools of AMPK during differing degrees of stress severity. | Yue Zong Chen-Song Zhang Mengqi Li Wen Wang Zhichao Wang Simon A. Hawley Teng Ma Jin-Wei Feng Xiao Tian Qu Qi Yu-Qing Wu Cixiong Zhang Zhiyun Ye Shu-Yong Lin Hai-Long Piao D. Grahame Hardie Sheng-Cai Lin | 2019 | Cell Research2019，29，6： | 8 |
| 9 | A new procedure combining GC-MS with accelerated solvent extraction for the analysis of phthalic acid esters in contaminated soils显示文摘An optimized procedure based on gas chromatography-mass spectrometry (GC-MS) combined with accelerated solvent extraction (ASE) is developed for the analysis of six phthalic acid esters (PAEs), which are priority soil pollutants nominated by United States Environmental Protection Agency (USEPA). Quantification of PAEs in soil employs ultrasonic extraction (UE) (USEPA 3550) and ASE (USEPA 3545), followed by clean up procedures involving three different chromatography columns and two combined elution methods. GC-MS conditions under selected ion monitoring (SIM) mode are described and quality assurance and quality control (QA/ QC) criteria with high accuracy and sensitivity for target analytes were achieved. Method reliability is assured with the use of an isotopically labeled PAE, di-n-butyl phthalate-d4 (DnBP-D4), as a surrogate, and benzyl benzoate (BB) as an internal standard, and with the analysis of certified reference materials (CRM). QA/QC for the developed procedure was tested in four PAE-spiked soils and one PAE-contaminated soil. The four spiked soils were originated from typical Chinese agricultural fields and the contaminated soil was obtained from an electronic waste dismantling area. Instrument detection limits (IDLs) for the six PAEs ranged 0.10-0.31 μg·L-1 and method detection limits (MDLs) of the four spiked soils varied from a range of 20-70 μg· kg -1 to a range of 90-290 μg· kg-1. Lineal-iVy of response between 20 μg· L-1 and 2mg.L~ was also established and the correlation coefficients (R) were a11〉0.998. Spiked soil matrix showed relative recovery rates between 75 and 120% for the six target compounds and about 93% for the surrogate substance. The developed procedure is anticipated to be highly applicable for field surveys of soil PAE pollution in China. | Tingting MA Ying TENG Peter CHRISTIE Yongming LUO Yongshan CHEN Mao YE | 2013 | Frontiers of Environmental Science & Engineering2013，7，1： | 8 |
| 10 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 11 | Molecular characterization and expression profiles of nicotinic acetylcholine receptors in the rice striped stem borer, Chilo suppressalis (Lepidoptera: Crambidae)显示文摘烟碱的醋胆素受体(nAChRs ) 是 cys 环的成员门 ligand 的离子隧道(cysLGIC ) 总科,调停的快 synaptic 在在昆虫的中央神经系统的胆碱能的传播。昆虫 nAChRs 是经济地重要的杀虫药剂的分子的目标,例如 neonicotinoids 和 spinosad。在米饭的 nAChR 基因家庭的鉴定和描述有斑纹的茎 borer, Chilo suppressalis,能关于这个重要受体基因家庭提供有益的信息并且为现在和将来的化学控制策略贡献杀虫药剂行动和电阻的分子的模式的调查。我们寻找了我们的 C。在本地强风搜索的 suppressalis transcriptome 数据库使用 Bombyx mori nAChR 序列并且获得了经由反向的抄写聚合酶链反应(RT-PCR ) 和 cDNA 的快速的扩大的互补 DNA (cDNAs ) 结束的通常认为的 nAChR 子单元方法。类似于 B。mori, C。suppressalis 拥有 12 个 nAChR 子单元,包括九种类型和三个类型子单元。量的 RT-PCR 分析在各种各样的纸巾揭示了 nAChR 子单元的表示侧面,包括大脑, subesophageal 中心,胸的中心,腹的中心,血球,胖身体,前肠, midgut, hindgut 并且肾小体小管。发展表示分析在整个 C 显示出 nAChR 子单元的清楚的微分表示。suppressalis 生命周期。在这研究的 nAChR 子单元的鉴定将为调查 nAChRs 在 C 起的多样的作用提供一个基础。suppressalis 并且为为控制农业害虫的化学药品探索特定的目标地点当时 sparing 有益的种类。 | Gang Xu Shun-Fan Wu Zi-Wen Teng Hong-Wei Yao Qi Fang Jia Huang Gong-Yin Ye | 2017 | Insect Science2017，24，3： | 6 |
| 12 | State-of-art of Geosynchronous SAR显示文摘Geosynchronous Earth Orbit Synthetic Aperture Radar(GEO SAR) runs in the height of 36000Km geosynchronous earth orbit,compared with traditional Low Earth Orbit(LEO) SAR(orbit height under 1000Km),GEO SAR has advantages of shorter repeat period,wider swath and so on.Firstly,the basic principle and state-of-art of GEO SAR in domestic and overseas are introduced.Secondly,coverage characteristic of GEO SAR is analyzed.Thirdly,the key problems of yaw steering and imaging on curved trajectory in GEO SAR are discussed in detail,and the corresponding primary solutions are presented in order to promote future research on GEO SAR. | MAO Er-ke LONG Teng ZENG Tao HU Cheng TIAN Ye | 2012 | 信号处理2012，28，4： | 6 |
| 13 | Novel dual fluorescence temperature-sensitive chameleon DNA-templated silver nanocluster pair for intracellular thermometry显示文摘第一次,我们正在报导双荧光的一种新奇类型温度敏感的模板 DNA 的银 nanocluster (AgNC ) 通过杂交在最近配对搁浅单人赛的 AgNC,它包含二。两变色龙 AgNC 对, A-NCP 和 B-NCP,拥有从 15 ~ 45 修改 tioxidant 的 chitosan 聚合物完成相应于温度变化的敏感变化的二座明亮的荧光山峰被开发。修改聚合物能有效地与 perovskite 保护太古的 AgNWs 免受方面反应的伤害,而它不通过绝缘的聚合物的接口堵住搬运人飘移。同样准备的 AgNW/polymer 合成电极在 50 m 的一种扫描尺寸在 10 nm 下面展出了根平均数平方粗糙 ????? | Weijun Zhou Jinbo Zhu Ye Teng Baoji Du Xu Han Shaojun Dong | 2018 | Nano Research2018，11，4： | 5 |
| 14 | Differentially expressed microRNAs at different stages of atherosclerosis in ApoE-deficient mice显示文摘 | SHAN Zhen YAO Chen LI Zi-lun TENG Yuan LI Wen WANG Jin-song YE Cai-sheng CHANG Guang-qi HUANG Xue-ling LI Xiao-xi WANG Wen-jian WANG Shen-ming | 2013 | Chinese Medical Journal2013，，3： | 5 |
| 15 | prognostic significance of pretreatment serum carcinoembryonic antigen levels in gastric cancer with pathological lymph node-negative: A large sample singlecenter retrospective study显示文摘AIM To assess whether elevated serum carcinoembryonic antigen(CEA) is in the inferior prognosis for pathological lymph node-negative(p N_0) gastric cancer(GC) patients who underwent D_2 gastrectomy.METHODS About 469 p N0 GC patients,who received D^2 radical gastrectomy were retrospectively analyzed. The X-tile plots cut-off point for CEA were 30.02 ng/m L using minimum P-value from log-rank χ~2 statistics,and p N_0 GC patients were assigned to two groups: those more than 30.02 ng/m L(n = 48;CEA-high group) and those less than 30.02 ng/m L(n = 421;CEA-low group). Clinicopathologic characteristics were compared usingPearson's χ2 or Fisher's exact tests,and survival curves were so manufactured using the Kaplan-Meier method. Univariate and multivariate analysis were carried out using the logistic regression method.RESULTS The percentage of vessel carcinoma embolus(31.35% vs 17.1%) and advanced GC(T_(2-4b))(81.25% vs 65.32%) were higher in CEA-high group than CEA-low group. The CEA-positive patients had a significantly poorer prognosis than the CEA-nagetive patients in terms of overall survival(57.74% vs 90.69%,P < 0.05),and no different was found between subgroup of T category,differentiation,nerve invasion,and vessel carcinoma embolus(all P > 0.05). Multivariate survival analysis showed that CEA(OR = 4.924),and T category(OR = 2.214) were significant prognostic factors for stage p N0 GC(all P < 0.05). Besides,only T category(OR = 1.962) was an independent hazard factor in the CEA-high group(P < 0.05).CONCLUSION Those pretreatment serum CEA levels over 30.02 ng/m L on behalf of worse characteristics and unfavourable tumor behavior,and a poor prognosis for a nearly doubled risk of mortality in GC patients. | Jun Xiao Zai-Sheng Ye Sheng-Hong Wei Yi Zeng Zhen-Meng Lin Yi Wang Wen-Hao Teng Lu-Chuan Chen | 2017 | World Journal of Gastroenterology2017，23，48： | 4 |
| 16 | Short-term wind power prediction based on extreme learning machine with error correction显示文摘Introduction:Large-scale integration of wind generation brings great challenges to the secure operation of the power systems due to the intermittence nature of wind.The fluctuation of the wind generation has a great impact on the unit commitment.Thus accurate wind power forecasting plays a key role in dealing with the challenges of power system operation under uncertainties in an economical and technical way.Methods:In this paper,a combined approach based on Extreme Learning Machine(ELM)and an error correction model is proposed to predict wind power in the short-term time scale.Firstly an ELM is utilized to forecast the short-term wind power.Then the ultra-short-term wind power forecasting is acquired based on processing the short-term forecasting error by persistence method.Results:For short-term forecasting,the Extreme Learning Machine(ELM)doesn’t perform well.The overall NRMSE(Normalized Root Mean Square Error)of forecasting results for 66 days is 21.09%.For the ultra-short term forecasting after error correction,most of forecasting errors lie in the interval of[-10 MW,10 MW].The error distribution is concentrated and almost unbiased.The overall NRMSE is 5.76%.Conclusion:The ultra-short-term wind power forecasting accuracy is further improved by using error correction in terms of normalized root mean squared error(NRMSE). | Zhi Li Lin Ye Yongning Zhao Xuri Song Jingzhu Teng Jingxin Jin | 2016 | Protection and Control of Modern Power Systems2016，1，1： | 3 |
| 17 | Review on grid-forming converter control methods in high-proportion renewable energy power systems显示文摘Grid-forming(GFM)converters can provide inertia support for power grids through control technology,stabilize voltage and frequency,and improve system stability,unlike traditional grid-following(GFL)converters.Therefore,in future“double high”power systems,research on the control technology of GFM converters will become an urgent demand.In this paper,we first introduce the basic principle of GFM control and then present five currently used control strategies for GFM converters:droop control,power synchronization control(PSC),virtual synchronous machine control(VSM),direct power control(DPC),and virtual oscillator control(VOC).These five strategies can independently establish voltage phasors to provide inertia to the system.Among these,droop control is the most widely used strategy.PSC and VSM are strategies that simulate the mechanical characteristics of synchronous generators;thus,they are more accurate than droop control.DPC regulates the active power and reactive power directly,with no inner current controller,and VOC is a novel method under study using an oscillator circuit to realize synchronization.Finally,we highlight key technologies and research directions to be addressed in the future. | Yuting Teng Wei Deng Wei Pei Yifeng Li Li Ding Hua Ye | 2022 | Global Energy Interconnection2022，5，3： | 3 |
| 18 | A trilogy antimicrobial strategy for multiple infections of orthopedic implants throughout their life cycle显示文摘Bacteria-associated infection represents one of the major threats for orthopedic implants failure during their life cycles.However,ordinary antimicrobial treatments usually failed to combat multiple waves of infections during arthroplasty and prosthesis revisions etc.As these incidents could easily introduce new microbial pathogens in/onto the implants.Herein,we demonstrate that an antimicrobial trilogy strategy incorporating a sophisticated multilayered coating system leveraging multiple ion exchange mechanisms and fine nanotopography tuning,could effectively eradicate bacterial infection at various stages of implantation.Early stage bacteriostatic effect was realized via nano-topological structure of top mineral coating.Antibacterial effect at intermediate stage was mediated by sustained release of zinc ions from doped CaP coating.Strong antibacterial potency was validated at 4 weeks post implantation via an implanted model in vivo.Finally,the underlying zinc titanate fiber network enabled a long-term contact and release effect of residual zinc,which maintained a strong antibacterial ability against both Staphylococcus aureus and Escherichia coli even after the removal of top layer coating.Moreover,sustained release of Sr2+and Zn2+during CaP coating degradation substantially promoted implant osseointegration even under an infectious environment by showing more peri-implant new bone formation and substantially improved bone-implant bonding strength. | Yikai Wang Wangsiyuan Teng Zengjie Zhang Xingzhi Zhou Yuxiao Ye Peng Lin An Liu Yan Wu Binghao Li Chongda Zhang Xianyan Yang Weixu Li Xiaohua Yu Zhongru Gou Zhaoming Ye | 2021 | Bioactive Materials2021，6，7： | 3 |
| 19 | Establishing Gene Delivery Systems Based on Small-Sized Chitosan Nanoparticles显示文摘Chitosan is a natural cationic polysaccharide,which is often used for preparing biomedical materials because of its high biocompatibility.In this study,chitosan with a molecular weight of 160 k Da was chosen to prepare chitosan nanoparticles(CSNPs) as gene vectors by ionic cross-linking with tripolyphosphate(TPP).CSNPs were characterized in terms of particle size,zeta potential,and polydispersity index(PDI) using a Zetasizer,and morphology was evaluated by transmission electron microscopy(TEM).Furthermore,the cytotoxicity and biocompatibility of CSNPs were correspondingly examined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay and histological examination.Agarose gel electrophoresis and UV spectrophotometric methods were performed to measure the loading capacity.The cell transfection efficiency of CSNPs loaded with plasmids or si RNA was analyzed by fluorescence microscopy or laser scanning confocal microscopy.The results showed that CSNPs were prepared successfully by the ionic gelation method,which had a smaller particle size(100 nm-200 nm),stable dispersibility,low cytotoxicity,good tissue-biocompatibility,and high gene-loading efficiency.These CSNPs could transfer the plasmids or si RNA to cells.However,CSNPs might have a much higher transfection efficiency for si RNAs than for plasmids,which implies that CSNPs might be a safer and more efficient vector for delivering si RNAs rather than plasmids. | WANG Liping ZHANG Wenhua ZHOU Quan LIU Shihai XU Wenhua SUN Teng LIANG Ye | 2018 | Journal of Ocean University of China2018，17，5： | 2 |
| 20 | Metamodel-based multidisciplinary design optimization methods for aerospace system显示文摘The design of complex aerospace systems is a multidisciplinary design optimization(MDO)problem involving the interaction of multiple disciplines.However,because of the necessity of evaluating expensive black-box simulations,the enormous computational cost of solving MDO problems in aerospace systems has also become a problem in practice.To resolve this,metamodel-based design optimization techniques have been applied to MDO.With these methods,system models can be rapidly predicted using approximate metamodels to improve the optimization efficiency.This paper presents an overall survey of metamodel-based MDO for aerospace systems.From the perspective of aerospace system design,this paper introduces the fundamental methodology and technology of metamodel-based MDO,including aerospace system MDO problem formulation,metamodeling techniques,state-of-the-art metamodel-based multidisciplinary optimization strategies,and expensive black-box constraint-handling mechanisms.Moreover,various aerospace system examples are presented to illustrate the application of metamodel-based MDOs to practical engineering.The conclusions derived from this work are summarized in the final section of the paper.The survey results are expected to serve as guide and reference for designers involved in metamodel-based MDO in the field of aerospace engineering. | Renhe Shi Teng Long Nianhui Ye Yufei Wu Zhao Wei Zhenyu Liu | 2021 | Astrodynamics2021，5，3： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员