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| 1 | Safflower yellow injection combined with conventional therapy in treating unstable angina pectoris:a meta-analysis显示文摘OBJECTIVE:To evaluate the clinical efficacy of safflower yellow injection combined with conventional therapy in treating unstable angina pectoris.METHODS:We searched online databases:Chinese journal full-text database,China National Knowledge Infrastructure,Wanfang database,Chinese journal full-text database,Pubmed,ScienceDirect,Embase,and the Cochrane Library with manual-screening of relevant literature.Eligible randomized controlled trials(RCT)on angina pectoris were included.We conducted meta-analysis using the RevMan 5.1 software from The Cochrane Collaboration.We treated the relief rate of angina symptoms and electrocardiograph(ECG)as evaluation.RESULTS:Seven articles,including in 1134 patients,were enrolled after the evaluation.Therewas no significant heterogeneity among the studies(χ2=1.08,df=6,P=0.98,I2=0%).The safflower yellow injection with conventional therapy has a higher effective rate than the control group in relieving the symptoms of angina pectoris[odds ratio(OR)=2.95,95%(CI)(1.81,4.81)]and improving ischemic ECG[OR=2.85,95%CI(1.67,4.86)].The difference was statistically significant in the'80 mg dosage'and'100 mg dosage'subgroups(P<0.05)for improving clinical symptoms and ECG.The funnel graphic was nearly symmetrical.Sensitivity analysis suggested that the results were stable.CONCLUSION:Safflower yellow injection as an adjunct therapy with conventional drugs shows advantages in easing the clinical symptoms of unstable angina and improving ECG over basic therapy alone.However,the conclusions should be interpreted with care until more high-quality RCTs are reported.2013 JTCM.All rights reserved. | Dezhao Kong Wei Xia Zhe Zhang Lei Xiao Dongchao Yuan Yue Liu Guanlin Yang | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 20 |
| 2 | Characterization of odorous charge and photochemical reactivity of VOC emissions from a full-scale food waste treatment plant in China显示文摘Food waste treatment plants(FWTPs) are usually associated with odorous nuisance and health risks, which are partially caused by volatile organic compound(VOC) emissions. This study investigated the VOC emissions from a selected full-scale FWTP in China. The feedstock used in this plant was mainly collected from local restaurants. For a year, the FWTP was closely monitored on specific days in each season. Four major indoor treatment units of the plant, including the storage room, sorting/crushing room, hydrothermal hydrolysis unit, and aerobic fermentation unit, were chosen as the monitoring locations.The highest mean concentration of total VOC emissions was observed in the aerobic fermentation unit at 21,748.2–31,283.3 μg/m3, followed by the hydrothermal hydrolysis unit at 10,798.1–23,144.4 μg/m3. The detected VOC families included biogenic compounds(oxygenated compounds, hydrocarbons, terpenes, and organosulfur compounds) and abiogenic compounds(aromatic hydrocarbons and halocarbons). Oxygenated compounds,particularly alcohols, were the most abundant compounds in all samples. With the use of odor index analysis and principal components analysis, the hydrothermal hydrolysis and aerobic fermentation units were clearly distinguished from the pre-treatment units, as characterized by their higher contributions to odorous nuisance. Methanthiol was the dominant odorant in the hydrothermal hydrolysis unit, whereas aldehyde was the dominant odorant in the aerobic fermentation unit. Terpenes, specifically limonene, had the highest level of propylene equivalent concentration during the monitoring periods. This concentration can contribute to the increase in the atmospheric reactivity and ozone formation potential in the surrounding air. | Zhe Ni Jianguo Liu Mingying Song Xiaowei Wang Lianhai Ren Xin Kong | 2015 | Journal of Environmental Sciences2015，27，3： | 7 |
| 3 | Protection of Mice from Lethal Endotoxemia by Chimeric Human BPI-Fcγ1 Gene Delivery显示文摘To evaluate the potentiality of applying gene therapy to endotoxemia in high-risk patients, we investigated the effects of transferring an adeno-associated virus serotype 2 (AAV2)-mediated BPI-Fcγ1 gene on protecting mice from challenge of lethal endotoxin. The chimeric BPI-Fcγ1 gene consists of two parts, one encods functional N-terminus (1 to 199 amino acidic residues) of human BPI, which is a bactericidal/permeability-increasing protein, and the other encodes Fc segment of human immunoglobulin G1(Fcγ1). Our results indicated that the target protein could be expressed and secreted into the serum of the gene-transferred mice. After lethal endotoxin challenge, the levels of endotoxin and TNF-αin the gene-transferred mice were decreased. The survival rate of the BPI-Fcγ1 gene-transferred mice was markedly increased. Our data suggest that AAV2-mediated chimeric BPI-Fcγ1 gene delivery can potentially be used clinically for the protection and treatment of endotoxemia and endotoxic shock in high-risk individuals. | Chen Li Jing Li Zhe Lv Xinghua Guo Qinghua Chen Qingli Kong Yunqing An | 2006 | Cellular & Molecular Immunology2006，3，3： | 7 |
| 4 | Characterization of inflammatory factor-induced changes in mesenchymal stem cell exosomes and sequencing analysis of exosomal microRNAs显示文摘BACKGROUND Treatments utilizing stems cells often require stem cells to be exposed to inflammatory environments,but the effects of such environments are unknown.AIM To examine the effects of inflammatory cytokines on the morphology and quantity of mesenchymal stem cell exosomes(MSCs-exo)as well as the differential expression of microRNAs(miRNAs)in the exosomes.METHODS MSCs were isolated from human umbilical tissue by enzymatic digestion.Exosomes were then collected after a 48-h incubation period in a serum-free medium with one of the following the inflammatory cytokines:None(control),vascular cell adhesion molecule-1(VCAM-1),tumor necrosis factor(TNF)α,and interleukin(IL)6.The morphology and quantity of each group of MSC exosomes were observed and measured.The miRNAs in MSCs-exo were sequenced.We compared the sequenced data with the miRBase and other non-coding databases in order to detect differentially expressed miRNAs and explore their target genes and regulatory mechanisms.In vitro tube formation assays and Western blot were performed in endothelial cells which were used to assess the angiogenic potential of MSCs-exo after inflammatory cytokine stimulation.RESULTS MSCs-exo were numerous,small,and regularly shaped in the VCAM-1 group.TNFαstimulated MSCs to secrete larger and irregular exosomes.IL6 led to a reduced quantity of MSCs-exo.Compared to the control group,the TNFαand IL6 groups had more downregulated differentially expressed miRNAs,particularly angiogenesis-related miRNAs.The angiogenic potential of MSCs-exo declined after IL6 stimulation.CONCLUSION TNFαand IL6 may influence the expression of miRNAs that down-regulate the PI3K-AKT,MAPK,and VEGF signaling pathways;particularly,IL6 significantly down-regulates the PI3K-AKT signaling pathway.Overall,inflammatory cytokines may lead to changes in exosomal miRNAs that abnormally impact cellular components,molecular function,and biological processes. | Chen Huang Wen-Feng Luo Yu-Feng Ye Li Lin Zhe Wang Ming-Hua Luo Qi-De Song Xue-Ping He Han-Wei Chen Yi Kong Yu-Kuan Tang | 2019 | World Journal of Stem Cells2019，11，10： | 7 |
| 5 | BPI_(700)-Fc∴1_(700) chimeric gene expression and its protective effect in a mice model of the lethal E. coli infection显示文摘Background Infections caused by gram-negative bacteria (GNB) often lead to high mortality in common clinical settings. The effect of traditional antibiotic therapy is hindered by drug-resistant bacteria and unneutralizable endotoxin. Few effective methods can protect high risk patients from bacterial infection. This study explored the protection of adeno-associated virus 2 (AAV2)-bacteriacidal permeability increasing protein 700 (BPI700) -fragment crystallizable gamma one 700 (Fc(1700) chimeric gene transferred mice against the minimal lethal dose (MLD) of E.coli and application of gene therapy for bacterial infection . Methods After AAV2-BPI700-Fc(1700 virus transfection,dot blotting and Western blotting were used to detect the target gene products in Chinese hamster ovary-K1 cells (CHO-K1cells). Reverse transcription-polymerase chain reaction and immunohistochemical assay were carried out to show the target gene expression in mice. Modified BPI-enzyme linked immunosorbent assay was used to identify the target gene products in murine serum. The protection of BPI700-Fc(1700 gene transferred mice was examined by survival rate after MLD E. coli challenge. Colony forming unit (CFU) count, limulus amebocyte lysate kit and cytokine kit were used to quantify the bacteria, the level of endotoxin, and proinflammatory cytokine. Results BPI1-199-Fc(1 protein was identified in the CHO-K1 cell culture supernatant, injected muscles and serum of the gene transferred mice. After MLD E. coli challenge, the survival rate of AAV2-BPI700-Fc(1700 gene transferred mice (36.7%) was significantly higher than that of AAV2-enhanced green fluorescent protein (AAV2- EGFP) gene transferred mice (3.3%) and PBS control mice (5.6%). The survival rate of AAV2-BPI700-Fc(1700 gene transferred mice treated with cefuroxime sodium was 65.0%. The bacterium number in main viscera, the levels of endotoxin and proinflammatory cytokine (tumor necrcsis factor-α and interleukin-1β) in serum of the AAV2-BPI700-Fc(1700 gene transferred mice were markedly lower than that of PBS control mice (P<0.01). Conclusions AAV2-BPI700-Fc(1700 gene transferred mice can resist MLD E. coli infection through expressing BPI1-199-Fc(1 protein. Our findings suggested that AAV2 mediated BPI700-Fc(1700 gene delivery could be used for protection and treatment of clinical GNB infection in high-risk individuals. | KONG Qing-li GUAN Yuan-zhi JING Xue-fang LI Chen GUO Xiang-hua LU Zhe AN Yun-qing | 2006 | Chinese Medical Journal2006，，6： | 5 |
| 6 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 7 | Effect of wrist-ankle acupuncture on propofol dosage during painless colonoscopy:A randomized controlled prospective study显示文摘BACKGROUND The clinical advantages of painless colonoscopy can reduce the fear and discomfort of patients and increase the detection rate of diseases.Propofol has the characteristics of fast effect and short action time.It is a common choice for painless endoscopic sedation and anesthetics.However,propofol can cause severe respiratory and circulatory depression.Therefore,it is important to find a way to reduce the dose of propofol.AIM To explore the effect of wrist-ankle acupuncture on propofol dose during colonoscopy.METHODS Two hundred patients who were going to receive selective painless colonoscopy in Hebei Hospital of Traditional Chinese Medicine were selected and divided into wrist-ankle acupuncture group(WAA group,n=100)and control group(CON group,n=100).After entering the operation room,patients were given 0.025 mg/kg nabufine intravenously and propofol at the initial dose of 0.5 mg/kg.In patients who did not fall asleep,propofol(10 mg/time)was given until loss of consciousness.Prior to anesthesia,patients in WAA group were punctured by specialist in the inferior 1,2 and 3 regions according to the zoning principle of wrist-ankle acupuncture.The primary endpoint was required dose of propofol,and the secondary endpoints were the incidence of hypoxemia and hypotension.Furthermore,the following data were recorded:The operation time,wake-up time,incidence of nausea and vomiting,incidence of abdominal distention,post colonoscopy pain,examiners'satisfaction,patients'satisfaction and Borg fatigue index.This study has been registered in the Chinese Clinical Trial Registry(Registration Code:ChiCTR1900022177).RESULTS The induced dose of propofol and the total dose of propofol in WAA group were 80 mg and 110 mg,respectively,which were significantly lower than those in CON group(P<0.05).The incidences of hypoxemia and hypotension in the WAA group were 2.2%and 3.3%,respectively,significantly lower than those in the CON group(P<0.05).The incidence of abdominal distension in the WAA group was 8.8%,which was significantly lower than that in the CON group(P<0.05,28.9%).The waking time of WAA group was 3.26±0.87 min,which was significantly lower than that of CON group(6.06±0.88 min,P<0.05).CONCLUSION Wrist-ankle acupuncture can reduce the induction dose and total dose of propofol as well as the incidence of adverse reactions in painless colonoscopy without affecting the satisfaction of examiners and patients.This procedure is simple in operation and easy to promote in clinical practice. | Tao He Chan Liu Zhi-Xia Lu Li-Li Kong Yan Li Zhe Xu Ya-Jing Dong Wei Hao | 2022 | World Journal of Clinical Cases2022，10，12： | 4 |
| 8 | Instantaneous lighting quality within higher educational classrooms in Singapore显示文摘This paper presents a field study that explores lighting qualities within higher educational classrooms in Singapore.Eight classrooms of three typesdcomputer labs,collaborative learning spaces and lecture hallsdare studied.Lighting simulation models are calibrated and validated by measurements taken onsite and utilized to generate both instantaneous and annual physical lighting data.A questionnaire survey is distributed to 333 participants to gather subjective responses to current lighting perception.The results show that electrically lit lecture halls present more uniform distributions of lighting environments,while daylit computer labs and daylit collaborative learning spaces present relatively lower daylighting conditions.For daylit computer labs,horizontal illuminance is an effective predictor in terms of controlling lighting levels;For electrically lit lecture halls,the mean luminance of the horizontal 40_band is an effective predictor in terms of subjective lighting comfort. | Zhe Kong J.Alstan Jakubiec | 2021 | Frontiers of Architectural Research2021，10，4： | 4 |
| 9 | Desertification: China provides a solution to a global challenge显示文摘Desertification has been caused by various factors and is a major environmental problem and development bottleneck faced by the world. It is also a serious threat to ecological security and to sustainable economic and social development. As a stubborn world problem, focused on by the United Nations 2030 sustainable development goal 15.3, China aims to combat desertification by implementing the 'eight-column fourbeam' strategy, and also suggest the 'four-medicine'approach for global desertification governance. This includes the development of the United Nations Convention to Combat Desertification protocol, unified global compliance and compliance metrics; building a global observation network, and monitoring land changes based on remote sense; preparing the global natural desert(heritage) list, leaving the original deserts for future generations; initiating the global action of combating desertification, and striving to achieve a land degradationneutral world by 2030. | Yingshuang BAO Leilei CHENG Yanfeng BAO Liu YANG Lina JIANG Chao LONG Zhe KONG Peng PENG Jun XIAO Qi LU | 2017 | Frontiers of Agricultural Science and Engineering2017，4，4： | 3 |
| 10 | Aligned fibrin/functionalized self-assembling peptide interpenetrating nanofiber hydrogel presenting multi-cues promotes peripheral nerve functional recovery显示文摘Nerve guidance conduits with hollow lumen fail to regenerate critical-sized peripheral nerve defects(15 mm in rats and 25 mm in humans),which can be improved by a beneficial intraluminal microenvironment.However,individual cues provided by intraluminal filling materials are inadequate to eliminate the functional gap between regenerated nerves and normal nerves.Herein,an aligned fibrin/functionalized self-assembling peptide(AFG/fSAP)interpenetrating nanofiber hydrogel that exerting synergistic topographical and biochemical cues for peripheral nerve regeneration is constructed via electrospinning and molecular self-assembly.The hydrogel possesses an aligned structure,high water content,appropriate mechanical properties and suitable biodegradation capabilities for nerve repair,which enhances the alignment and neurotrophin secretion of primary Schwann cells(SCs)in vitro,and successfully bridges a 15-mm sciatic nerve gap in rats in vivo.The rats transplanted with the AFG/fSAP hydrogel exhibit satisfactory morphological and functional recovery in myelinated nerve fibers and innervated muscles.The motor function recovery facilitated by the AFG/fSAP hydrogel is comparable with that of autografts.Moreover,the AFG/fSAP hydrogel upregulates the regeneration-associated gene expression and activates the PI3K/Akt and MAPK signaling pathways in the regenerated nerve.Altogether,the AFG/fSAP hydrogel represents a promising approach for peripheral nerve repair through an integration of structural guidance and biochemical stimulation. | Shuhui Yang Jinjin Zhu Changfeng Lu Yi Chai Zheng Cao Jiaju Lu Zhe Zhang He Zhao Yin-Yuan Huang Shenglian Yao Xiangdong Kong Peixun Zhang Xiumei Wang | 2022 | Bioactive Materials2022，7，2： | 3 |
| 11 | SIZ1-Mediated SUMOylation of ROS1 Enhances Its Stability and Positively Regulates Active DNA Demethylation in Arabidopsis显示文摘The 5-methylcytosine DNA glycosylase/lyase REPRESSOR OF SILENCING 1(ROS1)-mediated active DNA demethylation is critical for shaping the genomic DNA methylation landscape in Arabidopsis.Whether and how the stability of ROS1 may be regulated by post-translational modifications is unknown.Using a methylation-sensitive PCR(CHOP-PCR)-based forward genetic screen forArabidopsis DNA hyper-methyl-ation mutants,we identified the SUMO E3 ligase SIZ1 as a critical regulator of active DNA demethylation.Dysfunction of SIZ1 leads to hyper-methylation at approximately 1000 genomic regions.SIZ1 physically in-teracts with ROS1 and mediates the SUMOylation of ROS1.The SUMOylation of ROS1 is reduced in siz1 mutant plants.Compared with that in wild-type plants,the protein level of ROS1 is significantly decreased,whereas there is an increased level of ROS1 transcripts in siz1 mutant plants.Our results suggest that SIZ1-mediated SUMOylation of ROS1 promotes its stability and positively regulates active DNA demethylation. | Xiangfeng Kong Yechun Hong Yi-Feng Hsu Huan Huang Xue Liu Zhe Song Jian-Kang Zhu | 2020 | Molecular Plant2020，13，12： | 3 |
| 12 | Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2显示文摘Receptor recognition and subsequent membrane fusion are essential for the establishment of successful infection by SARS-CoV-2.Halting these steps can cure COVID-19.Here we have identified and characterized a potent human monoclonal antibody,HB27,that blocks SARS-CoV-2 attachment to its cellular receptor at sub-nM concentrations.Remarkably,HB27 can also prevent SARS-CoV-2 membrane fusion.Consequently,a single dose of HB27 conferred effective protection against SARS-CoV-2 in two established mouse models.Rhesus macaques showed no obvious adverse events when administrated with10 times the effective dose of HB27.Cryo-EM studies on complex of SARS-CoV-2 trimeric S with HB27 Fab reveal that three Fab fragments work synergistically to occlude SARS-CoV-2 from binding to the ACE2 receptor.Binding of the antibody also restrains any further conformational changes of the receptor binding domain,possibly interfering with progression from the prefusion to the postfusion stage.These results suggest that HB27 is a promising candidate for immuno-therapies against COVID-19. | Ling Zhu Yong-Qiang Deng Rong-Rong Zhang Zhen Cui Chun-Yun Sun Chang-Fa Fan Xiaorui Xing Weijin Huang Qi Chen Na-Na Zhang Qing Ye Tian-Shu Cao Nan Wang Lei Wang Lei Cao Huiyu Wang Desheng Kong Juan Ma Chunxia Luo Yanjing Zhang Jianhui Nie Yao Sun Zhe Lv Neil Shaw Qianqian Li Xiao-Feng Li Junjie Hu Liangzhi Xie Zihe Rao Youchun Wang Xiangxi Wang Cheng-Feng Qin | 2021 | National Science Review2021，8，3： | 3 |
| 13 | Atomic layer deposition-induced integration of N-doped carbon particles on carbon foam for flexible supercapacitor显示文摘Flexible devices have attracted abundant attention in energy storage systems.In this paper,we presented a novel approach for fabricating flexible supercapacitor based on metal organic frameworks-derived material.In this approach,a uniform zeolitic imidazolate frameworks-8 layer with a high mass loading was deposited on a flexible carbon foam(CF)skeleton efficiently by the induction of a uniform ZnO nanomembrane prepared via an atomic layer deposition technique.A flexible N-doped carbon particle-carbon foam(N-CP-CF)composite with a hierarchically porous structure and a large specific surface area(i.e.,538 m^(2) g^(-1))was obtained in a subsequent pyrolysis process.The resultant materials have the excellent electrochemical performance(i.e.,a high specific capacitance of 300 F g^(-1) and a high energy density of 20.8 W h kg^(-1)).The N-CP-CF composite can provide a stable capacitance(i.e.,250 F g^(-1))and an energy density(i.e.,17.36 W h kg^(-1))under large deformation(25% of original thickness).This work could propose a promising strategy in fabrication of flexible electrode with a large potential towards energy storage applications in the future. | Zhe Zhao Ye Kong Chang Liu Jinrun Liu Zhijie Wang Gengfeng Zheng Gaoshan Huang Yongfeng Mei | 2020 | Journal of Materiomics2020，6，1： | 3 |
| 14 | A novel low voltage ride through strategy for cascaded power electronic transformer显示文摘In view of the operating characteristics for voltage sags of AC side of the power electronic transformer(PET),a low-voltage ride through(LVRT)strategy adapted to bidirectional power exchange of PET is proposed for the purposes of maintaining the system stability,assisting the system voltage recovery and protecting PET safety.During the asymmetric voltage sag,the negative sequence current of PET is eliminated to ensure the symmetry of the injected current.According to the degree of positive sequence voltage sag,the reactive current injection is provided to assist in voltage recovery.According to the PET active power condition before the voltage sag,the level and direction of which are maintained as far as possible without exceeding the limit,for which the disturbance to the AC and DC grids is reduced.Finally,the effectiveness of the proposed LVRT strategy is verified by simulation model. | Jiexiang Han Xiangping Kong Peng Li Zhe Zhang Xianggen Yin | 2019 | Protection and Control of Modern Power Systems2019，4，1： | 3 |
| 15 | Protection of Immuno-Compromised Mice from Lethal Infection of Klebsiella pneumonia by rAAV2-BPI23-Fcγ1 Gene Transfer显示文摘In previous research, chimerical BPI23-Fcγ1 gene which consisted of human bactericidal/permeability increasing protein (BPI) gene of encoding the functional N terminus (amino acid residues 1 to 199) of human BPI and Fcγ1 gene of encoding the Fc segment of human immunoglobulin G1 was successfully reconstructed within a recombinant adeno-associated virus serotype 2 (rAAV2) vector as rAAV2-BPI23-Fcγ1. Here, to evaluate the potentiality of applying gene therapy to gram negative bacterial (GNB) infection in high-risk patients, we investigated protection of immuno-compromised mice and immunocompetent mice from challenge with minimal lethal dose (MLD) Klebsiella pneumonia infection after rAAV2-BPI23-Fcγ1 gene transferred. The results showed that the survival rate of rAAV2-BPI23-Fcγ1 transferred immunocompetent mice as well as immuno-compromised mice (40.0% and 44.4%, respectively) were significantly higher than that of corresponding control mice (6.7% and 4.4%, respectively); the bacteria counting, level of endotoxin and proinflammatory cytokines in the rAAV2-BPI23- Fcγ1 transferred immuno-compromised mice were markedly lower than that of rAAV2-EGFP and rAAV2-Null transferred immuno-compromised mice. Our data suggest that rAAV2-BPI23-Fcγ1 gene transferring offered immuno-compromised mice with resistance against GNB infection, so it is quite potential in preventing GNB infection of clinical high-risk patients. | Jing Li Qingli Kong Zhe Lv Yuanzhi Guan Yong Qiu Chen Li Mingjie Sun Zhenlong Liu Yunqing An | 2008 | Cellular & Molecular Immunology2008，5，6： | 2 |
| 16 | O-linked N-acetylglucosamine transferase(OGT) is overexpressed and promotes O-linked protein glycosylation in esophageal squamous cell carcinoma显示文摘The aim of this present study was to explore the expression and clinical significance of O-linked N-acetylglucosamine(O-GlcNAc) transferase(OGT) and enzymatic O-linked glycosylation(O-GlcNAcation) through the addition of O-linked-β-N-acetylglucosamine in esophageal squamous cell carcinoma.OGT expression and O-GlcNAcation in 40 samples from patients with esophageal squamous cell carcinoma was detected by immunohistochemical staining with anti-OGT antib ody and O-GlcNAc-specific antibody RL 2,respectively.The relationship between pathological and clinical factors of patients was analyzed.We found that the expression of OGT was higher in esophageal squamous cell carcinoma samples compared to the normal tissues.RL 2 antibody level was positively correlated with OGT expression,and the metastasis of lymph node,which means the level of O-GlcNAcation was high and related to the metastasis of lymph node in esophageal squamous cell carcinoma.In conclusion,OGT activation is the main reason for promoting the level of O-GlcNAcation in esophageal squamous cell carcinoma.O-GlcNAcylation may play an important role in esophageal squamous cell carcinoma. | Zhe Qiao Chengxue Dang Bin Zhou Shaomin Li Wei Zhang Jiantao Jiang Jin Zhang Ranran Kong Yuefeng Ma | 2012 | The Journal of Biomedical Research2012，26，4： | 2 |
| 17 | Effect of Tianshu capsule in treatment of migraine:a meta-analysi of randomized control trials显示文摘OBJECTIVE: To review the efficacy of Tianshu cap sule in the treatment of migraine. METHODS: Retrieving papers from Pubmed, co chrane central register of controlled trials (CEN TRAL), Weipu database (VIP) , China biology medi cine (CBM), China national knowledge infrastruc ture (CNKI), and Wanfang Data. Two reviewers retrieved and extracted the information indepen dently. Retrieval time scale is up to August 2012,Software Review Manager 5.1 was used for analysis. RESULTS: A total of 10 studies including 937 migraine patients. The merged data shows Tianshu capsule had a higher effective rate in treating migraine, and there is no significant heterogeneity between Tianshu capsule group and control group (χ2=6.33, df=9, P=0.71, I2=0% ), OR=4.18 [95% CI (2.93,5.95)]. Tianshu capsule alone compared to conventional therapy also showed advantages, and there was low heterogeneity (χ2=4.53, df=3, P=0.21, I2 = 34%), OR=3.95 [95% CI (2.32, 6.72)]. Meta-analysis results show that clinical efficacy of Tianshu capsule was better than that of the control group in the treatment of migraine and there was a significant difference (P<0.000 01). CONCLUSION: Tianshu capsule had better efficacy in the treatment of migraine with fewer adverse effects. | Wei Xia Mingjin Zhu Zhe Zhang Deizhao Kong Wei Xiao Lianqun Jia Guanlin Yang | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 2 |
| 18 | Assessment of Water Resources Carrying Capacity in Tianjin City of China显示文摘 | Xiao- meng Song Fan- zhe Kong Che- sheng Zhan | 2011 | Water Resources Management2011，25，3： | 1 |
| 19 | Voltage sag source location based on instantaneous energy detection显示文摘 | Kong Wei Dong Xinzhou Chen Zhe | 2008 | Electric Power Systems Research2008，78，3： | 1 |
| 20 | Thyroid cancer incidence in China between 2005 and 2009显示文摘 | Xufeng Fei Daxing Yang Zhe Kong Zhaohan Lou Jiaping Wu | 2014 | Stochastic Environmental Research and Risk Assessment2014，，： | 1 |
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