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16篇 您的检索式:作者名="ZHU Junqing"
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1Estimated cancer incidence and mortality in Hebei province,2012显示文摘Objective: This study estimates the numbers of new cancer cases and cancer deaths in Hebei province using incidence and mortality data from 9 population-based cancer registries in 2012.Methods: The data of new diagnosed cancer cases and cancer deaths in 2012 were collected from 9 population-based cancer registries of Hebei province in 2015. All the data met the National Central Cancer Registry of China(NCCR) criteria of data quality. The pooled data analysis was stratified by areas(urban/rural), gender, age group(0, 1-4, 5-9, 10-14, …, 85+) and cancer type. New cancer cases and deaths in Hebei province were estimated using age-specific rates and corresponding provincial population in 2012. The 10 most common cancers in different groups and the cumulative rates were calculated. Chinese population census in 2000 and Segi's population were used for age-standardized incidence/mortality rates. Results: All cancer registries covered 4,986,847 populations, 6.84% of Hebei provincial population(2,098,547 in urban and 2,888,300 in rural areas). The percentage of cases morphologically verified(MV%) and death certificate-only cases(DCO%) were 76.40% and 4.72%, respectively. The mortality to incidence rate ratio(M/I) was 0.64. In 2012, it is estimated that there were about 187,900 new diagnosed cancer cases and 119,800 cancer deaths in Hebei province. The incidence rate of cancer was 258.12/100,000(275.75/100,000 in males, 239.78/100,000 in females), and the age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 210.65/100,000 and 208.50/100,000, with the cumulative incidence rates(0-74 years old) of 24.46%. The cancer incidence and ASIRC were 256.99/100,000 and 211.32/100,000 in urban areas and 258.94/100,000 and 209.99/100,000 in rural areas, respectively. The cancer mortality rate was 164.63/100,000(201.85/100,000 in males, 125.92/100,000 in females). Agestandardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were 137.30/100,000 and 137.39/100,000 with the cumulative mortality rate(0-74 years old) of 14.58%, respectively. The cancer mortality rate in rural areas(167.16/100,000) was higher than that in urban areas(161.16/100,000). The most common cancers were lung cancer, stomach cancer, breast cancer, esophageal cancer, liver cancer and colorectal cancer, which accounted for 72.31% of all cancer cases. Lung cancer, stomach cancer, liver cancer, esophageal cancer and colorectal cancer were the major causes of cancer death in Hebei province, which accounted for 75.24% of all cancer deaths. The cancer spectrum differs between urban and rural, males and females in both incidence and mortality rates.Conclusions: The most common cancers were lung cancer, stomach cancer, esophageal cancer, breast cancer, liver cancer and colorectal cancer in Hebei province.Yutong He Di Liang Daojuan Li Jingbo Zhai Junqing Zhu Jing Jin Denggui Wen Baoen Shan 2016Chinese Journal of Cancer Research2016,28,3:8
2In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids显示文摘Unlike most organs that mature during the fetal period,the male reproductive system reaches maturity only at puberty with the commencement of spermatogenesis.Robust modelling of human testicular organogenesis in vitro would facilitate research into mechanisms of and factors affecting human spermatogenic failure and male fertility preservation in prepubertal tumor patients.Here,we report successful recapitulation of human testicular organogenesis in vitro from fetal gonadal ridge.Our model displayed the formation of mature seminiferous epithelium and self-renewing spermatogonia.Remarkably,in vitro-derived haploid spermatids have undergone meiotic recombination,and showed increased genetic diversity as indicated by genetic analysis.Moreover,these spermatids were able to fertilize oocytes and support subsequent blastocyst formation.The in vitro testicular organogenesis system described here will play an important role in elucidating the regulation of human testis development and maintaining male fertility in prepubertal cancer patients.Yan Yuan Laihua Li Qing Cheng Feiyang Diao Qiao Zeng Xiaoyu Yang Yibo Wu Hao Zhang Mingqian Huang Junqing Chen Quan Zhou Yunfei Zhu Rong Hua Jianyu Tian Xin Wang Zuomin Zhou Jie Hao Jinjin Yu Dong Hua Jiayin Liu Xuejiang Guo Qi Zhou Jiahao Sha 2020Cell Research2020,30,3:6
3Effects of lanthanum on the growth and essential oil components of lavender under osmotic stress显示文摘The effects of lanthanum on growth, soluble sugar content, essential oil contents and quality were studied in lavender plant(Lavandula Angustifolia Mill, Variety 701) under osmotic stress by means of PEG-6000 solution. The results show that osmotic stress could reduce the growth rate of lavender, and increase the content of SSC(soluble sugar concentration) to some extent. Compared with control group,the contents of essential oil in flowers and leaves respectively increase by 45.6% and 48.3% in the osmotic stress group induced by 15% PEG-6000. However, the presence of lanthanum can make the contents of essential oil in the flowers and leaves of stressed lavender plants enhance by 19.4% and 18.6%, respectively. Under osmotic stress, the relative contents of four kinds of lavender essential oil compositions of camphor, linalool, linalyl acetate and lavandulol acetate in the lavender flowers were successively 22.63%,0.61%,25.46%,7.03%,and 20.17%,0.62%,20.72%,10.80%,respectively in the presence and absence of lanthanum. The contents of all four main components of lavender essential oils meet the requirements of the national standard under osmotic stress in the presence of lanthanum. However, in the absence of lanthanum, the contents of linalyl acetate and lavandulol acetate does not meet the requirements of the national standard under osmotic stress. Moreover, the contents of five components of borneol, camphor,eudesmol, caryophyllene oxide and bicyclic sesquiphellandrene from the essential oil of lavender leaves are 12.89%, 3.84%, 8.76%, 11.30% and 8.10%, respectively. The total content of above five components accounts for 44.89% of the essential oil of the lavender leaves. Particularly, the borneol content in leaf essential oil is up to 12.89%. It is 125.2 times the amount of borneol in the flower essential oil. In conclusion, the suitable concentration of lanthanum can improve the adaptability of lavender plants, and heighten the content and quality of lavender essential oil to some extent under osmotic stress.Liyun Zhu Linzhen Song Yongsheng Gao Junqing Qian Xiaodong Zhang Sufang Li 2018Journal of Rare Earths2018,36,8:5
4Surface disorder engineering in ZnCdS for cocatalyst free visible light driven hydrogen production显示文摘Metal chalcogenide solid solution,especially ZnCdS,has been intensively investigated in photocatalytic H_(2) generation due to their cost-effective synthetic procedure and adjustable band structures.In this work,we report on the defect engineering of ZnCdS with surface disorder layer by simple room temperature Li-ethylenediamine(Li-EDA)treatment.Experimental results confirm the formation of unusual Zn and S dual vacancies,where rich S vacancies(Vs)served as electron trapping sites,meanwhile Zn vacancies(Vzn)served as hole trapping sites.The refined structure significantly facilitates the photo charge carrier transfer and improves photocatalytic properties of ZnCdS.The disordered ZnCdS shows a highest photocatalytic H_(2) production rate of 33.6 mmol·g^(-1)·h^(-1) under visible light with superior photocatalytic stabilities,which is 7.3 times higher than pristine ZnCdS and 7 times of Pt(1 wt.%)loaded ZnCdS.Enna Ha Shuhong Ruan Danyang Li Yuanmin Zhu Yanping Chen Jiangyuan Qiu Zhaohui Chen Tingting Xu Jingyun Su Luyang Wang Junqing Hu 2022Nano Research2022,15,2:3
5Alteration of sperm protein profile induced by cigarette smoking显示文摘香烟吸烟与更低的精液质量被联系,但是香烟吸烟怎么改变精液质量,仍然保持不清楚。这研究的目的是屏蔽在有到香烟的每日的暴露的老鼠的精子的表示蛋白质吸的差别。2D 胶化电气泳动(2DE ) 和集体 spectrometry (MS ) 分析显示出的结果老鼠精子蛋白质侧面被香烟吸烟改变。并且对应于表示的差别的 22 最丰富的蛋白质在精子的 2DE 胶化看到样品被识别。这些蛋白质基于他们的功能被分类进不同的组,例如精力新陈代谢,复制,和结构的分子。而且,五蛋白质(Aldoa, ATP5a1, Gpx4, C,和 Spatc1 ) 的 2DE 和 MS 结果被西方的污点分析和反向的 transcriptase 聚合酶链反应验证。结果证明除了 Spatc1,另外的四蛋白质显示出在吸烟的组和控制组之间的统计上重要的不同蛋白质层次(P < 0.05 ) 。三基因(Aldoa, Gpx4,和 Spatc1 ) 的表达式是显著地不同的(P < 0.05 ) 在在吸烟的组和控制组之间的抄写水平。另外,在从 30 个男吸烟者和 30 个不抽烟的人的人的精子样品的五蛋白质(Aldoa, ATP5a1, Spatc1, C,和 Gpx4 ) 被西方的污点分析检测。与精力生产被联系的二蛋白质(Aldoa 和 C ) 被发现显著地被改变,建议这些蛋白质可以是为吸在精子的风险的评估的潜在的诊断标记。这些蛋白质的进一步的学习可以提供卓见进在吸人位于不孕下面的病原的机制。Xiaohui Chen Wangjie Xu Maohua Miao Zijue Zhu Jingbo Dai Zhong Chen Peng Fang Junqing Wu Dongsheng Nie Lianyun Wang Zhaoxia Wang Zhongdong Qiao Huijuan Shi 2015Acta Biochimica et Biophysica Sinica2015,47,7:2
6Clinical observation of Qushi Xiezhuo formula in reducing monosodium urate crystal deposition in patients with axial spondyloarthritis显示文摘OBJECTIVE: To investigate effect of Qushi Xiezhuo formula (QSXZF) on axial spondyloarthritis (AxSpA) with a high incidence of monosodium serum urate (MSU) crystal deposition.METHODS: In this prospective cohort study, 62 Ax- SpA patients diagnosed with MSU crystal deposition from October 2012 to July 2015 were recruited for follow-up observation for 1 year after discharge from the hospital. Patients were divided into a case group with QSXZF treatment and a control group without any interventions. X-ray and dual-energy computed tomography were used to assess structural damage in the pelvis and sacroiliac joint and the volume of the MSU crystals. The Wilcoxon rank-sum test and Fisher's exact test were used to compare the proportion and distribution between the groups. RESULTS: A decrease in C-reactive protein (CRP) level, relief from back pain, and an increase in MSU crystal depositions were found in control patients. Compared with the control group, QSXZF reduced CRP levels and back pain to a greater extent, as well as reduced erythrocyte sedimentation rate levels, serum uric acid levels, Ankylosing Spondylitis Disease Activity Score, morning stiffness and MSU crystal deposition. CONCLUSION: QSXZF can lower progress of radiogrphaic grade at sacroiliac joint in AxSpA/AS patients with MSU crystal deposition by decreasing the inflammation response and reducing the serum uric acid and volume of MSU crystal deposition in sacroiliac joint. The above process may be attributed to the relieving the Qi-movement disturbance in the body, and eliminating turbidity and dampness by QSXZF.Li Aiwu Huang Yinger Zheng Songyuan Tang Cuiping Zhu Junqing Li Juan 2019Journal of Traditional Chinese Medicine2019,39,5:1
7An FPS-ZM1-encapsulated zeolitic imidazolate framework as a dual proangiogenic drug delivery system for diabetic wound healing显示文摘Inhibitors that target diabetes pathology-related signaling pathways have great therapeutic potential for diabetic wound healing.Metal–organic frameworks(MOFs)are increasingly popular drug delivery systems that have high loading capacity and can release their intrinsic metal ions to act as bioactive agents.In light of this,a receptor for advanced glycation end products(RAGE)inhibitor,4-chloro-N-cyclohexyl-N-(phenylmethyl)-benzamide(FPS-ZM1),was loaded into a cobalt(Co)-based MOF(zeolitic imidazolate framework-67,ZIF-67)to fabricate FPS-ZM1 encapsulated ZIF-67(FZ@ZIF-67)nanoparticles(NPs).As a result,FZ@ZIF-67 NPs could dually deliver Co ions and FPS-ZM1 in a controlled manner for over 14 days.Our in vitro study showed that FZ@ZIF-67 NPs not only enhanced angiogenesis by delivering Co ions but also released FPS-ZM1 to promote M2 macrophage polarization and attenuated high glucose(HG)-and/or inflammation-induced impairment of angiogenesis through RAGE inhibition.Moreover,in an in vivo study,FZ@ZIF-67 NPs markedly improved re-epithelialization,collagen deposition,neovascularization,and relieved inflammation in diabetic wounds in rats.This study not only provides a low-cost,effective,and synergistic proangiogenic bioactive agent but also demonstrates that targeting diabetes-related pathological signaling pathways is necessary to ameliorate vascularization impairment during diabetic wound healing.Yi Sun Bingbo Bao Yu Zhu Junjie Shen Xuanzhe Liu Tao Gao Junqing Lin Tengli Huang Jia Xu Yimin Chai Xianyou Zheng 2022Nano Research2022,15,6:0
82 - 2 Half-Lives of α Decay by Unified Fission Model显示文摘Li Junqing Zhang Hongfei Zhu Tianbao Zhou Xiaohong Gan Zaiguo 2010IMP & HIRFL Annual Report2010,,1:0
9Biological evaluation on ^(125)I-ADAM as serotonin transporter ligand显示文摘ADAM (2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine) is suggested as a promising serotonin transporter (SERT) imaging agent for central nervous system. In this paper, biodistribution studies in rats showed that the initial uptake of 131I-ADAM in the brain was high (1.087%ID at 2 min post-injection), and consistently displayed the highest binding (between 60~240 min post-injection) in hypothalamus, a region known with the highest density of SERT. The specific binding((T/CB)-1) of 131I-ADAM in hypothalamus were 2.94, 3.03 and 3.09 at 60, 120 and 240 min post-injection, respectively. The (T/CB)-1 was significantly blocked by pretreatment with paroxetine, which is known as a serotonin site reuptake inhibitor, while another nonselective competing drug (5HT2A antagonist) Ketanserin, showed no block effect. The rat brain autoradiography and analysis showed that there was a high 131I-ADAM uptake in hypothalamus, the ratio of hypothalamus/cerebellum was significantly reduced from 7.94±0.39 to 1.30±0.56 by pretreatment with paroxetine at 60 min post-injection. Blood clearance kinetics was performed in rats, and the initial half-life of 13.79 min and late half-life of 357.14 min were obtained. The kinetic equation is: C=3.6147e-0.0725t + 1.0413e-0.0028t. The thyroid uptake was 0.009% ID and 1.421% ID at 2 min and 120 min post-injection, respectively, suggesting that in vivo deiodination may be the major route of metabolism. Toxicity trial showed that the dose per kilogram administered to mice was 1000 times greater than that to humans, assuming a weight of 50kg. These data suggest that 131I-ADAM may be useful for SPECT imaging of SERT binding sites in the brain.LEI Bei ZHU Junqing LU Chunxiong JIANG Quanfu ZOU Meifeng WANG Songpei LI Xiaomin WU Chunying 2007Nuclear Science and Techniques2007,18,4:0
10A Novel Aquila Optimizer Based PV Array Reconfiguration Scheme to Generate Maximum Energy under Partial Shading Condition显示文摘This paper develops a real-time PV arrays maximum power harvesting scheme under partial shading condition(PSC)by reconfiguring PV arrays using Aquila optimizer(AO).AO is based on the natural behaviors of Aquila in capturing prey,which can choose the best hunting mechanism ingeniously and quickly by balancing the local exploitation and global exploration via four hunting methods of Aquila:choosing the searching area through high soar with the vertical stoop,exploring in different searching spaces through contour flight with quick glide attack,exploiting in convergence searching space through low flight with slow attack,and swooping through walk and grabbing prey.In general,PV arrays reconfiguration is a problem of discrete optimization,thus a series of discrete operations are adopted in AO to enhance its optimization performance.Simulation results based on 10 cases under PSCs show that the mismatched power loss obtained by AO is the smallest compared with genetic algorithm,particle swarm optimization,ant colony algorithm,grasshopper optimization algorithm,and butterfly optimization algorithm,which reduced by 4.34%against butterfly optimization algorithm.Dong An Junqing Jia Wenchao Cai Deyu Yang Chao Lv Jiawei Zhu Yingying Jiao 2022Energy Engineering2022,119,4:0
11Effect of superabsorbent polymer on mechanical properties of cement stabilized base and its mechanism显示文摘Superabsorbent polymers(SAPs)are cross-linked polymers that can absorb and retain large amounts of water.In recent years,a growing interest was seen in applying SAPs in concrete to improve its performance due to its efficiency in mitigating shrinkage.This paper presents findings in a study on effect of SAPs on performance of cement-treated base(CTB),using the experience of internal curing of concrete.CTB specimens with and without SAPs were prepared and tested in the laboratory.Tests conducted include mechanical property testing,dry shrinkage testing,differential thermal analysis,mercury intrusion porosimetry and scanning electron microscope testing.It was found that 7-day and 28-day unconfined compressive strength of CTB specimens with SAPs was higher than regular CTB specimens.28d compressive strength of CTB specimens with SAPs made by Static pressure method was 5.87 MPa,which is 27%higher than that of regular CTB specimens.Drying shrinkage of CTB specimens with SAPs was decreased by 52.5%comparing with regular CTB specimens.Through the microstructure analysis it was found that CTB specimens with SAPs could produce more hydration products,which is also the reason for the strength improvement.Yongsheng Guan Zhixiang Zhang Xiaorui Zhang Junqing Zhu Wen Zhou Qi Huang Yuqing Zhang 2020Transportation Safety and Environment2020,2,1:0
12A K-nearest Neighbor Model to Predict Early Recurrence of Hepatocellular Carcinoma After Resection显示文摘Background and Aims:Patients with hepatocellular carci-noma(HCC)surgically resected are at risk of recurrence;however,the risk factors of recurrence remain poorly un-derstood.This study intended to establish a novel machine learning model based on clinical data for predicting early re-currence of HCC after resection.Methods:A total of 220 HCC patients who underwent resection were enrolled.Clas-sification machine learning models were developed to predict HCC recurrence.The standard deviation,recall,and preci-sion of the model were used to assess the model’s accura-cy and identify efficiency of the model.Results:Recurrent HCC developed in 89(40.45%)patients at a median time of 14 months from primary resection.In principal compo-nent analysis,tumor size,tumor grade differentiation,por-tal vein tumor thrombus,alpha-fetoprotein,protein induced by vitamin K absence or antagonist-II(PIVKA-II),aspartate aminotransferase,platelet count,white blood cell count,and HBsAg were positive prognostic factors of HCC recurrence and were included in the preoperative model.After compar-ing different machine learning methods,including logistic re-gression,decision tree,naïve Bayes,deep neural networks,and k-nearest neighbor(K-NN),we choose the K-NN model as the optimal prediction model.The accuracy,recall,preci-sion of the K-NN model were 70.6%,51.9%,70.1%,respec-tively.The standard deviation was 0.020.Conclusions:The K-NN classification algorithm model performed better than the other classification models.Estimation of the recurrence rate of early HCC can help to allocate treatment,eventually achieving safe oncological outcomes.Chuanli Liu Hongli Yang Yuemin Feng Cuihong Liu Fajuan Rui Yuankui Cao Xinyu Hu Jiawen Xu Junqing Fan Qiang Zhu Jie Li 2022Journal of Clinical and Translational Hepatology2022,10,4:0
13Activation of AMPKα1 is essential for regulatory T cell function and autoimmune liver disease prevention显示文摘Regulatory T cells(Treg cells)are crucial for maintaining immune tolerance.Compromising the regulatory function of Treg cells can lead to autoimmune liver disease.However,how Treg cell function is regulated has not been fully clarified.Here,we report that mice with AMP-activated protein kinase alpha 1(AMPKα1)globally knocked out spontaneously develop immune-mediated liver injury,with massive lymphocyte infiltration in the liver,elevated serum alanine aminotransferase levels,and greater production of autoantibodies.Both transplantation of wild-type bone marrow and adoptive transfer of wild-type Treg cells can prevent liver injury in AMPKα1-KO mice.In addition,Treg cell-specific AMPKα1-KO mice display histological features similar to those associated with autoimmune liver disease,greater production of autoantibodies,and hyperactivation of CD4^(+)T cells.AMPKα1 deficiency significantly impairs Treg cell suppressive function but does not affect Treg cell differentiation or proliferation.Furthermore,AMPK is activated upon T cell receptor(TCR)stimulation,which triggers Foxp3 phosphorylation,suppressing Foxp3 ubiquitination and proteasomal degradation.Importantly,the frequency of Treg cells and the phosphorylation levels of AMPK at T172 in circulating blood are significantly lower in patients with autoimmune liver diseases.Conclusion:Our data suggest that AMPK maintains the immunosuppressive function of Treg cells and confers protection against autoimmune liver disease.Huaiping Zhu Zhaoyu Li Junqing An Miao Zhang Yu Qiu Ming-Hui Zou 2021Cellular & Molecular Immunology2021,18,12:0
14n-Octyloxyallene homopolymerization and random copolymerization with styrene using catalyst system composed of lanthanide Schiff-base complexes and Al(i-Bu)_3显示文摘The catalyst system composed of lanthanide Schiff-base complexes with [3,5-tBu2 -2-(O)C6H2 CH=NC6H5]3 Ln(THF)(Ln(Salen)3 , Ln = Sc, Y, La, Nd, Sm, Gd, Yb) and triisobutyl aluminum shows high activity for n-octyloxyallene (A) homopolymerization with narrow molecular weight distribution (MWD). The influences of reaction conditions on polymerization behavior are investigated, and poly(n-octyloxyallene) has a weight average molecular weight (M w ) of 20.6 × 10 3 with MWD of 1.39 and 100% yield is obtained under the optimum conditions: [Al]/[Y] = 50 mol/mol, [A]/[Y] = 100 mol/mol, with polymerization at 80 ℃ for 16 h in bulk. The kinetic studies of n-octyloxyallene homopolymerization indicate that the polymerization rate is first-order with respect to the monomer concentration and shows some controlled polymerization characteristics. Random copolymer of n-octyloxyallene with styrene is obtained by using the same binary catalyst system; the reactivity ratios of the comonomer determined by Kelen Tüd s method are r A = 1.20 and r St = 0.35, respectively, the ratio of each segment and M w of the resulting copolymer could be controlled by varying the feed ratio of each monomer. Determined by differential scanning calorimetry, the copolymers obtained show only one glass transition temperature, which increases gradually with the increase of styrene content in the copolymer.JIAO JunQing ZHU WeiWei NI XuFeng SHEN ZhiQuan 2013Science China Chemistry2013,56,7:0
15Sharing casting technological data on web site显示文摘Based on database and asp.net technologies,a web platform of scientific data in the casting technology field has been developed.This paper presents the relevant data system structure,the approaches to the data collection,the applying methods and policy in data sharing,and depicts the collected and shared data recently finished.Statistics showed that there are about 20,000 visitors in China every day visiting the related data through the web,proving that many engineers or other relevant persons are interested in the data.Sun Xun Li Hailan Wang Junqing Piao Dongxue Hou Gang Guan Yang Wang Penghua Zhu Qiang Xie Huasheng 2008China Foundry2008,5,4:0
16Distributed Aggregation Algorithms for Mobile Sensor Networks with Group Mobility Model显示文摘In many applications of mobile sensor networks, such as water flow monitoring and disaster rescue, the nodes in the network can move together or separate temporarily. The dynamic network topology makes traditional spanning-tree-based aggregation algorithms invalid in mobile sensor networks. In this paper, we first present a distributed clustering algorithm which divides mobile sensor nodes into several groups, and then propose two distributed aggregation algorithms, Distance-AGG (Aggregation based on Distance), and Probability-AGG (Aggregation based on Probability). Both of these two algorithms conduct an aggregation query in three phases: query dissemination, intra-group aggregation, and inter-group aggregation. These two algorithms are efficient especially in mobile networks. We evaluate the performance of the proposed algorithms in terms of aggregation accuracy, energy efficiency, and query delay through ns-2 simulations. The results show that Distance-AGG and Probability-AGG can obtain higher accuracy with lower transmission and query delay than the existing aggregation algorithms.Qianqian Ren Longjiang Guo Jinghua Zhu Meirui Ren Junqing Zhu 2012Tsinghua Science and Technology2012,17,5:0
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