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| 1 | Global analysis of lysine succinylation in patchouli plant leaves显示文摘Lysine succinylation is a novel,naturally occurring posttranslational modification(PTM)in living organisms.Global lysine succinylation identification has been performed at the proteomic level in various species;however,the study of lysine succinylation in plant species is relatively limited.Patchouli plant(P.cablin(Blanco)Benth.,Lamiaceae)is a globally important industrial plant and medicinal herb.In the present study,lysine succinylome analysis was carried out in patchouli plants to determine the potential regulatory role of lysine succinylation in patchouli growth,development,and physiology.The global succinylation sites and proteins in patchouli plants were screened with an immunoprecipitation affinity enrichment technique and advanced mass spectrometry-based proteomics.Several bioinformatic analyses,such as function classification and enrichment,subcellular location predication,metabolic pathway enrichment and protein−protein interaction networking,were conducted to characterize the functions of the identified sites and proteins.In total,1097 succinylation sites in 493 proteins were detected in patchouli plants,among which 466 succinylation sites in 241 proteins were repeatedly identified within three independent experiments.The functional characterization of these proteins indicated that the tricarboxylic acid(TCA)cycle,oxidative phosphorylation,photosynthesis processes,and amino acid biosynthesis may be regulated by lysine succinylation.In addition,these succinylated proteins showed a wide subcellular location distribution,although the chloroplast and cytoplasm were the top two preferred cellular components.Our study suggested the important role of lysine succinylation in patchouli plant physiology and biology and could serve as a useful reference for succinylation studies in other medicinal plants. | Xiaobing Wang Xiuzhen Chen Junren Li Xuanxuan Zhou Yanting Liu Liting Zhong Yun Tang Hai Zheng Jiyun Liu Ruoting Zhan Likai Chen | 2019 | Horticulture Research2019，6，1： | 2 |
| 2 | Production of hydrolysate with antioxidative activity by enzymatic hydrolysis of extruded corn gluten显示文摘 | ZHENG Xiqun LI Lite LIU Xiaolan | 2006 | Appl Microbiol Bioteclmol2006，73，4： | 1 |
| 3 | Evolution of heavy metal speciation during the aerobic composting process of sewage sludge显示文摘 | Yangsheng Liu Lanlan Ma Yaqiong Li Liting Zheng | 2006 | Chemosphere2006，，5： | 1 |
| 4 | Production ofilydrolysatewith antioxidative activity by enzymatic hy-drolysis of extruded corn gluten显示文摘 | ZHENG Xiqan LI Lite LIU Xiaolan | | Appl Microbiol Biotechno 2 0060，73，4： | 1 |
| 5 | Effect of endoxylanases on dough properties and making performance of Chinese steamed bread显示文摘 | Dongmin Su Changhe Ding Lite Li Donghai Su Xinyu Zheng | 2005 | European Food Research and Technology (-)2005，，5： | 1 |
| 6 | Effects of di-(2-ethylhexyl) phthalate on the hypothalamus-pituitary-ovarian axis in adult female rats显示文摘 | Te Liu Na Li Jian Zhu Guangyan Yu Kun Guo Liting Zhou Dongchun Zheng Xiaofeng Qu Jian Huang Xin Chen Shuyue Wang Lin Ye | 2014 | Reproductive Toxicology2014，，： | 1 |
| 7 | Directed orthogonal self-assembly of homochiral coordination polymers for heterogeneous enantioselective hydrogenation显示文摘 | Yu Liting Wang Zheng Wu Jiang | 2010 | Angew Chem Int Ed2010，49，： | 1 |
| 8 | Production of hydrolysate with antioxidative activity by enzymatic hydrolysis of extruded corn gluten 显示文摘 | Zheng X Q Li Lite Liu X L | 2006 | Applied Microbiology and Biotechnolo gy2006，73，4： | 1 |
| 9 | Detection and molecular characterization of recombinant avian leukosis viruses in commercial egg-type chickens in China显示文摘 | Chaonan Liu Shimin Zheng Yongqiang Wang Long Jing Honglei Gao Yulong Gao Xiaole Qi Liting Qin Wei Pan Xiaomei Wang | 2011 | Avian Pathology2011，，3： | 1 |
| 10 | SEM/EDS and XRD characterization, of raw and washed MSWI flyash sintered at different tem peratures显示文摘 | LIU Yangsheng ZHENG Liting LI Xiaodong | 2009 | Journal of HazardousMaterials2009，162，1： | 1 |
| 11 | Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc显示文摘Actin filament associated protein 1 antisense RNA 1(named AFAP1-AS1)is a long non-coding RNA and overexpressed in many cancers.This study aimed to identify the role and mechanism of AFAP1-AS1 in lung cancer.The AFAP1-AS1 expression was firstly assessed in 187 paraffin-embedded lung cancer and 36 normal lung epithelial tissues by in situ hybridization.The migration and invasion abilities of AFAP1-AS1 were investigated in lung cancer cells.To uncover the molecular mechanism about AFAP1-AS1 function in lung cancer,we screened proteins that interact with AFAP1-AS1 by RNA pull down and the mass spectrometry analyses.AFAP1-AS1 was highly expressed in lung cancer clinical tissues and its expression was positively correlated with lung cancer patients'poor prognosis.In vivo experiments confirmed that AFAP1-AS1 could promote lung cancer metastasis.AFAP1-AS1 promoted lung cancer cells migration and invasion through interacting with Smad nuclear interacting protein 1(named SNIP1),which inhibited ubiquitination and degradation of c-Myc protein.Upregulation of c-Myc molecule in turn promoted the expression of ZEB1,ZEB2,and SNAIL gene,which ultimately enhanced epithelial to mesenchymal transition(EMT)and lung cancer metastasis.Understanding the molecular mechanism by which AFAP1-AS1 promotes lung cancer's migration and invasion may provide novel therapeutic targets for lung cancer patients'early diagnosis and therapy. | Yu Zhong Liting Yang Fang Xiong Yi He Yanyan Tang Lei Shi Songqing Fan Zheng Li Shanshan Zhang Zhaojian Gong Can Guo Qianjin Liao Yujuan Zhou Ming Zhou Bo Xiang Xiaoling Li Yong Li Zhaoyang Zeng Guiyuan Li Wei Xiong | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 1 |
| 12 | First detection of cutavirus DNA in stools of patients with rheumatic diseases in Guangzhou,China显示文摘Cutavirus(CuV)is a novel protoparvovirus possibly associated with diarrhea and cutaneous T-cell lymphomas.Patients with rheumatic disease are immunosuppressed and may be more vulnerable to pathogenic viruses.A descriptive study was conducted among hospitalized patients with rheumatic diseases and individuals undergoing medical health check-ups between June 2019 and June 2022 in Guangzhou,China.Stool samples of subjects were tested for CuV DNA.Demographic and fecal examination data of patients were obtained from electronic medical records.A total of 505 patients with rheumatic diseases and 244 individuals who underwent medical health check-ups were included in the study.Of the patients with rheumatic disease,5.74%[95%confidence interval(CI):4.03%–8.12%]were positive for CuV DNA,while no individual in the medical health check-up group was positive,indicating a close correlation between CuV and rheumatic disease.Men and patients with rheumatoid arthritis or ankylosing spondylitis,according to the disease classification,were more susceptible to being infected with CuV(P<0.01).After adjustments,being male remained the only significant factor,with an adjusted odd ratio(OR)of 4.4(95%CI:1.7–11.4,P?0.002).Phylogenetic analysis of the CuV VP2 sequences showed three diverse clades,one of which was segregated to be a single branching independent of previously known sequences,which is possible a new genotype. | Yongzhi Li Liting Zheng Huan He Husheng Xiong Jiaqi Chen Hengbiao Sun Caiyun Chen Qiushuang Li Jiaqi Fu Fei Wu Yuhan Gao Juxian Xian Minyi Liang Gang Xiao Qing Chen | 2023 | Virologica Sinica2023，38，6： | 0 |
| 13 | Identification of broad neutralizing antibodies against Omicron subvariants from COVID-19 convalescents and vaccine recipients显示文摘Dear Editor,Omicron(B.1.1.529)was designated a variant of concern(VOC)on November 26,2021(Callaway,2021),and its subvariants BA.1,BA.2,and BA.3 emerged and circulated almost simultaneously(Desingu et al.,2022).BA.2 was more efficient in transmission and quickly overtook BA.1 to become the variant most frequently detected worldwide(Yamasoba et al.,2022a).Compared to the prototype SARS-CoV-2 spike protein(S),the BA.1 and BA.2 spike proteins harbor more than 30 mutations,of which 21 are identical between the two subvariants,while the BA.3 spike differs from BA.1 and BA.2 by 3 mutations in the receptor binding domain(RBD)(Fig.1A).More recently,BA.4 and BA.5(hereafter BA.4/5)emerged,sharing the same spike sequence and containing four additional mutations,Del69–70,L452R,F486V,and R493Q,compared with BA.2.BA.4/5 were detected first in South Africa and evolved independently of BA.2;they have spread widely and replaced BA.2 as the predominant VOC(Gruell et al.,2022b;Tegally et al.,2022).In addition,BA.2.75,derived from the BA.2 subvariant,harbors nine additional mutations in the spike protein compared with BA.2(Fig.1A).BA.4/5 and BA.2.75 have led to the continuous emergence of novel Omicron subvariants,including BF.7 and BQ.1.These new subvariants may be driving waves of pandemics. | Jun Chen Jing Yang Fangfang Chang Yabin Hu Qian Wu Shishan Teng Yongchen Liu Jian Zhang Rongzhang He Bo Liu Xingyu Zheng Ze Liu Yanxi Peng Zhenhua Xie Yuanfang Zhang Rui Lu Dong Pan You Wang Liting Peng Wenpei Liu Yi-Ping Li Xiaowang Qu | 2023 | Virologica Sinica2023，38，2： | 0 |
| 14 | SARS-CoV-2 spike-specific TFH cells exhibit unique responses in infected and vaccinated individuals显示文摘Long-term humoral immunity to SARS-CoV-2 is essential for preventing reinfection. The production of neutralizing antibody (nAb)and B cell differentiation are tightly regulated by T follicular help (T_(FH)) cells. However, the longevity and functional role of T_(FH) cellsubsets in COVID-19 convalescents and vaccine recipients remain poorly defined. Here, we show that SARS-CoV-2 infection andinactivated vaccine elicited both spike-specific CXCR3^(+) T_(FH) cell and CXCR3^(-) T_(FH) cell responses, which showed distinct responsepatterns. Spike- specific CXCR3^(+) T_(FH) cells exhibit a dominant and more durable response than CXCR3^(-) T_(FH) cells that positivelycorrelated with antibody responses. A third booster dose preferentially expands the spike-specific CXCR3^(+) T_(FH) cell subset inducedby two doses of inactivated vaccine, contributing to antibody maturation and potency. Functionally, spike-specific CXCR3^(+) T_(FH) cellshave a greater ability to induce spike-specific antibody secreting cells (ASCs) differentiation compared to spike-specific CXCR3^(-) T_(FH)cells. In conclusion, the persistent and functional role of spike-specific CXCR3^(+) T_(FH) cells following SARS-CoV-2 infection andvaccination may play an important role in antibody maintenance and recall response, thereby conferring long-term protection. Thefindings from this study will inform the development of SARS-CoV-2 vaccines aiming to induce long-term protective immunememory. | Rongzhang He Xingyu Zheng Jian Zhang Bo Liu Qijie Wang Qian Wu Ziyan Liur Fangfang Chang Yabin Hu Ting Xie Yongchen Liu Jun Chen Jing Yang Shishan Teng Rui Lu Dong Pan You Wang Liting Peng Weijin Huang Velislava Terzieva Wenpei Liu Youchun Wang Yi-Ping Li Xiaowang Qu | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 15 | Volunteer rescue dispatch during the Coronavirus Disease 2019 epidemic:Using the recruitment of volunteers for pneumonia epidemic prevention and control in Chun’an County as an example显示文摘To solve the problem of volunteer dispatch during the Coronavirus Disease 2019(COVID-19)epidemic,a many-to-many two-sided matching volunteer dispatch method based on an improved predator-search algorithm is pro-posed.First,different evaluation index sets for volunteers and rescue tasks were developed,and weightings were determined using the analytic hierarchy process.Subsequently,the actual and expected values of the different indicators of the two parties were determined,and the triangular fuzzy number was used to calculate the satis-faction of the two parties.Based on this number,we used a linear weighting method to calculate the combined satisfaction and build a many-to-many two-sided matching model according to the demands of both parties.Sub-sequently,an improved predator-search algorithm was used to solve the model.Finally,taking the recruitment of volunteers for pneumonia epidemic prevention and control in Chun’an County as an example,the method proposed in our study was verified.A comparison and analysis of the results further demonstrated the feasibility and advantages of this method. | Liting Chen Shengqun Chen Jing Zheng Jianqing Gao | 2022 | Journal of Safety Science and Resilience2022，3，4： | 0 |
| 16 | Antioxidant,flavor profile and quality of wheat dough bread incorporated with kiwifruit fermented byβ-glucosidase producing lactic acid bacteria strains显示文摘This study aimed to investigate the effect of incorporation of kiwifruit substrate fermented by 3 highβ-glucosidase producing lactic acid bacteria(LAB)of Lactobacillus harbinensis(M12,M24)and Pediococcus pentosaceus(J28)on physicochemical and rheo-fermentation properties during proofing of wheat dough.Quality,sensory evaluation,antioxidant content and activity,and flavor profiles of bread was evaluated.Results revealed that LAB strains adequately adapted(J28>M12>M24)and produced enzymes during substrate fermentation.In dough,incorporation of fermented substrate increased acidity,soluble dietary fiber,β-glucosidase andα-amylase activity and gas retention during proofing,in a strain dependent manner(J28>M12>M24).The subsequent breads exhibited higher specific volume and had softer crumbs.Furthermore,total flavonoid,total phenolic,antioxidant activity,flavor content and intensity increased in breads incorporated with fermented substrate.Overall sensory acceptance was in order,bread containing substrates fermented by J28(KFB-J28)>M12(KFB-M12)>M24(KFB-M24)>wheat bread(WB)>bread containing unfermented substrate(KFB).Changes observed were attributed to biotransformation byβ-glucosidase which increasingly degraded dietary fibers into soluble dietary fiber,increased acidity,released glycosylated aroma compounds and phenolic compounds in substrate.When incorporated in dough,fermented kiwifruit substrates stabilized gluten network,increased yeast metabolism and gas retention during proofing.Subsequently,KFB-J28,KFB-M12,and KFB-M24 had higher antioxidant content and activity,higher flavor content and intensity,better quality and were more accepted compared to WB and KFB.This suggested the potential role played byβ-glucosidases through LAB fermentation on functionally enriching and adding value to kiwifruit substrate as a novel functional ingredient in bakery industry. | Liting Liang Jacob Ojobi Omedi Weining Huang Jianxian Zheng Yongqing Zeng Jing Huang Binle Zhang Liyuan Zhou Ning Li Tiecheng Gao Ruijun Guo | 2022 | Food Bioscience2022，46，2： | 0 |
| 17 | X-ray sensitive high-Z metal nanocrystals for cancer imaging and therapy显示文摘Radiotherapy(RT)based on X-ray irradiation is a widely applied cancer treatment strategy in the clinic.However,treating cancer based on RT alone usually results in insufficient radiation energy deposition,which inevitably has serious side effects on healthy parts of the body.Interestingly,high atomic number(high-Z)metal nanocrystals as X-ray sensitizers can reduce the radiation dose effectively due to their high X-ray absorption,which has attracted increased attention in recent years.High-Z metal nanocrystals produce Auger and photoelectrons electrons under X-ray irradiation,which could generate large amounts of reactive oxygen species,and induce cellular damages.The sensitization effect of high-Z metal nanocrystals is closely related with their composition,morphologies,and size,which would strongly impact their performances in the application of cancer imaging and therapy.In this review,we summarize diverse types of X-ray sensitizers such as bismuth,hafnium,gold,and gadolinium for cancer RT and imaging applications.In addition,current challenges and the outlook of RT based on high-Z metal nanocrystals are also discussed. | Liting Zheng Rong Zhu Lanlan Chen Qinrui Fu Jingying Li Chen Chen Jibin Song Huanghao Yang | 2021 | Nano Research2021，14，11： | 0 |
| 18 | Carbon Monoxide Promotes the Catalytic Hydrogenation on Metal Cluster Catalysts显示文摘Size effect plays a crucial role in catalytic hydrogenation.The highly dispersed ultrasmall clusters with a limited number of metal atoms are one candidate of the next generation catalysts that bridge the single-atom metal catalysts and metal nanoparticles.However,for the unfavorable electronic property and their interaction with the substrates,they usually exhibit sluggish activity.Taking advantage of the small size,their catalytic property would be mediated by surface binding species.The combination of metal cluster coordination chemistry brings new opportunity.CO poisoning is notorious for Pt group metal catalysts as the strong adsorption of CO would block the active centers.In this work,we will demonstrate that CO could serve as a promoter for the catalytic hydrogenation when ultrasmall Pd clusters are employed.By means of DFT calculations,we show that Pd_(n)(n=2-147)clusters display sluggish activity for hydrogenation due to the too strong binding of hydrogen atom and reaction intermediates thereon,whereas introducing CO would reduce the binding energies of vicinal sites,thus enhancing the hydrogenation reaction.Experimentally,supported Pd_(2)CO catalysts are fabricated by depositing preestablished[Pd_(2)(μ-CO)_(2)Cl_(4)]2-clusters on oxides and demonstrated as an outstanding catalyst for the hydrogenation of styrene.The promoting effect of CO is further verified experimentally by removing and reintroducing a proper amount of CO on the Pd cluster catalysts. | Ruixuan Qin Pei Wang Pengxin Liu Shiguang Mo Yue Gong Liting Ren Chaofa Xu Kunlong Liu Lin Gu Gang Fu Nanfeng Zheng | 2020 | Research2020，，1： | 0 |
| 19 | Intrinsic spin shielding effect in platinum-rare-earth alloy boosts oxygen reduction activity显示文摘Oxygen reduction reactions(ORRs)involve a multistep proton-coupled electron process accompanied by the conversion of the apodictic spin configuration.Understanding the role of spin configurations of metals in the adsorption and desorption of oxygen intermediates during ORRs is critical for the design of efficient ORR catalysts.Herein,a platinum-rare-earth-metal-based alloy catalyst,Pt_(2)Gd,is introduced to reveal the role of spin configurations in the catalytic activity of materials.The catalyst exhibits a unique intrinsic spin reconfiguration because of interactions between the Gd-4f and Pt-5d orbitals.The adsorption and desorption of the oxygen species are optimized by modifying the spin symmetry and electronic structures of the material for increased ORR efficiency.The Pt_(2)Gd alloy exhibits a half-wave potential of 0.95 V and a superior mass activity of 1.5 A·mg Pt^(−1)in a 0.1 M HClO_(4)electrolyte,as well as higher durability than conventional Pt/C catalysts.Theoretical calculations have proven that the spin shielding effect of Gd pairs increases the spin symmetry of Pt-5d orbitals and adsorption preferences toward spin-polarized intermediates to facilitate ORR.This work clarifies the impact of modulating the intrinsic spin state of Pt through the interaction with the local high spin 4f orbital electrons in rare-earth metals,with the aim of boosting the spin-related oxygen reduction reaction,thus fundamentally contributing to the understanding of new descriptors that control ORR activity. | Siyuan Zhu Mingzi Sun Bingbao Mei Liting Yang Yuyi Chu Zhaoping Shi Jingsen Bai Xian Wang Zheng Jiang Changpeng Liu Bolong Huang Junjie Ge Wei Xing | 2023 | National Science Review2023，10，9： | 0 |
| 20 | 26 brands open first stores at Wuhan Tiandi显示文摘Having lunch,shopping for fashion brands,enjoying afternoon tea,then spending time at a bar in the evening...during this year's Mid-Autumn Festival,Ms.Li and her friend spent almost a whole day at Wuhan Tiandi.What partly enabled this consumption scenario was the various brands that have opened their first stores at the Wuhan Tiandi business circle. | Wang Zheng Wang Liting | 2022 | Changjiang Weekly2022，，37： | 0 |
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