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| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | Wheat powdery mildew resistance gene Pm64 derived from wild emmer (Triticum turgidum var.dicoccoides) is tightly linked in repulsion with stripe rust resistance gene Yr5显示文摘Stripe rust and powdery mildew are both devastating diseases for durum and common wheat.Pyramiding of genes conferring resistance to one or more diseases in a single cultivar is an important breeding approach to provide broader spectra of resistances in wheat improvement. A new powdery mildew resistance gene originating from wild emmer(Triticum turgidum var.dicoccoides) backcrossed into common wheat(T. aestivum) line WE35 was identified. It conferred an intermediate level of resistance to Blumeria graminis f. sp. tritici isolate E09 at the seedling stage and a high level of resistance at the adult plant stage. Genetic analysis showed that the powdery mildew resistance in WE35 was controlled by a dominant gene designated Pm64. Bulked segregant analysis(BSA) and molecular mapping indicated that Pm64 was located in chromosome bin 2 BL4-0.50–0.89. Polymorphic markers were developed from the corresponding genomic regions of Chinese Spring wheat and wild emmer accession Zavitan to delimit Pm64 to a 0.55 cM genetic interval between markers WGGBH1364 and WGGBH612, corresponding to a 15 Mb genomic region on Chinese Spring and Zavitan 2 BL, respectively. The genetic linkage map of Pm64 is critical for fine mapping and cloning. Pm64 was completely linked in repulsion with stripe rust resistance gene Yr5. Analysis of a larger segregating population might identify a recombinant line with both genes as a valuable resource in breeding for resistance to powdery mildew and stripe rust. | Deyun Zhang Keyu Zhu Lingli Dong Yong Liang Genqiao Li Tilin Fang Guanghao Guo Qiuhong Wu Jingzhong Xie Yongxing Chen Ping Lu Miaomiao Li Huaizhi Zhang Zhenzhong Wang Yan Zhang Qixin Sun Zhiyong Liu | 2019 | The Crop Journal2019，7，6： | 8 |
| 3 | Arsenic trioxide promotes senescence and regulates the balance of adipogenic and osteogenic differentiation in human mesenchymal stem cells显示文摘砷三氧化物(ATO ) 能在肿瘤房间作为反肿瘤药导致区别和 apoptosis。间充质的干细胞(MSC ) 在骨头髓的造血作用起重要作用。许多报告证明了 MSC adipogenic 和 osteogenic 区别的混乱发生在一些疾病。然而,关于 MSC 上的 ATO 的效果的报告是有限的。在这研究,我们发现 1 M ATO 主要通过 p21 支持了 MSC 老朽,尽管它没在这剂量在 apoptosis 上有效果。而且, ATO 支持了 adipogenic 区别,但是在 MSC 禁止了 osteogenic 区别。我们的学习也显示出那 CCAAT/enhancer-binding 蛋白质 alpha C/EBP 和 peroxisome 激活 proliferator 的受体 gamma PPAR 可能涉及 ATO 导致的 adipogenic 和 osteogenic 区别的规定。我们的结果显示 ATO 可以由影响骨头髓微型环境施加反肿瘤效果。而且,它可以调整 MSC 的 adipogenic 和 osteogenic 区别。 | Huanchen Cheng Lin Qiu Hao Zhang Mei Cheng Wei Li Xuefei Zhao Keyu Liu Lei Lei Jun Ma | 2011 | Acta Biochimica et Biophysica Sinica2011，43，3： | 8 |
| 4 | A new type of dehydration unit of natural gas and its design considerations显示文摘A new type of dehydration unit for natural gas is described and its basic structure and working principles are presented.The key factors affecting the performance and dehydration efficiency of the unit such as nucleation rate, droplet growth rate, the strength of the swirl, and the position at which the shock wave occurs are discussed. And accordingly the design considerations of each component of the unit are provided. Experimental investigations on the working performance of the unit justified the design considerations. | LIU Hengwei LIU Zhongliang ZHANG Jian GU Keyu YAN Tingmin | 2005 | Progress in Natural Science:Materials International2005，15，12： | 7 |
| 5 | Thermal stability of LiFePO_4/C-LiMn_2O_4 blended cathode materials显示文摘Safety is important to lithium ion battery materials. The thermal stability of LiFePO_4/C-LiMn_2O_4 blended cathode materials is characterized by using TG, XRD, and SEM etc. The results show that LiFePO_4/C-LiMn_2O_4 possesses a worse thermal stability than pure spinel LiMn_2O_4 and pure olivine LiFePO_4/C. When LiFePO_4/C-LiMn_2O_4 blended cathode materials are sintered at 500°C under Ar atmosphere, the sintered cathode materials emit O_2, and appear impurity phases(Li_3PO_4, Fe_2O_3, Mn_3O_4). It is deduced that some chemical reactions take place between different materials, which leads to a worse discharge specific capacity. LiFePO_4/C-LiMn_2O_4 blended cathode materials, therefore, need to be managed and controlled strictly for the sake of thermal stability and safety. | DU YuanChao HUANG XiaoPeng ZHANG KeYu LIANG Feng LI QiuXia YAO YaoChun DAI YongNian | 2017 | Science China(Technological Sciences)2017，60，1： | 5 |
| 6 | Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering显示文摘A close relationship has been reported to exist between cadherin-mediated cell-cell adhesion and integrin-mediated cell mobility,and protein tyrosine phosphatase 1B(PTP1B)may be involved in maintaining this homeostasis.The stable residence of mesenchymal stem cells(MSCs)and endothelial cells(ECs)in their niches is closely related to the regulation of PTP1B.However,the exact role of the departure of MSCs and ECs from their niches during bone regeneration is largely unknown.Here,we show that the phosphorylation state of PTP1B tyrosine-152(Y152)plays a central role in initiating the departure of these cells from their niches and their subsequent recruitment to bone defects.Based on our previous design of a PTP1B Y152 region-mimicking peptide(152RM)that significantly inhibits the phosphorylation of PTP1B Y152,further investigations revealed that 152RM enhanced cell migration partly via integrinαvβ3 and promoted MSCs osteogenic differentiation partly by inhibiting ATF3.Moreover,152RM induced type H vessels formation by activating Notch signaling.Demineralized bone matrix(DBM)scaffolds were fabricated with mesoporous silica nanoparticles(MSNs),and 152RM was then loaded onto them by electrostatic adsorption.The DBM-MSN/152RM scaffolds were demonstrated to induce bone formation and type H vessels expansion in vivo.In conclusion,our data reveal that 152RM contributes to bone formation by coupling osteogenesis with angiogenesis,which may offer a potential therapeutic strategy for bone defects. | Yong Tang Keyu Luo Yin Chen Yueqi Chen Rui Zhou Can Chen Jiulin Tan Moyuan Deng Qijie Dai Xueke Yu Jian Liu Chengmin Zhang Wenjie Wu Jianzhong Xu Shiwu Dong Fei Luo | 2021 | Bioactive Materials2021，6，7： | 3 |
| 7 | Basic fibroblast growth factor protects against influenza A virus-induced acute lung injury by recruiting neutrophils显示文摘Influenza virus (IAV)infection is a major cause of severe respiratory illness that affects almost every country in the world.IAV infections result in respiratory illness and even acute lung injury and death,but the underlying mechanisms responsible for IAV pathogenesis have not yet been fully elucidated.In this study,the basic fibroblast growth factor 2 (FGF2)level was markedly increased in H1N1 virus-infected humans and mice.FGF2,which is predominately derived from epithelial cells,recruits and activates neutrophils via the FGFR2-PI3K-AKT-NFKB signaling pathway.FGF2 depletion or knockout exacerbated influenzaassociated disease by impairing neutrophil recruitment and activation.More importantly,administration of the recombinant FGF2 protein significantly aUeviated the severity of IAV-induced lung injury and promoted the survival of IAV-infected mice.Based on the results from experiments in which neutrophils were depleted and adoptively transferred,FGF2 protected mice against IAV , infection by recruiting neutrophils.Thus,FGF2 plays a critical role in preventing IAV-induced lung injury,and FGF2 is a promising potential therapeutic target during IAV infection. | Keyu Wang Chengcai Lai Tieling Li Cheng Wang Wei Wang Bing Ni Changqing Bai Shaogeng Zhang Lina Han Hongjing Gu Zhongpeng Zhao Yueqiang Duan Xiaolan Yang Li Xing Lingna Zhao Shanshan Zhou Min Xia Chengyu Jiang Xiliang Wang Penghui Yang | 2018 | Journal of Molecular Cell Biology2018，10，6： | 3 |
| 8 | Geochemistry of Palaeozoic marine petroleum from the Tarim Basin, NW China: Part 3. Thermal cracking of liquid hydrocarbons and gas washing as the major mechanisms for deep gas condensate accumulations显示文摘 | Shuichang Zhang Jin Su Xiaomei Wang Guangyou Zhu Haijun Yang Keyu Liu Zhenxi Li | 2011 | Organic Geochemistry2011，，： | 2 |
| 9 | Depletion of VPS35 attenuates metastasis of hepatocellular carcinoma by restraining the Wnt/PCP signaling pathway显示文摘Vesicle Protein Sorting 35(VPS35)is a novel oncogene that promotes tumor growth through the PI3K/AKT signaling in hepatocellular carcinoma(HCC).However,the role of VPS35 in HCC metastasis and the underlying mechanisms remain largely unclear.In this study,we observed that overexpression of VPS35 enhanced hepatoma cell invasion and metastasis by inducing epithelialemesenchymal transition(EMT)-related gene expression.Conversely,knockout of VPS35 significantly inhibited hepatoma cell migration and invasion.Furthermore,depletion of VPS35 decreased the lung metastasis of HCC in nude mice.By transcriptome analysis,we determined that VPS35 promoted HCC metastasis by activating the Wnt/non-canonical planar cell polarity(PCP)pathway.Mechanistically,VPS35 activated the PCP pathway by regulating membrane sorting and trafficking of Frizzled-2(FZD2)and ROR1 in hepatoma cells.Collectively,our results indicate that VPS35 promotes HCC metastasis via enhancing the Wnt/PCP signaling,thus providing a potential prognostic marker and therapeutic target for HCC. | Yi Liu Haijun Deng Li Liang Guiji Zhang Jie Xia Keyue Ding Ni Tang Kai Wang | 2021 | Genes & Diseases2021，8，2： | 2 |
| 10 | Implications from Subseasonal Prediction Skills of the Prolonged Heavy Snow Event over Southern China in Early 2008显示文摘An exceptionally prolonged heavy snow event(PHSE)occurred in southern China from 10 January to 3 February 2008,which caused considerable economic losses and many casualties.To what extent any dynamical model can predict such an extreme event is crucial for disaster prevention and mitigation.Here,we found the three S2S models(ECMWF,CMA1.0 and CMA2.0)can predict the distribution and intensity of precipitation and surface air temperature(SAT)associated with the PHSE at 10-day lead and 10−15-day lead,respectively.The success is attributed to the models’capability in forecasting the evolution of two important low-frequency systems in the tropics and mid-latitudes[the persistent Siberian High and the suppressed phase of the Madden−Julian Oscillation(MJO)],especially in the ECMWF model.However,beyond the 15-day lead,the three models show almost no skill in forecasting this PHSE.The bias in capturing the two critical circulation systems is responsible for the low skill in forecasting the 2008 PHSE beyond the 15-day lead.On one hand,the models cannot reproduce the persistence of the Siberian High,which results in the underestimation of negative SAT anomalies over southern China.On the other hand,the models cannot accurately capture the suppressed convection of the MJO,leading to weak anomalous southerly and moisture transport,and therefore the underestimation of precipitation over southern China.The Singular Value Decomposition(SVD)analyses between the critical circulation systems and SAT/precipitation over southern China shows a robust historical relation,indicating the fidelity of the predictability sources for both regular events and extreme events(e.g.,the 2008 PHSE). | Keyue ZHANG Juan LI Zhiwei ZHU Tim LI | 2021 | Advances in Atmospheric Sciences2021，38，11： | 2 |
| 11 | Identification of long non-coding RNA p34822 as a potential plasma biomarker for the diagnosis of hepatocellular carcinoma显示文摘Dear Editor,Hepatocellular carcinoma(HCC)is the third leading cause of cancer-related deaths worldwide(Li and Satomura,2015).Early diagnosis and treatment are vital for reducing mortality.Currently,biomarkers such as serum alpha fetoprotein(AFP),AFP-L2,and carcinoembryonic antigen are widely used tumor markers for managing HCC in patients(Shi et al.,2016).However,because of their low diagnostic sensitivity and specificity,novel biomarkers with high sensitivity and specificity for early HCC diagnosis are needed. | Cheng Wang Tianyu Ren Keyu Wang Shaogeng Zhang Shubin Liu Hu Chen Penghui Yang | 2017 | Science China(Life Sciences)2017，60，9： | 2 |
| 12 | Preparation and characterization of nanocrystal grain TiO2 porous microsphere 显示文摘 | Zhang Baolong Chen Baishun Shi Keyu | 2003 | App lied Catalysis B : Enviromental2003，，40： | 1 |
| 13 | Structure and digestibility of endosperm water-soluble α-glucans from different sugary maize mutants显示文摘 | Ming Miao Rong Li Bo Jiang Steve W. Cui Keyu Lu Tao Zhang | 2014 | Food Chemistry2014，，： | 1 |
| 14 | CM-Droid: Secure Container for Android Password Misuse Vulnerability显示文摘Android applications are associated with a large amount of sensitive data,therefore application developers use encryption algorithms to provide user data encryption,authentication and data integrity protection.However,application developers do not have the knowledge of cryptography,thus the cryptographic algorithm may not be used correctly.As a result,security vulnerabilities are generated.Based on the previous studies,this paper summarizes the characteristics of password misuse vulnerability of Android application software,establishes an evaluation model to rate the security level of the risk of password misuse vulnerability and develops a repair strategy for password misuse vulnerability.And on this basis,this paper designs and implements a secure container for Android application software password misuse vulnerability:CM-Droid. | Wen Zhang Keyue Li Tianyang Li Shaozhang Niu Zhenguang Gao | 2019 | Computers, Materials & Continua2019，，4： | 1 |
| 15 | Effect of laser remelting on corrosion behavior of plasma-sprayed Ni-coated WC coatings显示文摘 | Xie Guozhi Zhang Jingxian Lu Yijun Wang Keyu Mo Xiangyin Lin Pinghua | 2007 | Materials Science & Engineering A2007，，： | 1 |
| 16 | Preparation and characterization of nanocrystal grain TiO2 porous microsphere显示文摘 | ZHANG Baolong CHEN Baishun SHI Keyu | 2003 | Applied Catalysis:B:Enviromental2003，40，： | 1 |
| 17 | Tight gas sandstone reservoirs in China: characteristics and recognition criteria显示文摘 | Caineng Zou Rukai Zhu Keyu Liu Ling Su Bin Bai Xiangxiang Zhang Xuejian Yuan Jinhong Wang | 2012 | Journal of Petroleum Science and Engineering2012，，： | 1 |
| 18 | Highly ordered iron oxide nanotube arrays as electrodes for electrochemical energy storage显示文摘 | Keyu Xie Jie Li Yanqing Lai Wei Lu Zhi’an Zhang Yexiang Liu Limin Zhou Haitao Huang | 2011 | Electrochemistry Communications2011，，6： | 1 |
| 19 | Evaluation of 40^Ar/39^Ar Geochronology of Authigenic Illites in Determining Hydrocarbon Charge Timing: A Case Study from the Silurian Bituminous Sandstone Reservoirs, Tarim Basin, China显示文摘The Silurian bituminous sandstones(SBS) in the Tarim Basin, China are important basinwide reservoirs with an estimated area of approximately 249000 km2. We investigated the ages of authigenic illites in the SBS reservoirs and constrained their formation timing by using the ^(40)Ar/^(39)Ar step wise heating method. The age spectra, ^(39)Ar recoil loss and their controlling factors were investigated systematically. The ^(40)Ar/^(39)Ar ages were compared with the conventional K/Ar ages of identical clay fractions. The clay in the SBS reservoirs is dominated by orderly mixed-layer illite/smectite(I/S) with 5%–30% smectite layers. The I/S minerals morphology comprises primarily honeycomb, short filamentous and curved-lath particles, characteristic of authigenic illites. The unencapsulated ^(40)Ar/^(39)Ar total gas ages(UTGA) of the authigenic illites range from 188.56 ± 6.20 Ma to 491.86 ± 27.68 Ma, which are 7% to 103% older than the corresponding K/Ar ages of 124.87 ± 1.11 Ma to 383.45 ± 2.80 Ma, respectively. The K-Ar ages indicate multistage accumulations with distinct distribution patterns in the Tarim Basin: older(late Caledonian-early Hercynian) around the basin margin, younger(late Hercynian) in the basin centre, and the youngest(middle to late Yanshanian) in the Ha-6 well-block, central area of the North Uplift. The age difference is believed to have been caused by the ^(39)Ar recoil loss during the irradiation process. Compared with the K/Ar ages, the estimated ^(39)Ar recoil losses in this study are in the range from 7% to 51%. The ^(39)Ar recoil loss appears to increase not only with the decreasing particle sizes of the I/S, but also with increasing percentage of smectite layers(IR) of the I/S, and smectite layer content(SLC) of the samples. We conclude that due to significant ^(39)Ar recoil losses, UTGA may not offer any meaningful geological ages of the authigenic illite formation in the SBS and thus can not be used to represent the hydrocarbon charge timing. ^(39)Ar recoil losses during ^(40)Ar/^(39)Ar dating can not be neglected when dating fine authigenic illite, especially when the ordered mixed-layer I/S containing small amount of smectite layers(IR<30%) in the reservoir formations. Compared with the unencapsulated Ar-Ar method, the conventional K-Ar method is less complicated, more accurate and reliable in dating authigenic illites in petroleum reservoirs. | ZHANG Youyu LIU Keyu LUO Xiuquan | 2016 | Acta Geologica Sinica(English Edition)2016，90，2： | 1 |
| 20 | Hydrocarbon charge history of the Silurian bituminous sandstone reservoirs in the Tazhong Uplift,Tarim Basin,China显示文摘 | Zhang Youyu Zwingmann H Liu Keyu | 2011 | AAPG Bulletin2011，95，3： | 1 |
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