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| 1 | Myeloid-specific targeting of Notch ameliorates murine renal fibrosis via reduced infiltration and activation of bone marrowderived macrophage显示文摘Macrophages play critical roles in renal fibrosis.However,macrophages exhibit ontogenic and functional heterogeneities,and which population of macrophages contributes to renal fibrosis and the underlying mechanisms remain unclear.In this study,we genetically targeted Notch signaling by disrupting the transcription factor recombination signal binding protein-JK(RBP-J),to reveal its role in regulation of macrophages during the unilateral ureteral obstruction(UUO)-induced murine renal fibrosis.Myeloid-specific disruption of RBP-J attenuated renal fibrosis with reduced extracellular matrix deposition and myofibroblast activation,as well as attenuated epithelial-mesenchymal transition,likely owing to the reduced expression of TGF-β.Mean while,RBP-J deletion significantly hampered macrophage infiltration and activation in fibrotic kidney,although their proliferation appeared unaltered.By using macrophage clearance experiment,we found that kidney resident macrophages made negligible contribution,but bone marrow(BM)-derived macrophages played a major role in renal fibrogenesis.Further mechanistic analyses showed that Notch blockade reduced monocyte emigration from BM by down-regulating CCR2 expression.Finally,we found that myeloid-specific Notch activation aggravated renal fibrosis,which was mediated by CCR2^+macrophages infiltration.In summary,our data have unveiled that myeloid-specific targeting of Notch could ameliorate renal fibrosis by regulating BM-derived macrophages recruitment and activation,providing a novel strategy for intervention of this disease. | Yali Jiang Yuanyuan Wang Pengfei Ma Dongjie An Junlong Zhao Shiqian Liang Yuchen Ye Yingying Lu Peng Zhang Xiaowei Liu Hua Han Hongyan Qin | 2019 | Protein & Cell2019，10，3： | 10 |
| 2 | The Late Pleistocene activity of the eastern part of east Kunlun fault zone and its tectonic significance显示文摘The nearly EW-trending East Kunlun fault zone is the north boundary of the Bayan Har block.The activity characteristics and the position of the eastern end of its eastward extension are of great significance to probing into the dynamic mechanism of formation of the east edge of the Tibetan Plateau,and also lay the foundation for seismic risk assessment of the fault zone.The following results are obtained by analysis based on satellite image interpretation of landforms,surface rupture survey,terrace scarp deformation survey,and terrace dating data on the eastern part of the East Kunlun fault zone:(1)the Luocha segment is a Holocene active fault,where a reverse L-shape paleoearthquake surface rupture zone of about 50 km long is located;(2)the Luocha segment is characterized by left-lateral slip movement under the compression-shear condition since the later period of the Late Pleistocene,with a rate of 7.68–9.37 mm/a and a vertical slip rate of 0.7–0.9 mm/a,which are basically in accord with the activity rate of segments on its west side.The results indicate that it is a part of eastward extension of the East Kunlun fault zone;(3)the high-speed linear horizontal slip of the nearly EW-trending East Kunlun fault zone is blocked by the South China block at east,and transforms into the vertical movement of the nearly SN-NNE trending Minjiang fault zone and the Longmenshan fault zone,and the uplift of Longmenshan and Minjiang.The area where transform of the two tectonic systems occurred confines the position of the east end;(4)Luocha segment and Maqu segment constitute the'Maqu seismic gap',so,seismic risk at Maqu segment is higher than that at Luocha segment,which should attract more attention. | ZHANG JunLong REN JinWei CHEN ChangYun FU JunDong YANG PanXin XIONG RenWei HU ChaoZhong | 2014 | Science China Earth Sciences2014，57，3： | 8 |
| 3 | The radioactive abnormality characteristics of typical regions in Ordos Basin and its geological implications显示文摘There are many results of single mineral enrichment characteristic, such as oil, gas, coal and uranium, but little is known about the synergistic research of these important minerals and the study of uranium enrichment features in the deep basin. So, the study on the paragenesis regularity and coexisting relation of many minerals in the basin will promote the integrated forecast and cooperative exploitation of the basin. Based on the plentiful logging data and geological data, this paper studies the distributing feature of higher Gamma abnormality. The analysis on 33 core samples' test results indicates that the increasing of Gamma abnormality is due to the increasing of the uranium element, and the enrichment of uranium is a result of the activation and conglomeration of uranium. On the basis of the recognization of radioactive abnormality and the study about the reality of oil,gas,coal or uranium coexisting in a basin and its mechanism, the paper shows that there is a certain mutual promotion in oil, gas, coal and uranium in the basin, which provides an important theory basis for cooperative exploitation of energy resources. | TAN ChengQian LIU ChiYang ZHAO JunLong ZHANG RongRong | 2007 | Science China Earth Sciences2007，50，z2： | 6 |
| 4 | A New Method of Thermal Protection by Opposing Jet for a Hypersonic Aeroheating Strut显示文摘This paper presents the numerical investigation of thermal protection of scramjet strut by opposing jet in supersonic stream of Mach number 6 with a hydrogen fueled scramjet strut model using CFD software. Simulation results indicate that when a small amount of fuel is injected from the nose of the strut, the bow shock is pushed away from the strut, and the heat flux is reduced in the strut, especially at the leading edge. Opposing jet forms a recirculation region near the nozzle so that the strut is covered with low temperature fuel and separated from free stream. An appropriate total pressure ratio can be used to reduce not only aerodynamic heating but also the drag of strut. It is therefore concluded that thermal protection of scramjet strut by opposing jet is one of the promising ways to protect scramjet strut in high enthalpy stream. | QIN Jiang NING Dongpo FENG Yu ZHANG Junlong FENG Shuo BAO Wen | 2017 | Journal of Thermal Science2017，26，3： | 4 |
| 5 | Parametric modeling of hypersonic ballistic data based on time varying auto-regressive model显示文摘For describing target motion in hypersonic vehicle defense,a parametric analyzing and modeling method on ballistic data is proposed based on time varying auto-regressive method.Ballistic data are regarded as non-stationary random signal,where the hidden internal law is studied.Firstly,ballistic data are decomposed into smooth linear trend signal and non-stationary periodic skip signal with ensemble empirical mode decomposition method to avoid mutual interference between different modal data.Secondly,the linear trend signal and the periodic skip signal are modeled separately.The linear trend signal is approximated by power function regressive estimator and the periodic skip signal is modeled based on time varying auto-regressive method.In order to determine optimal model orders,a novel method is presented based on information theoretic criteria and the criteria of minimizing the mean absolute error.Finally,the consistency test is conducted by investigating the time-frequency spectrum characteristics and statistical properties of outputs of the parametric model established above and dynamics model under the same initial condition.Simulation results demonstrate that the parametric model established by the proposed method shares a high consistency with the original dynamics model. | HU YuDong LI JunLong ZHANG Zhao JING WuXing GAO ChangSheng | 2020 | Science China(Technological Sciences)2020，63，8： | 3 |
| 6 | Tenofovir vs.entecavir on recurrence of hepatitis B virus-related hepatocellular carcinoma beyond Milan criteria after hepatectomy显示文摘Background:Hepatectomy for hepatocellular carcinoma(HCC)beyond the Milan criteria is shown to be beneficial.However,a high rate of post-operative HCC recurrence hinders the long-term survival of the patients.This study aimed to investigate and compare the impacts of tenofovir(TDF)and entecavir(ETV)on the recurrence of hepatitis B viral(HBV)-related HCC beyond the Milan criteria.Methods:Data pertaining to 1532 patients who underwent hepatectomy and received antiviral therapy between January 2014 and January 2019 were collected from five centers.Recurrence-free survival(RFS)analysis was performed using the Kaplan-Meier method.Cox proportional hazards regression analysis was performed to determine prognostic factors for HCC recurrence.Results:The analysis incorporates 595 HBV-related HCC patients.The overall 5-year RFS was 21.3%.Among them,533 and 62 patients received ETV and TDF treatment,respectively.The 1-,3-,and 5-year RFS rates were 46.3%,27.4%,and 19.6%,respectively,in the ETV group compared with 65.1%,41.8%,and 37.2%,respectively,in the TDF group(P<0.001).Multivariate analysis showed that TDF treatment(hazard ratio[HR]:0.604,P=0.005),cirrhosis(HR:1.557,P=0.004),tumor size(HR:1.037,P=0.008),microvascular invasion(MVI)(HR:1.403,P=0.002),portal vein tumor thrombus(PVTT)(HR:1.358,P=0.012),capsular invasion(HR:1.228,P=0.040),and creatinine levels(CREA)(HR:0.993,P=0.031)were statistically significant prognostic factors associated with RFS.Conclusions:Patients with HCC beyond the Milan criteria exhibited a high rate of HCC recurrence after hepatectomy.Compared to the ETV therapy,TDF administration significantly lowered the risk of HCC recurrence. | Junyi Shen Weili Qi Junlong Dai Shusheng Leng Kangyi Jiang Yu Zhang Shun Ran Chuan Li Tianfu Wen | 2022 | Chinese Medical Journal2022，，3： | 3 |
| 7 | Structural variation during dog domestication: insights from gray wolf and dhole genomes显示文摘Several processes like phenotypic evolution, disease susceptibility and environmental adaptations, which fashion the domestication of animals, are largely attributable to structural variations(SVs) in the genome.Here, we present high-quality draft genomes of the gray wolf(Canis lupus) and dhole(Cuon alpinus) with scaffold N50 of 6.04 Mb and 3.96 Mb, respectively. Sequence alignment comprising genomes of three canid species reveals SVs specific to the dog, particularly 16 315 insertions, 2565 deletions, 443 repeats, 16 inversions and 15 translocations. Functional annotation of the dog SVs associated with genes indicates their enrichments in energy metabolisms, neurological processes and immune systems. Interestingly, we identify and verify at population level an insertion fully covering a copy of the AKR1 B1(Aldo-Keto Reductase Family 1 Member B) transcript. Transcriptome analysis reveals a high level of expression of the new AKR1 B1 copy in the small intestine and liver, implying an increase in de novo fatty acid synthesis and antioxidant ability in dog compared to gray wolf, likely in response to dietary shifts during the agricultural revolution. For the first time, we report a comprehensive analysis of the evolutionary dynamics of SVs during the domestication step of dogs. Our findings demonstrate that retroposition can birth new genes to facilitate domestication, and affirm the importance of large-scale genomic variants in domestication studies. | Guo-Dong Wang Xiu-Juan Shao Bing Bai Junlong Wang Xiaobo Wang Xue Cao Yan-Hu Liu Xuan Wang Ting-Ting Yin Shao-Jie Zhang Yan Lu Zechong Wang Lu Wang Wenming Zhao Bing Zhang Jue Ruan Ya-Ping Zhang | 2019 | National Science Review2019，6，1： | 3 |
| 8 | Certificateless Public Verification for Data Storage and Sharing in the Cloud显示文摘By advances in cloud computing,users are allowed to remotely store their data in the cloud,manage the stored data without limitation of time and place,and give rights to visitors that want to access to their data.As may no longer possess data physically,the data owner has to ensure the integrity of the data with the public key given by Public key infrastructure(PKI).However,there are many security risks of the traditional PKI and the certificate management is complex.We utilize elliptic curve group to propose a certificateless signature to solve the above problem.To check the integrity of files stored in the cloud,we design a certificateless public verification mechanism based on the signature and further extend it to support batch auditing tasks.Meanwhile,an efficient key updating method is proposed to provide visitors a friendly data success environment.The security analysis proves that the proposed scheme is secure under the discrete logarithm assumption.Extensive theoretical analyses and experimental results show the effectiveness of the proposed scheme. | HUANG Longxia ZHOU Junlong ZHANG Gongxuan ZHANG Mingyue | 2020 | Chinese Journal of Electronics2020，29，4： | 3 |
| 9 | Report of epibenthic macrofauna found from Haima cold seeps and adjacent deep-sea habitats,South China Sea显示文摘This work reports on a preliminary taxonomic study of epibenthic macroinvertebrates collected or observed by underwater video at the Haima cold seeps and in adjacent deep-sea habitats,including a mud volcano feld and Ganquan Plateau,during an expedition in the South China Sea by the Chinese-manned submersible Shenhai Yongshi in May 2018.A total of 41 species belonging to 6 phyla were identifed,among which 34 species were collected from the Haima cold seeps.Mollusks and crustaceans that are specialized in reducing habitats were predominant in biotopes of the Haima cold seeps,whereas sponges and cold-water corals and their commensals were prominent in communities of the mud volcano feld and the slopes of Ganquan Plateau.The distribution and faunal composition of each taxonomic group are discussed. | Dong Dong Xinzheng Li Mei Yang Lin Gong Yang Li Jixing Sui Zhibin Gan Qi Kou Ning Xiao Junlong Zhang | 2021 | Marine Life Science & Technology2021，3，1： | 3 |
| 10 | Preseismic deformation associated with the 2014 Ms7.3 Yutian earthquake derived from GPS data显示文摘Based on analysis of the GPS data during 1999-2007,2009-2011,and 2011-2013 mainly from the Crustal Motion Observation Network of China,we obtained the GPS horizontal velocity field,the GPS strain rate field,and the profiles across the southwestern segment of the Altyn Tagh Fault zone and its adjacent regions and identified the different characteristics of horizontal crustal deformation fields and profiles during different periods. The results show that,before the February 12,2014,Ms7. 3 Yutian earthquake,the laevorotation deformation along the southwestern segment of the Altyn Tagh Fault zone increased about 3. 3 mm /a during 2011-2013,relative to that in 2009-2011,and the GPS strain rate field distributed in the southeastern segment of the Altyn Tagh Fault during 2011-2013 increased obviously. These abnormal changes may be regarded as precursors to the Ms7. 3 Yutian earthquake. | Chen Changyun Chen Fuchao Zheng Zhijiang Zhu Shuang Zhang Junlong Yang Panxin | 2014 | Geodesy and Geodynamics2014，5，2： | 3 |
| 11 | Light-induced protein translocation by genetically encoded unnatural amino acid in Caenorhabditis elegans显示文摘Dear Editor,Living systems such as Caenorhabditis elegans are organized by interaction networks of biopolymer and small mol-ecules.The molecular engineering of specifi c targets to monitor and control these biological molecules has led to significant advances in our understand-ing of how biological systems are organ-ized,maintain themselves and disin-tegrate(Prescher and Bertozzi,2005).For instance,green fl uorescent protein(GFP)derived from jellyfi sh Aequorea Victoria helps us to accurately locate and observe proteins over long term periods.In addition,many novel LOV(light,oxy-gen,or voltage)domains such as LOV2-Jαand Vivid offer the possibility of cell-based motility management and tissue-based gene expression control(Wu et al.,2009;Wang et al.,2012). | Hao Chang Mei Han Wenming Huang Guifeng Wei Juanjuan Chen Peng R.Chen Runsheng Chen Junlong Zhang Tao Xu Pingyong Xu | 2013 | Protein & Cell2013，4，12： | 2 |
| 12 | Synthesis of novel hierarchical porous polymers with a nanowire-interconnected network structure from core-shell polymer nanoobjects显示文摘Design and fabrication of the micro/nanostructures of the network units is a critical issue for porous nanonetwork structured materials. Significant progress has been attained in construction of the network units with zero-dimensional spherical shapes.However, owing to the limitations of synthetic methods, construction of porous building blocks in one dimension featuring high aspect ratios for porous nanonetwork structured polymer(PNSP) remains largely unexplored. Here we present the successful design and preparation of PNSP with a novel type of one-dimensional network unit, i.e., microporous heterogeneous nanowire. Well-defined core-shell polymer nanoobjects prepared from a gelable block copolymer, poly(3-(triethoxysilyl)propyl methacrylate)-block-polystyrene are employed as building blocks, and facilely transformed into PNSP via hypercrosslinking of polystyrene shell. The as-prepared PNSP exhibits unique three-dimensional hierarchical nanonetwork morphologies with large surface area. These findings could provide a new avenue for fabrication of unique well-defined PNSP, and thus generate valuable breakthroughs in many applications. | yeru liang yingbo ruan junlong huang bo peng chen-yang liu ruowen fu mingqiu zhang yongming chen dingcai wu | 2017 | Science China Chemistry2017，60，8： | 2 |
| 13 | Are Acila divaricata and Acila mirabilis One Species or Two Distinct Species? Evidence from COI Mitochondrial DNA显示文摘Acila divaricata(Hinds, 1843) and A. mirabilis(Adams and Reeve, 1850) are common benthic bivalves in China. A number of researchers have proposed that the latter species is a junior synonym of the former species. Because of morphological similarities, it is difficult to distinguish these two species based on visual examination only. For better understanding of their taxonomy, the mitochondrial COI gene fragments of five individuals of A. divaricata from the East China Sea and six individuals of A. mirabilis from the Yellow Sea were sequenced in this study. The phylogenetic relationships of the obtained COI sequences, together with nineteen sequences of three species of the genus Nucula, were analyzed. The pairwise intra- and inter-specific distances for the COI sequences ranged from 0.002 to 0.017 and from 0.128 to 0.134, respectively, and no overlap was found. Phylogenetically, A. divaricata and A. mirabilis form distinct clades and cluster into a sister to all other Nucula species. The results indicated that A. divaricata and A. mirabilis are two distinct species. The differences in the morphology and distribution between the two species were briefly discussed. | ZHANG Junlong SHI Huafeng XU Fengshan SHA Zhongli | 2014 | Journal of Ocean University of China2014，13，2： | 2 |
| 14 | Surface Rupture and Coseismic Displacement of the M_S7.1 Yushu Earthquake显示文摘On April 14,2010,a devastating earthquake measured 7.1 on the Richter scale struck Yushu county,Qinghai Province,China.Field geological investigation and remote sensing interpretation show that this earthquake generated an inverse 'L-shaped' surface rupture zone,approximately 50km long.The surface rupture zone can be divided into three segments.Between the northern and middle segments of the surface rupture,there is a 16km-long segment,where no rupture was observed.The middle and the southern segments are arranged in a left-step manner,and there are right-step en echelon ruptures developed in the stepovers.The seismogenic structure is the Yushu fault,which is dominated by strike-slip with a small amount of thrust component.The earthquake results from the differential movements between the southern Qiangtang Block and northern Bayan Har Block.The earthquake recurrence interval is 185a^108a.Along an approximately 20km-long part of the Garzê-Yushu fault,between the southern surface rupture of Yushu MS7.1 earthquake and the 1896 earthquake,there is no surface rupture,its seismic risk needs further research. | Zhang Junlong Chen Changyun Hu Chaozhong Yang Panxin Xiong Renwei Li Zhimin Ren Jinwei | 2011 | Earthquake Research in China2011，25，2： | 2 |
| 15 | A novel and smart automatic light-seeking flowerpot for monitoring flower growth environment显示文摘Although the flowerpot is widely used for indoor flowers,it cannot meet the needs of intelligent management during the uncared-for period.The objective of this study was to design a new microcontroller-based smart flowerpot.Its overall system was composed of three parts:information collection layer,automatic control layer and data transmission layer.Firstly,in the process of collecting information,the Laiyite criterion and the normalized weighted average algorithm were adopted to improve the accuracy of information collection.Secondly,for making precise control decisions,the fuzzy control was used to achieve automatic on-demand watering.Finally,the method for comparative analysis of regional light intensity was utilized to achieve light-seeking and light-supplementing.Experimental results showed that the smart flowerpot had strong anti-jamming performance for information collection,the relative soil moisture of flowers could be stably maintained near the optimum humidity(65%),and the light was well-distributed on the flower with the error angle of light-supplementing ranged from-3°to 3°. | Xihai Zhang Dong Liu Chengguo Fan Jiali Du Fanfeng Meng Junlong Fang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，2： | 2 |
| 16 | A Preliminary Study on a Seismotectonic Model for the Active Faults in the Xining Urban Area显示文摘On the basis of the Xining active urban fault survey,we studied the relationship between the active urban fault and fold deformation.The result of this research shows that the Huangshuihe fault and the NW-striking fault on the northern bank of the Huangshuihe River are tensional faults on top of an anticline,the Nanchuanhe fault is a transverse tear fault resulting from differential folding on two sides of the fault,the east bank of the Beichuanhe River fault is a compressional fault developed on the core or climb of a syncline.By balance profile analysis of fold deformation and inversion of gravity anomaly data,we obtained the depth of the detachment plane and established the seismotectonic model of the Xining urban area.Based on the seismotectonic model,we analyzed the earthquake potential of the active urban fault. | Tian Qinjian Li Zhimin Zhang Junlong Ren Zhikun | 2008 | Earthquake Research in China2008，22，1： | 2 |
| 17 | Survey and analysis of energy consumption in office buildings in Tianjin显示文摘 | Junlong LI Huan ZHANG Shijun YOU Zhenhui XIE | 2013 | Frontiers in Energy2013，7，1： | 2 |
| 18 | Fabrication of paper-based devices for in vitro tissue modeling显示文摘Paper devices have recently attracted considerable attention as a class of cost-effective cell culture substrates for various biomedical applications.The paper biomaterial can be used to partially mimic the in vivo cell microenvironments mainly due to its natural three-dimensional characteristic.The paper-based devices provide precise control over their structures as well as cell distributions,allowing recapitulation of certain interactions between the cells and the extracellular matrix.These features have shown great potential for the development of normal and diseased human tissue models.In this review,we discuss the fabrication of paper-based devices for in vitro tissue modeling,as well as the applications of these devices toward drug screening and personalized medicine.It is believed that paper as a biomaterial will play an essential role in the field of tissue model engineering due to its unique performances,such as good biocompatibility,eco-friendliness,cost-effectiveness,and amenability to various biodesign and manufacturing needs. | Hongbin Li Feng Cheng Juan A.Robledo-Lara Junlong Liao Zixuan Wang Yu Shrike Zhang | 2020 | Bio-Design and Manufacturing2020，3，3： | 1 |
| 19 | Sugar transfer of nanomaterials and flexible electrodes显示文摘Nanomaterials with various dimensionalities(e.g.,nanowires,nanofilms,two-dimensional materials,and three-dimensional nanostructures)have shown great potential in the recent development of flexible electronics.Conventionally,organic solvents are inevitable while integrating nanomaterials onto flexible substrates,where polymer mediator-assisted transfer techniques are involved.This often damages the flexible substrate and thus hamper the large-scale application of nanomaterials.Here we report a method using watersoluble sugar as a mediator to facilely transfer nanomaterials onto rigid or flexible substrates.This method requires no organic solvent during transfer.More importantly,the morphology and properties of transferred nanomaterials,such as shape,microstructure,resistivity,and transmittance are well preserved on the target substrate.We believe that this universal and rapid transfer method can greatly advance the applications of nanomaterials in the field of flexible devices and beyond. | Tianzeng Hong Tianze Shen Junlong Yang Yichen Sun Jianming Zhang Haiyang Pan Ying Hong Yan Wang Shuo Chen Yue Zhao Chuan Fei Guo | 2020 | International Journal of Smart and Nano Materials2020，11，1： | 1 |
| 20 | A compari- son study on microwave-assisted extraction of Artemisia sphaerocephala polysaccharides with conventional method: molecule structure and antioxidant activities evaluation 显示文摘 | Wang Junlong Zhang Ji Wang Xiaofang | 2009 | Int J Biol Marchomo12009，45，： | 1 |
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