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您的检索式：作者名="Zechong Wang"
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| 1 | Structural variation during dog domestication: insights from gray wolf and dhole genomes显示文摘Several processes like phenotypic evolution, disease susceptibility and environmental adaptations, which fashion the domestication of animals, are largely attributable to structural variations(SVs) in the genome.Here, we present high-quality draft genomes of the gray wolf(Canis lupus) and dhole(Cuon alpinus) with scaffold N50 of 6.04 Mb and 3.96 Mb, respectively. Sequence alignment comprising genomes of three canid species reveals SVs specific to the dog, particularly 16 315 insertions, 2565 deletions, 443 repeats, 16 inversions and 15 translocations. Functional annotation of the dog SVs associated with genes indicates their enrichments in energy metabolisms, neurological processes and immune systems. Interestingly, we identify and verify at population level an insertion fully covering a copy of the AKR1 B1(Aldo-Keto Reductase Family 1 Member B) transcript. Transcriptome analysis reveals a high level of expression of the new AKR1 B1 copy in the small intestine and liver, implying an increase in de novo fatty acid synthesis and antioxidant ability in dog compared to gray wolf, likely in response to dietary shifts during the agricultural revolution. For the first time, we report a comprehensive analysis of the evolutionary dynamics of SVs during the domestication step of dogs. Our findings demonstrate that retroposition can birth new genes to facilitate domestication, and affirm the importance of large-scale genomic variants in domestication studies. | Guo-Dong Wang Xiu-Juan Shao Bing Bai Junlong Wang Xiaobo Wang Xue Cao Yan-Hu Liu Xuan Wang Ting-Ting Yin Shao-Jie Zhang Yan Lu Zechong Wang Lu Wang Wenming Zhao Bing Zhang Jue Ruan Ya-Ping Zhang | 2019 | National Science Review2019，6，1： | 3 |
| 2 | Enhanced methane recovery and exoelectrogen-methanogen evolution from low-strength wastewater in an up-flow biofilm reactor with conductive granular graphite fillers显示文摘 | Zechong Guo Lei Gao Ling Wang Wenzong Liu Aijie Wang | 2018 | Frontiers of Environmental Science & Engineering2018，12，4： | 2 |
| 3 | Enhanced hydrogen production in microbial electrolysis through strategies of carbon recovery from alkaline/thermal treated sludge显示文摘The aim of this study was to investigate the biohydrogen production from thermal(T),alkaline(A)or thermal-alkaline(TA)pretreated sludge fermentation liquid(SFL)in a microbial electrolysis cells(MECs)without buffer addition.Highest hydrogen yield of 36.87±4.36 mgH_(2)/gVSS(0.026 m^(3)/kg COD)was achieved in TA pretreated SFL separated by centrifugation,which was 5.12,2.35 and 43.25 times higher than that of individual alkaline,thermal pretreatment and raw sludge,respectively.Separating SFL from sludge by centrifugation eliminated the negative effects of particulate matters,was more conducive for hydrogen production than filtration.The accumulated short chain fatty acid(SCFAs)after pretreatments were the main substrates for MEC hydrogen production.The maximum utilization ratio of acetic acid,propionic acid and n-butyric acid was 93.69%,90.72%and 91.85%,respectively.These results revealed that pretreated WAS was highly efficient to stimulate the accumulation of SCFAs.And the characteristics and cascade bioconversion of complex substrates were the main factor that determined the energy efficiency and hydrogen conversion rate of MECs. | Ling Wang Chunxue Yang Sangeetha Thangavel Zechong Guo Chuan Chen Aijie Wang Wenzong Liu | 2021 | Frontiers of Environmental Science & Engineering2021，15，4： | 0 |
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